-
公开(公告)号：EP4356971A3
公开(公告)日：2024-07-24
申请号：EP23213609.3
申请日：2017-05-05
发明人： SIDRAUSKI, Carmela , PLIUSHCHEV, Marina , FROST, Jennifer, M. , BLACK, Lawrence, A. , XU, Xiangdong , SWEIS, Ramzi, Farath , SHI, Lei , ZHANG, Qingwei , TONG, Yunsong , HUTCHINS, Charles, W. , CHUNG, Seungwon , DART, Michael, J.
IPC分类号： C07D213/73 , C07D317/64 , C07D231/56 , C07D401/04 , C07D237/14 , C07D237/16 , C07D405/08 , C07D241/18 , C07D471/04 , C07D261/08 , C07D261/20 , C07C235/00 , C07D271/113 , C07D213/30 , C07D213/64 , C07D213/66 , A61K31/44 , A61P35/00
CPC分类号： C07D213/73 , C07D317/64 , C07D231/56 , C07C311/13 , C07D401/04 , C07C311/24 , C07D237/14 , C07D237/16 , C07C317/22 , C07D405/08 , C07D241/18 , C07D261/08 , C07D261/20 , C07C235/22 , C07D271/113 , C07D213/30 , C07D213/64 , C07D213/66 , C07C2602/3820170501 , C07C2602/4020170501 , C07C2602/4220170501 , C07C2602/4420170501 , C07C2603/9020170501 , C07D471/04 , A61P25/28
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
-
公开(公告)号：EP3864003A1
公开(公告)日：2021-08-18
申请号：EP19795413.4
申请日：2019-10-11
发明人： MARTIN, Kathleen, Ann , SIDRAUSKI, Carmela , DART, Michael, J. , FROST, Jennifer, M. , TONG, Yunsong , XU, Xiangdong , SHI, Lei , MURAUSKI, Kathleen , PLIUSHCHEV, Marina , BROWN, Brian, S. , VOIGHT, Eric , RANDOLPH, John, T.
IPC分类号： C07C235/36 , C07C271/34 , C07C303/34 , C07D221/00 , C07F9/09
-
公开(公告)号：EP3452448A1
公开(公告)日：2019-03-13
申请号：EP17723899.5
申请日：2017-05-05
发明人： SIDRAUSKI, Carmela , PLIUSHCHEV, Marina , FROST, Jennifer, M. , BLACK, Lawrence, A. , XU, Xiangdong , SWEIS, Ramzi, Farath , SHI, Lei , ZHANG, Qinwei, I. , TONG, Yunsong , HUTCHINS, Charles, W. , CHUNG, Seungwon , DART, Michael, J.
IPC分类号： C07D213/73 , C07D317/64 , C07D231/56 , C07D401/04 , C07D237/14 , C07D237/16 , C07D405/08 , C07D241/18 , C07D471/04 , C07D261/08 , C07D261/20 , C07C235/00 , C07D271/113 , C07D213/30 , C07D213/64 , C07D213/66 , A61K31/44 , A61P35/00
-
公开(公告)号：EP3778575A1
公开(公告)日：2021-02-17
申请号：EP20184319.0
申请日：2017-05-05
发明人： SIDRAUSKI, Carmela , PLIUSHCHEV, Marina , FROST, Jennifier M. , BLACK, Lawrence A. , XU, Xiangdong , SWEIS, Ramzi Farah , SHI, Lei , ZHANG, Qingwei I. , TONG, Yunsong , HUTCHINS, Charles W. , CHUNG, Seungwon , DART, Michael J.
IPC分类号： C07D233/64 , C07D401/12 , C07D413/12 , C07D471/04 , C07D271/06 , C07D271/10 , A61K31/4245 , A61P35/00
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
-
5.发明公开6-PHENYL- OR 6-(PYRIDIN-3-YL)INDAZOLE DERIVATIVES AND METHODS OF USE 审中-公开6-PHENYL-ODER 6-（PYRIDIN-3-YL）INDAZOL-DERIVATE UND VERFAHREN ZUR VERWENDUNG
公开(公告)号：EP3097091A1
公开(公告)日：2016-11-30
申请号：EP15703161.8
申请日：2015-01-16
申请人： AbbVie Inc.
发明人： SCANIO, Marc , BUNNELLE, William , KOENIG, John Robert , DRIZIN, Irene , PLIUSHCHEV, Marina , COWART, Marlon
IPC分类号： C07D401/14 , C07D401/10 , C07D403/10 , C07D403/14 , C07D407/14 , A61K31/416
CPC分类号： C07D231/56 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D413/10 , C07D417/14 , C07D471/04 , C07D487/10
摘要： Compounds of formula (I) and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein R1, R2, R3, R4, R5, R6, and X are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by Tropomysin receptor kinases (Trk). Methods for making the compounds are disclosed. Also disclosed are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.
摘要翻译： 式（I）化合物及其药学上可接受的盐，酯，酰胺或放射性标记形式，其中R 1，R 2，R 3，R 4，R 5，R 6和X如说明书中所定义，可用于治疗病症或障碍 由Tropomysin受体激酶（Trk）改善或改善。 公开了制备化合物的方法。 还公开了式（I）化合物的药物组合物，以及使用这些化合物和组合物的方法。
-
公开(公告)号：EP2665711A1
公开(公告)日：2013-11-27
申请号：EP12701822.4
申请日：2012-01-20
申请人： Abbvie Inc.
IPC分类号： C07D213/81 , C07D401/12 , C07D409/12 , C07D413/12 , A61K31/444 , A61P35/00
CPC分类号： C07D401/12 , C07D213/81 , C07D409/12 , C07D413/12
摘要： The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R
1 , R
2 , R
3 , A, B, Z, n, and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as ALK and methods of treating diseases such as cancer.-
公开(公告)号：EP4356971A2
公开(公告)日：2024-04-24
申请号：EP23213609.3
申请日：2017-05-05
发明人： SIDRAUSKI, Carmela , PLIUSHCHEV, Marina , FROST, Jennifer, M. , BLACK, Lawrence, A. , XU, Xiangdong , SWEIS, Ramzi, Farath , SHI, Lei , ZHANG, Qingwei , TONG, Yunsong , HUTCHINS, Charles, W. , CHUNG, Seungwon , DART, Michael, J.
IPC分类号： A61P35/00
CPC分类号： C07D213/73 , C07D317/64 , C07D231/56 , C07C311/13 , C07D401/04 , C07C311/24 , C07D237/14 , C07D237/16 , C07C317/22 , C07D405/08 , C07D241/18 , C07D261/08 , C07D261/20 , C07C235/22 , C07D271/113 , C07D213/30 , C07D213/64 , C07D213/66 , C07C2602/3820170501 , C07C2602/4020170501 , C07C2602/4220170501 , C07C2602/4420170501 , C07C2603/9020170501 , C07D471/04 , A61P25/28
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
-
公开(公告)号：EP4209483A1
公开(公告)日：2023-07-12
申请号：EP22210424.2
申请日：2019-10-11
发明人： MARTIN, Kathleen Ann , SIDRAUSKI, Carmela , DART, Michael J. , FROST, Jennifer M. , TONG, Yunsong , XU, Xiangdong , SHI, Lei , MURAUSKI, Kathleen , PLIUSHCHEV, Marina , BROWN, Brian S. , VOIGHT, Eric , RANDOLPH, John T.
IPC分类号： C07C235/36 , C07C271/34 , C07C303/34 , C07D221/00 , C07F9/09
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
-
公开(公告)号：EP3452453A1
公开(公告)日：2019-03-13
申请号：EP17724209.6
申请日：2017-05-05
发明人： SIDRAUSKI, Carmela , PLIUSHCHEV, Marina , FROST, Jennifer, M. , BLACK, Lawrence, A. , XU, Xiangdong , SWEIS, Ramzi, Farah , SHI, Lei , ZHANG, Qinwei, I , TONG, Yunsong , HUTCHINS, Charles, W. , CHUNG, Seungwon , DART, Michael, J.
IPC分类号： C07D231/12 , C07D237/08 , C07D239/34 , C07D241/12 , C07D471/04 , C07D261/08 , C07D263/32 , C07D271/07 , C07D277/28 , C07D209/14 , C07D213/40 , C07D213/64 , C07D307/52 , A61K31/4402 , A61P35/00
-
公开(公告)号：EP2665725A1
公开(公告)日：2013-11-27
申请号：EP12736704.3
申请日：2012-01-20
申请人： AbbVie Inc.
发明人： VASUDEVAN, Anil , PENNING, Thomas Dale , CHEN, Huanming , LIANG, Bo , WANG, Shaohui , ZHAO, Zhongqiang , CHAI, Dikun , YANG, Leifu , GAO, Yingxiang , PLIUSHCHEV, Marina
IPC分类号： C07D471/04 , C07D217/24 , C07D239/88 , A61K31/435 , A61K31/495 , A61P35/00
CPC分类号： C07D471/04 , C07D401/12
摘要： The present invention relates to compounds of formula (1) or pharmaceutical acceptable salts, Formula (1) wherein R
1 , R
2 , R
3 , X, Y, Z, A, B, G
1 , m, and n are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as ALK and methods of treating diseases such as cancer.摘要翻译： 本发明涉及式（1）化合物或其药学上可接受的盐，其中R 1，R 2，R 3，X，Y，Z，A，B，G 1，m和n在 说明。 本发明还涉及含有可用于抑制激酶如ALK的所述化合物的组合物和治疗疾病如癌症的方法。
-
-
-
-
-
-
-
-
-
搜索结果
11 条记录 (耗时 0.017 秒)
