公开(公告)号：EP2575878B1

公开(公告)日：2018-06-13

申请号：EP11727536.2

申请日：2011-05-27

申请人： Zoetis Belgium S.A.

发明人： DAVIS, Heather, Lynn ,  DOMINOWSKI, Paul, Joseph ,  WEERATNA, Risini, Dhammika

IPC分类号： A61K39/39 ,  A61K39/10 ,  A61K39/155 ,  A61K39/12 ,  A61K39/265

CPC分类号： A61K39/39 ,  A61K39/099 ,  A61K39/12 ,  A61K39/155 ,  A61K39/265 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/55505 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/55577 ,  A61K2039/60 ,  A61K2039/6037 ,  A61K2039/70 ,  C12N2710/16734 ,  C12N2760/18534 ,  C12N2760/18634 ,  C12N2770/24334 ,  C12N2770/32334

摘要： Described are vaccines having one or more antigens cholesterol and CpG. Aspects of the invention relate to the use of the vaccines of the invention for the treatment and/or prevention of human and animal disorders.

公开(公告)号：EP2575878A1

公开(公告)日：2013-04-10

申请号：EP11727536.2

申请日：2011-05-27

申请人： Pfizer Animal Health S.A.

发明人： DAVIS, Heather, Lynn ,  DOMINOWSKI, Paul, Joseph ,  WEERATNA, Risini, Dhammika

IPC分类号： A61K39/39 ,  A61K39/10 ,  A61K39/155 ,  A61K39/12 ,  A61K39/265

CPC分类号： A61K39/39 ,  A61K39/099 ,  A61K39/12 ,  A61K39/155 ,  A61K39/265 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/55505 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/55577 ,  A61K2039/60 ,  A61K2039/6037 ,  A61K2039/70 ,  C12N2710/16734 ,  C12N2760/18534 ,  C12N2760/18634 ,  C12N2770/24334 ,  C12N2770/32334

摘要： Described are vaccines having one or more antigens cholesterol and CpG. Aspects of the invention relate to the use of the vaccines of the invention for the treatment and/or prevention of human and animal disorders.

摘要翻译： 描述了具有一种或多种抗原胆固醇和CpG的疫苗。 本发明的方面涉及本发明的疫苗用于治疗和/或预防人和动物疾病的用途。

公开(公告)号：EP2481423A1

公开(公告)日：2012-08-01

申请号：EP12165409.9

申请日：2007-01-15

申请人： Pfizer Products Inc.

发明人： Dominowski, Paul Joseph ,  Mannan, Ramasamy Mannar ,  Mediratta, Sangita

IPC分类号： A61K39/39 ,  C07H15/12 ,  C07H13/12 ,  A61K39/155 ,  A61K39/265

CPC分类号： A61K39/39 ,  A61K39/12 ,  A61K39/155 ,  A61K39/265 ,  A61K2039/552 ,  A61K2039/55511 ,  A61K2039/55572 ,  C07H13/12 ,  C07H15/12 ,  C12N2710/16051 ,  C12N2710/16734 ,  C12N2760/18351 ,  C12N2760/18534 ,  C12N2760/18634 ,  C12N2760/18651

摘要： This invention relates to compositions and methods of preparing stable adjuvant diluent stock solutions and final adjuvant solutions comprising glycolipids, weak acids, alcohols, nonionic surfactants and buffers.

摘要翻译： 本发明涉及制备稳定的佐剂稀释剂储备溶液和包含糖脂，弱酸，醇，非离子表面活性剂和缓冲剂的最终佐剂溶液的组合物和方法。

公开(公告)号：EP2337582A1

公开(公告)日：2011-06-29

申请号：EP09793230.5

申请日：2009-10-01

申请人： Novartis AG ,  Cornell University

发明人： RAJU SEETHARAMAN, Gopinath ,  HARLAND, Richard ,  ALBEE II, Lee David ,  PATEL, Mayur Navnitbhai ,  OSTERRIEDER, Nikolaus ,  KAUFER, Benedikt B.

IPC分类号： A61K39/265 ,  A61K39/102 ,  C07K14/05 ,  C12N15/869

CPC分类号： A61K39/102 ,  A61K2039/5254 ,  A61K2039/552 ,  A61K2039/55566 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/16721 ,  C12N2710/16722 ,  C12N2710/16761

摘要： The disclosure relates generally to the treatment or prevention of disease in cattle. More particularly, the invention is directed to the production and use of modified bovine herpesvirus 1 (BHV-1) and their use in compositions and vaccines that protect cattle from BHV-1 infection while not suppressing the immunological response in the host. In one example, the invention is directed to the use of modified BHV-1, administered with additional immunogens, either through co-administration and/or through administration in combination vaccines, and the use of these vaccines for the protection of cattle from disease. In one example, use of the modified BHV-1 in the administered compositions facilitates an immune response to or against the additional immunogens.

公开(公告)号：EP1743652A1

公开(公告)日：2007-01-17

申请号：EP06122758.3

申请日：2003-08-14

申请人： Pfizer Products Inc.

发明人： Dominowski, Paul Joseph

IPC分类号： A61K39/295 ,  A61K39/12 ,  A61K39/155 ,  A61K39/02 ,  A61K39/265

CPC分类号： A61K39/295 ,  A61K39/00 ,  A61K39/0225 ,  A61K39/39 ,  A61K2039/5252 ,  A61K2039/5254 ,  C07K14/005 ,  C12N2710/16722 ,  C12N2720/10022 ,  C12N2760/18522 ,  C12N2760/18622 ,  C12N2770/24322 ,  C12N2770/28022

摘要： The present invention relates to combination vaccines and methods for treating or preventing diseases or disorders in an animal caused by infection by one or more of the following : Bovine Viral Diarrhea Virus (BVDV) Types 1 and 2, Leptospira hardjo-bovis and Leptospira pomona by administering to the animal an effective amount of a combination vaccine. The combination vaccine can be a whole or partial cell inactivated or modified live preparation.

摘要翻译： 本发明涉及用于治疗或预防动物由以下一种或多种感染引起的疾病或病症的组合疫苗和方法：1型和2型牛病毒性腹泻病毒（BVDV），硬链球菌属钩端螺旋体和钩端螺旋体 向动物施用有效量的组合疫苗。 组合疫苗可以是全部或部分细胞灭活或修饰的活体制剂。

公开(公告)号：EP0655072B1

公开(公告)日：2004-02-11

申请号：EP93909700.2

申请日：1993-05-28

申请人： THE UNIVERSITY OF MELBOURNE

发明人： CRABB, Brendan, Scott ,  STUDDERT, Michael, Justin

IPC分类号： C12N15/12 ,  C12N15/70 ,  C12N1/21 ,  C07K14/03 ,  C07K16/08 ,  G01N33/569 ,  A61K39/265

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/12 ,  A61K39/245 ,  C12N7/00 ,  C12N2710/16722 ,  C12N2710/16723 ,  C12N2710/16734 ,  Y10S435/975 ,  Y10T436/143333

摘要： Disclosed are serological assays based on unique sequence type-specifice gG proteins and polypeptides capable of distinguishing the closely related EHV4 and EHV1 viruses. The assays are capable of clearly and unambiguously distinguishing animals infected with EHV4 or EHV1 and thereby distinguishing the EHV4 infection: equine rhinopheumonitis, causing 'snotty noses' from the more dramatic consequences of EHV1 infection; equine abortion, which often results in an 'abortion storm' and high loss of livestock. Further disclosed are the unique type-specific epitopes of EHV4 and EHV1, recombinantly derived novel nucleic acid sequences and proteins which are useful in providing assay reagents, antibodies, vaccines, probes and associated peripherals for diagnosis and control.

公开(公告)号：EP0888777A2

公开(公告)日：1999-01-07

申请号：EP98108774.5

申请日：1992-12-11

申请人： UNIVERSITY OF SASKATCHEWAN

发明人： Babiuk, Lorne ,  Van den Hurk, Sylvia ,  Zamb, Tim ,  Fitzpatrick, David

IPC分类号： A61K39/265 ,  C07K14/03 ,  C12N15/38

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/245 ,  A61K2039/53 ,  A61K2039/70 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2710/14143 ,  C12N2710/16622 ,  C12N2710/16634 ,  C12N2710/16722 ,  C12N2710/16734 ,  C12N2710/16771 ,  C12N2710/24143 ,  C12N2830/30 ,  G01N33/6854 ,  G01N2333/03

摘要： Recombinant subunit vaccines against bovine herpesvirus type 1 (BHV-1) are provided, as well as methods of vaccination and methods of recombinantly producing the subunit antigens or nucleotide sequences employed in the vaccines. Preferably, the subunit is a truncated BHV-1 gIV antigen.

摘要翻译： 提供了针对牛疱疹病毒1型（BHV-1）的重组亚单位疫苗，以及疫苗接种方法和重组产生疫苗中使用的亚基抗原或核苷酸序列的方法。 优选地，亚基是截短的BHV-1 gIV抗原。

公开(公告)号：EP1212045A4

公开(公告)日：2008-02-20

申请号：EP00955789

申请日：2000-08-21

申请人： TEVA PHARMA

发明人： GALLILI GILAD ,  FRYDMAN NORBERT

IPC分类号： A61K9/08 ,  A61K9/00 ,  A61K9/12 ,  A61K9/19 ,  A61K9/20 ,  A61K9/46 ,  A61K39/00 ,  A61K39/02 ,  A61K39/12 ,  A61K39/17 ,  A61K39/215 ,  A61K39/265 ,  A61K39/275 ,  A61K39/395 ,  A61K47/04 ,  A61K47/12 ,  A61P31/04 ,  A61P31/12 ,  A61K9/28 ,  A61K9/30

CPC分类号： A61K9/0007 ,  A61K39/02 ,  A61K2039/52 ,  A61K2039/525

公开(公告)号：EP1731612A1

公开(公告)日：2006-12-13

申请号：EP05720839.9

申请日：2005-03-09

申请人： ZEON CORPORATION

发明人： Okuda, Takashi ,  Saitoh, Shuji ,  Saeki, Sakiko

IPC分类号： C12N15/38 ,  C12N15/869 ,  A61K39/255 ,  A61K39/265 ,  C12N7/01 ,  C12R1/93

CPC分类号： C12N15/86 ,  A61K39/12 ,  A61K39/245 ,  A61K2039/5256 ,  C07K14/005 ,  C12N2710/16022 ,  C12N2710/16034 ,  C12N2710/16043 ,  C12N2710/16334

摘要： A recombinant herpesvirus (excluding infectious laryngotracheitis virus) having a DNA that encodes a polypeptide comprising 429 amino acids at the amino terminal end of a protein encoded by the gB gene of infectious laryngotracheitis virus or a polypeptide in which one or a plurality of amino acids have been deleted, added, or substituted in said polypeptide.

摘要翻译： 具有编码由感染性喉气管炎病毒的gB基因编码的蛋白质的氨基末端的429个氨基酸的多肽的重组疱疹病毒（不包括感染性喉气管炎病毒）或其中一个或多个氨基酸具有的多肽 在所述多肽中被删除，添加或替代。

公开(公告)号：EP1155119A1

公开(公告)日：2001-11-21

申请号：EP00904385.2

申请日：2000-01-18

申请人： KANSAS STATE UNIVERSITY RESEARCH FOUNDATION

发明人： CHOWDHURY, Shafiqul, I.

IPC分类号： C12N7/01 ,  C12N15/38 ,  A61K39/265 ,  C12Q1/70

CPC分类号： C07K14/005 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/543 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/16722 ,  C12N2710/16743 ,  C12N2710/16761

摘要： A safe live recombinant virus as well as a vaccine is produced by the deletion of a portion of the native glycoprotein E(gE) coding region of bovine herpesvirus 1(BHV-1) followed by the insertion of a plasmid including a foreign functional β-gal at the gE locus. The deletion of gE gene stably attenuates the virus and serves as an immunological marker differentiating vaccinated animals from infected animals. Moreover, production of β-gal allows easy assessment of gEΔ3.1IBRβ virus replication in vaccinated animals and serves as a phenotypic marker which distinguishes it from wild type virus replication in infected animals.