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1.发明授权PROCÉDÉ ET SYSTÈME DE MICROSCOPIE NON-LINÉAIRE COHÉRENTE À MODULATION DE VOLUME FOCAL POUR SONDER LA NANOSTRUCTURATION DE MATÉRIAUX ORGANISÉS 有权相干不是线性的观测系统，变异聚集体积方法，探索有组织材料的纳米结构
公开(公告)号：EP2304488B1
公开(公告)日：2013-11-27
申请号：EP09769543.1
申请日：2009-06-26
申请人： Ecole Polytechnique
发明人： BEAUREPAIRE, Emmanuel, Jean-Marc , OLIVIER, Nicolas , DEBARRE, Delphine , SCHANNE-KLEIN, Marie-Claire , MARTIN, Jean Louis
CPC分类号： G01N21/636 , G01N2021/1785 , G01N2021/653 , G01N2021/655 , G01N2021/656
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2.发明授权
公开(公告)号：EP2795390B1
公开(公告)日：2018-03-28
申请号：EP12816697.2
申请日：2012-12-03
发明人： SCHANNE-KLEIN, Marie-Claire , BEAUREPAIRE, Emmanuel, Jean-Marc , STRUPLER, Mathias , DEBARRE, Delphine , OLIVIER, Nicolas , MAHOU, Pierre
CPC分类号： G02B21/06 , G01N21/6486 , G01N21/65 , G01N33/4833 , G01N2021/653 , G01N2201/0697 , G02B21/0032 , G02B21/004 , G02B21/0076 , G02B21/26 , G02B21/365
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3.发明公开PROCÉDÉ ET SYSTÈME DE MICROSCOPIE NON-LINÉAIRE COHÉRENTE À MODULATION DE VOLUME FOCAL POUR SONDER LA NANOSTRUCTURATION DE MATÉRIAUX ORGANISÉS 有权相干不是线性的观测系统，变异聚集体积方法，探索有组织材料的纳米结构
公开(公告)号：EP2304488A2
公开(公告)日：2011-04-06
申请号：EP09769543.1
申请日：2009-06-26
申请人： Ecole Polytechnique
发明人： BEAUREPAIRE, Emmanuel, Jean-Marc , OLIVIER, Nicolas , DEBARRE, Delphine , SCHANNE-KLEIN, Marie-Claire , MARTIN, Jean Louis
CPC分类号： G01N21/636 , G01N2021/1785 , G01N2021/653 , G01N2021/655 , G01N2021/656
摘要： The invention relates to a method for the dimensional characterization of a structured material, in which method : an excitation laser beam suitable for coherent nonlinear microscopy is generated, this excitation laser beam being focused in a focal volume within the structured material; signals emitted by the structured material are detected; a plurality of emission patterns, each corresponding to one particular shape of the focal volume, is produced, the particular shapes being obtained for various non-Gaussian spatial profiles of the excitation laser beam wavefront; and on the basis of the emission patterns thus produced, dimensional characteristics of said structured material are deduced therefrom.
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4.发明公开MODULE D'EXCITATION MULTI-COULEURS POUR UN SYSTEME D'IMAGERIE MULTI-PHOTONIQUE, SYSTEME ET PROCEDE ASSOCIES 审中-公开多色激励器模块用于多光子图片系统和相关方法和系统
公开(公告)号：EP2810050A1
公开(公告)日：2014-12-10
申请号：EP13705115.7
申请日：2013-02-01
发明人： MAHOU, Pierre , BEAUREPAIRE, Emmanuel, Jean-Marc , DEBARRE, Delphine , SUPATTO, Willy , MARTIN, Jean Louis
CPC分类号： G01N21/6456 , G01N21/3151 , G01N21/6402 , G01N21/6458 , G01N2021/6419 , G01N2201/06113 , G01N2201/0668 , G01N2201/0697 , G02B17/023 , G02B21/16
摘要： The present invention concerns a multicolour excitation module 1 for a multiphoton imaging system 100. Such a module is used for imaging a sample 7 comprising at least three chromophores. The module 1 comprises: a first femtosecond laser source 2, emitting a first excitation beam 20; a second femtosecond laser source 3 emitting a second excitation beam 30. The first excitation beam 20 comprises a so-called "pumping" portion, said pumping portion acting as a pump beam to synchronously excite the second laser source 3, and a so-called "excitation" portion. An optical delay line 4 is arranged to spatially and temporally superpose the second excitation beam 30 and the excitation portion of the first excitation beam, so as to excite at least a third of the chromophores by multiphoton absorption, said absorbed photons coming from the first and second excitation beams 20, 30. The invention also concerns the complete multiphoton imaging system 100, and a method implemented in this module 1.
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5.发明公开MICROSCOPIE OPTIQUE NON-LINEAIRE QUANTITATIVE UTILISANT UN FAISCEAU MIS EN FORME 有权定量尼古丁美食MIKROSKOPIE MIT EINEM GEFORMTEN STRAHL
公开(公告)号：EP2795390A1
公开(公告)日：2014-10-29
申请号：EP12816697.2
申请日：2012-12-03
发明人： SCHANNE-KLEIN, Marie-Claire , BEAUREPAIRE, Emmanuel, Jean-Marc , STRUPLER, Mathias , DEBARRE, Delphine , OLIVIER, Nicolas , MAHOU, Pierre
CPC分类号： G02B21/06 , G01N21/6486 , G01N21/65 , G01N33/4833 , G01N2021/653 , G01N2201/0697 , G02B21/0032 , G02B21/004 , G02B21/0076 , G02B21/26 , G02B21/365
摘要： The invention relates to a nonlinear optical microscope using a Bessel laser beam so as to image a sample with good lateral resolution and extended field depth. This microscope incorporates a slide scanner. The sample is disposed on a slide, which is loaded automatically onto a motorized platen, so that the laser beam can sweep the entire slide. The useful signals originating from the sample are combined with the conventional image of the slide scanner so as to obtain a global image which clearly reveals, with good resolution, elements of interest.
摘要翻译： 提供非线性光学显微镜，包括脉冲激光束源; 用于调制脉冲激光束的空间分布的空间光调制器; 用于将调制束引导到用于携带样本的载玻片的目的; 以及用于收集源自样本的信号的检测器，其中空间光调制器被设计成调制物镜的后瞳孔上的脉冲激光束的强度和/或相位，以产生轴向延伸并限制在其中的光束 在被物镜聚焦之后的一个或两个横向方向，并且其中滑块被放置在组织学幻灯片扫描器组件的机动台上。
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6.发明授权PROCEDE ET SYSTEME DE CALIBRATION D'UN MODULATEUR OPTIQUE SPATIAL DANS UN MICROSCOPE OPTIQUE 有权方法和系统校准的空间光调制器与光学显微镜
公开(公告)号：EP2643728B1
公开(公告)日：2015-03-18
申请号：EP11799763.5
申请日：2011-11-21
申请人： Ecole Polytechnique
CPC分类号： G02B21/00 , G02B21/06 , G02B26/06 , G02B27/0068
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7.发明公开PROCEDE ET SYSTEME DE CALIBRATION D'UN MODULATEUR OPTIQUE SPATIAL DANS UN MICROSCOPE OPTIQUE 有权方法和系统校准的空间光调制器与光学显微镜
公开(公告)号：EP2643728A1
公开(公告)日：2013-10-02
申请号：EP11799763.5
申请日：2011-11-21
申请人： Ecole Polytechnique
CPC分类号： G02B21/00 , G02B21/06 , G02B26/06 , G02B27/0068
摘要： The invention relates to a method and a system for calibrating an optical device having a spatial optical modulator (6) and comprising: an optical lens (8) of a large numerical aperture, capable of receiving an incident beam and/or collecting an optical beam reflected by a sample; a camera (14) disposed in a plane optically conjugate with the focal plane of the lens (8); and a spatial optical modulator (6) disposed on the optical beam upstream of the camera (14). According to the invention, the method includes the following steps consisting in: acquiring three-dimensional images of the PSF in terms of intensity in a plane conjugate with the focal plane of the lens (8), reconstructing the profile in terms of amplitude and/or phase of the beam using a phase diversity algorithm, and determining the respective influence functions of a plurality of elements P
1 ,..., P
N of the spatial optical modulator (6) on the profile in terms of the amplitude A and/or phase ϕ of the beam.
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