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1.发明公开ISOLATED GUM OPERON FROM XYLLELA FASTIDIOSA, ISOLATED NUCLEIC ACID MOLECULES THEREFROM, AND USES THEREOF 有权ISOLATED GUM OPERON OFF XYLLELA fastidiosa，分离的核酸分子及其用途
公开(公告)号：EP1283868A2
公开(公告)日：2003-02-19
申请号：EP01934259.1
申请日：2001-05-07
发明人： Arruda, PauloUniversidade Estadual de Campinas , Da Silva, Felipe R.Uni. Estadual de Campinas , Kemper, Edson L.Universidade Estadual de Campinas , Vettore, AndreUniversidade Estadual de Campinas , Leite, AdilsonUniversidade Estadual de Campinas , Da Silva, Marcio J.Uni. Estadual de Campinas
IPC分类号： C12N1/00
CPC分类号： C12N15/52 , C07K14/195 , C12N9/1029 , C12N9/1048 , C12N9/1051 , C12P19/06
摘要： This invention relates to the isolation and characterization of an operon from the organism Xylella fastidiosa. This operon, referred to as the XfGUM operon, contains 9 genes, and is involved in the production of a compound with xanthan gum like properties. The expression products of the operon and genes are also a part of the invention, as are various uses of these.
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2.发明授权ISOLATED GUM OPERON FROM XYLLELA FASTIDIOSA, ISOLATED NUCLEIC ACID MOLECULES THEREFROM, AND USES THEREOF 有权ISOLATED GUM OPERON OFF XYLLELA fastidiosa，分离的核酸分子及其用途
公开(公告)号：EP1283868B1
公开(公告)日：2009-07-29
申请号：EP01934259.1
申请日：2001-05-07
发明人： Arruda, Paulo Universidade Estadual de Campinas , Da Silva, Felipe R. Uni. Estadual de Campinas , Kemper, Edson L. Universidade Estadual de Campinas , Vettore, Andre Universidade Estadual de Campinas , Leite, Adilson Universidade Estadual de Campinas , Da Silva, Marcio J. Uni. Estadual de Campinas
CPC分类号： C12N15/52 , C07K14/195 , C12N9/1029 , C12N9/1048 , C12N9/1051 , C12P19/06
摘要： This invention relates to the isolation and characterization of an operon from the organism Xylella fastidiosa . This operon, referred to as the XfGUM operon, contains 9 genes, and is involved in the production of a compound with xanthan gum like properties. The expression products of the operon and genes are also a part of the invention, as are various uses of these.
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3.发明公开USE OF POTHOMORPHE UMBELLATA EXTRACT, COMPOSITION ON BASIS OF POTHOMORPHE UMBELLATA EXTRACT AND METHOD OF APPLICATION OF THE POTHOMORPHE UMBELLATA EXTRACT 有权USING A POTHOMORPHE猪苓提取物和提取物基于POTHOMORPHE猪苓凝胶组合物。
公开(公告)号：EP1578433A1
公开(公告)日：2005-09-28
申请号：EP03797114.0
申请日：2003-09-17
IPC分类号： A61K35/78
CPC分类号： A61Q19/00 , A61K8/97 , A61K36/23 , A61K36/67 , A61K2800/522 , A61Q17/04 , A61Q19/004 , A61Q19/08
摘要： The present invention relates to the use of the Pothomorphe umbellata extract to prepare dermocosmetic and/or pharmaceutical compositions for the treatment and/or prevention of photodamage in the skin, cutaneous aging and/or skin cancer. It also refers to der mocosmetic and/or pharmaceutical compositions for treatment and/or prevention of such photodamage in the skin, cutaneous aging and/or skin cancer prepared on basis of the defined extract. In addition, it provides a method of application of the dermocosmetic and/or pharmaceutical compositions prepared on the basis of the extract of this plant, in way to treat and/or prevent the damage caused to the skin by the excessive exposure to ultraviolet rays of the sun and to artificial tanning lamps.
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4.发明授权PROCESS FOR PROTECTION OF INSOLUBLE ENZYMATIC BIOCATALYSTS, BIOCATALYST OBTAINED THEREOF AND BIOREACTOR WITH THE IMMOBILIZED BIOCATALYST 有权一种用于保护不溶性的酶法生物催化剂，文章和GOT生物催化剂，生物反应器中固定的生物催化剂
公开(公告)号：EP1565546B1
公开(公告)日：2010-11-03
申请号：EP03773360.7
申请日：2003-11-24
申请人： Fundaçao Universidade Federal De Sao Carlos , Fundacao de Amparo a Pesquisa do Estado de Sao Paulo - FAPESP
发明人： GIORDANO de Campos, Roberto , GIORDANO de Lima, Raquel Camargo , FERREIRA de Oliveira, Andrea Lopes
CPC分类号： C12Y305/01011 , C12M21/08 , C12M27/02 , C12M41/22 , C12N9/84 , C12N11/10 , C12P35/00 , C12P37/00
摘要： The purpose of the present invention is to provide a process for protection of enzymatic biocatalysts, constituted by a primary support, wrapped by a secondary matrix. More particularly, the invention is embodied as a bioreactor with a configuration that preserves the physical integrity and catalytic activity of the biocatalyst after long runs, and at the same time allows an easy separation of the protected biocatalyst from the solid, precipitated during the reaction course. Still more particularly, the invention refers to the use of the bioreactor herein described for the enzymatic synthesis of β-lactam antibiotics, including the insoluble enzymatic catalysts, which have a primary matrix for immobilization involved by a secondary matrix, which is able to preserve 100% of the catalyst physical integrity and approximately 100% of its catalytic activity.
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5.发明公开PHARMACEUTICAL COMPOSITION TO PREVENT AND TREAT EPITHELIAL WOUNDS, IMMUNOMODULATING PHARMACEUTICAL COMPOSITION, PHARMACEUTICAL COMPOSITION, INSECTICIDE, INSECTICIDE COMPOSITION, INSECTICIDE USE OF LECTIN KM+ TO TREAT CICATRIZATIONS, USE OF LECTIN KM+ TO PREPARE IMMUNOMODULATING MEDICAMENT 审中-公开药物组合物预防和上皮创伤治疗药物，免疫调节药物组合物，药物组合物，杀虫剂，用杀虫剂组合物，凝集素KM +疤痕训练中使用的凝集素KM +的用于生产药物的免疫调节治疗杀虫剂的使用
公开(公告)号：EP1635891A2
公开(公告)日：2006-03-22
申请号：EP04733749.8
申请日：2004-05-19
发明人： PINTO DA SILVA, Luis Lamberti , PANUNTO CASTELO, Ademilson , DE SOUZA GOLDMAN, Maria Helena , ROQUE ANTUNES BARREIRA, Maria Cristina , DE OLIVEIRA, Ricardo Santos , DIAS BARUFFI, Marcelo , BLANCO DE MOLFETTA MACHADO, Jeanne
IPC分类号： A61M1/00
CPC分类号： A61K38/168 , C07K14/42
摘要： The invention deals with a pharmaceutical composition comprising lectin KM+ to prevent and heal epithelial wounds. The invention also comprises the use of lectin KM+, obtained from the plant Artocarpus integrifolia or the use of recombinant lectin to prepare medicaments.
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公开(公告)号：EP1866332B1
公开(公告)日：2014-09-17
申请号：EP06721611.9
申请日：2006-03-17
发明人： YAMANE, Tetsuo , KERKIS, Irina , KERKIS, Alexandre , BAPTISTA, Gandhi, Rádis , HAYASHI, Mirian, Akemi, Furuie , KONNO, Katsuhiro , DA SILVA, Alvaro, Rossan, B., P. , PEREIRA, Lygia, da Veiga , DE OLIVEIRA, Eduardo, Brandt
CPC分类号： A61K9/0019 , A61K38/17 , A61K47/02 , A61K47/62 , A61K47/6951 , A61K49/0032 , A61K49/0047 , A61K49/0056 , B82Y5/00 , C07K14/46
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7.发明授权USE OF POTHOMORPHE UMBELLATA EXTRACT AND GEL COMPOSITION ON BASIS OF POTHOMORPHE UMBELLATA EXTRACT 有权USING A POTHOMORPHE猪苓提取物和提取物基于POTHOMORPHE猪苓凝胶组合物。
公开(公告)号：EP1578433B1
公开(公告)日：2010-08-18
申请号：EP03797114.0
申请日：2003-09-17
CPC分类号： A61Q19/00 , A61K8/97 , A61K36/23 , A61K36/67 , A61K2800/522 , A61Q17/04 , A61Q19/004 , A61Q19/08
摘要： The present invention relates to the use of the Pothomorphe umbellata extract to prepare dermocosmetic and/or pharmaceutical compositions for the treatment and/or prevention of photodamage in the skin, cutaneous aging and/or skin cancer. It also refers to der mocosmetic and/or pharmaceutical compositions for treatment and/or prevention of such photodamage in the skin, cutaneous aging and/or skin cancer prepared on basis of the defined extract. In addition, it provides a method of application of the dermocosmetic and/or pharmaceutical compositions prepared on the basis of the extract of this plant, in way to treat and/or prevent the damage caused to the skin by the excessive exposure to ultraviolet rays of the sun and to artificial tanning lamps.
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公开(公告)号：EP1866332A1
公开(公告)日：2007-12-19
申请号：EP06721611.9
申请日：2006-03-17
发明人： YAMANE, Tetsuo , KERKIS, Irina , KERKIS, Alexandre , BAPTISTA, Gandhi, Rádis , HAYASHI, Mirian, Akemi, Furuie , KONNO, Katsuhiro , DA SILVA, Alvaro, Rossan, B., P. , PEREIRA, Lygia, da Veiga , DE OLIVEIRA, Eduardo, Brandt
CPC分类号： A61K9/0019 , A61K38/17 , A61K47/02 , A61K47/62 , A61K47/6951 , A61K49/0032 , A61K49/0047 , A61K49/0056 , B82Y5/00 , C07K14/46
摘要： The present invention refers to uses of crotamine and compositions containing it, based on its characteristic of interaction with genetic material. Under submicromolar quantities, the polypeptide is no longer toxic, presenting the characteristics properties of cell penetration, transport of molecules to the surface, cytoplasm or cell nucleus and particularly, selective cell penetration. The invention also refers to compositions comprising a pharmaceutically effective concentration of crotamine and its use for the treatment of diseases and dysfunctions, based on its characteristics of interaction with genetic material, such as DNA and RNA, and cell selectivity. Further, the invention refers to a kit comprising crotamine as a reagent to: (i) transfect or carry molecules to the surface, cytoplasm or nucleus of the cell or (ii) identify and select actively proliferating cells in a mixed cell population, particularly the ones originated from the umbilical cord and/or bone marrow.
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9.发明公开KERATOMETRIC MODULE FOR COUPLING TO SLIT LAMPS AND OR OCULAR MICROSCOPES 审中-公开KERATOMETRISCHES模块，连接SLIT灯和/或眼显微镜
公开(公告)号：EP1641383A1
公开(公告)日：2006-04-05
申请号：EP03779589.5
申请日：2003-12-19
发明人： SCHIABEL, Liliane Ventura, Rua Demétrio Miltre , GROOTE, Jean-Jacques, Georges Soares de , SOUSA, Sidney Julio de Faria
IPC分类号： A61B3/107
摘要： The present invention refers to an ophthalmic instrument coupled to a Slit Lamp or Ocular Microscope (1) that utilizes imaging to selectively measure corneal curvature and examine its surface under examination mode of the instrument in reference, constituted of a ring or mask (2) projected by light, prisms and/or semi-transparent mirror, and an apparatus for observing the image reflected by the surface, which allows the passage of light reflected off the patient’s cornea through axes A and B, and indicates the eye to be measured, right or left.
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10.发明公开
公开(公告)号：EP1587819A2
公开(公告)日：2005-10-26
申请号：EP02704503.8
申请日：2002-03-18
发明人： MARTINS DE CAMARGO, Antônio Carlos , CALHETA VIERIA PORTARO, Fernanda , FERRAGINI MURBACK, A,Centro.Toxicologia Aplicada , ALVES IANZER, D.,Centro de Toxicologia Aplicada , POLISELLI FARSKY, S, H,Centro Toxicologia aplica. , PALMA, Mario Sergio,Centro Toxicologia Aplicada , MIRIAN,Akemi,Furuie,Hayashi,Centro de toxicologia
IPC分类号： C07K1/00
CPC分类号： C12N9/6418 , A61K38/00
摘要： The present invention patent refers to the isolation and purification of peptides secreted by serpent venom glands, specifically Bothrops jararaca; to the peptide thus obtained, as well as to the production procedures by genetic engineering techniques in procaryotic and eukaryotic systems; to the engineered peptide thus obtained; to the production of said peptide by chemical synthesis, as well as to the peptide resulting from this chemical processing. It also refers to the utilization of said peptides, obtained by different procedures, in distinct pharmaceutical compositions, and introduced into the organism by a variety of means, in order for them to act as inhibitors of vasopeptidases, and consequently reduce systemic arterial blood pressure, and show local vasodilating action.
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