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1.发明公开DIRECTED DIFFERENTIATION OF OLIGODENDROCYTE PRECURSOR CELLS TO A MYELINATING CELL FATE 审中-公开GEZIELTE DIFFERENZIERUNG VON OLIGODENDROZYTEN-VORLÄUFERZELLENFÜREIN MYELINIERUNGS-ZELLSCHICKSAL
公开(公告)号：EP2675893A4
公开(公告)日：2014-07-16
申请号：EP12747134
申请日：2012-02-17
申请人： SCRIPPS RESEARCH INST , IRM LLC
发明人： SCHULTZ PETER , LAIRSON LUKE , DESHMUKH VISHAL , LYSSIOTIS COSTAS
IPC分类号： C12N5/00
CPC分类号： A61K31/5415 , A61K31/135 , A61K31/137 , A61K31/138 , A61K31/216 , A61K31/40 , A61K31/439 , A61K31/46 , A61K31/495 , A61K38/215 , A61K39/3955
摘要： The present invention provides methods of inducing differentiation of oligodendrocyte progenitor cells to a mature myelinating cell fate with a neurotransmitter receptor modulating agent. The present invention also provides methods of stimulating increased myelination in a subject in need thereof by administering said neurotransmitter receptor modulating agent. Methods of treating a subject having a demyelinating disease using a neurotransmitter receptor modulating agent are also provided.
摘要翻译： 本发明提供了用神经递质受体调节剂诱导少突神经母细胞祖细胞分化为成熟髓鞘细胞命运的方法。 本发明还提供了通过施用所述神经递质受体调节剂刺激有需要的受试者中增加的髓鞘形成的方法。 还提供了使用神经递质受体调节剂治疗患有脱髓鞘疾病的受试者的方法。
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公开(公告)号：EP2453921A4
公开(公告)日：2012-12-19
申请号：EP10800425
申请日：2010-07-13
申请人： SCRIPPS RESEARCH INST , IRM LLC
发明人： JOHNSON KRISTEN , JENNINGS LORI , SCHULTZ PETER
IPC分类号： A61K39/395
CPC分类号： A61K38/1891 , A61K31/728 , A61K38/00 , A61K47/60 , C07K14/515 , A61K2300/00
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公开(公告)号：EP1794323A4
公开(公告)日：2008-08-27
申请号：EP05812008
申请日：2005-09-20
发明人： DEITERS ALEXANDER , SCHULTZ PETER
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4.发明公开SELECTIVE POSTTRANSLATIONAL MODIFICATION OF PHAGE-DISPLAYED POLYPEPTIDES 审中-公开噬菌体PRESENTED多肽的选择性翻译后修饰
公开(公告)号：EP1934343A4
公开(公告)日：2009-09-16
申请号：EP06825758
申请日：2006-10-11
发明人： TSAO MENG-LIN , TIAN FENG , SCHULTZ PETER
CPC分类号： C12P21/02 , C07K14/005 , C07K2319/00 , C07K2319/50 , C12N7/00 , C12N9/93 , C12N15/1037 , C12N15/67 , C12N2795/14122
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5.发明公开SELECTIVE INCORPORATION OF 5-HYROXYTRYPOPHAN INTO PROTEINS IN MAMMALIAN CELLS 审中-公开ÄELL ELL IN IN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN
公开(公告)号：EP1725251A4
公开(公告)日：2009-07-01
申请号：EP04822141
申请日：2004-12-16
发明人： ZHANG ZHIWEN , ALFONTA LITAL , SCHULTZ PETER
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公开(公告)号：EP1490483A4
公开(公告)日：2007-02-07
申请号：EP02725743
申请日：2002-04-19
发明人： SCHULTZ PETER , WANG LEI , ANDERSON JOHN CHRISTOPHER , CHIN JASON W , LIU DAVID R , MAGLIERY THOMAS J , MEGGERS ERIC L , MEHL RYAN AARON , PASTRNAK MIRO , SANTORO STEPHEN WILLIAM , ZHANG ZHIWEN
IPC分类号： C12N15/09 , A61K38/00 , A61K38/22 , A61P7/00 , C07K14/00 , C07K14/47 , C07K14/505 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N15/67 , C12P13/00 , C12P13/04 , C12P13/22 , C12P19/26 , C12P21/02 , C12Q1/02 , C12Q1/06 , C07H21/04 , C12N1/14 , C12N1/16 , C12N1/18 , C12N1/20 , C12P21/06
CPC分类号： C12P21/00 , C07K14/00 , C07K14/505 , C12N9/93 , C12N15/67 , C12P13/00 , C12P13/005 , C12P13/04 , C12P13/22 , C12P19/26 , C12P21/02
摘要： The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
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7.发明公开
公开(公告)号：EP2802603A4
公开(公告)日：2015-11-04
申请号：EP13735853
申请日：2013-01-09
发明人： BAZIRGAN OMAR A , MAO HONGYUAN HELEN , SMIDER VAUGHN , EKIERT DAMIAN , SCHULTZ PETER , WANG FENG , WILSON IAN , ZHANG YONG
CPC分类号： C07K16/10 , C07K14/53 , C07K16/00 , C07K16/46 , C07K2317/20 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/94 , C07K2319/00 , C07K2319/50 , C07K2319/55
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8.发明公开ORTHOGONAL TRANSLATION COMPONENTS FOR THE IN VIVO INCORPORATION OF UNNATURAL AMINO ACIDS 审中-公开正交翻译组件体内大会不要天然氨基酸
公开(公告)号：EP1807515A4
公开(公告)日：2008-06-18
申请号：EP05857733
申请日：2005-10-27
发明人： ALFONTA LITAL , SCHULTZ PETER , ZENG HUAQIANG , XIE JIANMING , WU NING , WANG JIANGYUN , TSAO MENG-LIN , SUMMERER DANIEL , GROFF DAN , DEITERS ALEXANDER , CHITTULURU JONATHAN R
CPC分类号： C12N9/93 , C12N15/1058 , C12P21/00 , C12P21/02
摘要： The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate unnatural amino acids into proteins produced in eubacterial host cells such as E.coli,or in a eukaryotic host such as a yeast cell. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing unnatural amino acids, and translation systems.
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9.发明公开METHODS AND COMPOSITION FOR THE PRODUCTION OF ORTHOGANAL TRNA-AMINOACYLTRNA SYNTHETASE PAIRS 有权方法和组合物用于生产ORTHOGANALEN tRNA /氨酰-tRNA合成酶配对
公开(公告)号：EP1456360A4
公开(公告)日：2005-05-25
申请号：EP02731454
申请日：2002-04-19
发明人： SCHULTZ PETER , WANG LEI , ANDERSON JOHN CHRISTOPHER , CHIN JASON W , LIU DAVID R , MAGLIERY THOMAS J , MEGGERS ERIC L , MEHL RYAN AARON , PASTRNAK MIRO , SANTORO STEPHEN WILLIAM , ZHANG ZHIWEN
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