公开(公告)号：EP1577004A3

公开(公告)日：2005-11-09

申请号：EP05013150.7

申请日：2002-01-21

Applicant: Symyx Technologies, Inc.

Inventor： Dales, Cameron G. ,  Troth, Jonah R. ,  Higashihara, Kenneth S. ,  Diamond, Gary ,  Murphy, Vince ,  Chandler, William H., Jr. ,  Frank, Trevor G. ,  Freitag, J. Christopher ,  Huffman, Dave

IPC: B01J19/00 ,  G01N35/00 ,  B25J9/02 ,  G01N1/22

CPC classification number: B01F7/167 ,  B01F7/00258 ,  B01F7/00266 ,  B01F7/00291 ,  B01F7/00416 ,  B01F7/00575 ,  B01F13/065 ,  B01F13/08 ,  B01F15/00207 ,  B01F15/00357 ,  B01F15/00396 ,  B01F2215/0037 ,  B01J19/0006 ,  B01J19/0013 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00029 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00333 ,  B01J2219/00335 ,  B01J2219/00337 ,  B01J2219/00342 ,  B01J2219/00351 ,  B01J2219/00353 ,  B01J2219/00367 ,  B01J2219/00373 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00466 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00497 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00745 ,  B01L3/50851 ,  B01L3/50853 ,  B01L7/54 ,  B01L2200/026 ,  B01L2300/049 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/14 ,  B01L2300/1805 ,  C40B40/14 ,  C40B40/18 ,  C40B60/14 ,  F28F27/00 ,  G01K13/00 ,  G01N1/2226 ,  G01N21/253 ,  G01N35/0099 ,  G01N35/1004 ,  G01N35/1079 ,  G01N2035/00514 ,  G01N2035/0406 ,  Y10T436/2575

Abstract: Apparatus for parallel processing of multiple reaction mixtures, said apparatus comprising a reactor having an exterior surface, one or more vessels in the reactor for holding said reaction mixtures, each vessel having a central longitudinal axis, a cannula having a longitudinal axis, a distal end, and a port generally adjacent said distal end for transfer of said reaction material to or from the cannula, one or more cannula passages in the reactor extending between said exterior surface of the reactor and said one or more vessels, the one or more cannula passages being adapted for insertion of the cannula through a selected cannula passage and into a respective vessel, and for withdrawal of the cannula from the selected cannula passage and respective vessel, and a sealing mechanism in each cannula passage for sealing against leakage of gas therepast when the cannula is inserted into or withdrawn from the selected cannula passage, wherein said sealing mechanism comprises a valve movable between a closed position for closing the cannula passage and an open position permitting movement of the cannula past the valve, and a seal in the passage sealingly engageable with the cannula when the valve is in its open position.

公开(公告)号：EP1260267A3

公开(公告)日：2005-09-21

申请号：EP02017947.9

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES

Inventor： Turner, Howard ,  Dales, Cameron G. ,  Van Erden, Lynn ,  Van Beek, Johannes A.M. ,  Hajduk, Damian A. ,  Nielsen, Ralph B. ,  Mansky, Paul ,  Matsiev, Leonid ,  Wang, Pei ,  McFarland, Eric

IPC: B01J19/00

CPC classification number: B01L3/50851 ,  B01F15/00207 ,  B01J19/0006 ,  B01J19/0013 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00029 ,  B01J2219/00056 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00333 ,  B01J2219/00335 ,  B01J2219/00351 ,  B01J2219/00367 ,  B01J2219/00373 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00745 ,  B01L3/50853 ,  B01L7/54 ,  B01L2200/026 ,  B01L2300/049 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/14 ,  B01L2300/1805 ,  C40B40/14 ,  C40B40/18 ,  G01K13/00 ,  G01N21/253

Abstract: A method of processing reaction mixtures in parallel, comprising: forming chemical reaction mixtures in a plurality of reactor vessels of a parallel reactor apparatus said apparatus comprising sensors for providing measured values relating to chemical reactions in said reactor vessels, and a processor for receiving data relating to said measured values; sealing the reaction mixture in each reactor vessel against fluid communication with the other vessels and at a pressure different than ambient pressure; injecting a fluid into at least one of the reactor vessels while the reaction mixture in said at least one vessel is sealed and at a pressure different than ambient pressure; agitating the reaction mixtures for at least a portion of the sealing step; and using the processor to receive said data relating to said measured values of the chemical reactions in said reactor vessels.

公开(公告)号：EP1586373A1

公开(公告)日：2005-10-19

申请号：EP05010983.4

申请日：1999-08-12

Applicant: Symyx Technologies, Inc.

Inventor： Turner, Howard ,  Dales, Cameron G. ,  Van Erden, Lynn ,  Van Beek, Johannes A. M. ,  Hajduk, Damian A. ,  Nielsen, Raloph B. ,  Mansky, Paul ,  Matsiev, Leonid ,  Wang, Pei ,  McFarland, Eric

IPC: B01J19/00 ,  G05D21/00

CPC classification number: G05D27/02

Abstract: A reactor control system for monitoring and controlling parallel chemical reactions during which sensors provide measured values relating to one or more properties of parallel reactions occurring in a plurality of reactor vessels of a parallel reactor, the parallel reactions being performed under conditions defined by one or more reaction parameters, said system comprising (a) a user interface operable to selectively display a representation of measured values, or experimental variables calculated from the measured values, associated with the contents of each of the plurality of reactor vessels and a detailed data representation of the received measured values, or experimental variables calculated from the measured values, for an individual one of the plurality of reactor vessels according to operator input, the user interface being further operable to receive operator input modifying one or more of the reaction parameters associated with one or more of the plurality of reactor vessels during the course of the parallel reactions, and (b) a system control module for controlling the parallel reactions, the system control module being operable to modify the one or more of the reaction parameters according to the received operator input during the course of the parallel chemical reactions.

Abstract translation: 一种用于监测和控制并联化学反应的反应器控制系统，在该反应器控制系统中，传感器提供与在并联反应器的多个反应器容器中发生的并行反应的一个或多个特性相关的测量值，并行反应在由一个或多个 反应参数，所述系统包括（a）用户界面，其可操作以选择性地显示与多个反应堆容器中的每一个的内容相关联的测量值或从测量值计算的实验变量的表示，以及 根据操作员输入，从多个反应堆容器中的单独一个反应器容器计算的接收的测量值或实验变量，用户界面还可操作以接收操作者输入，修改与一个或多个反应器容器相关联的一个或多个反应参数， 更多的反应堆容器 在并行反应过程中，以及（b）用于控制并联反应的系统控制模块，所述系统控制模块可操作以根据所述接收的操作者输入在所述并行过程中修改所述反应参数中的一个或多个 化学反应。

公开(公告)号：EP1577004A2

公开(公告)日：2005-09-21

申请号：EP05013150.7

申请日：2002-01-21

Applicant: Symyx Technologies, Inc.

Inventor： Dales, Cameron G. ,  Troth, Jonah R. ,  Higashihara, Kenneth S. ,  Diamond, Gary ,  Murphy, Vince ,  Chandler, William H., Jr. ,  Frank, Trevor G. ,  Freitag, J. Christopher ,  Huffman, Dave

IPC: B01J19/00 ,  G01N35/00 ,  B25J9/02

CPC classification number: B01F7/167 ,  B01F7/00258 ,  B01F7/00266 ,  B01F7/00291 ,  B01F7/00416 ,  B01F7/00575 ,  B01F13/065 ,  B01F13/08 ,  B01F15/00207 ,  B01F15/00357 ,  B01F15/00396 ,  B01F2215/0037 ,  B01J19/0006 ,  B01J19/0013 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00029 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00333 ,  B01J2219/00335 ,  B01J2219/00337 ,  B01J2219/00342 ,  B01J2219/00351 ,  B01J2219/00353 ,  B01J2219/00367 ,  B01J2219/00373 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00466 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00497 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00745 ,  B01L3/50851 ,  B01L3/50853 ,  B01L7/54 ,  B01L2200/026 ,  B01L2300/049 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/14 ,  B01L2300/1805 ,  C40B40/14 ,  C40B40/18 ,  C40B60/14 ,  F28F27/00 ,  G01K13/00 ,  G01N1/2226 ,  G01N21/253 ,  G01N35/0099 ,  G01N35/1004 ,  G01N35/1079 ,  G01N2035/00514 ,  G01N2035/0406 ,  Y10T436/2575

Abstract: Apparatus for parallel processing of multiple reaction mixtures, said apparatus comprising a reactor having an exterior surface, one or more vessels in the reactor for holding said reaction mixtures, each vessel having a central longitudinal axis, a cannula having a longitudinal axis, a distal end, and a port generally adjacent said distal end for transfer of said reaction material to or from the cannula, one or more cannula passages in the reactor extending between said exterior surface of the reactor and said one or more vessels, the one or more cannula passages being adapted for insertion of the cannula through a selected cannula passage and into a respective vessel, and for withdrawal of the cannula from the selected cannula passage and respective vessel, and a sealing mechanism in each cannula passage for sealing against leakage of gas therepast when the cannula is inserted into or withdrawn from the selected cannula passage, wherein said sealing mechanism comprises a valve movable between a closed position for closing the cannula passage and an open position permitting movement of the cannula past the valve, and a seal in the passage sealingly engageable with the cannula when the valve is in its open position.

Abstract translation: 一种用于多反应混合物的并行处理，所述设备包括具有外表面的反应器，在反应器中的一个或多个容器，用于保持所述反应混合物中，每个容器具有中心纵向轴线，具有纵向轴线的套管，远端 和用于所述反应材料转移到或从套管端口基因反弹邻近所述远端，在反应器中的反应器的所述外表面之间延伸的一个或多个套管通道和所述一个或多个容器，所述一个或多个套管的通道 是用于套管的插入angepasst通过选定的套管通道并进入respectivement容器，以及用于从所选择的套管通道和相应的容器中，并且用于密封气体的泄漏在每个套管通道的密封机构插管撤出有过去当 插管插入或从选定的套管通道抽出，worin所述密封机构包括一个阀movabl 用于封闭所述套管通道的关闭位置和打开位置，允许插管经过阀的运动，并在所述通道与所述套管密封地接合的密封件之间e出现在阀处于其打开位置。

公开(公告)号：EP1260267A2

公开(公告)日：2002-11-27

申请号：EP02017947.9

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES

Inventor： Turner, Howard ,  Dales, Cameron G. ,  Van Erden, Lynn ,  Van Beek, Johannes A.M. ,  Hajduk, Damian A. ,  Nielsen, Ralph B. ,  Mansky, Paul ,  Matsiev, Leonid ,  Wang, Pei ,  McFarland, Eric

IPC: B01J19/00

CPC classification number: B01L3/50851 ,  B01F15/00207 ,  B01J19/0006 ,  B01J19/0013 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00029 ,  B01J2219/00056 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00333 ,  B01J2219/00335 ,  B01J2219/00351 ,  B01J2219/00367 ,  B01J2219/00373 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00745 ,  B01L3/50853 ,  B01L7/54 ,  B01L2200/026 ,  B01L2300/049 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/14 ,  B01L2300/1805 ,  C40B40/14 ,  C40B40/18 ,  G01K13/00 ,  G01N21/253

Abstract: A method of processing reaction mixtures in parallel, comprising: forming chemical reaction mixtures in a plurality of reactor vessels of a parallel reactor apparatus said apparatus comprising sensors for providing measured values relating to chemical reactions in said reactor vessels, and a processor for receiving data relating to said measured values; sealing the reaction mixture in each reactor vessel against fluid communication with the other vessels and at a pressure different than ambient pressure; injecting a fluid into at least one of the reactor vessels while the reaction mixture in said at least one vessel is sealed and at a pressure different than ambient pressure; agitating the reaction mixtures for at least a portion of the sealing step; and using the processor to receive said data relating to said measured values of the chemical reactions in said reactor vessels.