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    CULTURE MEDIUM COMPOSITION
    3.
    发明公开
    CULTURE MEDIUM COMPOSITION 审中-公开
    KULTURMEDIUMZUSAMMENSETZUNG

    公开(公告)号：EP3098300A1

    公开(公告)日：2016-11-30

    申请号：EP15740159.7

    申请日：2015-01-23

    申请人： Nissan Chemical Industries, Ltd. ,  Kyoto University

    发明人： HAYASHI, Hisato ,  OTANI, Misayo ,  SARUHASHI, Koichiro ,  NISHINO, Taito ,  IWAMA, Takehisa ,  KANAKI, Tatsuro ,  AIHARA, Ayako

    IPC分类号： C12N1/00 ,  C12N1/02 ,  C12N5/00 ,  C12N5/10

    摘要： The present invention provides a culture method of cells and/or tissues including culturing cells and/or tissues in a suspended state by using a medium composition having an effect of preventing sedimentation of cells and/or tissues, which is afforded by substantially retaining the cells and/or tissues without substantially increasing the viscosity of the solution by nanofibers which have been added to the solusion and uniformly dispersed in the liquid medium, and the like.

    摘要翻译： 本发明通过使用具有抑制细胞和/或组织沉淀的作用的培养基组合来提供细胞和/或组织的培养方法，所述细胞和/或组织包括培养细胞和/或组织处于悬浮状态，所述培养组合物通过基本上保持细胞 和/或组织，而基本上不增加已经加入到溶液中并均匀分散在液体介质中的纳米纤维的溶液的粘度等。

    NOVEL LIPID-TRIPEPTIDE BASED HYDROGEL-FORMING AGENT AND HYDROGEL
    4.
    发明公开
    NOVEL LIPID-TRIPEPTIDE BASED HYDROGEL-FORMING AGENT AND HYDROGEL 有权
    关于HYDROGELBILDENDES MITTEL AUF LIPID-TRIPEPTID-BASIS UND HYDROGEL

    公开(公告)号：EP2180027A1

    公开(公告)日：2010-04-28

    申请号：EP08790895.0

    申请日：2008-07-04

    申请人： Nissan Chemical Industries, Ltd. ,  Kyushu University

    发明人： MIYAJI, Nobuhide ,  IWAMA, Takehisa ,  GOTOH, Masahiro ,  MARUYAMA, Tatsuo ,  KOHDA, Daisuke

    IPC分类号： C09K3/00 ,  A23L1/05 ,  A61K8/44 ,  A61K9/06 ,  A61K47/42 ,  C07K5/02

    CPC分类号： B01F17/005 ,  A23L29/20 ,  A61K8/042 ,  A61K8/64 ,  A61Q19/00 ,  C07K5/0806 ,  C07K5/0808 ,  C07K5/0812 ,  C07K5/0821

    摘要： There is provided a hydrogelator that is capable of forming a hydrogel with an extremely small amount thereof over a liquid property range from acidic to alkaline, and a hydrogel having high environmental suitability, biocompatibility and biodegradability. A hydrogelator comprising a lipid peptide represented by Formula (1):

    (where R 1 represents an aliphatic group having 9 to 21 carbon atoms;
    R 2 , R 3 and R 4 independently represent a hydrogen atom, an alkyl group having 1 to 4 carbon atom(s) which may have a branched chain having 1 or 2 carbon atom(s), a phenylmethyl group or a -(CH 2 ) n -X group, and at least one of R 2 , R 3 and R 4 represents a -(CH 2 ) n -X group; n represents the number of 1 to 4; X represents an amino group, a guanidino group, a -CONH 2 group or a 5-membered ring, a 6-membered ring or a fused heterocyclic ring composed of a 5-membered ring and a 6-membered ring which may have 1 to 3 nitrogen atom(s)) or a salt thereof, and a hydrogel comprising the hydrogelator.

    摘要翻译： 提供一种水凝胶化剂，其能够在从酸性到碱性的液体性质范围内形成极少量的水凝胶，以及具有高环境适应性，生物相容性和生物降解性的水凝胶。 包含由式（1）表示的脂质肽的水凝胶剂：（其中R 1表示具有9-21个碳原子的脂族基团; R 2，R 3和R 4独立地表示氢原子，具有1至4个碳原子的烷基 可具有1或2个碳原子的支链的原子，苯基甲基或 - （CH 2）n -X基，R 2，R 3和R 4中的至少一个表示 - （CH 2）n -X基; n表示1至4的数; X表示氨基，胍基，-CONH 2基或5元环，6元环或稠合杂环 由5元环和可以具有1〜3个氮原子的6元环组成的环）或其盐，以及包含该水凝胶体的水凝胶。

    UNDIFFERENTIATED MAINTENANCE CULTURE MATERIAL
    7.
    发明公开
    UNDIFFERENTIATED MAINTENANCE CULTURE MATERIAL 审中-公开
    不同的文化遗产

    公开(公告)号：EP3098306A1

    公开(公告)日：2016-11-30

    申请号：EP15740165.4

    申请日：2015-01-23

    申请人： Nissan Chemical Industries, Ltd. ,  Kyushu University

    发明人： KIDOAKI, Satoru ,  TUJI, Yukie ,  HAYASHI, Hisato ,  IWAMA, Takehisa ,  HORIKAWA, Masato

    IPC分类号： C12N5/077

    CPC分类号： C12N5/0668 ,  B82Y30/00 ,  C12N5/0018 ,  C12N5/0663 ,  C12N2500/34

    摘要： There is provided a culture method (a preservation method) of somatic stem cells without using a chemical such as DMSO that affects a differentiation function of somatic stem cells. A material for an undifferentiated state-maintaining culture for a somatic stem cell, comprising a naturally occurring polysaccharide; a culture liquid in which the material for the undifferentiated state-maintaining culture is dispersed; a somatic stem cell-containing culture liquid in which the somatic stem cell is suspended in the culture liquid; and a culture method for mesenchymal stem cells in which a naturally occurring polysaccharide is used.

    摘要翻译： 提供体细胞干细胞的培养方法（保存方法），而不使用影响体细胞干细胞分化功能的化学物质如DMSO。 用于体细胞干细胞的未分化状态保持培养物的材料，其包含天然存在的多糖; 其中分散有维持不分化培养物质的培养液; 体细胞干细胞悬浮在培养液中的体细胞干细胞培养液; 以及使用天然存在的多糖的间充质干细胞的培养方法。