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公开(公告)号：EP2374794B1
公开(公告)日：2015-11-04
申请号：EP09834889.9
申请日：2009-12-22
发明人： NAKAO, Akira , GOTANDA, Kentoku , AOKI, Kazumasa , HIRANO, Shimpei , HIRUMA, Yoshiharu , SHIIKI, Takeshi
IPC分类号： C07D205/04 , A61K31/397 , A61K31/40 , A61K31/41 , A61P1/02 , A61P3/14 , A61P5/18 , A61P19/00 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , C07D207/08 , C07D207/10 , C07D207/12 , C07D403/12 , C07D409/06 , C07D409/14
CPC分类号： C07D205/04 , C07D207/08 , C07D207/10 , C07D207/12 , C07D403/12 , C07D409/06 , C07D409/14
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公开(公告)号：EP2374788B1
公开(公告)日：2013-04-03
申请号：EP09834890.7
申请日：2009-12-22
发明人： NAKAO, Akira , GOTANDA, Kentoku , AOKI, Kazumasa , HIRANO, Shimpei , HIRUMA,Yoshiharu , SHIIKI,Takeshi
IPC分类号： C07C217/28 , A61K31/195 , A61K31/216 , A61K31/41 , A61P1/02 , A61P3/14 , A61P5/18 , A61P19/02 , A61P19/08 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07D257/04
CPC分类号： C07D257/04 , C07C217/28 , C07C255/57 , C07C2601/02 , C07C2602/08
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公开(公告)号：EP2565185A1
公开(公告)日：2013-03-06
申请号：EP11775045.5
申请日：2011-04-27
发明人： AOKI, Kazumasa , MATSUI, Satoshi , YOSHIKAWA, Kenji , SHIMIZU,Hiroki , SASAKI, Junko , NAKAJIMA, Katsuyoshi , KANNO, Osamu , OIZUMI, Kiyoshi
IPC分类号： C07D235/06 , A61K31/4184 , A61K31/4188 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , A61P5/18 , A61P19/08 , A61P19/10 , C07D401/04 , C07D403/04 , C07D405/12 , C07D405/14 , C07D417/04 , C07D471/04
CPC分类号： C07D235/06 , A61K31/4184 , A61K31/4188 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/5377 , C07D401/04 , C07D403/04 , C07D405/12 , C07D405/14 , C07D417/04 , C07D471/04 , C07D491/056
摘要： Abstract: An object of the present invention is to provide a novel low molecular weight compound exhibiting an osteogenesis-promoting action. This object is achieved by a compound having the general formula (I) or a pharmacologically acceptable salt thereof. In the general formula (I), R 1 and R 2 represent hydrogen atoms, and the like; R 3 represents a hydrogen atom, and the like; X, Y, and Z represent nitrogen atoms, and the like; A represents a phenylene group, and the like; n represents 1 or 2, and the like; and V and W represent oxygen atoms, and the like.
摘要翻译： 摘要：本发明的目的是提供一种表现出成骨促进作用的新型低分子化合物。 该目的通过具有通式（I）的化合物或其药理学上可接受的盐来实现。 在通式（I）中，R 1和R 2表示氢原子等; R 3表示氢原子等; X，Y和Z表示氮原子等; A表示亚苯基等; n表示1或2，等等; V和W表示氧原子等。
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公开(公告)号：EP2210886A1
公开(公告)日：2010-07-28
申请号：EP08840535.2
申请日：2008-10-15
IPC分类号： C07D401/14 , A61K31/506 , A61P3/04 , A61P3/10
CPC分类号： C07D401/14
摘要： It is intended to provide a pyrimidyl indoline compound which structurally differs from compounds used as active ingredients in conventional oral hypoglycemic agents and has excellent hypoglycemic effect. The present invention provides a compound represented by the general formula (I) or a pharmaceutically acceptable salt thereof:
摘要翻译： 旨在提供一种嘧啶基二氢吲哚化合物，其与用作常规口服降血糖剂中的活性成分的化合物结构不同，并具有优异的降血糖作用。 本发明提供了由通式（I）表示的化合物或其药学上可接受的盐：
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公开(公告)号：EP2418203B1
公开(公告)日：2013-12-11
申请号：EP10761614.6
申请日：2010-03-29
IPC分类号： C07D217/14 , A61K31/4375 , A61K31/4545 , A61K31/472 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/675 , A61P3/14 , A61P19/08 , A61P19/10 , C07D217/16 , C07D401/04 , C07D401/10 , C07D405/12 , C07D417/04 , C07D471/04
CPC分类号： C07D217/14 , C07D217/16 , C07D401/04 , C07D401/10 , C07D405/12 , C07D417/04 , C07D471/04
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公开(公告)号：EP2418203A1
公开(公告)日：2012-02-15
申请号：EP10761614.6
申请日：2010-03-29
IPC分类号： C07D217/14 , A61K31/4375 , A61K31/4545 , A61K31/472 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/675 , A61P3/14 , A61P19/08 , A61P19/10 , C07D217/16 , C07D401/04 , C07D401/10 , C07D405/12 , C07D417/04 , C07D471/04
CPC分类号： C07D217/14 , C07D217/16 , C07D401/04 , C07D401/10 , C07D405/12 , C07D417/04 , C07D471/04
摘要： An object of the present invention is to provide a novel low molecular weight compound exhibiting an osteogenesis-promoting action. This object is achieved by a compound having the general formula (I) or a pharmacologically acceptable salt thereof:
wherein each substituent is defined as follows: R 1 represents an alkyl group or the like; R 2 represents an alkyl group or the like; R 3 represents a hydrogen atom or the like; and Z represents -CH= or -N=.摘要翻译： 本发明的目的是提供一种显示成骨促进作用的新型低分子量化合物。 该目的通过具有通式（I）的化合物或其药理学上可接受的盐来实现：其中各取代基定义如下：R 1表示烷基等; R2表示烷基等; R3代表氢原子等; Z表示-CH =或-N =。
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公开(公告)号：EP2380878A1
公开(公告)日：2011-10-26
申请号：EP10731232.4
申请日：2010-01-12
发明人： KANNO, Osamu , NAKAJIMA, Katsuyoshi , AOKI, Kazumasa , TANAKA, Ryoichi , HIRANO, Shimpei , OIZUMI, Kiyoshi , ASANO, Daigo
IPC分类号： C07D217/22 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/5513 , A61P19/08 , A61P19/10 , C07D401/04 , C07D401/12 , C07D405/14 , C07D413/04 , C07D417/12 , C07D471/04
CPC分类号： C07D217/22 , C07D217/24 , C07D401/04 , C07D401/12 , C07D405/14 , C07D413/04 , C07D413/12 , C07D417/12 , C07D471/04
摘要： An object of the present invention is to provide a novel low molecular weight compound exhibiting an osteogenesis-promoting action. This object is achieved by a compound having the general formula (I) or a pharmacologically acceptable salt thereof:
wherein each substituent is defined as follows: A is a 3- to 10-membered heterocyclyl group and the like, B is an amino group and the like, and X is N and the like.摘要翻译： 本发明的目的是提供一种表现出成骨促进作用的新型低分子量化合物。 该目的通过具有通式（I）的化合物或其药理学上可接受的盐来实现：其中每个取代基定义如下：A是3-至10-元杂环基等，B是氨基， 类似物，X是N等。
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公开(公告)号：EP2133330A1
公开(公告)日：2009-12-16
申请号：EP08740010.7
申请日：2008-04-08
CPC分类号： C07D207/34
摘要： [Object] A prophylactic or therapeutic agent for a cardiovascular disease is provided.
[Means for Resolution] An atropisomer of a compound represented by the following general formula (I):
(wherein R 1 is a C1-C3 alkyl group or a hydroxy-C1-C3 alkyl group; and R 2 is a hydrogen atom or a C1-C3 alkoxy group).摘要翻译： 提供了一种用于心血管疾病的预防或治疗剂。 [解决方法]由以下通式（I）表示的化合物的阻转异构体：（其中R 1是C 1 -C 3烷基或羟基-C 1 -C 3烷基; R 2是氢原子或 C1-C3烷氧基）。
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9.发明公开SUBSTITUTED ACRYLAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 有权取代的丙烯酰胺衍生物和药物组合物含有该
公开(公告)号：EP1880720A1
公开(公告)日：2008-01-23
申请号：EP06746254.9
申请日：2006-05-11
发明人： AOKI, Kazumasa , SUDA, Koji , KANEKO, Toshio , KIMURA, Tomio
IPC分类号： A61K31/166
CPC分类号： A61K31/166 , C07C237/22 , C07C2601/02 , C07C2601/04 , C07C2601/10 , C07C2602/08 , C07D207/327 , C07D277/30 , C07D295/13 , C07D307/54 , C07D317/54 , C07D333/16 , C07D407/04 , C07D409/04 , Y02P20/55
摘要： A pharmaceutical composition comprising a compound having Formula (I) or a pharmacologically acceptable salt thereof as an active ingredient:
[wherein,
R 1 is, for example, a C 6 -C 10 aryl group which may be substituted with one group or more than one group selected from substituent group α; R 2 is, for example, a C 6 -C 10 aryl group which may be substituted with one group or more than one group selected from substituent group α; and X is, for example, a hydroxyl group or a C 1 -C 6 alkoxy group].-
公开(公告)号：EP4032883A1
公开(公告)日：2022-07-27
申请号：EP21212977.9
申请日：2017-03-29
发明人： SAITO, Keiji , NAKAJIMA, Katsuyoshi , TANIGUCHI, Toru , IWAMOTO, Osamu , SHIBUYA, Satoshi , OGAWA, Yasuyuki , AOKI, Kazumasa , KURIKAWA, Nobuya , TANAKA, Shinji , OGITANI, Momoko , KIOI, Eriko , ITO, Kaori , NISHIHAMA, Natsumi , MIKKAICHI, Tsuyoshi , SAITOH, Wataru
IPC分类号： C07D307/94 , A61K31/343 , A61K31/4155 , A61K31/4245 , A61P29/00 , A61P43/00 , C07D405/04 , C07D413/04
摘要： An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof.
The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof.
wherein the symbols in the formula are defined below: R 1 : e.g., a C1-C6 alkyl group; R 2 : a C1-C6 alkyl group; A: e.g., an oxygen atom; and R 3 : e.g., a C1-C6 alkyl group.
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