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公开(公告)号：EP3183348A4
公开(公告)日：2018-01-17
申请号：EP15834609
申请日：2015-08-21
申请人： EPIMERON INC
发明人： FACCHINI PETER JAMES
IPC分类号： C12N15/53 , A01H1/00 , A01H1/04 , A01H5/00 , C07D489/08 , C12N9/04 , C12N9/90 , C12N15/00 , C12N15/61 , C12N15/63 , C12N15/82 , C12P17/18 , C12Q1/68
CPC分类号： C07D489/02 , C07D489/08 , C12N9/0006 , C12N9/90 , C12P17/18 , C12P17/188 , C12Y101/01247
摘要： Methods that may be used for the manufacture of a class of chemical compounds known as morphinans, including neopine, are provided. Compositions useful for the synthesis of morphinans, including neopine, are also provided.
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2.发明公开
公开(公告)号：EP3137618A4
公开(公告)日：2017-12-13
申请号：EP15785253
申请日：2015-04-27
申请人： EPIMERON INC
发明人： FACCHINI PETER JAMES
IPC分类号： C12N13/00 , C12N15/00 , C12N15/10 , C12N15/52 , C12N15/54 , C12N15/62 , C12N15/63 , C12P13/00 , C12P17/00 , C12P17/12 , C12Q1/68 , C40B10/00 , C40B20/00 , C40B30/00
CPC分类号： C12P17/12 , C12N15/1082 , C12N15/1096 , C12N15/63 , C12Y201/01 , C40B10/00 , C40B20/00
摘要： Novel methods that may be used for the manufacture of plant alkaloid compounds and novel polynucleotide compounds are provided. The plant alkaloid compounds are useful as medicinal compounds.
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3.发明公开COMPOSITIONS AND METHODS FOR MAKING NOSCAPINE AND SYNTHESIS INTERMEDIATES THEREOF 审中-公开组合物及其制造方法诺斯卡与合成及其中间体
公开(公告)号：EP3033347A4
公开(公告)日：2017-04-12
申请号：EP14836518
申请日：2014-08-15
申请人： EPIMERON INC
IPC分类号： C07D491/056 , C12P17/18
CPC分类号： C07D491/056 , C12P17/18
摘要： Methods for the manufacture of the therapeutic chemical compound noscapine and noscapine synthesis intermediates comprising contacting a noscapine pathway precursor selected from a first canadine derivative, a first papaveroxine derivative and narcotine hemiacetal with at least one of the enzymes selected from the group CYP82Y1, CYP82X1, AT1, CYP82X2, OMT, CXE1 and NOS.
摘要翻译： 用于治疗性化合物诺斯卡品和诺斯卡品合成中间体包括使从第一canadine衍生物，第一papaveroxine衍生物和可汀半缩醛与选自CYP82Y1，CYP82X1，AT1选择的酶的至少一个中选择的诺斯卡品途径前体的制造方法 ，CYP82X2，OMT，CXE1和NOS。
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公开(公告)号：EP3158073A4
公开(公告)日：2017-11-22
申请号：EP15810408
申请日：2015-06-12
申请人： EPIMERON INC
发明人： FACCHINI PETER JAMES
IPC分类号： C12P17/12 , C12N9/02 , C12N9/06 , C12N9/88 , C12N15/52 , C12N15/53 , C12N15/60 , C12N15/63 , C12P7/24 , C12P7/42 , C12P7/44 , C12P13/00 , C12P13/22
CPC分类号： C12P17/12 , C12N9/0022 , C12N9/0059 , C12N9/88 , C12P7/24 , C12P13/001 , C12P13/22
摘要： Methods that may be used for the manufacture of the chemical compound (S)-norcoclaurine, (S)-norlaudanosoline, and (S)-norcoclaurine or [S]-norlaudanosoline synthesis intermediates are provided. (S)-Norcoclaurine, (S)-norlaudanosoline, and (S)-norcoclaurine or (S)-norlaudanosoline synthesis intermediates are useful as precursor products in the manufacture of certain medicinal agents.
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5.发明公开IMPROVED METHODS FOR MAKING AND USING POLYNUCLEOTIDE SEQUENCES IN THE SYNTHESIS OF ALKALOID COMPOUNDS 审中-公开改进方法生物碱合成的制备和核苷酸的使用
公开(公告)号：EP3137618A1
公开(公告)日：2017-03-08
申请号：EP15785253.4
申请日：2015-04-27
申请人： Epimeron Inc.
IPC分类号： C12P17/12 , C12N15/00 , C12N15/52 , C12N15/54 , C12N15/62 , C12N15/63 , C12N13/00 , C12P13/00 , C12P17/00 , C12Q1/68 , C40B20/00 , C40B30/00
CPC分类号： C12P17/12 , C12N15/1082 , C12N15/1096 , C12N15/63 , C12Y201/01 , C40B10/00 , C40B20/00
摘要： Novel methods that may be used for the manufacture of plant alkaloid compounds and novel polynucleotide compounds are provided. The plant alkaloid compounds are useful as medicinal compounds.
摘要翻译： 新方法也可用于植物生物碱化合物和新的多核苷酸的化合物的制造中提供。 所述植物生物碱化合物用作药用化合物是有用的。
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6.发明公开COMPOSITIONS AND METHODS FOR MAKING NOSCAPINE AND SYNTHESIS INTERMEDIATES THEREOF 审中-公开组合物及其制造方法诺斯卡与合成及其中间体
公开(公告)号：EP3033347A1
公开(公告)日：2016-06-22
申请号：EP14836518.2
申请日：2014-08-15
申请人： Epimeron Inc.
IPC分类号： C07D491/147 , A61K31/4741 , C07D217/20 , C07D405/04 , C07D491/056 , C12P17/10 , C12P17/16 , C12P17/18
CPC分类号： C07D491/056 , C12P17/18
摘要： Methods for the manufacture of the therapeutic chemical compound noscapine and noscapine synthesis intermediates comprising contacting a noscapine pathway precursor selected from a first canadine derivative, a first papaveroxine derivative and narcotine hemiacetal with at least one of the enzymes selected from the group CYP82Y1, CYP82X1, AT1, CYP82X2, OMT, CXE1 and NOS.
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公开(公告)号：EP3183348A1
公开(公告)日：2017-06-28
申请号：EP15834609.8
申请日：2015-08-21
申请人： Epimeron Inc.
IPC分类号： C12N15/53 , A01H1/00 , A01H1/04 , A01H5/00 , C12N15/00 , C12N15/61 , C12N15/63 , C12N15/82 , C12N9/04 , C12N9/90 , C12P17/18 , C12Q1/68 , C07D489/02
CPC分类号： C07D489/02 , C07D489/08 , C12N9/0006 , C12N9/90 , C12P17/18 , C12P17/188 , C12Y101/01247
摘要： Methods that may be used for the manufacture of a class of chemical compounds known as morphinans, including neopine, are provided. Compositions useful for the synthesis of morphinans, including neopine, are also provided.
摘要翻译： 提供了可用于制造一类称为吗啡喃的化学化合物的方法，包括氯苯灵。 还提供了可用于合成吗啡喃类化合物的组合物，包括氯苯灵。
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8.发明公开COMPOSITIONS AND METHODS FOR MAKING (R)-RETICULINE AND PRECURSORS THEREOF 审中-公开ZUSAMMENSETZUNGEN UND VERFAHREN ZUR HERSTELLUNG VON（R）-RETICULIN UNDVORLÄUFERNDAVON
公开(公告)号：EP3077513A4
公开(公告)日：2017-06-21
申请号：EP14867017
申请日：2014-12-03
申请人： EPIMERON INC
IPC分类号： C12N15/63 , A01H1/04 , A01H1/06 , A01H5/00 , C12N9/02 , C12N9/04 , C12N9/10 , C12N15/52 , C12N15/82 , C12P17/10 , C12P17/12 , C12Q1/68
CPC分类号： C12P17/12 , A01H1/06 , C12N9/0006 , C12N9/1085 , C12N15/8218 , C12N15/8243 , C12Y101/01247 , C12Y205/01059
摘要： Methods that may be used for the manufacture of the chemical compound (R)-Reticuline and synthesis precursors thereof. Compositions useful for the synthesis (R)-Reticuline and synthesis precursors are also provided.
摘要翻译： 可用于制造化合物（R） - 网状番荔枝碱及其合成前体的方法。 还提供了用于合成（R） - 网状番荔枝碱和合成前体的组合物。
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9.发明公开COMPOSITIONS AND METHODS FOR MAKING (S)-NORCOCLAURINE AND (S)-NORLAUDANOSOLINE, AND SYNTHESIS INTERMEDIATES THEREOF 有权组合物和方法（S）AND -NORCOCLAURIN（S）AND -NORLAUDANOSOLIN合成中间体物的制备
公开(公告)号：EP3158073A1
公开(公告)日：2017-04-26
申请号：EP15810408.3
申请日：2015-06-12
申请人： Epimeron Inc.
IPC分类号： C12P17/12 , C12N15/52 , C12N15/53 , C12N15/60 , C12N15/63 , C12N9/02 , C12N9/88 , C12P13/00 , C12P13/22 , C12P7/42 , C12P7/44
摘要： Methods that may be used for the manufacture of the chemical compound (S)-norcoclaurine, (S)-norlaudanosoline, and (S)-norcoclaurine or [S]-norlaudanosoline synthesis intermediates are provided. (S)-Norcoclaurine, (S)-norlaudanosoline, and (S)-norcoclaurine or (S)-norlaudanosoline synthesis intermediates are useful as precursor products in the manufacture of certain medicinal agents.
摘要翻译： 方法都可以被用于化学化合物（S）-norcoclaurine，（S）-norlaudanosoline，和（S）-norcoclaurine或[S]提供-norlaudanosoline合成中间体的制造。 （S）-Norcoclaurine，（S）-norlaudanosoline，和（S）-norcoclaurine或（S）-norlaudanosoline合成中间体是作为前体产品中某些药剂的制造中是有用的。
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10.发明公开COMPOSITIONS AND METHODS FOR MAKING (R)-RETICULINE AND PRECURSORS THEREOF 审中-公开组合物和方法的（R）-RETICULIN和前体及其制备
公开(公告)号：EP3077513A1
公开(公告)日：2016-10-12
申请号：EP14867017.7
申请日：2014-12-03
申请人： Epimeron Inc.
IPC分类号： C12N15/63 , A01H1/04 , A01H1/06 , A01H5/00 , C12N15/52 , C12N15/82 , C12N9/02 , C12P17/10 , C12Q1/68
CPC分类号： C12P17/12 , A01H1/06 , C12N9/0006 , C12N9/1085 , C12N15/8218 , C12N15/8243 , C12Y101/01247 , C12Y205/01059
摘要： Methods that may be used for the manufacture of the chemical compound (
R )- Reticuline and synthesis precursors thereof. Compositions useful for the synthesis (
R) -Reticuline and synthesis precursors are also provided.摘要翻译： 方法都可以被用于化学化合物（R）和-Reticuline合成前体的制造。 用于合成有用的组合物因此，提供（R）-Reticuline和合成前体。
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