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    PROCESS FOR PURIFYING 1,4,7,10-TETRAAZACYCLODODECANE-1,4,7,10-TETRAACETIC ACID
    2.
    发明授权
    PROCESS FOR PURIFYING 1,4,7,10-TETRAAZACYCLODODECANE-1,4,7,10-TETRAACETIC ACID 有权

    公开(公告)号：EP3102566B1

    公开(公告)日：2018-09-12

    申请号：EP15702255.9

    申请日：2015-02-02

    申请人： T2Pharma GmbH

    发明人： BUFFEL, Diederik ,  BOI, Xavier ,  PYPE, Judith

    IPC分类号： C07D257/02

    CPC分类号： A61K49/108 ,  A61K47/18 ,  B01D61/027 ,  B01D2311/2649 ,  B01D2311/2673 ,  B01D2315/16 ,  C07D257/02 ,  C07D295/15 ,  C07F5/003

    摘要： includes the following steps: a) adding an acid to an aqueous solution of the compound of formula 1, including salts and hydrates thereof so as to obtain a slurry having a pH≦3; and b) filtering the slurry and at least one time washing the obtained precipitate with a liquid comprising water; and c) dissolving the precipitate obtained in step b) in water to obtain an aqueous solution; and d) filtering of the solution obtained in step c) over a nanofiltration membrane having a Molecular Weight Cut Off in the range from 150 to 500 and wherein optionally, between step c) and step d) the pH of the aqueous solution is adjusted to a pH value in the pH range as specified by the manufacturer of the nanofiltration membrane. A process for preparing a gadolinium complex of the purified compound of formula 1 is also disclosed. This gadolinium complex can be used for making a pharmaceutical composition as a contrast agent for magnetic resonance imaging.

    SEAWATER DESALINATION DEVICE, SEAWATER DESALINATION METHOD AND POTION CLEANING METHOD
    6.
    发明公开
    SEAWATER DESALINATION DEVICE, SEAWATER DESALINATION METHOD AND POTION CLEANING METHOD 审中-公开
    海水淡化装置，海水淡化方法和清洁方法

    公开(公告)号：EP3127870A1

    公开(公告)日：2017-02-08

    申请号：EP15773944.2

    申请日：2015-03-25

    申请人： Romer Environmental Protection (Shenzhen) Co., Ltd.

    发明人： WANG, Guilin ,  DONG, Wanzhang

    IPC分类号： C02F1/44 ,  C02F103/08

    CPC分类号： B01D61/12 ,  B01D61/025 ,  B01D61/04 ,  B01D61/08 ,  B01D65/02 ,  B01D2311/04 ,  B01D2313/18 ,  B01D2313/24 ,  B01D2313/243 ,  B01D2313/365 ,  B01D2313/50 ,  B01D2321/16 ,  B01D2321/205 ,  C02F1/001 ,  C02F1/441 ,  C02F2103/08 ,  C02F2201/005 ,  C02F2209/001 ,  C02F2209/003 ,  C02F2209/005 ,  C02F2209/44 ,  F16K11/076 ,  F16K31/061 ,  Y02A20/131 ,  B01D2311/2649

    摘要： The present invention relates to a seawater desalination device, a seawater desalination method and a potion cleaning method. The seawater desalination device comprises a seawater introducing and filtering device and a seawater reverse osmosis filtering device. A first control valve is arranged between the filtering device after the introduction of seawater and the seawater reverse osmosis filtering device; and a second control valve is arranged at the end of pipeline of the seawater reverse osmosis filtering device. The seawater desalination device further comprises a control circuit. The seawater introducing and filtering device is consisted of a seawater inlet valve, a seawater pump and a filter which are communicated in turn via pipeline; the seawater reverse osmosis filtering device is consisted of the first control valve, a high-pressure pump, a reverse osmosis membrane group, a pressure regulating valve, the second control valve and a clean water tank which are communicated in turn via pipeline. By adopting the above structure, the seawater desalination device, the seawater desalination method and the potion cleaning method are controlled by a variety of combination of manual control and electronic control. And, seawater desalination stop cleaning step and potion cleaning step are reduced, the structure is simplified, and the efficiency is improved.

    摘要翻译： 海水淡化装置，海水淡化方法和清洁方法技术领域本发明涉及海水淡化装置，海水淡化方法和清洁方法。 该海水淡化装置包括海水引入过滤装置和海水反渗透过滤装置。 第一控制阀设置在海水引入后的过滤装置与海水反渗透过滤装置之间， 在海水反渗透过滤装置的管道末端设置有第二控制阀。 海水淡化装置还包括控制电路。 海水引入过滤装置由海水进水阀，海水泵和过滤器组成，通过管道依次相通， 海水反渗透过滤装置由管道依次通过的第一控制阀，高压泵，反渗透膜组，压力调节阀，第二控制阀和清水箱组成。 通过采用上述结构，海水淡化装置，海水淡化方法和药水清洗方法通过手动控制和电子控制的各种组合来控制。 而且，减少了海水淡化停止清洁步骤和药水清洁步骤，简化了结构，提高了效率。