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公开(公告)号：EP2076278A4
公开(公告)日：2012-12-26
申请号：EP07839705
申请日：2007-10-19
CPC分类号： C07K5/0812 , A61K38/00 , C07K5/0808
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公开(公告)号：EP2079479A4
公开(公告)日：2010-12-22
申请号：EP07839703
申请日：2007-10-19
发明人： LIVERTON NIGEL J , SUMMA VINCENZO , VACCA JOSEPH P
CPC分类号： C07D498/18 , C07F9/6561
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3.发明公开N-BENZYL-3,4-DIHYROXYPYRIDINE-2-CARBOXAMIDE AND N-BENZYL-2,3-DIHYDROXYPYRIDINE-4-CARBOXAMIDE COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS 审中-公开N-苄基-3,4-二羟基吡啶-2-羧酸酰胺和N-苄基-2,3-二羟基吡啶-4-羧酸适合作为HIV整合SUITABLE抑制剂酸酰胺化合物
公开(公告)号：EP1713773A4
公开(公告)日：2009-09-23
申请号：EP05726383
申请日：2005-01-26
IPC分类号： C07D211/74 , A61K31/44
CPC分类号： C07D213/64 , C07D213/69 , C07D213/81 , C07D401/12 , C07D401/14 , C07D403/14 , C07D409/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
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4.发明公开2'-AZIDO SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 审中-公开2'-叠氮取代的核苷及使用方法进行病毒疾病治疗
公开(公告)号：EP2697242A4
公开(公告)日：2014-10-01
申请号：EP12771707
申请日：2012-04-11
申请人： MERCK SHARP & DOHME
发明人： GIRIJAVALLABHAN VINAY , NJOROGE F GEORGE , BOGEN STEPHANE , BENNETT FRANK , VERMA VISHAL , ARASAPPAN ASHOK , CHEN KEVIN , HUANG YING , KEREKES ANGELA , NAIR LATHA , PISSARNITSKI DMITRI , DANG QUN , DAVIES IAN , OLSEN DAVID B , STAMFORD ANDREW , VACCA JOSEPH P
IPC分类号： C07H21/02 , C07H19/06 , C07H19/10 , C07H19/11 , C07H19/12 , C07H19/16 , C07H19/20 , C07H19/207 , C07H19/213
CPC分类号： C07H19/06 , A61K31/7056 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/708 , A61K45/06 , C07H19/10 , C07H19/11 , C07H19/12 , C07H19/16 , C07H19/20 , C07H19/207 , C07H19/213
摘要： The present invention relates to 2′-Azido Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, X, R1, R2 and R3 are as defined herein. The present invention also relates to compositions comprising at least one 2′-Azido Substituted Nucleoside Derivative, and methods of using the 2′-Azido Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.
摘要翻译： 本发明涉及式（I）的2'-叠氮取代的核苷衍生物：它们，worin B，X，R1，R2和R3如在定义和药学上可接受的盐。 因此，本发明涉及组合物，其包括至少一个2'-叠氮取代的核苷衍生物，以及使用该2'-叠氮取代的核苷衍生物用于治疗或在患者中预防HCV感染症的方法。
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5.发明公开2'-SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 审中-公开2'-取代的核苷及使用方法进行病毒疾病治疗
公开(公告)号：EP2696681A4
公开(公告)日：2014-10-01
申请号：EP12771566
申请日：2012-04-11
申请人： MERCK SHARP & DOHME
发明人： GIRJAVALLABHAN VINAY , NJOROGE F GEORGE , BOGEN STEPHANE , VERMA VISHAL , BENNETT FRANK , KEREKES ANGELA , ARASAPPAN ASHOK , PISSARNITSKI DIMITRI , DANG QUN , DAVIES IAN , OLSEN DAVID B , STAMFORD ANDREW , VACCA JOSEPH P
IPC分类号： C07H21/02 , A61K31/7042 , A61K31/7068 , A61K31/7072 , A61K45/06 , C07H19/06 , C07H19/10 , C07H19/11 , C07H19/12 , C07H19/16 , C07H19/20 , C07H19/207 , C07H19/213
CPC分类号： A61K31/7072 , A01N47/36 , A61K31/7042 , A61K31/7068 , A61K45/06 , C07H17/02 , C07H19/10 , C07H19/11 , C07H19/207 , C07H19/213 , A01N2300/00 , A01N43/54 , A01N43/56 , A01N43/653 , A01N43/76 , A01N43/82 , A01N43/84 , A01N43/90
摘要： The present invention relates to 2′-Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, X, R1, R2 and R3 are as defined herein. The present invention also relates to compositions comprising at least one 2′-Substituted Nucleoside Derivative, and methods of using the 2′-Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.
摘要翻译： 本发明涉及式（I）的2'-取代的核苷衍生物：及其药学上可接受的盐，worin A，B，X，R 1，R 2和R 3如所定义。 因此，本发明涉及组合物，其包含至少一个2'-取代的核苷衍生物，以及使用该2'-取代的核苷衍生物用于治疗或在患者中预防HCV感染症的方法。
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6.发明公开POLYCYCLIC HETEROCYCLE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 审中-公开多环芳烃HETEROFLEXIBLE病毒疾病的治疗周期衍生物及其使用方法
公开(公告)号：EP2621501A4
公开(公告)日：2014-04-09
申请号：EP11833019
申请日：2011-09-28
申请人： MERCK SHARP & DOHME
IPC分类号： A61K31/675 , A61K31/404 , A61K31/4178 , A61K31/423 , A61K31/517 , A61K31/519 , A61K31/555 , A61K31/7056 , A61K38/00 , A61K38/12 , A61K45/06 , A61P31/12
CPC分类号： A61K31/5365 , A61K31/404 , A61K31/4178 , A61K31/423 , A61K31/4985 , A61K31/517 , A61K31/519 , A61K31/555 , A61K31/7056 , A61K38/05 , A61K38/07 , A61K38/21 , A61K38/212 , A61K45/06 , A61K2300/00
摘要： The present invention relates to Polycyclic Heterocycle Derivatives, such as compound 1: (1) compositions comprising the Polycyclic Heterocycle Derivatives, and methods of using the Polycyclic Heterocycle Derivatives for treating or preventing HCV infection in a patient.
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公开(公告)号：EP2410844A4
公开(公告)日：2012-11-14
申请号：EP10756840
申请日：2010-03-25
申请人： MERCK SHARP & DOHME
发明人： COBURN CRAIG A , MCCAULEY JOHN A , LUDMERER STEVEN W , LIU KUN , VACCA JOSEPH P , WU HAO , HU BIN , SOLL RICHARD , SUN FEI , WANG XINGHAI , YAN MAN , ZHANG CHENGREN , ZHENG MINGWEI , ZHONG BIN , ZHU JIAN
IPC分类号： C07D471/04 , A01K31/16 , A61K31/404 , A61K31/438 , A61P31/00 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D487/04 , C07D498/04
CPC分类号： C07D498/04 , A61K31/4025 , A61K31/404 , A61K31/4178 , A61K31/4184 , A61K31/423 , A61K31/437 , A61K31/4439 , A61K31/4985 , A61K31/506 , A61K31/5365 , A61K31/5377 , A61K31/5383 , A61K31/553 , A61K38/05 , A61K38/06 , A61K45/06 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D498/10 , C07K5/06 , C07K5/08
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公开(公告)号：EP2435037A4
公开(公告)日：2012-10-17
申请号：EP10781008
申请日：2010-05-18
申请人： MERCK SHARP & DOHME
CPC分类号： C07D207/14
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公开(公告)号：EP3212619A4
公开(公告)日：2018-05-30
申请号：EP15855693
申请日：2015-10-26
申请人： MERCK SHARP & DOHME
发明人： DING FA-XIANG , DONG SHUZHI , JIANG JINLONG , SUZUKI TAKAO , VACCA JOSEPH P , XU SHOUNING
IPC分类号： C07D471/10 , A61K31/401 , A61K31/41 , A61K31/4178 , A61K31/4184 , A61K31/435 , A61K31/4422 , A61K31/55 , A61P9/10 , A61P9/12 , A61P13/12
CPC分类号： C07D471/10 , A61K31/401 , A61K31/41 , A61K31/4178 , A61K31/4184 , A61K31/435 , A61K31/4422 , A61K31/444 , A61K31/501 , A61K31/55 , A61K2300/00
摘要： The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
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公开(公告)号：EP3169672A4
公开(公告)日：2018-03-14
申请号：EP15821391
申请日：2015-07-09
申请人： MERCK SHARP & DOHME
发明人： PASTERNAK ALEXANDER , DAVIES IAN , DING FA XIANG , JIANG JINLONG , DONG SHUZHI , GU XIN , SUZUKI TAKAO , VACCA JOSEPH P , PU ZHIFA , XU SHOUNING
IPC分类号： C07D401/00 , A61K31/435 , A61K31/4375 , A61K31/4745 , A61P1/00 , A61P5/48 , A61P7/02 , A61P9/00 , A61P13/00
CPC分类号： C07D519/00 , A61K31/435 , A61K31/4375 , A61K31/4745 , A61K45/06
摘要： The present invention provides compounds of Formula (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
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