公开(公告)号：EP3224584A1

公开(公告)日：2017-10-04

申请号：EP15798447.7

申请日：2015-11-24

Applicant: Freie Universität Berlin

Inventor： SÜSS, Björn

IPC: G01J3/02 ,  G01J3/28 ,  G01J3/453 ,  G02B26/10

CPC classification number: G01J3/2889 ,  G01J3/021 ,  G01J3/4532 ,  G01J3/4535 ,  G02B26/001

Abstract: The present invention provides a reflector (1) adapted to oscillate comprising a resonator (10), an energy beam reflecting surface (20), and a means for inducing oscillations in the resonator (10). The reflecting surface (20) of the reflector (1) adapted to oscillate is provided by a surface of the oscillating resonator (10) itself. Furthermore, an interferometer (100) with a reflector (1) adapted to oscillate according to the invention is provided as well as an infrared Fourier transform spectrometer (200) with an interferometer (100) according to the invention.

Abstract translation: 本发明提供一种适于振荡的反射器（1），该反射器包括谐振器（10），能量束反射表面（20）和用于在谐振器（10）中引起振荡的装置。 适于振荡的反射器（1）的反射表面（20）由振荡谐振器（10）本身的表面提供。 此外，提供具有根据本发明振荡的反射器（1）的干涉仪（100）以及具有根据本发明的干涉仪（100）的红外傅立叶变换光谱仪（200）。

公开(公告)号：EP3214428A1

公开(公告)日：2017-09-06

申请号：EP14905239.1

申请日：2014-11-14

Applicant: Korea Advanced Institute of Science and Technology

Inventor： BAE, Hyeon Min ,  CHOI, Jong Kwan ,  CHOI, Min Gyu ,  KIM, Jae Myoung ,  HWANG, Gun Pil

IPC: G01N21/35 ,  G01J3/28

CPC classification number: G01J3/2889 ,  A61B5/0059 ,  A61B5/0075 ,  A61B5/14553 ,  A61B2562/0238 ,  A61B2562/046 ,  G01J3/28 ,  G01J3/42 ,  G01N21/35

Abstract: Disclosed are a time division spread spectrum code-based optical spectroscopy system capable of controlling irradiation power and a method for controlling the optical spectroscopy system. The optical spectroscopy system may comprise: a light transmission unit for irradiating light to a particular region of a subject by means of a light source, wherein the light is irradiated so that the overall energy is consistently maintained by reducing the light irradiation time and increasing the strength of the light; and a light receiving unit for collecting emergent light which has passed through the particular region.

Abstract translation: 公开了一种能够控制照射功率的基于时分扩频码的光学光谱系统和一种用于控制光学光谱系统的方法。 光学光谱系统可以包括：光传输单元，用于借助于光源将光照射到对象的特定区域，其中照射光以使得通过减少光照射时间并且增加 光线的强度; 以及用于收集穿过特定区域的出射光的光接收单元。

公开(公告)号：EP3062088A2

公开(公告)日：2016-08-31

申请号：EP16159834.7

申请日：2012-09-20

Applicant: Carl Zeiss Microscopy GmbH

Inventor： Möhler, Gunter ,  Schmidt, Dietmar ,  Holub, Oliver ,  Hauschild, Robert

IPC: G01N21/64 ,  G02B21/00 ,  G01J3/28 ,  G01J3/44

CPC classification number: G01N21/64 ,  G01J1/44 ,  G01J3/2889 ,  G01J3/44 ,  G01N21/6408 ,  G01N21/6458 ,  G02B21/0076 ,  G02B21/0084

Abstract: Die Erfindung betrifft eine Auswerteschaltung (1) zum Auswerten der elektrischen Signale (A) eines zur Detektion von Photonen ausgebildeten optoelektronischen Detektors (32) bei der Aufnahme von Fluoreszenzereignissen unter Anregung mittels Lichtpulsen, umfassend einen Analog-Digital-Wandler (2) oder einen Trigger mit einem Eingang zur Verbindung mit einem Ausgang des Detektors (32) und mit einem Ausgang zur Ausgabe eines Digitalwerts (a), ein Schieberegister (3), wobei die Auswerteschaltung (1) so konfiguriert ist, dass während eines Beleuchtungszyklus zu unterschiedlichen Zeitpunkten aufgenommene Lichtintensitäten unabhängig voneinander in den Stufen des Schieberegister gespeichert werden.
Die Erfindung betrifft ferner die Verwendung der Auswerteschaltung (1) zur zeitlichen Trennung von Fluoreszenz- und Streulicht von Fluoreszenzereignissen sowie ein Verfahren zum Aufzeichnen von Fluoreszenzereignissen.

Abstract translation: 本发明涉及一种评估电路（1）根据激发​​荧光事件的通过光脉冲的装置的记录期间评估的一个训练有素的用于检测的光子的光电检测器（32）的电信号（A），其包括一个模拟数字转换器（2）或一个触发器 具有用于连接到检测器（32）的输出的输入，并具有用于输出数字值的输出（a）中，一个移位寄存器（3），其中所述评估电路（1）被配置成使得光强度的照明周期期间记录在不同的时间 独立地存储在移位寄存器的这些级。 本发明还涉及使用荧光的时间分离和散射光从荧光事件以及用于荧光事件记录的方法评估电路（1）的。

公开(公告)号：EP2761276B1

公开(公告)日：2016-04-13

申请号：EP12778605.1

申请日：2012-09-20

Applicant: Carl Zeiss Microscopy GmbH

Inventor： MÖHLER, Gunter ,  SCHMIDT, Dietmar ,  HOLUB, Oliver ,  HAUSCHILD, Robert

IPC: G01N21/64 ,  G02B21/00 ,  G01J3/28 ,  G01J3/44

CPC classification number: G01N21/64 ,  G01J1/44 ,  G01J3/2889 ,  G01J3/44 ,  G01N21/6408 ,  G01N21/6458 ,  G02B21/0076 ,  G02B21/0084

公开(公告)号：EP2527901B1

公开(公告)日：2014-11-19

申请号：EP12168589.5

申请日：2012-05-18

Applicant: Aeon Imaging, LLC

Inventor： Muller, Matthew Stefan

IPC: G02B21/14 ,  G02B21/00 ,  A61B3/10 ,  G01J3/51 ,  G01J3/28 ,  H04N5/353 ,  G01J3/02

CPC classification number: G02B21/0032 ,  A61B3/1025 ,  G01J3/0208 ,  G01J3/0224 ,  G01J3/0229 ,  G01J3/0232 ,  G01J3/2803 ,  G01J3/2889 ,  G01J3/513 ,  G02B21/004 ,  G02B21/0064 ,  G02B21/008 ,  G02B21/14 ,  H04N5/3532

公开(公告)号：EP2609407A2

公开(公告)日：2013-07-03

申请号：EP11819225.1

申请日：2011-08-19

Applicant: Honeywell Asca, Inc.

Inventor： MOUSAVI, Payam ,  DODGE, Steven ,  HARAN, Frank, Martin ,  SAVARD, Stéphane ,  JEZ, David ,  HEATH, Stuart, James

IPC: G01J3/42 ,  G01J3/28

CPC classification number: G01J3/42 ,  D21F7/06 ,  D21G9/0009 ,  G01B11/0625 ,  G01J3/28 ,  G01J3/2889 ,  G01N21/3559 ,  G01N21/3586 ,  G01N21/86 ,  G01N2021/8663

Abstract: An apparatus for incorporation into time-domain spectroscopy systems that creates a continuous reference whereby a sample pulses' phase and amplitude can be tracked and corrected employs a beam splitter to generate sample and reference pulses. A detector is positioned for receiving the reference radiation pulses that do not interact with the sample. The same detector is also positioned for receiving the sample radiation pulses that emerge from the sample. The apparatus can be readily implemented by being configured between the emitter and detector of a terahertz time-domain spectrometer. The reference pulse is used to trace the changes in time and amplitude of the sample pulse. Since any changes in the reference pulse will most likely manifest in the sample pulse, the reference pulse is monitored and used to correct the sample pulse and thereby reduce the effects of jitter.

公开(公告)号：EP1886139B1

公开(公告)日：2011-08-17

申请号：EP06758550.5

申请日：2006-04-20

Applicant: Amnis Corporation

Inventor： ORTYN, William ,  BASIJI, David ,  LYNCH, David

IPC: G01N33/53

CPC classification number: G01N33/505 ,  G01J3/2889 ,  G01J3/36 ,  G01J3/4406 ,  G01N15/1429 ,  G01N15/147 ,  G01N15/1475 ,  G01N21/53 ,  G01N21/6428 ,  G01N21/6456 ,  G01N21/6458 ,  G01N33/5005 ,  G01N2015/1006 ,  G01N2015/1497 ,  G01N2021/6421 ,  G01N2021/6441 ,  G06K9/00127

Abstract: Aspects of the present invention encompass the collection of multispectral images from a population of objects, and the analysis of the collected images to measure at least one characteristic of the population, using photometric and/or morphometric features identifiable in the collection of images. In an exemplary application, the objects are biological cells. In a particularly preferred, but not limiting implementation, the plurality of images for each individual object are collected simultaneously. In an empirical study, the characteristic being measured involves the synapse between conjugated cells. The conjugated cells may represent a subpopulation of the overall population of objects that were imaged. In a particularly preferred, yet not limiting embodiment, the present invention enables the quantization of the redistribution of cellular molecules due to the conjugation of different biological cells. Significantly, such quantization is not feasible with standard microscopy and flow cytometry.

公开(公告)号：EP2005128A2

公开(公告)日：2008-12-24

申请号：EP07754032.6

申请日：2007-03-26

Applicant: Chemimage Corporation

Inventor： TUSCHEL, David ,  ZHANG, Jingyun

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0294 ,  G01J3/2803 ,  G01J3/2889 ,  G01J2003/4424 ,  G01N21/6456 ,  G01N21/65 ,  G01N2021/6417 ,  G01N2021/6423

Abstract: A system and method for collecting Raman data sets without the 'contaminating' effect of luminescence emitted photons. Using a fram transfer CCD for time resolved data collection, Raman imaging may be performed without photobleaching the sample. The system may include a light source, a frame transfer CCD, an optical lens and at least one controller. The light source illuminates the sample with a plurality of photons to generate scattered photons from the sample. The frame transfer CCD has an image array and a storage array. The optical lens collects scattered photons and directs the scattered photons to the image array. The controller transfers a Raman data set representative of the scattered photons from the image array to the storage array.

公开(公告)号：EP1593957B1

公开(公告)日：2008-12-10

申请号：EP04710981.4

申请日：2004-02-13

Applicant: HAMAMATSU PHOTONICS K. K.

Inventor： WATANABE, Hirohiko, c/o Hamamatsu Photonics K.K. ,  WATANABE, Motoyuki, c/o Hamamatsu Photonics K.K. ,  INOUE, Takayuki, c/o Hamamatsu Photonics K.K. ,  MARUNO, Tadashi, Hamamatsu Photonics K.K., ,  IWASE, Fumio Hamamatsu Photonics K.K.,

IPC: G01N21/64

CPC classification number: G01N21/6456 ,  G01J3/2803 ,  G01J3/2823 ,  G01J3/2889 ,  G01J3/4406 ,  G01J2003/2813 ,  G01J2003/282 ,  G01N21/645 ,  G01N2021/6417 ,  G01N2021/6423 ,  H04N5/3454 ,  H04N5/372

Abstract: A fluorescent correlated spectrometric analysis device (1) includes an excitation light radiation optical system (21), a fluorescent focusing optical system (22), a CCD camera (15), and a data analysis device (16). The excitation light radiation optical system (21) applies excitation light to a predetermined region of a sample S to be measured. The fluorescent focusing optical system (22) focuses the fluorescent light generated by the sample S on the light detection surface of the CCD camera (15). The CCD camera (15) photo-electrically converts the fluorescent light incident on the light detection surface for each pixel and outputs the electric charge generated by the photo-electric conversion as a detection signal from the output terminal. The data analysis device (16) inputs a detection signal obtained by the electric charge generated in the pixels belonging to the analysis object pixel group among the pixels of the CCD camera (15) and calculates the self-correlation function of the input detection signal for each pixel. Thus, it is possible to obtain a fluorescent correlated spectrometric analysis device capable of performing fluorescent correlated spectrometric analysis for multiple points of a sample simultaneously and at a high speed.

公开(公告)号：EP1460410B1

公开(公告)日：2008-08-06

申请号：EP02803925.3

申请日：2002-11-25

Applicant: Japan Science and Technology Agency

Inventor： SHIGEKAWA, Hidemi ,  TAKEUCHI, Osamu ,  YAMASHITA, Mikio ,  MORITA, Ryuji

IPC: G01N13/12 ,  G01N13/16 ,  G12B21/22

CPC classification number: G01J3/433 ,  G01J3/2889 ,  G01J2001/4242 ,  G01N21/6408 ,  G01N21/6458 ,  G01N2021/6415 ,  G01Q30/02 ,  G01Q60/12 ,  Y10S977/85

Abstract: An apparatus for measuring a physical phenomenon caused by light excitation having an extreme resolution in both time and space domains, particularly a delay time modulation time-resolved probe scanning microscope. The apparatus comprises an ultra-short light laser pulse generator (2), a delay modulation circuit (6) for splitting an ultra-short light laser pulse (3) generated by the ultra-short light laser pulse generator (2) into two pulses and frequency-modulating (ω) the delay time td between the two ultra-short light laser pulses (4, 5), a scanning probe microscope (17), and a lock-in detector (8) for detecting lock-in of a probe signal of the microscope (17) with a modulation frequency (ω) of the delay time. The delay-time dependence of the probe signal (11) on the delay time is determined as a change of rate without being influenced by the fluctuation of the intensity of the ultra-short light laser pulse (3) and without thermal expansion and thermal contraction of the chip of the probe (19) caused by the application of the ultra-short light laser pulse (3). With a femtosecond-order time resolution and an angstrom-order space resolution, a light excitation physical phenomenon depending on the delay time between ultra-short light pulses can be measured.