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1.发明授权NOVEL PIPERIDINE-SUBSTITUTED INDOLES-OR HETERO-DERIVATIVES THEREOF AND THEIR USE AS MODULATORS OF CHEMOKINE RECEPTOR (CCR-3) 有权哌啶取代的吲哚衍生物或其HETERO及其作为趋化因子受体（CCR-3）调节剂
公开(公告)号：EP1687294B1
公开(公告)日：2014-05-21
申请号：EP04818773.6
申请日：2004-11-11
发明人： MARTYRES, Domnic , ANDERSKEWITZ, Ralf , DOLLINGER, Horst , POUZET, Pascale , BIRKE, Franz , BOUYSSOU, Thierry
IPC分类号： C07D401/04 , A61K31/454 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D513/04
CPC分类号： C07D413/14 , A61K31/454 , A61K31/496 , C07D401/04 , C07D401/14 , C07D417/14 , C07D471/04 , C07D513/04
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公开(公告)号：EP1776356B1
公开(公告)日：2008-09-17
申请号：EP05778384.7
申请日：2005-07-30
IPC分类号： C07D401/06 , A61K31/445 , A61K31/4184 , A61P37/08
CPC分类号： C07D401/06
摘要： A compound of general formula (1a) wherein R1, R5, R6, A, B, Y, i, j and m are defined as in the description and claims. It is another object of the present invention to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof.
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公开(公告)号：EP1776356A1
公开(公告)日：2007-04-25
申请号：EP05778384.7
申请日：2005-07-30
IPC分类号： C07D401/06 , A61K31/445 , A61K31/4184 , A61P37/08
CPC分类号： C07D401/06
摘要： A compound of general formula (1a) wherein R1, R5, R6, A, B, Y, i, j and m are defined as in the description and claims. It is another object of the present invention to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof.
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公开(公告)号：EP1490042A2
公开(公告)日：2004-12-29
申请号：EP03708263.3
申请日：2003-03-24
发明人： BIRKE, Franz , MATZEK, Kandace
IPC分类号： A61K31/155 , A61P11/06 , A61P11/00 , A61P11/14
CPC分类号： A61K31/192 , A61K31/155 , A61K31/165 , A61K31/352 , A61K31/44
摘要： The invention relates to the use of LTB4 antagonists for producing a medicament for the treatment or prevention of respiratory diseases in pets and working animals.
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5.发明授权PHARMACEUTICAL COMPOSITION COMPRISING A LTB4 ANTAGONIST AND A COX-2 INHIBITOR OR A COMBINED COX1/2 INHIBITOR 有权药物组合物含有LTB 4抑制剂及其甲COX-2抑制剂或组合的COX-1/2抑制剂
公开(公告)号：EP1572179B1
公开(公告)日：2007-02-28
申请号：EP03795825.3
申请日：2003-11-18
IPC分类号： A61K31/155 , A61K31/5415 , A61K45/06 , A61P29/00 , A61P19/02 , A61P11/06 , A61P11/00 , A61P17/00 , A61P17/06 , A61P35/04 , A61P1/04 , A61P1/00 , A61P25/00 , A61P9/10
CPC分类号： A61K45/06 , A61K31/155 , A61K31/18 , A61K31/381 , A61K31/407 , A61K31/415 , A61K31/42 , A61K31/444 , A61K2300/00
摘要： The invention relates to a pharmaceutical formulation comprising a LTB4 antagonist having a hydroxy and a benzamidine group or a tautomer, a pharmaceutically acceptable salt or solvate thereof, in particular a compound of formula (I), wherein R and A are as defined in the claims, or a tautomer, a pharmaceutically acceptable salt or solvate thereof (1) and at least one cyclooxygenase-2 inhibitor, a combined cox1/2 inhibitor or a pharmaceutically acceptable salt or solvate thereof (2), and a pharmaceutically acceptable carrier or excipient, and optionally one or more other therapeutic ingredients.
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6.发明公开PHARMACEUTICAL COMPOSITION COMPRISING A LTB4 ANTAGONIST AND A COX-2 INHIBITOR OR A COMBINED COX1/2 INHIBITOR 有权药物组合物含有LTB 4抑制剂及其甲COX-2抑制剂或组合的COX-1/2抑制剂
公开(公告)号：EP1572179A1
公开(公告)日：2005-09-14
申请号：EP03795825.3
申请日：2003-11-18
IPC分类号： A61K31/155 , A61K31/444 , A61K31/42 , A61K31/18 , A61K31/381 , A61K31/407 , A61K31/415 , A61K45/06 , A61P29/00 , A61P19/02 , A61P11/06 , A61P11/00 , A61P17/00 , A61P17/06 , A61P35/04 , A61P1/04 , A61P1/00 , A61P25/00 , A61P9/10
CPC分类号： A61K45/06 , A61K31/155 , A61K31/18 , A61K31/381 , A61K31/407 , A61K31/415 , A61K31/42 , A61K31/444 , A61K2300/00
摘要： The invention relates to a pharmaceutical formulation comprising a LTB4 antagonist having a hydroxy and a benzamidine group or a tautomer, a pharmaceutically acceptable salt or solvate thereof, in particular a compound of formula (I), wherein R and A are as defined in the claims, or a tautomer, a pharmaceutically acceptable salt or solvate thereof (1) and at least one cyclooxygenase-2 inhibitor, a combined cox1/2 inhibitor or a pharmaceutically acceptable salt or solvate thereof (2), and a pharmaceutically acceptable carrier or excipient, and optionally one or more other therapeutic ingredients.
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7.发明公开
公开(公告)号：EP1648888A1
公开(公告)日：2006-04-26
申请号：EP04740684.8
申请日：2004-07-06
发明人： ANDERSKEWITZ, Ralf , BIRKE, Franz , BOUYSSOU, Thierry , DOLLINGER, Horst , MARTYRES, Domnic , POUZET, Pascale, Arielle, Jane-Josee
IPC分类号： C07D451/02 , A61K31/46 , A61P29/00
CPC分类号： C07D451/04 , A61K31/46 , Y02A50/465 , A61K2300/00
摘要： Use of a compound of general formula 1 for manufacturing a medicament to provide agonists or antagonists of CCR-3, or pharmaceutically acceptable salts thereof, in particular compounds of formula 1: wherein R , R , R , A, B, X, W, Z, i, j, k, l and m are defined as in the description and claims. It is another object of the present invention to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof.
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8.发明公开
公开(公告)号：EP0929516A1
公开(公告)日：1999-07-21
申请号：EP97942007.0
申请日：1997-09-09
发明人： SCHROMM, Kurt , ANDERSKEWITZ, Ralf , RENTH, Ernst-Otto , BIRKE, Franz , JENNEWEIN, Hans, Michael , MEADE, Christopher, John, Montague
IPC分类号： A61K31 , B01J25 , A61P1 , A61P9 , A61P11 , A61P17 , A61P19 , A61P25 , C07B61 , C07C257 , C07C271 , C07D295 , C07D311 , C07D317
CPC分类号： C07D295/088 , C07C257/18 , C07C271/64
摘要： The current invention relates to new benzamidine derivatives, a process for the manufacture and the use thereof as medicaments. The new benzamidine derivatives have the general formula (1).
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公开(公告)号：EP1594873B1
公开(公告)日：2010-12-15
申请号：EP04708347.2
申请日：2004-02-05
发明人： ANDERSKEWITZ, Ralf , DOLLINGER, Horst , HEINE, Claudia , POUZET, Pascale, Arielle, Jane-Josee , BIRKE, Franz , BOUYSSOU, Thierry
IPC分类号： C07D487/04 , C07D471/14
CPC分类号： C07D487/04 , C07D491/14 , C07D495/14
摘要： The invention relates to the novel compounds of formula (I) or stereoisomers or pharmaceutically acceptable salts thereof, wherein the groups Ar1, Ar2, A, R1, R2, R3, E1, E2, X and n are as defined in the description and claims, which are effective modulators of chemokine activity.
摘要翻译： 本发明涉及式（I）的新化合物或其立体异构体或药学上可接受的盐，其中基团Ar1，Ar2，A，R1，R2，R3，E1，E2，X和n如说明书和权利要求书中所定义。 ，它们是趋化因子活性的有效调节剂。
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公开(公告)号：EP0931087A1
公开(公告)日：1999-07-28
申请号：EP97944867.0
申请日：1997-09-10
发明人： ANDERSKEWITZ, Ralf , SCHROMM, Kurt , RENTH, Ernst-Otto , BIRKE, Franz , JENNEWEIN, Hans, Michael , MEADE, Christopher, John, Montague , DING, Andreas
CPC分类号： C07H15/04
摘要： The present invention relates to novel pyranoside derivatives having general formula (I), process for the manufacture thereof and their use as medicaments.
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