公开(公告)号：EP1663962A2

公开(公告)日：2006-06-07

申请号：EP04781589.9

申请日：2004-08-20

申请人： DENDREON CORPORATION ,  Natarajan, Sateesh K. ,  Moreno, Ofir ,  Graddis, Thomas J. ,  Duncan, David ,  Laus, Reiner ,  Chen, Feng

发明人： NATARAJAN, Sateesh K. ,  MORENO, Ofir ,  GRADDIS, Thomas J. ,  DUNCAN, David ,  LAUS, Reiner ,  CHEN, Feng

IPC分类号： C07C303/00 ,  C07C321/00 ,  C07C69/95 ,  C07C69/76 ,  C07C35/08 ,  C07C31/12 ,  C07D345/00

CPC分类号： C07C233/60 ,  A61K31/498 ,  A61K31/517 ,  A61K45/06 ,  C07C233/58 ,  C07C243/36 ,  C07C243/38 ,  C07C311/20 ,  C07C311/37 ,  C07C323/40 ,  C07C323/44 ,  C07C333/06 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/42 ,  C07D207/06 ,  C07D207/09 ,  C07D207/325 ,  C07D209/08 ,  C07D209/14 ,  C07D209/16 ,  C07D209/20 ,  C07D209/48 ,  C07D211/06 ,  C07D213/40 ,  C07D215/04 ,  C07D215/08 ,  C07D215/46 ,  C07D217/06 ,  C07D223/04 ,  C07D231/12 ,  C07D231/14 ,  C07D231/56 ,  C07D235/18 ,  C07D235/26 ,  C07D239/42 ,  C07D241/18 ,  C07D241/44 ,  C07D241/54 ,  C07D251/54 ,  C07D263/34 ,  C07D263/57 ,  C07D279/12 ,  C07D295/096 ,  C07D295/135 ,  C07D295/155 ,  C07D295/26 ,  C07D307/52 ,  C07D311/16 ,  C07D317/66 ,  C07D333/34 ,  C07D401/04 ,  C07D403/14 ,  C07D405/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04 ,  C07D493/08 ,  C07D495/04 ,  C07D513/04 ,  G01N33/5011 ,  G01N33/6872 ,  G01N2500/10 ,  A61K2300/00

摘要： Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Tip-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Trp-p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Trp-p8 expression.

公开(公告)号：EP1986622B1

公开(公告)日：2013-10-02

申请号：EP07750861.2

申请日：2007-02-15

申请人： DENDREON CORPORATION

发明人： MORENO, Ofir ,  NATARAJAN, Sateesh ,  DUNCAN, David F.

IPC分类号： A61K31/12 ,  C07C233/60 ,  C07D231/40

CPC分类号： C07C237/04 ,  C07C233/60 ,  C07C233/62 ,  C07C237/10 ,  C07C237/42 ,  C07C237/44 ,  C07C323/40 ,  C07C323/63 ,  C07C2601/14 ,  C07D231/40 ,  C07D235/26 ,  C07D401/12 ,  C07D403/04 ,  C07D405/04

公开(公告)号：EP2268273A1

公开(公告)日：2011-01-05

申请号：EP08852382.4

申请日：2008-11-17

申请人： DENDREON CORPORATION

发明人： MORENO, Ofir ,  NATARAJAN, Sateesh ,  DUNCAN, David F.

IPC分类号： A61K31/015 ,  A61K31/095 ,  A61K31/10 ,  A61K31/16 ,  A61K31/165 ,  A61K31/4155 ,  A61K31/4166 ,  A61K31/4184 ,  A61K31/4188 ,  A61P13/08 ,  A61P35/00

CPC分类号： C07C233/60 ,  A61K31/015 ,  A61K31/095 ,  A61K31/10 ,  A61K31/16 ,  A61K31/165 ,  A61K31/4155 ,  A61K31/4166 ,  A61K31/4184 ,  A61K31/4188 ,  C07C233/62 ,  C07C237/04 ,  C07C237/10 ,  C07C237/42 ,  C07C237/44 ,  C07C323/40 ,  C07C323/63 ,  C07C2601/14 ,  C07D231/40 ,  C07D235/26 ,  C07D401/12 ,  C07D403/04 ,  C07D405/04

摘要： Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Trp-p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Trp-p8 expression.

公开(公告)号：EP1986622A2

公开(公告)日：2008-11-05

申请号：EP07750861.2

申请日：2007-02-15

申请人： DENDREON CORPORATION

发明人： MORENO, Ofir ,  NATARAJAN, Sateesh ,  DUNCAN, David F.

IPC分类号： A61K31/12

CPC分类号： C07C237/04 ,  C07C233/60 ,  C07C233/62 ,  C07C237/10 ,  C07C237/42 ,  C07C237/44 ,  C07C323/40 ,  C07C323/63 ,  C07C2601/14 ,  C07D231/40 ,  C07D235/26 ,  C07D401/12 ,  C07D403/04 ,  C07D405/04

摘要： Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Trp-p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Trp-p8 expression.