公开(公告)号：EP0787725A4

公开(公告)日：1998-01-07

申请号：EP95934864

申请日：1995-10-20

申请人： NIPPON CHEMIPHAR CO

发明人： NOMURA YUTAKA ,  SAKUMA SHOGO ,  MASUI SEIICHIRO

IPC分类号： A61K31/4709 ,  A61P3/10 ,  C07D413/06 ,  C07D417/06 ,  C07D417/14 ,  A61K31/47

CPC分类号： C07D413/06 ,  C07D417/06 ,  C07D417/14

摘要： Derivatives typified by a novel thiazolidine-2,4-dione derivative having no benzyl group at the 5-position, which is presented by general formula (I) and has a hypoglycemic effect, in particular, novel quinoline derivatives exhibiting a hypoglycemic effect when administered orally, wherein R1 represents hydrogen, C¿1?-C6 alkyl, amino represented by -NR?4R5 (R4 and R5¿ being independently hydrogen, C¿1?-C6 alkyl, phenyl, pyridyl, pyrimidyl or benzoyl), phenyl, naphthyl or C3-C8 cycloalkyl which may be substituted by C1-C6 alkyl, C1-C6 alkoxy, halogeno, hydroxy, C1-C6 halogenoalkyl, C1-C6 halogenoalkoxy, nitro, amino, phenyl, thienyl, furyl, thiazolyl or pyridyl, or a five- to eight-membered heterocyclic group having one or two nitrogen, oxygen or sulfur atoms with the rest of carbon atoms as the constituent atoms of the ring; z represents O, S, C=O or CH2; E represents S or O; m is an integer of 0 to 4; p is an integer of 0 to 4; q is an integer of 0 to 4; and -- represents a single or double bond.

公开(公告)号：EP1916247A4

公开(公告)日：2009-07-15

申请号：EP06780910

申请日：2006-07-04

申请人： NIPPON CHEMIPHAR CO

发明人： SAKUMA SHOGO ,  MOCHIDUKI NOBUTAKA ,  TAKAHASHI RIE ,  HIRAI TOSHITAKE ,  YAMAKAWA TOMIO ,  MASUI SEIICHIRO

IPC分类号： C07D413/06 ,  A61K31/42 ,  A61P1/00 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P15/00 ,  A61P17/00 ,  A61P25/00 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00

CPC分类号： C07D413/06 ,  C07D405/06 ,  C07D409/06 ,  C07D413/14 ,  C07D417/06

摘要： A compound represented by the general formula (II) below or a slat thereof is used as an activator of a PPAR δ. (In the formula, W3 represents a nitrogen atom or CH; Z1 represents an oxygen atom or a sulfur atom; R11 and R12 respectively represent a hydrogen atom, a halogen atom, an alkyl group having 1-8 carbon atoms, an alkoxy group having 1-8 carbon atoms, or an alkyl group substituted with a halogen atom and having 1-8 carbon atoms; R13 and R14 respectively represent a hydrogen atom of an alkyl group having 1-8 carbon atoms; A1 represents an optionally substituted pyrazole or a thiophene; and m represents an integer of 2-4.)

公开(公告)号：EP1424330A4

公开(公告)日：2004-10-27

申请号：EP02755779

申请日：2002-08-02

申请人： NIPPON CHEMIPHAR CO

发明人： SAKUMA SHOGO ,  YAMAKAWA TOMIO ,  KANDA TAKASHI ,  MASUI SEIICHIRO

IPC分类号： A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P5/14 ,  A61P9/00 ,  A61P9/10 ,  A61P19/10 ,  A61P21/04 ,  A61P25/28 ,  A61P31/00 ,  A61P35/00 ,  A61P43/00 ,  C07D233/54 ,  C07D263/32 ,  C07D263/62 ,  C07D277/24 ,  C07D277/26 ,  A61K31/421 ,  A61K31/426

CPC分类号： C07D263/62 ,  C07D263/32 ,  C07D277/24

摘要： A compound represented by the following general formula (I): (I) (wherein R1 represents optionally substituted phenyl, etc.; R2 represents C1-8 alkyl, etc.; A represents oxygen, etc.; X represents a C1-8 alkylene chain, etc.; Y represents C(=O), etc.; R3, R4, and R5 each represents hydrogen, C1-8 alkyl, etc.; B represents CH, etc.; Z represents oxygen or sulfur; R6 and R7 each represents hydrogen, etc.; and R8 represents hydrogen, etc.; provided that at least one of R3, R4, and R5 is not hydrogen) or a salt of the compound; and a PPAR-δ activator which contains the compound or salt as the active ingredient.

公开(公告)号：EP2014652A4

公开(公告)日：2010-10-06

申请号：EP07742334

申请日：2007-04-18

申请人： NIPPON CHEMIPHAR CO

发明人： SAKUMA SHOGO ,  MOCHIDUKI NOBUTAKA ,  USHIODA MASATOSHI ,  TAKAHASHI RIE ,  YAMAKAWA TOMIO ,  MASUI SEIICHIRO

IPC分类号： C07D263/32 ,  A61K31/381 ,  A61K31/421 ,  A61K31/426 ,  A61P1/04 ,  A61P1/12 ,  A61P1/16 ,  A61P1/18 ,  A61P3/06 ,  A61P3/10 ,  A61P7/02 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P11/06 ,  A61P17/00 ,  A61P17/06 ,  A61P17/10 ,  A61P17/14

CPC分类号： C07D277/22 ,  C07D263/32 ,  C07D277/20 ,  C07D277/30 ,  C07D333/22

公开(公告)号：EP1371650A4

公开(公告)日：2005-05-04

申请号：EP02712457

申请日：2002-02-19

申请人： NIPPON CHEMIPHAR CO

发明人： SAKUMA SHOGO ,  ENDO TSUYOSHI ,  KANDA TAKASHI ,  MASUI SEIICHIRO

IPC分类号： A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P19/10 ,  A61P25/00 ,  A61P25/28 ,  A61P27/02 ,  A61P35/00 ,  A61P43/00 ,  C07D233/54 ,  C07D233/64 ,  C07D233/88 ,  C07D233/90 ,  C07D263/32 ,  C07D263/34 ,  C07D263/48 ,  C07D277/24 ,  C07D277/28 ,  C07D277/30 ,  C07D277/42 ,  C07D403/04 ,  C07D409/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  A61K31/421 ,  C07D401/14

CPC分类号： C07D233/64 ,  C07D233/88 ,  C07D233/90 ,  C07D263/32 ,  C07D263/34 ,  C07D263/48 ,  C07D277/24 ,  C07D277/28 ,  C07D277/30 ,  C07D277/42 ,  C07D403/04 ,  C07D409/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

摘要： A phenylacetic acid derivative represented by the following general formula (II) (II) (wherein R?11 and R12¿ each represents hydrogen, C¿1-8? alkyl, C1-8 alkoxy, C1-8 alkyl substituted by one to three halogen atoms, an optionally substituted phenyl, naphthyl, pyridyl, thienyl, or furyl group, etc.; X?1 and Z1¿ each represents -C(=O)-, -C(=O)NH-, -NH(C=O)-, -CH=CH-, a bond, etc.; and Y1 represents a C¿1-8? alkylene chain) or a salt of the derivative; and a PPAR d activator which contains the derivative or salt as the active ingredient.

公开(公告)号：EP1445258A4

公开(公告)日：2006-01-04

申请号：EP02801515

申请日：2002-10-09

申请人： NIPPON CHEMIPHAR CO

发明人： SAKUMA SHOGO ,  YAMAKAWA TOMIO ,  KANDA TAKASHI ,  MASUI SEIICHIRO

IPC分类号： A61K31/00 ,  A61K31/423 ,  A61K31/427 ,  A61K31/454 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P19/10 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00 ,  C07D403/06 ,  C07D405/06 ,  C07D409/06 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14

CPC分类号： C07D403/06 ,  A61K31/00 ,  A61K31/423 ,  A61K31/427 ,  A61K31/454 ,  C07D405/06 ,  C07D409/06 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14

摘要： A compound represented by the general formula (I): (I) (wherein A represents oxygen, sulfur, etc.; B1 represents nitrogen, etc.; B2 represents oxygen, etc.; X1 and X2 each represents oxygen, sulfur, a bond, etc.; Y represents a C1-8 alkylene chain; Z represents oxygen or sulfur; R1 represents optionally substituted aryl, etc.; R2 represents C2-8 alkyl, etc.; R3 represents C1-8 alkyl, C2-8 alkenyl, etc.; R4 and R5 each represents hydrogen, C1-8 alkyl, etc.; and R6 represents hydrogen, etc.; provided that Z and R3 are bonded to the benzene ring and X2 is not bonded to the benzene ring) or a salt of the compound; and a PPARδ activator containing the compound or salt as an active ingredient.

公开(公告)号：EP1310494A4

公开(公告)日：2004-10-20

申请号：EP01955606

申请日：2001-08-09

申请人： NIPPON CHEMIPHAR CO

发明人： SAKUMA SHOGO ,  ENDO TSUYOSHI ,  TENDO ATSUSHI ,  TAKAHASHI TOSHIHIRO ,  YOSHIDA SHINICHI ,  KOBAYASHI KUNIO ,  MOCHIZUKI NOBUTAKA ,  YAMAKAWA TOMIO ,  KANDA TAKASHI ,  MASUI SEIICHIRO

IPC分类号： A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P5/38 ,  A61P9/00 ,  A61P9/10 ,  A61P19/10 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D233/64 ,  C07D233/70 ,  C07D233/88 ,  C07D233/90 ,  C07D263/32 ,  C07D277/24 ,  C07D277/28 ,  C07D277/38 ,  C07D413/04 ,  A61K31/4164 ,  A61K31/421 ,  A61K31/422 ,  A61K31/426 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/4725 ,  A61K31/506 ,  C07D263/34 ,  C07D263/40 ,  C07D263/48 ,  C07D277/26 ,  C07D417/04

CPC分类号： C07D413/04 ,  C07D263/32 ,  C07D277/24

摘要： Compounds of the general formula (|) or salts thereof; and activators of PPARδ (peroxisome proliferator activated receptor δ) containing the compounds or the salts as the active ingredient: (I) wherein R?1 and R2¿ are each hydrogen, C¿1-8? alkyl, an aryl or heterocyclic group which may be substituted, or the like; A is oxygen, sulfur, or the like; X?1 and X2¿ are each a free valency, oxygen, S(O)¿p? (wherein p is an integer of 0 to 2), C(=O), C(=O)NH, NHC(=O), CH=CH, or the like; Y is optionally substituted C1-8 alkylene; Z is oxygen or sulfur; R?3 and R4¿ are each optionally substituted C¿1-8? alkyl; and R?8¿ is hydrogen or C¿1-8? alkyl, with the proviso that when X?1¿ is a free valency, X2 is not O or S(O)¿p?, while when X?1¿ is C(=O)NH, X2 is not a free valency.

公开(公告)号：EP0974348A4

公开(公告)日：2003-05-14

申请号：EP97911473

申请日：1997-11-07

申请人： NIPPON CHEMIPHAR CO

发明人： MASUI SEIICHIRO ,  NAKANO YOSHIHISA

IPC分类号： A61K31/421 ,  A61K31/422 ,  A61K31/426 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/47 ,  A61K31/4709 ,  A61P3/04 ,  A61K31/19 ,  A61K31/195 ,  A61K31/38 ,  A61K31/42 ,  A61K31/425

CPC分类号： A61K31/4709 ,  A61K31/421 ,  A61K31/422 ,  A61K31/426 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/47

摘要： A visceral fat lowering agent, a visceral fat accumulation inhibitor, and a body fat distribution improver, each comprising as the active ingredient a thiazolidine derivative represented by formula (IV) wherein A3 represents an optionally substituted phenyl or oxazolyl group.