公开(公告)号：EP2412020A4

公开(公告)日：2016-05-04

申请号：EP10756714

申请日：2010-03-23

申请人： UNIV CHICAGO

发明人： ISMAGILOV RUSTEM F ,  DU WENBIN ,  LI LIANG ,  SHEN FENG ,  NICHOLS KEVIN PAUL FLOOD ,  CHEN DELAI ,  KREUTZ JASON EUGENE

IPC分类号： H01L23/48

CPC分类号： B01L3/502715 ,  B01F13/0094 ,  B01L3/5025 ,  B01L3/502738 ,  B01L3/502761 ,  B01L7/52 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2300/0609 ,  B01L2300/0809 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2300/0893 ,  B01L2300/12 ,  B01L2300/168 ,  B01L2400/065 ,  C12Q1/025 ,  C12Q1/703 ,  G01N21/78 ,  G01N33/54386 ,  H01L2924/0002 ,  H01L2924/00

摘要： A device is described having a first surface having a plurality of first areas and a second surface having a plurality of second areas. The first surface and the second surface are opposed to one another and can move relative to each other from at least a first position where none of the plurality of first areas, having a first substance, are exposed to plurality of second areas, having a second substance, to a second position. When in the second position, the plurality of first and second areas, and therefore the first and second substances, are exposed to one another. The device may further include a series of ducts in communication with a plurality of first second areas to allow for a substance to be disposed in, or upon, the plurality of second areas when in the first position.

公开(公告)号：EP1866092A4

公开(公告)日：2010-01-06

申请号：EP06748381

申请日：2006-03-15

申请人： UNIV CHICAGO

发明人： ISMAGILOV RUSTEM F ,  GERDTS CORY J ,  ZHENG BO

IPC分类号： B01L3/02

CPC分类号： G05D7/0694 ,  B01F5/0471 ,  B01F13/0071 ,  B01J19/0046 ,  B01J2219/00522 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00599 ,  B01L3/0293 ,  B01L3/502746 ,  B01L3/502784 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2300/0838 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0487 ,  G01N1/38 ,  G01N35/08 ,  G01N2035/1034 ,  Y10T137/0318

摘要： A microfluidic system with a plurality of sequential T-junctions for performing reactions in a plurality of droplets (plugs) of micro- to femtoliter volumes is disclosed. The microfluidic system is configured such that the plurality of plugs are flowing through a loading component, with the loading component splitting the plurality of plugs at each of the plurality of downstream T-junctions and each inlet of the plurality of detachable holding components is configured to be operably coupled with at least one of outlets of the plurality of downstream T-junctions so that the holding components received a plurality of split plugs in the immiscible carrier fluid from the loading component.

公开(公告)号：EP1983889A4

公开(公告)日：2009-09-16

申请号：EP07762741

申请日：2007-01-31

申请人： UNIV CHICAGO

发明人： ISMAGILOV RUSTEM F ,  KASTRUP CHRISTIAN J ,  RUNYON MATTHEW K ,  SONG HELEN ,  SHEN FENG

IPC分类号： A61B5/00

CPC分类号： G01N33/86

公开(公告)号：EP2986554A4

公开(公告)日：2017-05-17

申请号：EP14785518

申请日：2014-04-18

申请人： CALIFORNIA INST OF TECHN ,  UNIV CHICAGO

发明人： PAN QICHAO ,  KARYMOV MIKHAIL ,  HUYNH TOAN ,  SAWICKI GEORGE ,  BEGOLO STEFANO ,  DU WENBIN ,  ISMAGILOV RUSTEM F ,  MA LIANG

IPC分类号： B81B7/04 ,  B01F13/00 ,  B01L3/00 ,  B01L9/00 ,  C12M1/12 ,  C12M3/00 ,  C12Q1/02 ,  C12Q1/68 ,  G01N35/00

CPC分类号： B01L3/502715 ,  B01F13/0071 ,  B01F13/0083 ,  B01L3/502738 ,  B01L9/527 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/0605 ,  B01L2200/0642 ,  B01L2300/045 ,  B01L2300/047 ,  B01L2300/048 ,  B01L2300/0627 ,  B01L2300/0816 ,  B01L2300/0829 ,  B01L2300/0864 ,  B01L2400/0487 ,  B01L2400/065 ,  C12M23/44 ,  C12M23/46 ,  C12M25/06 ,  C12Q1/02 ,  C12Q1/025 ,  C12Q1/686 ,  G01N2035/00158

摘要： Provided herein are methods, compositions, and devices for the parallel handling of samples, such as cells or other biological samples. The methods, compositions, and devices are suited for multiple levels of analysis, including genetic and functional assays, of samples.

摘要翻译： 本文提供了用于平行处理样品如细胞或其他生物样品的方法，组合物和装置。 该方法，组合物和装置适用于样品的多级分析，包括遗传和功能分析。

公开(公告)号：EP1508044A4

公开(公告)日：2008-09-10

申请号：EP03783044

申请日：2003-05-09

申请人： UNIV CHICAGO

发明人： ISMAGILOV RUSTEM F

IPC分类号： G01N33/577 ,  B01F1/00 ,  C30B1/00 ,  G01N20060101 ,  G01N1/00 ,  G01N31/00 ,  G01N35/08

CPC分类号： B01J19/0046 ,  B01F3/0861 ,  B01F5/0403 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0071 ,  B01F2215/0037 ,  B01J19/0093 ,  B01J2219/00286 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00599 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00736 ,  B01J2219/0074 ,  B01J2219/00756 ,  B01J2219/00783 ,  B01J2219/00837 ,  B01J2219/0086 ,  B01J2219/00867 ,  B01J2219/00869 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00975 ,  B01J2219/00977 ,  B01L3/502746 ,  B01L3/502761 ,  B01L3/502784 ,  B01L7/52 ,  B01L2200/0647 ,  B01L2200/0668 ,  B01L2200/0673 ,  B01L2200/10 ,  B01L2300/0867 ,  B01L2300/0883 ,  B01L2400/0424 ,  B01L2400/0448 ,  B01L2400/0454 ,  B01L2400/0487 ,  B82Y30/00 ,  C12P19/34 ,  C12Q1/44 ,  G01N15/1404 ,  G01N15/1484 ,  G01N35/08 ,  G01N35/085 ,  G01N2015/1409 ,  Y02A90/26 ,  Y10T436/118339 ,  Y10T436/12 ,  Y10T436/2575

摘要： The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.