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1.发明公开NEUE, GERUCHSSTOFFE BILDENDE GENPRODUKTE VON BACILLLUS LICHENIFORMIS UND DARAUF AUFBAUENDE VERBESSERTE BIOTECHNOLOGISCHE PRODUKTIONSVERFAHREN 审中-公开新，闻物质地衣芽孢杆菌，应该建设的FINE基因产物改良生物技术生产
公开(公告)号：EP1761628A2
公开(公告)日：2007-03-14
申请号：EP05752264.1
申请日：2005-06-17
发明人： BESSLER, Cornelius , FEESCHE, Jörg , EVERS, Stefan , MAURER, Karl-Heinz , EHRENREICH, Armin , VEITH, Birgit , LIESEGANG, Heiko , HENNE, Anke , HERZBERG, Christina , GOTTSCHALK, Gerhard
CPC分类号： C12N15/52 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0016 , C12N9/1025 , C12N9/1029 , C12N9/1096 , C12N9/1217 , C12N9/16 , C12N9/78 , C12N9/80 , C12N9/84 , C12N9/88 , C12N9/93 , C12N15/75 , C12P7/16 , C12P7/40 , C12P7/42 , C12P7/52 , C12P13/001 , C12Y101/01 , C12Y101/01035 , C12Y101/01157 , C12Y102/04002 , C12Y103/99 , C12Y203/01019 , C12Y206/01042 , C12Y207/02007 , C12Y305/01001 , C12Y305/01011 , C12Y401/01018 , C12Y401/01019 , C12Y402/01017 , C12Y402/01055 , C12Y602/01 , C12Y602/01001 , Y02E50/10 , Y02P20/52
摘要： The present invention relates to 25 hitherto undescribed genes of B. licheniformis and gene products derived therefrom and all sufficiently homologous nucleic acids and proteins thereof. They occur in five different metabolic pathways for the formation of odorous substances. The metabolic pathways in question are for the synthesis of: 1) isovalerian acid (as part of the catabolism of leucine), 2) 2-methylbutyric acid and/or isobutyric acid (as part of the catabolism of valine and/or isoleucine), 3) butanol and/or butyric acid (as part of the metabolism of butyric acid), 4) propyl acid (as part of the metabolism of propionate) and/or 5) cadaverine and/or putrescine (as parts of the catabolism of lysine and/or arginine). The identification of these genes allows biotechnological production methods to be developed that are improved to the extent that, to assist these nucleic acids, the formation of the odorous substances synthesised via these metabolic pathways can be reduced by deactivating the corresponding genes in the micro-organism used for the biotechnological production. In addition, these gene products are thus available for preparing reactions or for methods according to their respective biochemical properties.
摘要翻译： 二十五中细菌的生物合成所涉及的核酸序列（A），特别是在异戊酸，2-甲基，和异丁propylic酸，丁醇，尸胺和/或腐胺的芽孢杆菌licheniformisDSM 13是新的。 因此独立权利要求中包括了：（1）的基因产物（B）（A）; （2）在其中的微生物发酵的至少一个基因，参与代谢途径（ⅰ）异戊酸，（ⅱ）2-甲基和/或异丁酸，（III）丁醇和/或丁酸，（ⅳ ）propylic酸或（v）尸胺和/或腐胺，已经失活; （3）使用用于（i）的合成代谢途径的功能性失活的特定基因的 - 上述（v）的; （4），其中至少一个（A）的微生物已经失活; 和（5）的微生物发酵（4）。
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2.发明公开
公开(公告)号：EP1794293A2
公开(公告)日：2007-06-13
申请号：EP05796115.3
申请日：2005-09-22
CPC分类号： C11D3/38681 , C12N9/2417
摘要： The invention relates to α-amylase variants that are stabilized by the point mutagenesis of asparagine (N-) radicals or glutamine (Q-) radicals, these radicals being located on the surface of the molecule, to form other amino acids with regard to a hydrolysis performed via the solvent, in particular, at elevated temperatures or high pH values. The invention also relates to methods for increasing the stability of an α-amylase with regard to a hydrolysis performed via the solvent, in particular, at elevated temperatures or high pH values, whereby at least one asparagine (N-) radical or glutamine (Q-) radical located on the surface of the molecule is exchanged to form another amino acid radical. The α-amylase variants obtained in this manner exhibit a better stability with regard to influences by solvents, an increased processivity and are suited for numerous technical areas of application, particularly for use as active ingredients in detergents and cleansers.
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公开(公告)号：EP1756352A1
公开(公告)日：2007-02-28
申请号：EP05755082.4
申请日：2005-06-09
发明人： STEHR, Regina , BESSLER, Cornelius , MAURER, Karl-Heinz , WIELAND, Susanne , HOVEN, Nina , PRÜSER, Inken
IPC分类号： D06L3/11
CPC分类号： A61Q5/08 , A61K8/66 , A61K2800/59 , A61Q11/02 , C11D3/38636 , C11D3/38654 , C12N9/0006 , C12N9/54
摘要： A new enzymatic bleaching system is disclosed comprising at least one oxidase and at least one perhydrolase. Also disclosed are body care products, hair washing products, hair care products, mouth, tooth, and dental prosthesis care products, tooth brace care products, cosmetics, therapeutic agents, textile washing products, detergents, rinsing products, textile machine-washing products, textile hand-washing products, hand dish-washing products, machine dish-washing products, disinfectants and means for bleaching or disinfecting filter media, textiles, pelts, paper, fur or leather, containing the new enzymatic bleaching system, as well as corresponding uses of the new enzymatic bleaching system and these products.
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公开(公告)号：EP1572993A2
公开(公告)日：2005-09-14
申请号：EP03767793.7
申请日：2003-12-12
发明人： SAUTER, Kerstin , WEISS, Albrecht , MAURER, Karl-Heinz , EVERS, Stefan , HOVEN, Nina , WIELAND, Susanne , STEHR, Regina , BESSLER, Cornelius
CPC分类号： C12N9/0006 , A61K8/66 , A61Q5/02 , A61Q5/10 , A61Q11/02 , C12Y101/03017
摘要： The invention relates to choline oxidases, methods for obtaining the same, bodycare products, haircare products, shampoos, oral, dental and dental prosthesis care products, cosmetics, washing products, cleaning products, rinsing products, hand soaps, washing-up detergents and dishwasher detergents comprising novel choline oxidases and uses of the choline oxidases.
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5.发明公开
公开(公告)号：EP1794292A2
公开(公告)日：2007-06-13
申请号：EP05788794.5
申请日：2005-09-22
CPC分类号： C12N9/2417 , C11D3/38681
摘要： The invention relates to α-amylase variants, which are stabilized with regard to dimerization and/or multimerization by the point mutagenesis of positively polarized or charged or neutral surface amino acids into negatively polarized or charged amino acids. The invention also relates to methods for increasing the stability of an α-amylase with regard to a dimerization and/or multimerization induced by electrostatic interactions, whereby at least one amino acid radical of the starting molecule, which is located on the surface of the molecule and which exerts a neutral or positively polar or charged contribution to the electrostatic potential of the molecule, is replaced by a stronger negatively polar or negatively charged amino acid radical. The α-amylase variants obtained in this manner exhibit an improved processivity and are suited for numerous technical areas of application, particularly for use as active ingredients in detergents and cleansers.
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6.发明公开NEUE, POLYAMINOSÄUREN BILDENDE ODER ABBAUENDE GENPRODUKTE VON BACILLUS LICHENIFORMIS UND DARAUF AUFBAUENDE VERBESSERTE BIOTECHNOLOGISCHE PRODUKTIONSVERFAHREN 有权新聚FINE或减少地衣芽孢杆菌和SURE文苑END基因产物改良生物技术生产
公开(公告)号：EP1761557A1
公开(公告)日：2007-03-14
申请号：EP05750181.9
申请日：2005-06-11
发明人： FEESCHE, Jörg , BESSLER, Cornelius , EVERS, Stefan , MAURER, Karl-Heinz , EHRENREICH, Armin , VEITH, Birgit , LIESEGANG, Heiko , HENNE, Anke , HERZBERG, Christina , GOTTSCHALK, Gerhard
摘要： The invention relates to five or four novel genes and the gene products thereof from Bacillus licheniformis and sufficiently similar genes and proteins which are involved in vivo in the formation of polyamino acids. The gene in question is ywsC, ywsC', ywtA, ywtB and ywtD or proteins coded thereby. The gene ywsC, ywsC', ywtA and ywtB can be used to improve biotechnological production methods by microorganisms, wherein they are functionally inactivated; the gene ywtD which codes for a peptide decomposing poly-gamma glutamate can, inversely, contribute to the improvement of biotechnological production methods by increased expression. Said genes can be used positively, preferably to result in a modification or decomposition of poly-gamma glutamate.
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