公开(公告)号：EP1554246B1

公开(公告)日：2007-08-22

申请号：EP03790904.1

申请日：2003-08-18

申请人： Bayer HealthCare AG

发明人： GIELEN-HAERTWIG, Heike ,  MIN-JIAN LI, Volkhart ,  ROSENTRETER, Ulrich ,  SCHLEMMER, Karl-Heinz ,  ALLERHEILIGEN, Swen ,  TELAN, Leila ,  BÄRFACKER, Lars ,  KELDENICH, Jörg ,  FITZGERALD, Mary, F. ,  NASH, Kevin ,  ALBRECHT, Barbara ,  MEURER, Dirk

IPC分类号： C07D211/90 ,  C07D405/04 ,  C07D401/04 ,  C07F7/18 ,  A61K31/4545 ,  A61P29/00

CPC分类号： C07D401/04 ,  C07D211/90 ,  C07D405/04 ,  C07F7/1856

摘要： The invention relates to novel dihydropyridinone derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.

公开(公告)号：EP1648447A1

公开(公告)日：2006-04-26

申请号：EP04740582.4

申请日：2004-07-02

申请人： Bayer HealthCare AG

发明人： ALLERHEILIGEN, Swen ,  BROHM, Dirk ,  DIEDRICHS, Nicole ,  FRÖHLEN, Britta-Nicole ,  GERDES, Christoph ,  GNOTH, Mark, Jean ,  HECKROTH, Heike ,  HÜBSCH, Walter ,  PERZBORN, Elisabeth ,  STAHL, Elke ,  VÖHRINGER, Verena

IPC分类号： A61K31/4155 ,  A61P9/00 ,  C07D403/04 ,  C07D409/14 ,  C07D405/14 ,  C07D401/14 ,  C07D413/04 ,  C07D417/04 ,  C07D403/14 ,  C07D401/04 ,  C07D417/14 ,  C07D413/14

CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/04 ,  C07D417/14

摘要： The invention relates to pyrazolines of formula (I), where E = methylene, NH, O or S and R2 = a group of formula (II), methods for the production and use thereof for the production of medicaments for the treatment and/or prophylaxis of diseases, in particular, cardiovascular diseases, such as thromboembolitic diseases.

公开(公告)号：EP1824844A1

公开(公告)日：2007-08-29

申请号：EP05815232.3

申请日：2005-11-28

申请人： Bayer HealthCare AG

发明人： RÖHRIG, Susanne ,  JESKE, Mario ,  AKBABA, Metin ,  ROSENTRETER, Ulrich ,  BOYER, Stephen ,  FISCHER, Karin ,  POHLMANN, Jens ,  TUCH, Arounarith ,  PERZBORN, Elisabeth ,  GERDES, Christoph ,  SCHLEMMER, Karl-Heinz ,  BURKHARDT, Nils ,  ALLERHEILIGEN, Swen ,  NELL, Peter ,  ARNDT, Sabine ,  LOBELL, Mario

IPC分类号： C07D403/12 ,  C07D401/14 ,  C07D413/12 ,  C07D413/14 ,  A61K31/5377 ,  A61P7/02

CPC分类号： C07D491/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14

摘要： The invention relates to novel pyrazine dicarboxamides, methods for the use thereof, their use for treating and/or preventing diseases as well as to their use for producing medicaments for treating and/or preventing diseases, particularly thromboembolic disorders.

摘要翻译： 本发明涉及新的吡嗪二甲酰胺，其用途的方法，它们用于治疗和/或预防疾病的用途，以及它们用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。

公开(公告)号：EP1539710A1

公开(公告)日：2005-06-15

申请号：EP03794956.7

申请日：2003-08-28

申请人： Bayer HealthCare AG

发明人： GIELEN-HAERTWIG, Heike ,  MIN-JIAN LI ,Volkhart ,  ROSENTRETER, Ulrich ,  SCHLEMMER, Karl-Heinz ,  ALLERHEILIGEN, Swen ,  TELAN, Leila ,  BÄRFACKER, Lars ,  KELDENICH, Jörg ,  FITZGERALD, Mary F. ,  NASH, Kevin ,  ALBRECHT, Barbara ,  MEURER, Dirk

IPC分类号： C07D239/40 ,  C07D239/38 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12 ,  A61K31/505 ,  A61K31/506 ,  A61P9/00 ,  A61P29/00

CPC分类号： C07D239/22 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

摘要： The invention relates to novel heterocyclic derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.

公开(公告)号：EP1458682A1

公开(公告)日：2004-09-22

申请号：EP02796589.6

申请日：2002-12-09

申请人： Bayer HealthCare AG

发明人： GIELEN, Heike ,  LI, Volkhart, Min-Jian ,  ROSENTRETER, Ulrich ,  SCHLEMMER, Karl-Heinz ,  ALLERHEILIGEN, Swen ,  NASH, Kevin ,  FITZGERALD, Mary

IPC分类号： C07D211/90 ,  C07D401/04 ,  A61K31/44

CPC分类号： C07D401/04 ,  C07D211/90

摘要： The invention relates to novel 1,4-dihydro-1,4-diphenylpyridine derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases.

公开(公告)号：EP1406891A1

公开(公告)日：2004-04-14

申请号：EP02805269.4

申请日：2002-05-21

申请人： Bayer HealthCare AG

发明人： MEIER, Heinrich ,  ALLERHEILIGEN, Swen ,  GERISCH, Michael ,  SCHOHE-LOOP, Rudolf ,  VOERSTE, Arnd ,  MAULER, Frank ,  DE VRY, Jean, Marie, Victor ,  MÜLLER, Thomas ,  METHFESSEL, Christoph

IPC分类号： C07D335/06 ,  C07D335/16 ,  A61K31/382 ,  A61P25/28

CPC分类号： C07D409/04 ,  A61K31/382 ,  C07D335/04 ,  C07D335/16 ,  C07D409/10 ,  C07D409/12 ,  C07D413/04 ,  C07D413/12 ,  C07D491/10

摘要： The invention relates to thiochromenones, to methods for the production thereof, and to the use of the same for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of painful conditions and/or neurodegenerative diseases.

摘要翻译： 本发明涉及二氢苯并噻喃酮，其制备方法以及其用于治疗和/或预防疾病，特别是用于治疗和/或预防疼痛病症和/或神经退行性疾病的用途。

公开(公告)号：EP2173744A1

公开(公告)日：2010-04-14

申请号：EP08759099.8

申请日：2008-06-07

申请人： Bayer HealthCare AG

发明人： ALLERHEILIGEN, Swen ,  BAUSER, Marcus ,  SCHIROK, Hartmut ,  RESTER, Ulrich ,  HEITMEIER, Stefan ,  GERDES, Christoph ,  VON DEGENFELD, Georges ,  DITTRICH-WENGENROTH, Elke ,  SAATMANN, Uwe ,  STRASSBURGER, Julia ,  MÜNTER, Klaus ,  GNOTH, Mark, Jean ,  LANG, Dieter

IPC分类号： C07D413/14 ,  A61K31/4439 ,  A61P7/00

CPC分类号： C07D413/14

摘要： The invention relates to novel substituted oxazolidinones, methods for the production thereof, use thereof for treating and/or for the prophylaxis of diseases and use thereof for producing medicaments for treating and/or for the prophylaxis of diseases, in particular thromboembolic disorders.

摘要翻译： 本发明涉及新的取代的恶唑烷酮，其制备方法，其用于治疗和/或预防疾病的用途以及用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。

公开(公告)号：EP2170877A1

公开(公告)日：2010-04-07

申请号：EP08773372.1

申请日：2008-06-07

申请人： Bayer HealthCare AG

发明人： ALLERHEILIGEN, Swen ,  BAUSER, Marcus ,  HEIMBACH, Dirk ,  HEITMEIER, Stefan ,  GNOTH, Mark, Jean ,  GERDES, Christoph ,  VON DEGENFELD, Georges ,  RÖHRIG, Susanne ,  RESTER, Ulrich ,  DITTRICH-WENGENROTH, Elke ,  SAATMANN, Uwe ,  TERSTEEGEN, Adrian

IPC分类号： C07D413/14 ,  A61K31/4439 ,  A61P7/00

CPC分类号： C07D413/14

摘要： The invention relates to novel substituted oxazolidinones, methods for the production thereof, use thereof for treating and/or for the prophylaxis of diseases and use thereof for producing medicaments for treating and/or for the prophylaxis of diseases, in particular thromboembolic disorders.

公开(公告)号：EP2029546A1

公开(公告)日：2009-03-04

申请号：EP07725589.1

申请日：2007-05-25

申请人： Bayer HealthCare AG

发明人： HÄRTER, Michael ,  WUNBERG, Tobias ,  ALLERHEILIGEN, Swen ,  BAUSER, Marcus ,  RESTER, Ulrich ,  HEITMEIER, Stefan

IPC分类号： C07D231/12 ,  C07D401/04 ,  C07D417/12 ,  C07D417/14 ,  C07D419/14 ,  A61P7/02

CPC分类号： C07D409/14 ,  C07D231/12 ,  C07D413/14

摘要： The invention relates to aryl-substituted heterocycles, methods for the production thereof, the use thereof for treating and/or preventing diseases, and the use thereof for producing medicaments used for treating and/or preventing diseases, particularly thromboembolic diseases.

公开(公告)号：EP1824844B1

公开(公告)日：2008-11-05

申请号：EP05815232.3

申请日：2005-11-28

申请人： Bayer HealthCare AG

发明人： RÖHRIG, Susanne ,  JESKE, Mario ,  AKBABA, Metin ,  ROSENTRETER, Ulrich ,  BOYER, Stephen ,  FISCHER, Karin ,  POHLMANN, Jens ,  TUCH, Arounarith ,  PERZBORN, Elisabeth ,  GERDES, Christoph ,  SCHLEMMER, Karl-Heinz ,  BURKHARDT, Nils ,  ALLERHEILIGEN, Swen ,  NELL, Peter ,  ARNDT, Sabine ,  LOBELL, Mario

IPC分类号： C07D403/12 ,  C07D401/14 ,  C07D413/12 ,  C07D413/14 ,  A61K31/5377 ,  A61P7/02

CPC分类号： C07D491/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14

摘要： The invention relates to novel pyrazine dicarboxamides, methods for the use thereof, their use for treating and/or preventing diseases as well as to their use for producing medicaments for treating and/or preventing diseases, particularly thromboembolic disorders.