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公开(公告)号：EP3778575A1
公开(公告)日：2021-02-17
申请号：EP20184319.0
申请日：2017-05-05
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： SIDRAUSKI, Carmela , PLIUSHCHEV, Marina , FROST, Jennifier M. , BLACK, Lawrence A. , XU, Xiangdong , SWEIS, Ramzi Farah , SHI, Lei , ZHANG, Qingwei I. , TONG, Yunsong , HUTCHINS, Charles W. , CHUNG, Seungwon , DART, Michael J.
IPC: C07D233/64 , C07D401/12 , C07D413/12 , C07D471/04 , C07D271/06 , C07D271/10 , A61K31/4245 , A61P35/00
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：EP4356971A3
公开(公告)日：2024-07-24
申请号：EP23213609.3
申请日：2017-05-05
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： SIDRAUSKI, Carmela , PLIUSHCHEV, Marina , FROST, Jennifer, M. , BLACK, Lawrence, A. , XU, Xiangdong , SWEIS, Ramzi, Farath , SHI, Lei , ZHANG, Qingwei , TONG, Yunsong , HUTCHINS, Charles, W. , CHUNG, Seungwon , DART, Michael, J.
IPC: C07D213/73 , C07D317/64 , C07D231/56 , C07D401/04 , C07D237/14 , C07D237/16 , C07D405/08 , C07D241/18 , C07D471/04 , C07D261/08 , C07D261/20 , C07C235/00 , C07D271/113 , C07D213/30 , C07D213/64 , C07D213/66 , A61K31/44 , A61P35/00
CPC classification number: C07D213/73 , C07D317/64 , C07D231/56 , C07C311/13 , C07D401/04 , C07C311/24 , C07D237/14 , C07D237/16 , C07C317/22 , C07D405/08 , C07D241/18 , C07D261/08 , C07D261/20 , C07C235/22 , C07D271/113 , C07D213/30 , C07D213/64 , C07D213/66 , C07C2602/3820170501 , C07C2602/4020170501 , C07C2602/4220170501 , C07C2602/4420170501 , C07C2603/9020170501 , C07D471/04 , A61P25/28
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：EP3864003A1
公开(公告)日：2021-08-18
申请号：EP19795413.4
申请日：2019-10-11
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： MARTIN, Kathleen, Ann , SIDRAUSKI, Carmela , DART, Michael, J. , FROST, Jennifer, M. , TONG, Yunsong , XU, Xiangdong , SHI, Lei , MURAUSKI, Kathleen , PLIUSHCHEV, Marina , BROWN, Brian, S. , VOIGHT, Eric , RANDOLPH, John, T.
IPC: C07C235/36 , C07C271/34 , C07C303/34 , C07D221/00 , C07F9/09
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公开(公告)号：EP3452448A1
公开(公告)日：2019-03-13
申请号：EP17723899.5
申请日：2017-05-05
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： SIDRAUSKI, Carmela , PLIUSHCHEV, Marina , FROST, Jennifer, M. , BLACK, Lawrence, A. , XU, Xiangdong , SWEIS, Ramzi, Farath , SHI, Lei , ZHANG, Qinwei, I. , TONG, Yunsong , HUTCHINS, Charles, W. , CHUNG, Seungwon , DART, Michael, J.
IPC: C07D213/73 , C07D317/64 , C07D231/56 , C07D401/04 , C07D237/14 , C07D237/16 , C07D405/08 , C07D241/18 , C07D471/04 , C07D261/08 , C07D261/20 , C07C235/00 , C07D271/113 , C07D213/30 , C07D213/64 , C07D213/66 , A61K31/44 , A61P35/00
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公开(公告)号：EP4356971A2
公开(公告)日：2024-04-24
申请号：EP23213609.3
申请日：2017-05-05
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： SIDRAUSKI, Carmela , PLIUSHCHEV, Marina , FROST, Jennifer, M. , BLACK, Lawrence, A. , XU, Xiangdong , SWEIS, Ramzi, Farath , SHI, Lei , ZHANG, Qingwei , TONG, Yunsong , HUTCHINS, Charles, W. , CHUNG, Seungwon , DART, Michael, J.
IPC: A61P35/00
CPC classification number: C07D213/73 , C07D317/64 , C07D231/56 , C07C311/13 , C07D401/04 , C07C311/24 , C07D237/14 , C07D237/16 , C07C317/22 , C07D405/08 , C07D241/18 , C07D261/08 , C07D261/20 , C07C235/22 , C07D271/113 , C07D213/30 , C07D213/64 , C07D213/66 , C07C2602/3820170501 , C07C2602/4020170501 , C07C2602/4220170501 , C07C2602/4420170501 , C07C2603/9020170501 , C07D471/04 , A61P25/28
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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Patent Agency Ranking
公开(公告)号：EP4209483A1
公开(公告)日：2023-07-12
申请号：EP22210424.2
申请日：2019-10-11
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： MARTIN, Kathleen Ann , SIDRAUSKI, Carmela , DART, Michael J. , FROST, Jennifer M. , TONG, Yunsong , XU, Xiangdong , SHI, Lei , MURAUSKI, Kathleen , PLIUSHCHEV, Marina , BROWN, Brian S. , VOIGHT, Eric , RANDOLPH, John T.
IPC: C07C235/36 , C07C271/34 , C07C303/34 , C07D221/00 , C07F9/09
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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公开(公告)号：EP3452453A1
公开(公告)日：2019-03-13
申请号：EP17724209.6
申请日：2017-05-05
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： SIDRAUSKI, Carmela , PLIUSHCHEV, Marina , FROST, Jennifer, M. , BLACK, Lawrence, A. , XU, Xiangdong , SWEIS, Ramzi, Farah , SHI, Lei , ZHANG, Qinwei, I , TONG, Yunsong , HUTCHINS, Charles, W. , CHUNG, Seungwon , DART, Michael, J.
IPC: C07D231/12 , C07D237/08 , C07D239/34 , C07D241/12 , C07D471/04 , C07D261/08 , C07D263/32 , C07D271/07 , C07D277/28 , C07D209/14 , C07D213/40 , C07D213/64 , C07D307/52 , A61K31/4402 , A61P35/00
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8.发明公开6-PHENYL- OR 6-(PYRIDIN-3-YL)INDAZOLE DERIVATIVES AND METHODS OF USE 审中-公开6-PHENYL-ODER 6-（PYRIDIN-3-YL）INDAZOL-DERIVATE UND VERFAHREN ZUR VERWENDUNG
公开(公告)号：EP3097091A1
公开(公告)日：2016-11-30
申请号：EP15703161.8
申请日：2015-01-16
Applicant: AbbVie Inc.
Inventor： SCANIO, Marc , BUNNELLE, William , KOENIG, John Robert , DRIZIN, Irene , PLIUSHCHEV, Marina , COWART, Marlon
IPC: C07D401/14 , C07D401/10 , C07D403/10 , C07D403/14 , C07D407/14 , A61K31/416
CPC classification number: C07D231/56 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D413/10 , C07D417/14 , C07D471/04 , C07D487/10
Abstract: Compounds of formula (I) and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein R1, R2, R3, R4, R5, R6, and X are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by Tropomysin receptor kinases (Trk). Methods for making the compounds are disclosed. Also disclosed are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.
Abstract translation: 式（I）化合物及其药学上可接受的盐，酯，酰胺或放射性标记形式，其中R 1，R 2，R 3，R 4，R 5，R 6和X如说明书中所定义，可用于治疗病症或障碍 由Tropomysin受体激酶（Trk）改善或改善。 公开了制备化合物的方法。 还公开了式（I）化合物的药物组合物，以及使用这些化合物和组合物的方法。
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公开(公告)号：EP2665711A1
公开(公告)日：2013-11-27
申请号：EP12701822.4
申请日：2012-01-20
Applicant: Abbvie Inc.
Inventor： VASUDEVAN, Anil , PENNING, Thomas D. , PLIUSHCHEV, Marina
IPC: C07D213/81 , C07D401/12 , C07D409/12 , C07D413/12 , A61K31/444 , A61P35/00
CPC classification number: C07D401/12 , C07D213/81 , C07D409/12 , C07D413/12
Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R
1 , R
2 , R
3 , A, B, Z, n, and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as ALK and methods of treating diseases such as cancer.-
公开(公告)号：EP2665725A1
公开(公告)日：2013-11-27
申请号：EP12736704.3
申请日：2012-01-20
Applicant: AbbVie Inc.
Inventor： VASUDEVAN, Anil , PENNING, Thomas Dale , CHEN, Huanming , LIANG, Bo , WANG, Shaohui , ZHAO, Zhongqiang , CHAI, Dikun , YANG, Leifu , GAO, Yingxiang , PLIUSHCHEV, Marina
IPC: C07D471/04 , C07D217/24 , C07D239/88 , A61K31/435 , A61K31/495 , A61P35/00
CPC classification number: C07D471/04 , C07D401/12
Abstract: The present invention relates to compounds of formula (1) or pharmaceutical acceptable salts, Formula (1) wherein R
1 , R
2 , R
3 , X, Y, Z, A, B, G
1 , m, and n are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as ALK and methods of treating diseases such as cancer.Abstract translation: 本发明涉及式（1）化合物或其药学上可接受的盐，其中R 1，R 2，R 3，X，Y，Z，A，B，G 1，m和n在 说明。 本发明还涉及含有可用于抑制激酶如ALK的所述化合物的组合物和治疗疾病如癌症的方法。
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