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公开(公告)号：EP1908757A4
公开(公告)日：2010-05-19
申请号：EP06767927
申请日：2006-07-06
发明人： IMAMURA MASAKAZU , SUZUKI TAKAYUKI , MURAKAMI TAKESHI , NAKANISHI KEITA , UEBAYASHI HIROSHI , NAKAMURA HARUKA , YUDA MASAMICHI , AMENOMIYA NAOKO , AWAMURA YUUJI , TOMIYAMA HIROSHI
IPC分类号： C07D309/10 , A61K31/351 , A61P3/10 , C07C215/90
CPC分类号： C07C215/90 , C07D309/10
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公开(公告)号：EP1790641A4
公开(公告)日：2009-08-26
申请号：EP05783391
申请日：2005-09-14
申请人： ASTELLAS PHARMA INC
发明人： MURAKAMI TAKESHI , KAWANO TOMOAKI , SHIRAKI RYOTA , ISHII HIROFUMI , YOSHIMURA SEIJI , OHKAWA TAKEHIKO , HOSAKA MITSURU , FUKUDOME HIROKI , INOKI YUTAKA
IPC分类号： C07D249/08 , A61K31/4196 , A61K31/4439 , A61K31/454 , A61K31/55 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/12 , A61P19/10 , A61P25/28 , A61P27/06 , A61P43/00 , C07D401/08 , C07D403/08 , C07D409/08 , C07D487/04
CPC分类号： C07D409/14 , C07D249/08 , C07D401/04 , C07D401/08 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/06 , C07D409/08 , C07D417/12 , C07D471/04 , C07D487/04
摘要： [PROBLEMS] TO provide a compound usable in treating diseases in which 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) participates, in particular, diabetes and insulin resistance. [MEANS FOR SOLVING PROBLEMS] It is found out that a triazole derivative characterized by being substituted by a trisubstituted methyl group at the 2-position of the triazole ring or a pharmaceutically acceptable salt thereof has a potent 11β-HSD1 inhibitory activity. Moreover, this triazole derivative exhibits an excellent hypoglycemic effect, which makes it usable in treating diabetes and insulin resistance.
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公开(公告)号：EP1609785A4
公开(公告)日：2008-10-22
申请号：EP04720254
申请日：2004-03-12
发明人： IMAMURA MASAKAZU , MURAKAMI TAKESHI , SHIRAKI RYOTA , IKEGAI KAZUHIRO , SUGANE TAKASHI , IWASAKI FUMIYOSHI , KUROSAKI EIJI , TOMIYAMA HIROSHI , NODA ATSUSHI , KITTA KAYOKO , KOBAYASHI YOSHINORI
IPC分类号： A61K31/351 , A61K31/381 , A61K31/4035 , A61K31/404 , A61K31/41 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/4433 , A61K31/497 , A61K31/5377 , A61P3/04 , A61P3/10 , C07D207/06 , C07D309/10 , C07D333/12 , C07D333/16 , C07D333/54 , C07D405/04 , C07D405/10 , C07D407/04 , C07D409/04 , C07D409/10 , C07D409/14 , C07D413/10 , C07D417/10 , C07D493/04 , C07D495/04 , A61K31/49 , C07D407/10
CPC分类号： C07D495/04 , A61K31/351 , A61K31/381 , A61K31/4035 , A61K31/404 , A61K31/41 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/4433 , A61K31/497 , A61K31/5377 , C07D405/10 , C07D407/10 , C07D409/10 , C07D413/10 , C07D417/10
摘要： A C-glycoside derivative represented by the following general formula (I) or its salt which is a compound useful as a Na+-glucose co-transportation inhibitor in a remedy for, e.g., diabetes, in particular, insulin-independent diabetes (type 2 diabetes) and insulin-dependent diabetes (type 1 diabetes), as well as a remedy for insulin resistance diseases and various diseases relating to diabetes including obesity. This compound is characterized in that the ring B is bonded to the ring A via -X- and the ring A is bonded directly to a sugar residue.
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公开(公告)号：EP1553094A4
公开(公告)日：2006-10-11
申请号：EP03766722
申请日：2003-08-04
发明人： TOMIYAMA HIROSHI , NODA ATSUSHI , KITTA KAYOKO , KOBAYASHI YOSHINORI , IMAMURA MASAKAZU , MURAKAMI TAKESHI , IKEGAI KAZUHIRO , SUZUKI TAKAYUKI , KUROSAKI EIJI
IPC分类号： C07D309/12 , A61K31/351 , A61P3/04 , A61P3/10 , A61P43/00 , C07D309/10
CPC分类号： C07D309/12 , C07D309/10
摘要： Azulene derivatives represented by the following general formula (I) and salts thereof are useful as Na+-glucose cotransporter inhibitors in, for example, remedies for diabetes, etc., in particular, insulin-independent diabetes (type 2 diabetes), insulin-dependent diabetes (type 1 diabetes), etc., and remedies for various diabetes-related diseases such as insulin resistant disease and obesity. These compounds are characterized in that an azulene ring is bonded, either directly or via an optionally halogenated lower alkylene, to a benzene ring and the benzene ring is directly bonded to a sugar residue.
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