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公开(公告)号：EP3087060B1
公开(公告)日：2020-05-13
申请号：EP14873215.9
申请日：2014-12-17
发明人： SHEN, Dong-Ming , EGBERTSON, Melissa , BERGER, Richard , QIAN, XiaoXia , QIAN, Yimin , HARPER, Bart , YANG, Meng , GUO, Zack Zhi Qiang , RADA, Vanessa L. , WANG, Deping , CERNAK, Timothy A. , SINZ, Christopher J. , WANG, Ming , WILSON, Jonathan E. , XU, Shimin
IPC分类号： C07D239/36 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , A61K31/513 , A61P25/18 , A61P25/22 , A61P25/28
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2.发明公开
公开(公告)号：EP3873467A2
公开(公告)日：2021-09-08
申请号：EP19879545.2
申请日：2019-10-24
发明人： ACTON, John, J., III , EGBERTSON, Melissa , GAO, Xiaolei , HARRISON, Scott, T. , HENDERSON, Timothy, J. , LO, Michael Man-Chu , MAZZOLA, Robert, D., Jr. , MENG, Zhaoyang , MULHEARN, James , RADA, Vanessa, L. , SCHUBERT, Jeffrey, W. , SELYUTIN, Oleg, B. , TELLERS, David, M. , TONG, Ling , ZHANG, Fengqi , BAO, Jianming , LI, Chunsing
IPC分类号： A61K31/437 , A61K31/4439 , A61P25/16
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3.发明公开
公开(公告)号：EP3644992A1
公开(公告)日：2020-05-06
申请号：EP18825469.2
申请日：2018-06-22
发明人： ACTON, John, J., III , BAO, Jianming , DENG, Qiaolin , EGBERTSON, Melissa , FERGUSON, Ronald, III , GAO, Xiaolei , HARRISON, Scott Timothy , KNOWLES, Sandra L. , LI, Chunsing , LO, Michael Man-Chu , MAZZOLA, Robert D., Jr. , MENG, Zhaoyang , NA, Meng , RUDD, Michael T. , SELYUTIN, Oleg B. , TELLERS, David M. , TONG, Ling , ZHANG, Fengqi
IPC分类号： A61K31/4155 , C07D231/10
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4.发明公开
公开(公告)号：EP3393472A1
公开(公告)日：2018-10-31
申请号：EP16879916.1
申请日：2016-12-19
发明人： ACTON, John, J., III , BAO, Jianming , EGBERTSON, Melissa , GAO, Xiaolei , HARRISON, Scott T. , KNOWLES, Sandra L. , LI, Chunsing , LO, Michael Man-Chu , MAZZOLA, Robert D., Jr. , MENG, Zhaoyang , RUDD, Michael, T. , SELYUTIN, Oleg , TELLERS, David, M. , TONG, Ling , WAI, Jenny Miu-Chun
IPC分类号： A61K31/4155 , C07D231/10
摘要： The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
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5.发明授权
公开(公告)号：EP3393472B1
公开(公告)日：2020-08-12
申请号：EP16879916.1
申请日：2016-12-19
发明人： ACTON, John, J., III , BAO, Jianming , EGBERTSON, Melissa , GAO, Xiaolei , HARRISON, Scott T. , KNOWLES, Sandra L. , LI, Chunsing , LO, Michael Man-Chu , MAZZOLA, Robert D., Jr. , MENG, Zhaoyang , RUDD, Michael, T. , SELYUTIN, Oleg , TELLERS, David, M. , TONG, Ling , WAI, Jenny Miu-Chun
IPC分类号： A61K31/4155 , C07D231/10
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6.发明公开
公开(公告)号：EP3644991A1
公开(公告)日：2020-05-06
申请号：EP18824389.3
申请日：2018-06-22
发明人： ACTON, John, J., III , BAO, Jianming , DENG, Qiaolin , EGBERTSON, Melissa , FERGUSON, Ronald, III , GAO, Xiaolei , HARRISON, Scott Timothy , HENDERSON, Timothy, J. , KNOWLES, Sandra, L. , LO, Michael Man-Chu , MAZZOLA, Robert, D., Jr. , NA, Meng , SELYUTIN, Oleg, B. , SUZUKI, Takao , ZHANG, Fengqi
IPC分类号： A61K31/4155 , C07D231/10 , C07D471/04
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7.发明公开
公开(公告)号：EP3087060A1
公开(公告)日：2016-11-02
申请号：EP14873215.9
申请日：2014-12-17
发明人： SHEN, Dong-Ming , EGBERTSON, Melissa , BERGER, Richard , QIAN, XiaoXia , QIAN, Yimin , HARPER, Bart , YANG, Meng , GUO, Zack Zhi Qiang , RADA, Vanessa L. , WANG, Deping , CERNAK, Timothy A. , SINZ, Christopher J. , WANG, Ming , WILSON, Jonathan E. , XU, Shimin
IPC分类号： C07D239/36 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , A61K31/513 , A61P25/18 , A61P25/22 , A61P25/28
CPC分类号： C07D239/36 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/04 , C07D417/04 , C07D487/04
摘要： Disclosed are pyrimidine carboxamide compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2), pharmaceutical compositions and uses thereof.
摘要翻译： 公开了式（I）的嘧啶羧酰胺化合物，其可用作治疗与磷酸二酯酶2（PDE2）相关的中枢神经系统疾病，药物组合物及其用途的治疗剂。
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公开(公告)号：EP1881825B1
公开(公告)日：2013-07-24
申请号：EP06759135.4
申请日：2006-05-05
发明人： VACCA, Joseph, P. , WAI, John, S. , PAYNE, Linda, S. , ISAACS, Richard, C., A. , HAN, Wei , EGBERTSON, Melissa , PRACITTO, Richard
IPC分类号： A61K31/40 , A61K31/445 , C07D498/14 , A61K31/4353 , A61K31/4375 , C07D471/14
CPC分类号： C07D471/14 , A61K31/4353 , A61K31/4375 , C07D498/14
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公开(公告)号：EP3074402B1
公开(公告)日：2019-01-16
申请号：EP14866477.4
申请日：2014-11-24
发明人： LI, Dansu , LAYTON, Mark E. , ROECKER, Anthony J. , EGBERTSON, Melissa , JONES, Kristen L. G. , WANG, Xiu , PENG, Xuanjia
IPC分类号： C07D487/04 , C07D491/20 , C07D471/04 , C07D455/02 , A61K31/433 , A61K31/427 , A61K31/4439 , A61K31/506 , A61K31/501 , A61K31/437 , A61K31/4375 , A61P25/02
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10.发明公开BICYCLOAMINE-SUBSTITUTED-N-BENZENESULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS 审中-公开选择性活动BICYCLOAMINSUBSTITUIERTE的N-苯磺酰胺压控钠通道
公开(公告)号：EP3074402A1
公开(公告)日：2016-10-05
申请号：EP14866477.4
申请日：2014-11-24
发明人： LI, Dansu , LAYTON, Mark E. , ROECKER, Anthony J. , EGBERTSON, Melissa , JONES, Kristen L. G. , WANG, Xiu , PENG, Xuanjia
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , C07D213/76 , C07D237/20 , C07D239/42 , C07D277/52 , C07D285/135 , C07D471/04 , C07D487/10 , C07D491/20
摘要： Disclosed are compounds of Formula A-a, or a salt thereof: Where "B
1 " and "R
1 " through "R
5 " are as defined herein, which compounds have properties for blocking Na
v 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A-a or their salts, and methods of treating neuropathic pain disorders using the same.
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