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1.发明公开1,3,4-OXADIAZOLE AND 1,3,4-THIADIAZOLE BETA-LACTAMASE INHIBITORS 有权1,3,4-OXADIAZOL- UND 1,3,4-THIADIAZOL-BETA-LACTAMASE-INHIBITOREN
公开(公告)号：EP2831075A4
公开(公告)日：2015-09-09
申请号：EP13769724
申请日：2013-03-29
申请人： CUBIST PHARM INC
发明人： GU YU GUI , HE YONG , YIN NING , ALEXANDER DYLAN C , CROSS JASON B , METCALF CHESTER A III , BUSCH ROBERT
IPC分类号： C07D471/08 , A61K31/439 , A61P31/04
CPC分类号： A61K31/546 , A61K31/407 , A61K31/427 , A61K31/436 , A61K31/439 , A61K31/545 , A61K45/06 , C07D471/08 , A61K2300/00
摘要： &bgr;-Lactamase inhibitor compounds (BLIs) are disclosed, including compounds that have activity against class A, class C or class D &bgr;-lactamases. Methods of manufacturing the BLIs, and uses of the compounds in the preparation of pharmaceutical compositions and antibacterial applications are also disclosed.
摘要翻译： 公开了 - 内酰胺酶抑制剂化合物（BLI），包括具有针对A类，C类或D类β-内酰胺酶的活性的化合物。 还公开了制备BLI的方法和化合物在制备药物组合物和抗菌应用中的用途。
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公开(公告)号：EP0951557A4
公开(公告)日：2005-02-09
申请号：EP97946473
申请日：1997-10-24
申请人： CUBIST PHARM INC
发明人： PETERSON TODD C , FOSTER LYNDON M , BRIAN PAUL
IPC分类号： G06F17/30 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/10 , C12N15/64 , C12N15/66 , C12N15/81 , C12Q1/68
CPC分类号： C12Q1/6811 , C12N15/1027 , C12N15/1034 , C12N15/66
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3.发明公开COMPOSITIONS AND METHODS RELATING TO THE DAPTOMYCIN BIOSYNTHETIC GENE CLUSTER 审中-公开组合物和方法中涉及达托霉素生物合成基因
公开(公告)号：EP1421097A4
公开(公告)日：2005-07-06
申请号：EP02759231
申请日：2002-07-31
申请人： CUBIST PHARM INC
IPC分类号： C12N5/02 , C12N15/52 , C07H21/04 , C12N1/14 , C12N1/16 , C12N1/20 , C12N5/00 , C12N15/74 , C12P21/06 , C12Q1/68
CPC分类号： C12N15/52
摘要： The invention provides nucleic acid molecules comprising all or a part of a daptomycin biosynthetic gene cluster. The daptomycin biosynthetic gene cluster may be derived from Streptomyces , preferably from S. roseosporus . The invention also provides other nucleic acid molecules from S. roseosporus . The invention further provides polypeptides encoded by the nucleic acid molecules, antibodies that specifically bind to the polypeptides, and methods of using the nucleic acid molecules, polypeptides and antibodies to produce daptomycin and other compounds.
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公开(公告)号：EP1176959A4
公开(公告)日：2002-10-09
申请号：EP00932063
申请日：2000-05-05
申请人： MERCK & CO INC , CUBIST PHARM INC
发明人： LEEMAN AARON H , HAMMOND MILTON L , MALETIC MILANA , SANTORELLI GINA M , WADDELL SHERMAN F , FINN JOHN , MORYTKO MICHAEL , RAM SIYA , KEITH DENNIS
IPC分类号： C07D487/04 , A61K31/4184 , A61K31/42 , A61K31/427 , A61K31/437 , A61K31/519 , A61P31/00 , A61P31/04 , A61P31/10 , A61P43/00 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00 , C07D473/34 , A61K31/422 , A61K31/52 , C07D401/12 , C07D403/14
CPC分类号： C07D403/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00 , C07D473/34
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公开(公告)号：EP0991412A4
公开(公告)日：2000-06-21
申请号：EP97954582
申请日：1997-12-18
申请人： CUBIST PHARM INC
发明人： HILL JASON M , KLUGE ARTHUR F
IPC分类号： A61P17/06 , C07H19/16 , A61K31/70 , C07H19/167
CPC分类号： C07H19/16
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公开(公告)号：EP2504353A4
公开(公告)日：2014-04-02
申请号：EP10832379
申请日：2010-11-23
申请人： CUBIST PHARM INC
发明人： SUN SOPHIE , NAIK GAAURI , O'CONNOR SANDRA
CPC分类号： A61K47/26 , A61K9/00 , A61K9/0019 , A61K9/08 , A61K9/19 , A61K38/00 , A61K38/10 , A61K38/12 , A61K47/183 , C07K11/02
摘要： The present disclosure provides novel powder daptomycin formulations which have improved chemical stability and faster reconstitution times when in the solid state. Some examples of the compositions comprise daptomycin and sucrose.
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8.发明公开LIPOPEPTIDE STEREOISOMERS, METHODS FOR PREPARING SAME, AND USEFUL INTERMEDIATES 有权脂肽的立体异构体，方法用于生产和有用的中间体
公开(公告)号：EP1423137A4
公开(公告)日：2005-11-30
申请号：EP02789158
申请日：2002-08-06
申请人： CUBIST PHARM INC
发明人： MORYTKO MICHAEL , ZHANG YANZHI , JUNG MICHAEL , FINN JOHN , BOUCHARD MARIO
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公开(公告)号：EP1176958A4
公开(公告)日：2002-07-17
申请号：EP00930366
申请日：2000-05-05
申请人： MERCK & CO INC , CUBIST PHARM INC
发明人： LEEMAN AARON H , HAMMOND MILTON L , MALETIC MILANA , SANTORELLI GINA M , WADDELL SHERMAN F , FINN JOHN , MORYTKO MICHAEL , HILL JASON , KEITH DENNIS
IPC分类号： A61K31/4184 , A61K31/437 , A61K31/454 , A61P31/04 , A61P31/10 , C07D215/14 , C07D233/54 , C07D235/12 , C07D401/12 , C07D403/12 , C07D405/12 , C07D471/04 , C07D521/00 , A61K31/4178 , A61K31/4439 , A61K31/4709 , A61K31/5377 , A61P31/00 , C07D235/14 , C07D235/16
CPC分类号： C07D233/64 , C07D215/14 , C07D231/12 , C07D233/56 , C07D235/12 , C07D249/08 , C07D401/12 , C07D403/12 , C07D405/12
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公开(公告)号：EP2831069A4
公开(公告)日：2015-06-03
申请号：EP13769389
申请日：2013-03-29
申请人： CUBIST PHARM INC
发明人： GU YU GUI , HE YONG , YIN NING , ALEXANDER DYLAN C , CROSS JASON B , METCALF CHESTER A III , BUSCH ROBERT
IPC分类号： C07D451/06 , A61K31/46 , A61P31/00 , C07D471/08
CPC分类号： A61K31/439 , A61K31/397 , A61K31/407 , A61K31/427 , A61K31/4365 , A61K31/437 , A61K31/4545 , A61K31/545 , A61K31/546 , A61K45/06 , C07D471/08 , A61K2300/00
摘要： &bgr;-Lactamase inhibitor compounds (BLIs) are disclosed, including compounds that have activity against class A, class C or class D &bgr;-lactamases. Methods of manufacturing the BLIs, and uses of the compounds in the preparation of pharmaceutical compositions and antibacterial applications are also disclosed.
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