公开(公告)号：EP1390396A2

公开(公告)日：2004-02-25

申请号：EP02749524.1

申请日：2002-04-25

申请人： Incyte Genomics, Inc. ,  Gietzen, Kimberly J.

发明人： LAL, Preeti, G. ,  YUE, Henry ,  LU, Yan ,  YAO, Monique, G. ,  BECHA, Shanya, D. ,  BURFORD, Neil ,  BAUGHN, Mariah, R. ,  TANG, Y., Tom ,  BOROWSKY, Mark, L. ,  ELLIOTT, Vicki, S. ,  CHAWLA, Narinder, K. ,  LEE, Sally ,  YANG, Junming ,  EMERLING, Brooke, M. ,  NGUYEN, Danniel, B. ,  JACKSON, Jennifer L. ,  KHAN, Farrah, A. ,  HAFALIA, April, J., A. ,  ISON, Craig, H. ,  XU, Yuming ,  RICHARDSON, Thomas W. ,  FORSYTHE, Ian J. ,  SWARNAKAR, Anita ,  WARREN, Bridget A. ,  DING, Li ,  ZEBARJADIAN, Yeganeh ,  LEE, Soo Yeun ,  HONCHELL, Cynthia D. ,  THANGAVELU, Kavitha ,  DUGGAN, Brendan M. ,  TRAN, Uyen K. ,  GRAUL, Richard C. ,  POLICKY, Jennifer L. ,  LIANG, Shoudan ,  PETERSON, David P. ,  COCKS, Benjamin G. ,  SANJANWALA, Bharati ,  BANDMAN, Olga ,  HAWKINS, Phillip R. ,  BELL, Barrie D. ,  GORVAD, Ann E.

IPC分类号： C07K14/00

摘要： The invention provides human molecules for disease detection and treatment (MDDT) and polynucleotides which identify and encode MDDT. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of MDDT.

摘要翻译： 本发明提供了用于疾病检测和治疗的人分子（MDDT）和鉴定和编码MDDT的多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供诊断，治疗或预防与MDDT异常表达相关的病症的方法。

公开(公告)号：EP1519741A2

公开(公告)日：2005-04-06

申请号：EP02791393.8

申请日：2002-12-04

申请人： Incyte Genomics, Inc.

发明人： GRIFFIN, Jennifer, A. ,  RAMKUMAR, Jayalaxmi ,  EMERLING, Brooke, M. ,  KABLE, Amy, E. ,  ELLIOTT, Vicki, S. ,  MARQUIS, Joseph, P. ,  BAUGHN, Mariah, R. ,  GORVAD, Ann, E. ,  YUE, Henry ,  LEE, Ernestine, A. ,  BECHA, Shanya, D. ,  TANG, Y., Tom ,  TRAN, Uyen, K. ,  SWARNAKAR, Anita ,  LEE, Sally ,  ISON, Craig, H. ,  HAFALIA, April, J., A. ,  TRAN, Bao ,  SPRAGUE, William, W. ,  KHARE, Reena ,  GANDHI, Ameena, R.

IPC分类号： A61K38/00 ,  A61K39/395 ,  C12Q1/00 ,  C12Q1/68 ,  G01N33/53 ,  C07K7/00 ,  C07K17/00 ,  C07K16/00 ,  C07H21/04

CPC分类号： C07K14/47

摘要： Various embodiments of the invention provide human proteins associated with cell growth, differentiation, and death (CGDD) and polynucleotides which identify and encode CGDD. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of CGDD.

公开(公告)号：EP1485474A2

公开(公告)日：2004-12-15

申请号：EP02795774.5

申请日：2002-12-06

申请人： Incyte Genomics, Inc.

发明人： KABLE, Amy, E. ,  CHIEN, David ,  WILSON, Amy, D. ,  SWARNAKAR, Anita ,  GORVAD, Ann, E. ,  HAFALIA, April, J., A. ,  EMERLING, Brooke, M. ,  RAMKUMAR, Jayalaxmi ,  JIN, Pei ,  GRIFFIN, Jennifer, A. ,  MARQUIS, Joseph, P. ,  BAUGHN, Mariah, R. ,  CHAWLA, Narinder, K. ,  LEHR-MASON, Patricia, M. ,  KHARE, Reena ,  LEE, Sally ,  HAWKINS, Phillip, R. ,  BECHA, Shanya, D. ,  LEE, Soo, Yeun ,  ZEBARJADIAN, Yeganeh

IPC分类号： C12N9/16 ,  A61K38/00 ,  A61K38/46

CPC分类号： C12N9/1205 ,  C12N9/16

摘要： Various embodiments of the invention provide human kinases and phosphatases (KPP) and polynucleotides which identify and encode KPP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of KPP.

公开(公告)号：EP1481081A2

公开(公告)日：2004-12-01

申请号：EP02736944.6

申请日：2002-05-17

申请人： Incyte Genomics, Inc.

发明人： TANG, Y., Tom ,  YUE, Henry ,  AZIMZAI, Yalda ,  BAUGHN, Mariah, R. ,  BURFORD, Neil ,  REDDY, Roopa ,  WALIA, Narinder, K. ,  DAS, Debopriya ,  NGUYEN, Danniel, B. ,  YAO, Monique, G. ,  ARVIZU, Chandra, S. ,  LU, Yan ,  GANDHI, Ameena, R. ,  GRIFFIN, Jennifer, A. ,  ELLIOTT, Vicki, S. ,  RAMKUMAR, Jayalaxmi ,  LAL, Preeti, G. ,  LU, Dyung Aina, M. ,  LEE, Ernestine, A. ,  LEE, Soo Yeun ,  YUE, Huibin ,  YANG, Junming ,  TRIBOULEY, Catherine M. ,  KABLE, Amy E. ,  SWARNAKAR, Anita

IPC分类号： C12Q1/68 ,  G01N33/53 ,  A61K38/17 ,  C07K14/47 ,  C07K16/18

CPC分类号： C07K14/4702 ,  A61K38/00 ,  C12N9/20

摘要： The invention provides human lipid-associated molecules (LIPAM) and polynucleotides which identify and encode LIPAM. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of LIPAM.

摘要翻译： 本发明提供了鉴定和编码LIPAM的人类脂质相关分子（LIPAM）和多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供了用于诊断，治疗或预防与LIPAM异常表达相关的病症的方法。

公开(公告)号：EP1429806A2

公开(公告)日：2004-06-23

申请号：EP02761511.1

申请日：2002-08-22

申请人： Incyte Genomics, Inc.

发明人： DUGGAN, Brendan, M. ,  LEE, Sally ,  BAUGHN, Mariah, R. ,  HAFALIA, April, J.A. ,  CHAWLA, Narinder, K. ,  ELLIOTT, Vicki, S. ,  LEE, Soo, Yeun ,  KHARE, Reena ,  WILSON, Amy, D. ,  JIN, Pei ,  HAWKINS, Phillip, R. ,  TANG, Y., Tom ,  BURFORD, Neil ,  DING, Li ,  YAO, Monique, G. ,  BECHA, Shanya, D. ,  TRAN, Uyen, K. ,  CHIEN, David ,  ZEBARJADIAN, Yeganeh ,  RICHARDSON, Thomas W. ,  KABLE, Amy E. ,  CHANG, Hsin-Ru ,  SWARNAKAR, Anita ,  LEHR-MASON, Patricia M. ,  RAMKUMAR, Jayalaxmi

IPC分类号： A61K45/00 ,  C07K14/00 ,  C12P21/04

CPC分类号： C07K14/47

摘要： Various embodiments of the invention provide human extracellular messengers (EXMES) and polynucleotides which identify and encode EXMES. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of EXMES.

摘要翻译： 本发明的各种实施方案提供了鉴定和编码EXMES的人细胞外信使（EXMES）和多核苷酸。 本发明的实施方案还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 其他实施方案提供了用于诊断，治疗或预防与EXMES的异常表达相关的病症的方法。

公开(公告)号：EP1409677A2

公开(公告)日：2004-04-21

申请号：EP02709076.0

申请日：2002-01-16

申请人： Incyte Genomics, Inc.

发明人： LEE, Ernestine, A. ,  CHAWLA, Narinder, K. ,  BAUGHN, Mariah, R. ,  AZIMZAI, Yalda ,  TANG, Y., Tom ,  YUE, Henry ,  THANGAVELU, Kavitha ,  XU, Yuming ,  ARVIZU, Chandra ,  WARREN, Bridget, A. ,  YAO, Monique, G. ,  AU-YOUNG, Janice ,  HAFALIA, April, J., A. ,  ELLIOTT, Vicki, S. ,  KALLICK, Deborah, A. ,  GANDHI, Ameena, R. ,  RICHARDSON, Thomas, W. ,  KHAN, Farrah, A. ,  LU, Yan ,  SWARNAKAR, Anita ,  RAMKUMAR, Jayalaxmi ,  NGUYEN, Danniel B. ,  GRAUL, Richard C. ,  LU, Dyung Aina M.

IPC分类号： C12N15/12 ,  C07K14/705 ,  C12N5/10 ,  A01K67/027 ,  C07K16/28 ,  C12Q1/68 ,  A61K38/17 ,  G01N33/68 ,  A61K39/395

CPC分类号： C07K14/705 ,  A61K38/00

摘要： The invention provides human receptors and membrane-associated proteins (REMAP) and polynucleotides which identify and encode REMAP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of REMAP.

公开(公告)号：EP1409550A1

公开(公告)日：2004-04-21

申请号：EP02739996.3

申请日：2002-06-26

申请人： Incyte Genomics, Inc.

发明人： DELEGEANE, Angelo, M. ,  BOROWSKY, Mark, L. ,  KHAN, Farrah, A. ,  KEARNEY, Liam ,  RAMKUMAR, Jayalaxmi ,  CHAWLA, Narinder, K. ,  LU, Yan ,  HONCHELL, Cynthia, D. ,  KALLICK, Deborah, A. ,  EMERLING, Brooke, M. ,  GORVAD, Ann, E. ,  GRIFFIN, Jennifer, A. ,  WARREN, Bridget, A. ,  YUE, Henry ,  THANGAVELU, Kavitha ,  SPRAGUE, William, W. ,  ISON, Craig, H. ,  ELLIOTT, Vicki, S. ,  MASON, Patricia, M. ,  RICHARDSON, Thomas W. ,  TRAN, Uyen K. ,  SWARNAKAR, Anita ,  JIN, Pei ,  KABLE, Amy E.

IPC分类号： C07K17/00

CPC分类号： C07K14/47 ,  A61K38/00

摘要： Various embodiments of the invention provide human extracellular messengers (EXMES) and polynucleotides which identify and encode EXMES. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of EXMES.

公开(公告)号：EP1379654A2

公开(公告)日：2004-01-14

申请号：EP02713563.1

申请日：2002-02-07

申请人： Incyte Genomics, Inc.

发明人： DING, Li ,  WARREN, Bridge, A. ,  ELLIOTT, Vicki, S. ,  TANG, Y., Tom ,  YUE, Henry ,  BURFORD, Neil ,  LEE, Sally ,  RICHARDSON, Thomas, W. ,  LAL, Preeti ,  NGUYEN, Danniel, B. ,  YANG, Junming ,  HAFALIA, April, J., A. ,  ISON, Craig, H. ,  GURURAJAN, Rajagopal ,  BAUGHN, Mariah, R. ,  WANG, Yumei, E. ,  YAO, Monique, G. ,  THANGAVELU, Kavitha ,  SWARNAKAR, Anita ,  GRIFFIN, Jennifer, A. ,  FORSYTHE, Ian, J. ,  EMERLING, Brooke, M. ,  CHAWLA, Narinder, K.

IPC分类号： C12N15/12

CPC分类号： C07K14/47 ,  A01K2217/05

摘要： The invention provides human intracellular signaling molecules (INTSIG) and polynucleotides which identify and encode INTSIG. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of INSTSIG.

公开(公告)号：EP1572877A2

公开(公告)日：2005-09-14

申请号：EP02740014.2

申请日：2002-07-05

申请人： Incyte Genomics, Inc.

发明人： GRIFFIN, Jennifer, A. ,  RAMKUMAR, Jayalaxmi ,  EMERLING, Brooke, M. ,  RICHARDSON, Thomas, W. ,  LI, Joana, X. ,  WARREN, Bridget, A. ,  HONCHELL, Cynthia, D. ,  BAUGHN, Mariah, R. ,  TANG, Y., Tom ,  LEE, Ernestine, A. ,  ELLIOTT, Vicki, S. ,  YUE, Henry ,  LEE, Sally ,  SWARNAKAR, Anita ,  FORSYTHE, Ian, J. ,  SANJANWALA, Madhusudan, M. ,  YAO, Monique, G. ,  ZEBARJADIAN, Yeganeh ,  GORVAD, Ann, E. ,  BECHA, Shanya

IPC分类号： C12N1/00

CPC分类号： C07K14/47 ,  A61K38/00 ,  C12N9/00

摘要： Various embodiments of the invention provide human drug metabolizing enzymes (DME) and polynucleotides which identify and encode DME. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of DME.

摘要翻译： 本发明的各种实施方式提供了鉴定和编码DME的人类药物代谢酶（DME）和多核苷酸。 本发明的实施方案还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 其他实施方案提供了诊断，治疗或预防与DME异常表达相关的病症的方法。

公开(公告)号：EP1551872A2

公开(公告)日：2005-07-13

申请号：EP02746660.6

申请日：2002-06-20

申请人： Incyte Genomics, Inc.

发明人： BAUGHN, Mariah, R. ,  CHAWLA, Narinder, K. ,  RICHARDSON, Thomas, W. ,  ISON, Craig, H. ,  YANG, Junming ,  EMERLING, Brooke, M. ,  THORNTON, Michael ,  BOROWSKY, Mark, L. ,  RAMKUMAR, Jayalaxmi ,  YUE, Henry ,  GRAUL, Richard, C. ,  HAFALIA, April, J., A. ,  LU, Dyung Aina, M. ,  LU, Yan ,  KALLICK, Deborah, A. ,  GANDHI, Ameena, R. ,  WARREN, Bridget, A. ,  LEE, Ernestine, A. ,  SWARNAKAR, Anita ,  WALSH, Roderick, T. ,  YAO, Monique, G. ,  GRIFFIN, Jennifer, A. ,  AU-YOUNG, Janice, K. ,  KHAN, Farrah, A. ,  LEE, Soo, Yeun ,  ELLIOTT, Vicki, S.

IPC分类号： C07K14/705 ,  C12N15/12

CPC分类号： C07K14/705

摘要： Various embodiments of the invention provide human G-protein coupled receptors (GCREC) and polynucleotides which identify and encode GCREC. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of GCREC.

摘要翻译： 本发明的各种实施方案提供了鉴定和编码GCREC的人G蛋白偶联受体（GCREC）和多核苷酸。 本发明的实施方案还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 其他实施方案提供了用于诊断，治疗或预防与GCREC的异常表达相关的病症的方法。