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    TUBERCULOSIS BIOMARKERS AND USES THEREOF
    4.
    发明公开
    TUBERCULOSIS BIOMARKERS AND USES THEREOF 审中-公开
    结核生物标志物及其用途

    公开(公告)号：EP2836608A4

    公开(公告)日：2016-02-24

    申请号：EP13774934

    申请日：2013-04-12

    申请人： SOMALOGIC INC

    发明人： OCHSNER URS ,  STERLING DAVID G ,  JANJIC NEBOJSA

    IPC分类号： C12Q1/68 ,  G01N33/569

    CPC分类号： G01N33/6893 ,  A61K31/496 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/5695 ,  G01N2570/00 ,  G01N2800/52 ,  G01N2800/60

    摘要： The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection, treatment and diagnosis of tuberculosis (TB). In one aspect, the present application includes the identification of biomarkers that can be used alone or in various combinations for the detection of TB, including those set forth in Tables 1, 2, 4, 5, and 8 to 12. In another aspect, the application provides biomarkers that can be used alone or in various combinations to diagnose or prognose TB or follow treatment response. In another aspect, methods are provided for diagnosing TB in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Tables 1, 2, 4, 5, and 8 to 12, wherein the individual is classified as having TB, or the likelihood of the individual having TB is determined, based on the at least one biomarker value.

    摘要翻译： 本申请包括用于结核病（TB）的检测，治疗和诊断的生物标志物，方法，装置，试剂，系统和试剂盒。 在一个方面，本申请包括可以单独使用或以各种组合用于检测结核病的生物标志物的鉴定，包括表1,2,4,5和8至12中列出的那些。另一方面， 该应用提供可以单独使用或以各种组合使用以诊断或预测结核病或遵循治疗反应的生物标志物。 在另一方面，提供了用于诊断个体中的结核病的方法，其中所述方法包括在来自个体的生物样品中检测至少一种对应于至少一种生物标志物的生物标记值，所述至少一种生物标志物选自表1， 2，4，5和8至12，其中基于至少一种生物标记值，将个体分类为具有TB或者确定具有TB的个体的可能性。

    COMPOSITIONS AND METHODS FOR DETECTING MICROORGANISMS
    5.
    发明公开
    COMPOSITIONS AND METHODS FOR DETECTING MICROORGANISMS 审中-公开
    VORRICHTUNGEN UND VERFAHREN ZUR DETEKTION VON MIKROORGANISMEN

    公开(公告)号：EP3108045A4

    公开(公告)日：2017-08-16

    申请号：EP15751799

    申请日：2015-02-14

    申请人： SOMALOGIC INC

    发明人： OCHSNER URS A ,  JANJIC NEBOJSA

    IPC分类号： C40B30/04 ,  C12Q1/68 ,  C40B40/06 ,  G01N33/00 ,  G01N33/566

    CPC分类号： C12N15/115 ,  C12N15/1048 ,  C12N2310/16 ,  C12Q1/14 ,  G01N33/5308 ,  G01N33/569 ,  G01N2333/31

    摘要： Described herein are compositions and methods for detecting the presence or absence of a microorganism in a sample comprising contacting the sample with an aptamer capable of binding to a cell-surface protein of the microorganism to form a complex, contacting the mixture with a second aptamer capable of binding to the first cell-surface protein or a second cell-surface protein of the microorganism; and performing an assay to detect the second aptamer, wherein detecting the second aptamer indicates that the microorganism is present in the sample, and wherein not detecting the second aptamer indicates that the microorganism is absent from the sample.

    摘要翻译： 本文描述了用于检测样品中微生物的存在或不存在的组合物和方法，其包括使样品与能够结合微生物的细胞表面蛋白的适体接触以形成复合物，使混合物与能够与第二适体 结合至微生物的第一细胞表面蛋白质或第二细胞表面蛋白质; 并且进行检测以检测第二适体，其中检测第二适体表明微生物存在于样品中，并且其中未检测到第二适体表示微生物不存在于样品中。

    CYTIDINE-5-CARBOXAMIDE MODIFIED NUCLEOTIDE COMPOSITIONS AND METHODS RELATED THERETO
    10.
    发明公开
    CYTIDINE-5-CARBOXAMIDE MODIFIED NUCLEOTIDE COMPOSITIONS AND METHODS RELATED THERETO 审中-公开
    CYTIDIN-5-CARBOXAMID-MODIFIZIERTE NUKLEOTIDZUSAMMETETZUNGEN UNDZUGEHÖRIGEVERFAHREN

    公开(公告)号：EP3071588A4

    公开(公告)日：2017-08-02

    申请号：EP14864118

    申请日：2014-11-19

    申请人： SOMALOGIC INC

    发明人： ROHLOFF JOHN ,  JANJIC NEBOJSA ,  GAWANDE BHARATNATHU

    IPC分类号： C07H19/06 ,  C07H1/00 ,  C07H21/00 ,  C12Q1/68

    CPC分类号： C07H19/06 ,  C07H1/00 ,  C07H21/00 ,  C12Q1/6811 ,  C12Q2525/117

    摘要： Described herein are 5-position modified cytosines of formula I, nucleotides and nucleosides as well as phosphoramidites and triphosphates derivatives thereof. Further provided are methods of making and using the same, and compositions and uses of the modified nucleosides as part of a nucleic acid molecule (e.g., aptamer). Those modified nucleotides, bearing an N-substituted-carboxamine group at the 5 -position, are valuable tools for improving in vitro selection of protein-binding aptamers (SELEX process). wherein R is independently a -(CH 2 ) n , wherein n is 0,1,2,3,4,5,6,7,8,9 or 10; R X1 is independently selected from the group consisting of

    摘要翻译： 本文描述了5位修饰的胞嘧啶核苷酸和核苷以及其亚磷酰胺和三磷酸酯衍生物。 进一步提供了制备和使用它们的方法，以及修饰的核苷作为核酸分子（例如适体）的一部分的组合物和用途。