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公开(公告)号：EP2797592A1
公开(公告)日：2014-11-05
申请号：EP12862080.4
申请日：2012-12-28
发明人： WOLL, Matthew G. , CHEN, Guangming , CHOI, Soongyu , DAKKA, Amal , HUANG, Song , KARP, Gary Mitchell , LEE, Chang-Sun , LI, Chunshi , NARASIMHAN, Jana , NARYSHKIN, Nikolai , PAUSHKIN, Sergey , QI, Hongyan , TURPOFF, Anthony A. , WEETALL, Marla L. , WELCH, Ellen , YANG, Tianle , ZHANG, Nanjing , ZHANG, Xiaoyan , ZHAO, Xin , PINARD, Emmanuel , RATNI, Hasane
IPC分类号： A61K31/353
CPC分类号： C07D487/04 , C07D231/12 , C07D311/16 , C07D311/18 , C07D405/04 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04 , C07D519/00
摘要： Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy. In a specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN2 into mRNA that is transcribed from the SMN2 gene. In another specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 into mRNA that is transcribed from the SMN1 gene. In yet another embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 and SMN2 into mRNA that is transcribed from the SMN1 and SMN2 genes, respectively.
摘要翻译： 本文提供了化合物，其组合物以及用于治疗脊髓性肌萎缩的用途。 在具体的实施方案中，本文提供了可用于调节SMN2的外显子7包含到从SMN2基因转录的mRNA中的形式的化合物。 在另一个具体的实施方案中，本文提供了可用于调节SMN1的外显子7包含到从SMN1基因转录的mRNA中的形式的化合物。 在又一个实施方案中，本文提供了可用于调节SMN1和SMN2的外显子7包含在分别从SMN1和SMN2基因转录的mRNA中的形式的化合物。
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公开(公告)号：EP3013345A2
公开(公告)日：2016-05-04
申请号：EP14816651.5
申请日：2014-06-23
发明人： DAKKA, Amal , GREEN, Luke , KARP, Gary , NARASIMHAN, Jana , NARYSHKIN, Nikolai , PINARD, Emmanuel , QI, Hongyan , RATNI, Hasane , RISHER, Nicole , WEETALL, Marla , WOLL, Matthew
IPC分类号： A61K31/497 , A61K31/4965 , C07D401/00
CPC分类号： C07D519/00 , C07D263/56 , C07D413/12 , C07D471/04 , C07D487/04 , C07D487/10
摘要： The present invention provides compounds of formula (I) wherein A, B, X, Y, R1 and R2 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.
摘要翻译： 本发明提供了式（I）的化合物及其药学上可接受的盐，其中A，B，X，Y，R 1和R 2如本文所述。 此外，本发明涉及式（I）化合物的制备，包含它们的药物组合物以及它们作为药物的用途。
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公开(公告)号：EP2812004A2
公开(公告)日：2014-12-17
申请号：EP13747100.9
申请日：2013-02-08
发明人： QI, Hongyan , CHOI, Soongyu , DAKKA, Amal , KARP, Gary, Mitchell , NARASIMHAN, Jana , NARYSHKIN, Nikolai , TURPOFF, Anthony, A. , WEETALL, Marla, L. , WELCH, Ellen , WOLL, Matthew, G. , YANG, Tianle , ZHANG, Nanjing , ZHANG, Xiaoyan , ZHAO, Xin , GREEN, Luke , PINARD, Emmanuel , RATNI, Hasane
IPC分类号： A61K31/53 , A01N43/90 , A61K31/519 , C07D239/70
CPC分类号： C07D471/04 , A61K31/519 , C07D239/70 , C07D487/04 , C07D519/00
摘要： Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy.
摘要翻译： 本文提供了化合物，其组合物以及用于治疗脊髓性肌萎缩的用途。
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公开(公告)号：EP2750505A1
公开(公告)日：2014-07-09
申请号：EP12828566.5
申请日：2012-08-29
发明人： BRANSTROM, Arthur , JOSYULA, Vara Prasad, Venkata Nagendra , ARNOLD, Michael, Andrew , GERASYUTO, Aleksey, I. , KARP, Gary , WANG, Jiashi , BAIRD, John David , PEDDI, Srinivasa , ARASU, Tamil , DU, Wu , GORSKE, Yi Jin Kim , TURPOFF, Anthony Allan , WILDE, Richard Gerald , GINZBURG, Olya , ZHANG, Nanjing , QI, Hongyan , ZHANG, Xiaoyan , SMITH, Sean Wesley , YANG, Tianle , NARASIMHAN, Jana
CPC分类号： C07D515/04 , A01N43/40 , A01N43/50 , A01N43/56 , A01N43/60 , A01N43/647 , A01N43/84 , A01N43/90 , A01N47/38 , A61K31/4412 , A61K31/4427 , A61K31/4439 , A61K31/496 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D213/80 , C07D401/10 , C07D487/08 , Y02A50/473 , Y02A50/475 , A61K2300/00
摘要： The present description relates to compounds and forms and pharmaceutical compositions thereof and methods for use thereof to treat or ameliorate bacterial infections caused by wild-type and multi-drug resistant Gram-negative and Gram-positive pathogens.
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公开(公告)号：EP1737461B1
公开(公告)日：2012-12-12
申请号：EP05725560.6
申请日：2005-03-15
发明人： MOON, Young-Choon , CAO, Liangxian , TAMILARASU, Nadarajan , QI, Hongyan , CHOI, Soongyu , LENNOX, William Joseph , CORSON, Donald Thomas , HWANG, Seongwoo
IPC分类号： A61K31/497 , A61K31/437 , A61K31/506 , A61K31/5355 , A61K31/551 , A61K31/541 , C07D471/04 , A61P35/00
CPC分类号： A61K31/506 , A61K31/437 , A61K31/4745 , A61K31/497 , A61K31/5355 , A61K31/541 , A61K31/551 , C07D471/04
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公开(公告)号：EP2434891A1
公开(公告)日：2012-04-04
申请号：EP10781238.0
申请日：2010-05-27
发明人： ALMSTEAD, Neil , ARASU, Tamil , CHOI, Soongyu , CAO, Liangxian , CAMPBELL, Jeff , CORSON, Don , DAVIS, Thomas, W. , GRACI, Jason, D. , GU, Zhengxian , HWANG, Peter, Seongwoo , LENNOX, William , MIAO, Harry, H. , MILLER, Langdon , MOON, Young-Choon , QI, Hongyan , TROTTA, Christopher , WEETALL, Marla, L.
摘要： Compounds, such as compounds of Formula (I), that selectively inhibit pathological production of human vascular endothelial growth factor (VEGF) and compositions comprising such Compounds are described. Compounds that inhibit viral replication or the production of viral RNA or DNA or viral protein and compositions comprising such Compounds are described. Also described are methods of reducing VEGF using such Compounds and methods for treating cancer and non-neoplastic conditions involving the administration of such Compounds. Further described are methods of inhibiting viral replication or the production of viral RNA or DNA or viral protein using such Compounds and methods for treating viral infections involving the administration of such Compounds. The Compounds may be administered as a single agent therapy or in combination with one or more additional therapies to a human in need of such treatments.
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7.发明公开TETRAHYDROCARBAZOLES AS ACTIVE AGENTS FOR INHIBITING VEGF PRODUCTION BY TRANSLATIONAL CONTROL 审中-公开四氢咔唑AS活性物质用于抑制VEGF的产生通过平移控制
公开(公告)号：EP1817025A2
公开(公告)日：2007-08-15
申请号：EP05852075.0
申请日：2005-11-23
发明人： LENNOX, William Joseph , QI, Hongyan , LEE, Duck-Hyung, Sogang University , CHOI, Soongyu , MOON, Young-Choon
IPC分类号： A61K31/403
CPC分类号： A61K31/403 , A61K31/343 , A61K31/4035 , A61K31/407 , A61K31/4162 , A61K31/4184 , A61K31/4188 , A61K31/424 , A61K31/4245 , A61K31/506 , A61K31/5377 , C07D209/08 , C07D209/90 , C07D471/04
摘要： The present invention relates to methods, compounds, and compositions for inhibiting angiogenesis. More particularly, the present invention relates to methods, compounds, and compositions for inhibiting VEGF production.
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公开(公告)号：EP1732543A2
公开(公告)日：2006-12-20
申请号：EP05733369.2
申请日：2005-03-15
发明人： MOON, Young-Choon , CAO, Liangxian , TAMILARASU, Nadarajan , QI, Hongyan , CHOI, Soongyu , LENNOX, William, Joseph , CORSON, Donald, Thomas
IPC分类号： A61K31/4166 , A61P35/00 , A61P9/10 , A61P17/06 , A61P19/02 , A61P3/04 , A61P27/00 , A61P29/00
CPC分类号： A61K31/4166 , C07D221/18 , C07D235/02 , C07D239/26 , C07D241/04 , C07D265/30 , C07D307/78 , C07D317/48
摘要： In accordance with the present invention,tetracyclic caboline derivatives that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, these compounds useful in the inhibition of VEGF production, in the inhibition of angiogenesis, and/or in the treatment of cancer, diabetic retinopathy or exudative macular degeneration are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the inhibition of angiogenesis, and/or the treatment of cancer, diabetic retinopathy or exudative macular degeneration using the compounds of the invention.
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公开(公告)号：EP2812004B1
公开(公告)日：2018-06-27
申请号：EP13747100.9
申请日：2013-02-08
发明人： QI, Hongyan , CHOI, Soongyu , DAKKA, Amal , KARP, Gary, Mitchell , NARASIMHAN, Jana , NARYSHKIN, Nikolai , TURPOFF, Anthony, A. , WEETALL, Marla, L. , WELCH, Ellen , WOLL, Matthew, G. , YANG, Tianle , ZHANG, Nanjing , ZHANG, Xiaoyan , ZHAO, Xin , GREEN, Luke , PINARD, Emmanuel , RATNI, Hasane
IPC分类号： A61K31/53 , A61K31/519 , C07D471/04 , C07D487/04 , C07D519/00 , A61K31/4375 , A61P25/00
CPC分类号： C07D471/04 , A61K31/519 , C07D239/70 , C07D487/04 , C07D519/00
摘要： Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy.
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公开(公告)号：EP3013345B1
公开(公告)日：2017-11-22
申请号：EP14816651.5
申请日：2014-06-23
发明人： DAKKA, Amal , GREEN, Luke , KARP, Gary , NARASIMHAN, Jana , NARYSHKIN, Nikolai , PINARD, Emmanuel , QI, Hongyan , RATNI, Hasane , RISHER, Nicole , WEETALL, Marla , WOLL, Matthew
IPC分类号： C07D263/56 , C07D413/12 , C07D471/04 , C07D487/04 , C07D487/10 , A61K31/497 , A61K31/4965 , A61P25/28
CPC分类号： C07D519/00 , C07D263/56 , C07D413/12 , C07D471/04 , C07D487/04 , C07D487/10
摘要： The present invention provides compounds of formula (I) wherein A, B, X, Y, R1 and R2 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.
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