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    NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE
    2.
    发明公开
    NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE 审中-公开
    病毒性RNA依赖的RNA聚合酶的核苷作为抑制剂

    公开(公告)号：EP1572945A2

    公开(公告)日：2005-09-14

    申请号：EP03751779.4

    申请日：2003-06-23

    申请人： Merck & Co., Inc. ,  ISIS PHARMACEUTICALS, INC.

    发明人： OLSEN, David, B. ,  MACCOSS, Malcolm ,  BHAT, Balkrishen ,  ELDRUP, Anne, B.

    IPC分类号： C12N1/00

    CPC分类号： C07H19/22 ,  C07H19/14 ,  C07H19/16 ,  C07H19/20

    摘要： The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.

    NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE
    4.
    发明公开
    NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE 审中-公开
    核苷衍生物作为RNA依赖的RNA病毒聚合酶的抑制剂

    公开(公告)号：EP1556399A2

    公开(公告)日：2005-07-27

    申请号：EP03751791.9

    申请日：2003-07-11

    申请人： Merck & Co., Inc. ,  Isis Pharmaceuticals, Inc.

    发明人： BHAT, Balkrishen ,  CARROLL, Steven, S. ,  ELDRUP, Anne, B. ,  MACCOSS, Malcolm ,  OLSEN, David, B. ,  PRAKASH, Thazha, P.

    IPC分类号： C07H19/14 ,  A61K31/70

    CPC分类号： C07H19/14 ,  C07H19/22

    摘要： The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.