公开(公告)号：EP3186267B1

公开(公告)日：2019-10-02

申请号：EP15763482.5

申请日：2015-08-25

申请人： Ustav Organicke Chemie a Biochemie AV CR, v.v.i. ,  Fyziologicky Ustav AV CR, v.v.i.

发明人： KUDOVA, Eva ,  CHODOUNSKA, Hana ,  KAPRAS, Vojtech ,  VYKLICKY, Ladislav ,  VALES, Karel ,  JAHN, Ullrich

IPC分类号： C07J1/00 ,  C07J9/00 ,  C07J13/00 ,  C07J31/00 ,  C07J41/00 ,  C07J43/00 ,  C07J63/00 ,  C07J71/00 ,  A61K31/56 ,  A61P25/00 ,  A61P25/08 ,  A61P25/28 ,  A61P25/24 ,  A61P25/22 ,  A61P25/18 ,  A61P25/30 ,  C07C279/14 ,  C07C305/20 ,  C07C211/63 ,  C07C13/60 ,  C07C55/00

公开(公告)号：EP3260462A1

公开(公告)日：2017-12-27

申请号：EP17183215.7

申请日：2015-08-25

申请人： Ustav organicke chemie a biochemie AV CR, v.v.i. ,  Fyziologicky Ustav AV CR, v.v.i.

发明人： Kudova, Eva ,  Chodounska, Hana ,  Kapras, Vojtech ,  Vyklicky, Ladislav ,  Vales, Karel ,  Jahn, Ullrich

IPC分类号： C07J1/00 ,  C07J9/00 ,  C07J13/00 ,  C07J31/00 ,  C07J41/00 ,  C07J43/00 ,  C07J63/00 ,  C07J71/00 ,  A61K31/56 ,  A61P25/00 ,  A61P25/08 ,  A61P25/28 ,  A61P25/24 ,  A61P25/22 ,  A61P25/18 ,  A61P25/30 ,  C07C279/14 ,  C07C305/20 ,  C07C211/63 ,  C07C13/60 ,  C07C55/00

CPC分类号： C07J43/003 ,  C07C59/80 ,  C07C305/20 ,  C07C2603/26 ,  C07D209/36 ,  C07D213/18 ,  C07D317/72 ,  C07J1/0007 ,  C07J1/0011 ,  C07J9/00 ,  C07J9/005 ,  C07J13/007 ,  C07J31/006 ,  C07J41/0005 ,  C07J41/0033 ,  C07J41/0038 ,  C07J53/001 ,  C07J63/008 ,  C07J71/0005

摘要： The present invention provides amphiphilic compounds with a tetradecahydrophenanthrene skeleton of formula (I), wherein R1-R5 are as defined herein, and their enantiomers, exhibiting neuroprotective effects, for use as medicaments for treating neuropsychiatric disorders associated with an imbalance in glutamatergic neurotransmitter system, such as ischemic damage of CNS, neurodegenerative changes and disorders of CNS, affective disorders, depression, post-traumatic stress disorder and diseases related to stress, anxiety, schizophrenia and psychotic disorders, pain , addiction, multiple sclerosis, epilepsy, glioma, and a pharmaceutical composition containing said compound.

摘要翻译： 本发明提供了具有式（I）的十四氢菲构架的两亲化合物，其中R1-R5如本文所定义，并且它们的对映异构体具有神经保护作用，用作治疗与谷氨酸能神经递质系统失衡有关的神经精神病症的药物， 如中枢神经系统的缺血性损伤，神经退行性改变和中枢神经系统病症，情感障碍，抑郁症，创伤后应激障碍以及与压力，焦虑，精神分裂症和精神障碍有关的疾病，疼痛，成瘾，多发性硬化症，癫痫症，神经胶质瘤和 含有该化合物的药物组合物

公开(公告)号：EP1201632A1

公开(公告)日：2002-05-02

申请号：EP99943249.5

申请日：1999-09-10

申请人： DAINIPPON INK AND CHEMICALS, INC.

发明人： Ogawa, Shinji ,  Kawara, Tatsuo ,  Takehara, Sadao ,  Ohnishi, Hiroyuki ,  Takeuchi, Kiyofumi ,  Takatsu, Haruyoshi ,  Grahe, Gerwald ,  Frings, Rainer Bruno ,  Fugger, Christine ,  Pithart, Cornelia

IPC分类号： C07C13/60 ,  C07C25/22 ,  C07C25/24 ,  C07C39/17 ,  C07C43/225 ,  C07C49/675 ,  C07C255/50 ,  C07C255/55 ,  C09K19/32 ,  C09K19/34 ,  G02F1/13

CPC分类号： C07C255/55 ,  C07C22/08 ,  C07C25/18 ,  C07C25/22 ,  C07C25/24 ,  C07C49/675 ,  C07C49/697 ,  C07C255/50 ,  C09K19/0208 ,  C09K19/32 ,  C09K19/321 ,  C09K19/322 ,  C09K19/3483 ,  C09K2019/325 ,  C09K2019/326 ,  Y10T428/10

摘要： A novel compound represented by the general formula (I), and a nematic liquid crystal composition incorporating the same.
A compound represented by the general formula (I) can be produced industrially extremely easily, as shown in the examples, displays superior compatibility with current general purpose host liquid crystals as a nematic phase, and also shows little crystal precipitation at low temperatures. Moreover, by addition of a small amount of such a compound to a host liquid crystal, the liquid crystal temperature range at low temperatures can be effectively widened without any significant worsening of the various characteristics of the liquid crystal material. Consequently, a compound of the present invention is an extremely useful liquid crystal material which is suitable for various liquid crystal display elements which require a broad operating temperature range.

摘要翻译： 由通式（I）表示的新型化合物和含有该化合物的向列型液晶组合物。 由通式（I）表示的化合物可以在工业上非常容易地制造，如实施例所示，显示出与当前通用主体液晶作为向列相的优异的相容性，并且在低温下也显示出很小的晶体析出 。 此外，通过向主液晶中添加少量这样的化合物，可以有效地加宽低温下的液晶温度范围，而不会使液晶材料的各种特性显着恶化。 因此，本发明的化合物是适用于需要宽的工作温度范围的各种液晶显示元件的非常有用的液晶材料。

公开(公告)号：EP1591437B1

公开(公告)日：2009-11-25

申请号：EP05076500.7

申请日：2000-05-12

申请人： Nereus Pharmaceuticals, Inc. ,  The Regents of the University of California, Office of Technology Transfer, University of California

发明人： Palladino, Michael ,  Theodorakis, Emmanuel, A

IPC分类号： C07C61/35 ,  C07C61/29 ,  C07C69/753 ,  C07C69/757 ,  C07C69/007 ,  C07C69/00 ,  C07C33/14 ,  C07C13/60 ,  A61K31/22 ,  A61K31/215 ,  A61K31/19 ,  A61K31/045 ,  A61K31/015

CPC分类号： C07C62/32 ,  A61K31/12 ,  A61K31/16 ,  A61K31/215 ,  C07B2200/05 ,  C07C61/29 ,  C07C61/35 ,  C07C69/753 ,  C07C2603/26

公开(公告)号：EP1178952A1

公开(公告)日：2002-02-13

申请号：EP00932408.8

申请日：2000-05-12

申请人： Nereus Pharmaceuticals, Inc. ,  The Regents of the University of California

发明人： PALLADINO, Michael ,  THEODORAKIS, Emmanuel, A.

IPC分类号： C07C61/35 ,  C07C61/29 ,  C07C69/753 ,  C07C69/757 ,  C07C69/007 ,  C07C69/00 ,  C07C33/14 ,  C07C13/60 ,  A61K31/22 ,  A61K31/215 ,  A61K31/19 ,  A61K31/045 ,  A61K31/015

CPC分类号： C07C62/32 ,  A61K31/12 ,  A61K31/16 ,  A61K31/215 ,  C07B2200/05 ,  C07C61/29 ,  C07C61/35 ,  C07C69/753 ,  C07C2603/26

摘要： Compounds are disclosed that have the chemical structure of Formula (II) and (IIB) and their produg esters and acid-addition salts, and that are useful as Interleukin-1 and Tumor Necrosis Factor-a modulators, and thus are useful in the treatment of various diseases, wherein the R groups are defined in the claims.

摘要翻译： 具有以下化学结构的化合物：其produg酯和酸加成盐，如白介素-1和肿瘤坏死因子±调制器是有用的，worin R基团中的权利要求限定。

公开(公告)号：EP0033620A1

公开(公告)日：1981-08-12

申请号：EP81300328.2

申请日：1981-01-26

申请人： GULF RESEARCH & DEVELOPMENT COMPANY

发明人： Tsai, Shirley C. ,  McIlvried, Howard G. III

IPC分类号： C07C13/60 ,  C07C5/05 ,  C10G1/06

CPC分类号： C10G45/44 ,  C07C2603/26 ,  C10G1/042 ,  C10G45/50

摘要： The OHP content of an OHP- and THP-containing solvent is enriched by contacting the solvent with hydrogen in the presence of a supported catalyst (68) comprising Group VIB and Group VIII metals under conditions to increase the OHP/THP ratio in the solvent to a level greater than 0.4 and preferably greater than 1. The preferred catalyst contains tungsten where it is desired to provide an OHP/THP ratio greater than 1 in the OHP-enriched solvent, and also contains titanium to improve the hydrogen selectivity of the catalyst so as to enhance the preservation of aromatics in the hydrogenated solvent. The OHP-enriched solvent provides increased solvation of coal and improved yields of liquid fuel product in a coal liquefaction process which utilizes the solvent.

摘要翻译： 在包含VIB族和VIII族金属的负载型催化剂存在下，通过使溶剂与氢气接触使OHP和THP的溶剂的OHP含量在使溶剂中的OHP / THP比增至更高的条件下被富集 优选大于1.优选的催化剂含有钨，其中希望在富含OHP的溶剂中提供大于1的OHP / THP比，并且还含有钛以改善催化剂的氢选择性以增强 在氢化溶剂中保存芳族化合物。 富含OHP的溶剂在利用溶剂的煤液化过程中提高了煤的溶剂化度和提高了液体燃料产物的产率。

公开(公告)号：EP4257588A1

公开(公告)日：2023-10-11

申请号：EP21900085.8

申请日：2021-12-03

申请人： Reistone Biopharma Company Limited

发明人： HAO, Xin ,  GONG, Shuyi ,  SHEN, Defeng ,  DU, Xinming

IPC分类号： C07D471/14 ,  C07D493/14 ,  C07C13/60 ,  A61K31/4353 ,  A61K31/438 ,  A61K31/352 ,  A61P11/06 ,  A61P11/08 ,  A61P19/02 ,  A61P3/10 ,  A61P37/00 ,  A61P13/12

摘要： The present disclosure relates to a small molecule inhibitor of cathepsin C and the medicinal use thereof. Specifically, provided in the present disclosure are an amide nitrile compound represented by formula VI, a pharmaceutical composition containing the compound, and the use thereof in the inhibition of cathepsin C.

公开(公告)号：EP1201632B1

公开(公告)日：2006-03-29

申请号：EP99943249.5

申请日：1999-09-10

申请人： DAINIPPON INK AND CHEMICALS, INC.

发明人： Ogawa, Shinji ,  Kawara, Tatsuo ,  Takehara, Sadao ,  Ohnishi, Hiroyuki ,  Takeuchi, Kiyofumi ,  Takatsu, Haruyoshi ,  Grahe, Gerwald ,  Frings, Rainer Bruno ,  Fugger, Christine ,  Pithart, Cornelia

IPC分类号： C07C13/60 ,  C07C25/22 ,  C07C25/24 ,  C07C39/17 ,  C07C43/225 ,  C07C49/675 ,  C07C255/50 ,  C07C255/55 ,  C09K19/32 ,  C09K19/34 ,  C07C22/08 ,  C07C25/18 ,  C07C49/697 ,  C09K19/02

CPC分类号： C07C255/55 ,  C07C22/08 ,  C07C25/18 ,  C07C25/22 ,  C07C25/24 ,  C07C49/675 ,  C07C49/697 ,  C07C255/50 ,  C09K19/0208 ,  C09K19/32 ,  C09K19/321 ,  C09K19/322 ,  C09K19/3483 ,  C09K2019/325 ,  C09K2019/326 ,  Y10T428/10

摘要： A novel compound represented by general formula (I) and a nematic liquid crystal composition containing the same. A compound represented by general formula (I) can be produced with great ease as is shown in an example and has excellent compatibility with a mother liquid crystal of general use being currently used as a nematic liquid crystal, and further shows reduced precipitation at a low temperature. Moreover, the addition of only a small amount of the above compound to the mother liquid crystal results in expanding effectively the temperature range for liquid crystallinity, without detriment to various properties as a liquid crystal material. Accordingly, the above compound is suitable for use in various liquid crystal display elements which are required to have a wide range of working temperature and is greatly useful as a liquid crystal material.

公开(公告)号：EP1591437A2

公开(公告)日：2005-11-02

申请号：EP05076500.7

申请日：2000-05-12

申请人： Nereus Pharmaceuticals, Inc. ,  The Regents of the University of California, Office of Technology Transfer, University of California

发明人： Palladino, Michael ,  Theodorakis, Emmanuel, A

IPC分类号： C07C61/35 ,  C07C61/29 ,  C07C69/753 ,  C07C69/757 ,  C07C69/007 ,  C07C69/00 ,  C07C33/14 ,  C07C13/60 ,  A61K31/22 ,  A61K31/215 ,  A61K31/19 ,  A61K31/045 ,  A61K31/015

CPC分类号： C07C62/32 ,  A61K31/12 ,  A61K31/16 ,  A61K31/215 ,  C07B2200/05 ,  C07C61/29 ,  C07C61/35 ,  C07C69/753 ,  C07C2603/26

摘要： A compound having the following chemical structure:
its produg esters and acid-addition salts, useful as Interleukin-1 and Tumor Necrosis Factor-α modulators, wherein R groups are defined in the claims.

公开(公告)号：EP3260462B1

公开(公告)日：2019-04-17

申请号：EP17183215.7

申请日：2015-08-25

申请人： Ustav organicke chemie a biochemie AV CR, v.v.i. ,  Fyziologicky Ustav AV CR, v.v.i.

发明人： Kudova, Eva ,  Chodounska, Hana ,  Kapras, Vojtech ,  Vyklicky, Ladislav ,  Vales, Karel ,  Jahn, Ullrich

IPC分类号： C07J1/00 ,  C07J9/00 ,  C07J13/00 ,  C07J31/00 ,  C07J41/00 ,  C07J43/00 ,  C07J63/00 ,  C07J71/00 ,  A61K31/56 ,  A61P25/00 ,  A61P25/08 ,  A61P25/28 ,  A61P25/24 ,  A61P25/22 ,  A61P25/18 ,  A61P25/30 ,  C07C279/14 ,  C07C305/20 ,  C07C211/63 ,  C07C13/60 ,  C07C55/00