公开(公告)号：EP1981342A1

公开(公告)日：2008-10-22

申请号：EP06774300.5

申请日：2006-06-29

申请人： Reddy US Therapeutics, Inc. ,  Baruah, Anima ,  De, Dibyendu ,  Khanna, Ish Kumar ,  Pillarisetti, Sivaram ,  Alexander, Christopher W. ,  Sreenu, Jennepalli

发明人： BARUAH, Anima ,  DE, Dibyendu ,  KHANNA, Ish Kumar ,  PILLARISETTI, Sivaram ,  ALEXANDER, Christopher W. ,  SREENU, Jennepali ,  MAITRA, Santanu ,  ALIKINJU, Shanavas

IPC分类号： A01N43/66 ,  A01N43/54 ,  A01N43/42 ,  A01N43/40 ,  A61K31/44 ,  A61K31/47 ,  C07D221/06 ,  C07D471/02 ,  C07D491/02 ,  C07D498/02 ,  C07D513/02 ,  C07D515/02 ,  C07D215/00 ,  C07D215/38 ,  C07D215/46 ,  C07D215/04 ,  C07D417/00 ,  C07D211/72 ,  C07D211/84 ,  C07D213/62 ,  C07D403/00

CPC分类号： C07D215/36 ,  C07D215/38 ,  C07D215/48 ,  C07D221/06 ,  C07D401/12 ,  C07D403/12 ,  C07D471/04

摘要： The present invention provides, among other things, new benzylamine compounds, compositions comprising benzylamine compounds, methods of making benzylamine compounds, and methods of using benzylamine compounds for treating or preventing a variety of conditions or diseases associated with lipoprotein metabolism.

摘要翻译： 除其他之外，本发明提供了新的苄胺化合物，包含苄胺化合物的组合物，制备苄胺化合物的方法以及使用苄胺化合物治疗或预防与脂蛋白代谢相关的多种病症或疾病的方法。

公开(公告)号：EP1848430A2

公开(公告)日：2007-10-31

申请号：EP05855717.4

申请日：2005-12-28

申请人： Reddy US Therapeutics, Inc. ,  Baruah, Anima ,  De, Dibyendu ,  Khanna, Ish Kumar ,  Pillarisetti, Sivaram ,  Maitra, Santanu ,  Alexander, Christopher W. ,  Sreenu, Jennepalli ,  Dager, Indu

发明人： BARUAH, Anima Maruti Majestic Apartment Bollaram Road ,  DE, Dibyendu ,  KHANNA, Ish Kumar ,  PILLARISETTI, Sivaram ,  MAITRA, Santanu ,  ALEXANDER, Christopher W. ,  SREENU, Jennepalli ,  DAGER, Indu

IPC分类号： A61K31/44 ,  A61K31/47 ,  A61K31/495 ,  A61K31/4965 ,  C07D213/72 ,  C07D215/38 ,  C07D401/02 ,  C07D471/02

CPC分类号： A61K31/506 ,  A61K31/437 ,  A61K31/438 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/496 ,  C07D213/73 ,  C07D213/74 ,  C07D215/38 ,  C07D221/04 ,  C07D239/78 ,  C07D241/20 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D498/04

摘要： The present invention provides, among other things, new benzylamine compounds, compositions comprising benzylamine compounds, methods of making benzylamine compounds, and methods of using benzylamine compounds for treating or preventing a variety of conditions or diseases associated with lipoprotein metabolism.

公开(公告)号：EP1796673A2

公开(公告)日：2007-06-20

申请号：EP05799686.0

申请日：2005-09-23

申请人： Reddy US Therapeutics, Inc. ,  Kalleda, Srinivas ,  Padakanti, Srinivas ,  Swamy, Nalivela, Kumara ,  Rao, Yeleswarapu Koteswar ,  Alexander, Christopher W. ,  Khanna, Ish Kumar ,  Iqbal, Javed ,  Pillarisetti, Sivaram ,  Pal, Manojit ,  Barange, Deepak

发明人： PAL, Manojit ,  KALLEDA, Srinivas ,  PADAKANTI, Srivinas ,  KUMAR SWAMY, Nalivela, Plor 191, J.P.N. ,  YELESWARAPU, Koteswar, Rao,Flat 202,Krishna Arcade ,  ALEXANDER, Christopher, W. ,  KHANNA, Ish, Kumar ,  IQBAL, Javed, Flat 101, Sri Krishna Residency ,  PILLARISETTI, Sivaram ,  BARANGE, Deepak, H.No.235, c/o A. Srinivas

IPC分类号： A61K31/506 ,  C07D403/04 ,  C07D239/46

CPC分类号： C07D405/14 ,  C07D239/30 ,  C07D239/40 ,  C07D239/42 ,  C07D239/46 ,  C07D239/47 ,  C07D239/48 ,  C07D239/50 ,  C07D239/54 ,  C07D401/04 ,  C07D403/12 ,  C07D405/12

摘要： The present invention provides new heterocyclic compounds, particularly substituted pyrimidines, methods and compositions for making and using these heterocyclic compounds, and methods for treating a variety of diseases and disease states, including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan.

公开(公告)号：EP1368648A2

公开(公告)日：2003-12-10

申请号：EP01998128.1

申请日：2001-12-21

申请人： Reddy US Therapeutics, Inc.

发明人： PILLARISETTI, Sivaram ,  CAHOON, Shianlen ,  SAXENA, Uday

IPC分类号： G01N33/50 ,  G01N33/68 ,  A61P29/00

CPC分类号： G01N33/6893 ,  G01N33/5014 ,  G01N33/5023 ,  G01N33/6863 ,  G01N33/6869 ,  G01N33/6896

摘要： The present invention relates to compositions and methods for identification and development of compounds or therapeutic agents that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to methods for detecting compounds or therapeutic agents that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in cells. The present invention provides compositions for and methods of treatment of biological conditions including, but not limited to, vascular complications of type I and type II diabetic induced vasculopathies, other vasculopathies, microangiopathies, renal insufficiency, Alzheimer's syndrome, and inflammation-induced diseases such as atherosclerosis.

公开(公告)号：EP1334207A2

公开(公告)日：2003-08-13

申请号：EP01977875.2

申请日：2001-10-02

申请人： Reddy US Therapeutics, Inc.

发明人： PILLARISETTI, Sivaram ,  SAXENA, Uday ,  VINES, Angela ,  CAHOON, Shianlen

IPC分类号： C12Q1/48 ,  A61P29/00

CPC分类号： C12Q1/485 ,  C12Q1/6897 ,  G01N2333/91215

摘要： The present invention is directed to compositions and methods for treating inflammatory diseases comprising administration of compositions that effect glycogen synthase kinase 3β (GSK-3β) protein or gene. The present invention also comprises methods and compositions for the identification of compounds or therapeutic agents which modulate the activity of the protein. The present invention provides compositions for and methods off treatment of biological conditions including, but not limited to, type I and type II diabetic induced vasculopathy, other vasculopathies, asthma and inflammation-induced diseases such as atherosclerosis and cell proliferation.

公开(公告)号：EP2120959A1

公开(公告)日：2009-11-25

申请号：EP07863294.0

申请日：2007-12-28

申请人： Reddy US Therapeutics, Inc.

发明人： SAXENA, Uday ,  PILLARISETTI, Sivaram ,  KHANNA, Ish

IPC分类号： A61K31/54

CPC分类号： A61K31/445 ,  A61K31/5415 ,  Y10S514/866 ,  A61K2300/00

摘要： Methods for the treatment of insulin resistance, diabetes, and/or diabetes associated dyslipidemia by administering niacin and meloxicam are disclosed.

公开(公告)号：EP1410034A2

公开(公告)日：2004-04-21

申请号：EP02748391.6

申请日：2002-03-04

申请人： Reddy US Therapeutics, Inc.

发明人： PILLARISETTI, Sivaram

IPC分类号： G01N33/567 ,  C07K17/00 ,  C07K16/00 ,  C07K14/00 ,  C07K1/00 ,  A61K38/24 ,  C07H21/04 ,  A61K39/395 ,  A61K38/00 ,  A61K38/16

CPC分类号： G01N33/5061 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/5088 ,  G01N33/5091 ,  G01N33/5308 ,  G01N2333/4722 ,  G01N2400/40

摘要： The present invention is directed to methods and compositions for diagnosing, treating and preventing smooth muscle cell proliferation and hyperplasia, including vascular occlusive conditions. Such conditions include, but are not limited to, thrombosis, atherosclerosis and restenosis after angioplasty. Preferred embodiments comprise methods and compositions that effect HSPGs associated with smooth muscle cell proliferation and more preferably, effect perlecan.

公开(公告)号：EP1560817A1

公开(公告)日：2005-08-10

申请号：EP03797788.1

申请日：2003-03-26

申请人： Reddy US Therapeutics, Inc.

发明人： TIMMER, Richard, T. ,  ALEXANDER, Christopher, W. ,  PILLARISETTI, Sivaram ,  SAXENA, Uday ,  YELESWARAPU, Koteswar RaoFlat no 21003 ,  PAL, Manojit ,  REDDY, Jangalgar Tirupathy ,  REDDY, Velagala Venkata Rama Murali Krishna ,  ALLURI, Sesha, Sridevi ,  KUMAR, Potlapally, Rajender ,  REDDY, Gaddam, Om, H.No.1, Golden Glean

IPC分类号： C07D251/18 ,  C07D251/70 ,  C07D401/04 ,  C07D407/04 ,  C07D409/04 ,  C07D413/10 ,  C07D417/04 ,  A61K31/53 ,  A61P35/00 ,  A61P19/02 ,  A61P17/06

CPC分类号： C07D413/04 ,  A61K31/53 ,  C07D251/30 ,  C07D251/44 ,  C07D251/46 ,  C07D251/48 ,  C07D251/50 ,  C07D251/52 ,  C07D251/66 ,  C07D251/70 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D453/02 ,  C07D487/04 ,  C07F9/65217 ,  C07F9/65583

摘要： The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.

公开(公告)号：EP2037740A2

公开(公告)日：2009-03-25

申请号：EP07798237.9

申请日：2007-06-07

申请人： Reddy US Therapeutics, Inc.

发明人： SAXENA, Uday ,  PILLARISETTI, Sivaram ,  KHANNA, Ish

IPC分类号： A01N43/54 ,  A61K31/505

CPC分类号： A61K31/506 ,  C07D401/04

摘要： The present invention shows that pharmacological up regulation of SRB-1, ABC-A1 and LCAT genes collectively can be used to promote reverse cholesterol transport and increase circulating HDL cholesterol as treatment for atherosclerosis and related cardiovascular disorders.

公开(公告)号：EP1436266A2

公开(公告)日：2004-07-14

申请号：EP02799019.1

申请日：2002-09-23

申请人： Reddy US Therapeutics, Inc.

发明人： TIMMER, Richard, T. ,  ALEXANDER, Christopher, W. ,  PILLARISETTI, Sivaram ,  SAXENA, Uday ,  CAMPBELL, Karen, A.

IPC分类号： C07D251/44

CPC分类号： C07D401/12 ,  C07D251/44 ,  C07D251/46 ,  C07D251/48 ,  C07D251/50 ,  C07D251/52 ,  C07D251/70 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D453/02

摘要： The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.

摘要翻译： 本发明涉及包含治疗由炎症反应引起的病理生理状况的化合物的方法和组合物。 具体而言，本发明涉及抑制或阻断糖化蛋白质诱导内皮细胞中信号相关炎症反应的化合物。 本发明涉及抑制平滑肌增殖的化合物。 具体而言，本发明涉及通过调节HSPG例如Perlecan来抑制平滑肌细胞增殖的化合物。 本发明进一步涉及化合物用于治疗以平滑肌增殖为特征的血管阻塞性病症如再狭窄和动脉粥样硬化的用途。