公开(公告)号：EP3484621A1

公开(公告)日：2019-05-22

申请号：EP17828363.6

申请日：2017-07-12

申请人： Emulate, Inc. ,  Janssen Biotech, Inc.

发明人： LEVNER, Daniel ,  HINOJOSA, Christopher, David ,  WEN, Norman ,  FRASER, Jacob ,  NGUYEN, Justin ,  BARRILE, Riccardo ,  HAMILTON, Geraldine ,  KARALIS, Catherine ,  PARK, Hyoung Shin ,  VARONE, Antonio ,  VAN DER MEER, Andries ,  OTIENO, Monicah ,  CONEGLIANO, David

IPC分类号： B01L3/00

公开(公告)号：EP3630957A1

公开(公告)日：2020-04-08

申请号：EP18805036.3

申请日：2018-05-23

申请人： Emulate, Inc.

发明人： VILLENAVE, Remi ,  LUCCHESI, Carolina ,  NGUYEN, Justin ,  KARALIS, Catherine ,  HAMILTON, Geraldine ,  SALMON, Michael ,  BADDAL, Buket

IPC分类号： C12N5/22 ,  C12N5/16

公开(公告)号：EP3504319A1

公开(公告)日：2019-07-03

申请号：EP17847365.8

申请日：2017-08-29

申请人： Emulate, Inc. ,  Cedars-Sinai Medical Center

发明人： KERNS, S., Jordan ,  WEN, Norman ,  LUCCHESI, Carol ,  HINOJOSA, Christopher ,  FRASER, Jacob ,  HAMILTON, Geraldine ,  VATINE, Gad ,  SANCES, Samuel ,  SVENDSEN, Clive ,  LEVNER, Daniel ,  SAREEN, Dhruv

IPC分类号： C12N5/071 ,  C12N5/079 ,  C12N5/0793 ,  C12N5/0797 ,  C12N15/85

公开(公告)号：EP3383997A1

公开(公告)日：2018-10-10

申请号：EP16871664.5

申请日：2016-12-02

申请人： Emulate, Inc.

发明人： LEVNER, Daniel ,  HINOJOSA, Christopher David ,  WEN, Norman ,  VARONE, Antonio ,  NGUYEN, Justin ,  WILLIAMSON, Lina ,  KERNS, S., Jordan ,  KARALIS, Katia ,  HAMILTON, Geraldine ,  LUCCHESI, Carol

IPC分类号： C12M3/00 ,  C12M3/06 ,  G01N33/50

CPC分类号： C12M35/04 ,  C12M23/16 ,  C12M23/38 ,  C12M25/02 ,  C12M35/08 ,  C12N5/0619 ,  C12N5/0622 ,  C12N5/0629 ,  C12N5/0656 ,  C12N5/0688 ,  C12N5/069 ,  C12N5/0697 ,  C12N5/0698 ,  C12N2501/165 ,  G01N33/50 ,  G01N33/5082 ,  G01N33/54366

摘要： A microfluidic device is contemplated comprising an open-top cavity with structural anchors on the vertical wall surfaces that serve to prevent gel shrinkage-induced delamination, a porous membrane (optionally stretchable) positioned in the middle over a microfluidic channel(s). The device is particularly suited to the growth of cells mimicking dermal layers.

公开(公告)号：EP3411470A2

公开(公告)日：2018-12-12

申请号：EP17748084.5

申请日：2017-02-01

申请人： Emulate, Inc. ,  Cedars-Sinai Medical Center

发明人： KERNS, S. Jordan ,  WEN, Norman ,  LUCCHESI, Carol ,  HINOJOSA, Christopher David ,  FRASER, Jacob ,  PUERTA, Jefferson ,  HAMILTON, Geraldine ,  BARRETT, Robert ,  SVENDSEN, Clive ,  LEVNER, Daniel ,  TARGAN, Stephen R. ,  WORKMAN, Michael ,  SAREEN, Dhruv ,  RAJAMANI, Uthra ,  KASENDRA, Magdalena

IPC分类号： C12N5/02 ,  C12N5/074 ,  C12N5/0793 ,  C12N5/0797

CPC分类号： C12N5/0696 ,  C12M23/16 ,  C12N5/0679 ,  C12N2501/11 ,  C12N2501/119 ,  C12N2501/16 ,  C12N2501/24 ,  C12N2501/415 ,  C12N2501/998 ,  C12N2506/45 ,  C12N2535/00

摘要： Organs-on-chips are microfluidic devices for culturing living cells in micrometer sized chambers in order to model physiological functions of tissues and organs. Engineered patterning and continuous fluid flow in these devices has allowed culturing of intestinal cells bearing physiologically relevant features and sustained exposure to bacteria while maintaining cellular viability, thereby allowing study of inflammatory bowl diseases. However, existing intestinal cells do not possess all physiologically relevant subtypes, do not possess the repertoire of genetic variations, or allow for study of other important cellular actors such as immune cells. Use of iPSC-derived epithelium, including IBD patient-specific cells, allows for superior disease modeling by capturing the multi-faceted nature of the disease.

公开(公告)号：EP3383413A1

公开(公告)日：2018-10-10

申请号：EP16871652.0

申请日：2016-12-02

申请人： Emulate, Inc.

发明人： HAMILTON, Geraldine ,  JANG, Kyung, Jin ,  HANEY, Suzette ,  RONXHI, Janey ,  KODELIA, Konstantia ,  PARK, Hyoung, Shin ,  SLIZ, Josiah, Daniel ,  PETROPOLIS, Debora ,  LEVNER, Daniel

IPC分类号： A61K35/407 ,  C12N5/00 ,  C12N5/071

CPC分类号： A61K35/407 ,  C12N5/067 ,  C12N2502/28 ,  C12N2533/52 ,  C12N2533/90

摘要： Provided herein relates to devices for simulating a function of a tissue and methods of using the same. In some embodiments, the devices can be used to simulate a function of a human liver tissue. In some embodiments, the devices can be used to simulate a function of a dog liver tissue. Endothelial cell culture media for long-term culture of endothelial cells are also described herein.

公开(公告)号：EP3365424A1

公开(公告)日：2018-08-29

申请号：EP16858141.1

申请日：2016-10-19

申请人： Emulate, Inc. ,  Cedars-Sinai Medical Center

发明人： KERNS, S., Jordan ,  WEN, Norman ,  LUCCHESI, Carol ,  HINOJOSA, Chris ,  FRASER, Jacob ,  HAMILTON, Geraldine ,  VATINE, Gad ,  SANCES, Samuel ,  SVENDSEN, Clive ,  LEVNER, Daniel ,  SAREEN, Dhruv

IPC分类号： C12M1/34 ,  C12M3/00 ,  C12N5/0793 ,  C12N5/0797

CPC分类号： C12M23/16 ,  B01L3/5027 ,  B01L2200/0647 ,  B01L2300/0861 ,  C12M25/02 ,  C12M35/08 ,  C12N5/0618 ,  C12N5/0619 ,  C12N5/0622 ,  C12N5/069 ,  C12N5/0692 ,  C12N2502/081 ,  C12N2502/086 ,  C12N2502/28 ,  C12N2506/45 ,  C12N2531/00 ,  C12N2533/52 ,  C12N2533/54 ,  C12N2533/56 ,  C12N2535/10 ,  C12N2539/00 ,  C12Q1/02

摘要： The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems.