公开(公告)号：EP4053102B1

公开(公告)日：2024-06-12

申请号：EP21192976.5

申请日：2021-08-25

IPC分类号： C07C303/02 ,  C07C303/22 ,  C07C303/32 ,  C07C303/44 ,  C07C309/14 ,  C07C309/08

CPC分类号： C07C303/22 ,  C07C303/02 ,  C07C303/32 ,  C07C303/44

公开(公告)号：EP2899257B1

公开(公告)日：2018-05-30

申请号：EP13838551.3

申请日：2013-09-19

申请人： Kao Corporation

发明人： YOSHIKAWA, Yohei ,  MITSUDA, Yoshinori ,  HORI, Hiroshi ,  NISHIMOTO, Yoshifumi ,  DOI, Yasuhiro

IPC分类号： A61K8/46 ,  A61Q5/02 ,  A61Q19/10 ,  C07C309/08 ,  C07C309/20 ,  C11D1/14 ,  C11D1/37 ,  C11D3/00

CPC分类号： A61Q5/02 ,  A61K8/466 ,  A61K2800/596 ,  A61Q19/10 ,  C07C309/08 ,  C07C309/20 ,  C11D1/143 ,  C11D1/37 ,  C11D3/0094

摘要： Provided is an internal olefin sulfonate composition which is capable of exerting good foamability together with good volume of foam, foaming speed, foam dissipation property, foam quality, foam durability in the presence of sebum, and volume of foam in the presence of sebum at high levels, and a cleansing composition containing the same. The internal olefin sulfonate composition comprises (A) an internal olefin sulfonate having 16 carbon atoms and/or (B) an internal olefin sulfonate having 18 carbon atoms, in which a total content of the component (A) and the component (B) is from 50 to 100% by mass, a content mass ratio of the component (A) to the component (B), (A/B), is from 91/9 to 100/0, a content of the internal olefin sulfonate in which a sulfonate group is present at a C-2 position is 25% by mass or less, and in which a mass ratio of a content of a hydroxy form in the internal olefin sulfonate of the component (A) and the component (B) to a content of an olefin form in the internal olefin sulfonate of the component (A) and the component (B), (hydroxy form/olefin form), is from 75/25 to 100/0.

公开(公告)号：EP2899258A1

公开(公告)日：2015-07-29

申请号：EP13839557.9

申请日：2013-09-19

申请人： Kao Corporation

发明人： YOSHIKAWA, Yohei ,  MITSUDA, Yoshinori ,  HORI, Hiroshi ,  NISHIMOTO, Yoshifumi ,  DOI, Yasuhiro

IPC分类号： C11D1/14 ,  A61K8/46 ,  A61Q5/02 ,  A61Q19/10 ,  C07C309/08 ,  C07C309/20 ,  C11D1/29

CPC分类号： C07C309/20 ,  A61K8/046 ,  A61K8/466 ,  A61Q5/02 ,  A61Q19/10 ,  C07C309/08 ,  C11D1/143 ,  C11D1/37 ,  C11D3/0094

摘要： Provided is an internal olefin sulfonate composition which is capable of exerting good foamability together with good volume of foam, foaming speed, foam dissipation property, foam quality, foam durability in the presence of sebum, and volume of foam in the presence of sebum at high levels, and a cleansing composition containing the same.
The internal olefin sulfonate composition of the present invention comprises (A) an internal olefin sulfonate having 16 carbon atoms and/or (B) an internal olefin sulfonate having 18 carbon atoms, in which a total content of the component (A) and the component (B) is from 50 to 100% by mass, a content mass ratio (A/B) of the component (A) to the component (B) is from 0/100 to 70/30, a content of the internal olefin sulfonate in which a sulfonate group is present at a C-2 position is 25% by mass or less, and in which a mass ratio (hydroxy form/olefin form) of a content of a hydroxy form in the internal olefin sulfonate of the component (A) and the component (B) to a content of an olefin form in the internal olefin sulfonate of the component (A) and the component (B) is from 75/25 to 100/0.

摘要翻译： 本发明提供一种内烯烃磺酸盐组合物，其能够发挥良好的起泡性和良好的泡沫体积，发泡速度，泡沫消散性能，泡沫质量，皮脂存在下的泡沫耐久性和高皮脂存在下的泡沫体积 含有它们的清洁组合物。 本发明的内烯烃磺酸盐组合物含有（A）具有16个碳原子的内烯烃磺酸盐和/或（B）具有18个碳原子的内烯烃磺酸盐，其中组分（A）和组分 （B）的含量为50〜100质量％，组分（A）与组分（B）的含量质量比（A / B）为0/100〜70/30，内烯烃磺酸盐 其中磺酸盐基团存在于C-2位置的含量为25质量％以下，并且其中组分（A）的内烯烃磺酸盐中羟基形式的含量（羟基形式/烯烃形式） （A）和组分（B）的内烯烃磺酸盐中的烯烃磺酸盐的含量与组分（B）的摩尔比为75/25至100/0。

公开(公告)号：EP1706476A4

公开(公告)日：2010-03-10

申请号：EP04780752

申请日：2004-08-11

申请人： HUNTSMAN SPEC CHEM CORP

发明人： ANANTANENI PRAKASA R ,  GRAY JOHN ,  RENNER MARTY J ,  SMITH GEORGE A ,  LEWIS DAVID C ,  CHAMPION DONALD H ,  WHEWELL CHRISTOPHER J

IPC分类号： C11D17/00 ,  A61K8/46 ,  A61Q5/02 ,  A61Q19/10 ,  C07C303/00 ,  C07C303/02 ,  C07C303/22 ,  C07C309/08 ,  C07C309/12 ,  C11D1/28

CPC分类号： C07C303/32 ,  A61K8/466 ,  A61Q5/02 ,  A61Q19/10 ,  C07C303/02 ,  C07C303/22 ,  C07C309/12 ,  C11D1/28 ,  C07C309/08

摘要： Methods and compositions are provided for forming ester based compositions. The ester based compositions may be used in consumer products. In one aspect, a method is provided for producing acyl alkylisethionate esters by the esterification of a sulfonate composition having two or more sulfonate isomers with fatty acid(s). In another aspect, a method is provided for forming an ester based composition including a blend of acyl alkylisethionate and acylisethionate esters.

公开(公告)号：EP1931608A1

公开(公告)日：2008-06-18

申请号：EP06761817.3

申请日：2006-07-10

申请人： Universität Stuttgart ,  Häring, Thomas

发明人： KERRES, Jochen ,  HEIN, Martin ,  SCHÖNBERGER, Frank

IPC分类号： C07B45/04 ,  C07C309/08 ,  C07C303/04 ,  C07F9/38 ,  C08G65/334 ,  C08G65/335 ,  C08G75/12 ,  C08G75/23 ,  C08G85/00 ,  B01D71/52 ,  B01D71/68

CPC分类号： B01D71/52 ,  B01D71/66 ,  B01D71/68 ,  C07C303/02 ,  C07C317/22 ,  C07F9/3834 ,  C07F9/404 ,  C08F8/36 ,  C08F8/40 ,  H01M8/1025 ,  H01M8/1027 ,  H01M8/1032 ,  H01M8/1039 ,  H01M2300/0082 ,  Y02P70/56

摘要： The invention relates to producing monomer, oligomer and polymer non-fluorinated, partially fluorinated or perfluorinated sulphonic acids by reacting halogenated, low-molecular weight, oligomer or macromolecular arenes with (hydrogen) sulphites, dithionites, sulphides or other reducing sulfur salts, possibly by oxidising sulphur-containing arene intermediates which are formed at a sulphur oxidation degree less than +6 by means of appropriate oxidation agents with formation of corresponding sulphonate functional groups (sulphonic acid, sulfohalogenide, sulphonamide and sulphonic acid ester groups). The invention also relates to a method for producing monomer, oligomer or polymer non-halogenated, partially halogenated or perhalogenated phosphonic acid esters and the derivatives thereof (for example, a free phosphonic acid or a phosphonic acid salt) by a nucleophile aromatic substitution (Michaelis-Becker-reaktion, complete or partial substitution of halogenide functional groups by phosphate functional groups (phosphonic acid esters, phosphonic acid amides, phosphonic acids, phosphonic acid salts, phosphonic acid halogenides). Said invention also relates to a method for producing polymer or ionomer non-halogenated, partially halogenated or perhalogenated containing (CF2)xPO(OR)2- or (CF2)xSO2Me- or (CF2)xSO3Me- side chains, (wherein x = 1 - 20, R = any organic radical, Me = any monovalent cation). A method for carrying out a nucleophile polycondensation of said functionalised (i.e. sulphonated, sulphonated or phosphonated) monomers into oligomers or polymers is also disclosed.

摘要翻译： 非氟化，部分氟化或全氟化的芳族，单体，低聚和聚合的砜和/或膦酸（和/或其衍生物）（I），其中聚合物的部分或全氟化基团主要存在 链和侧链和（I）通过具有硫和/或磷亲核试剂的亲核芳族取代（SNAr）制备。 包括以下的独立权利要求：（1）通过亲核性芳香族取代与硫和/或磷亲核试剂生产（I）的方法，其中质子或偶极非质子和非质子溶剂如水（仅在磺化情况下）， 四氢呋喃，二乙醚，二恶烷，甘醇二甲醚，二甘醇二甲醚，三甘醇二甲醚，二甲基乙酰胺，二甲基甲酰胺，N-甲基-2-吡咯烷酮，环丁砜，碳酸亚丙酯，二甲基亚砜，乙腈，苯，甲苯和/或二甲苯， 和（2）化合物，优选通过上述方法制备的聚合物和低聚物。

公开(公告)号：EP1848705A2

公开(公告)日：2007-10-31

申请号：EP06718069.5

申请日：2006-01-12

申请人： Schering Corporation ,  Wu, George G. ,  Sudhakar, Anantha ,  Wang, Tao ,  Xie, Ji ,  Chen, Frank Xing ,  Poirier, Marc ,  Huang, Mingsheng ,  Sabesan, Vijay ,  Kwok, Daw-long ,  Cui, Jian ,  Yang, Xiaojing ,  Thiruvengadam, Tiruvettipuram, K. ,  Liao, Jing ,  Zavialov, Ilia ,  Nguyen, Hoa N. ,  Lim, Ngiap Kie

发明人： Schering Corporation ,  Wu, George G. ,  Sudhakar, Anantha ,  Wang, Tao ,  Xie, Ji ,  Chen, Frank Xing ,  Poirier, Marc ,  Huang, Mingsheng ,  Sabesan, Vijay ,  Kwok, Daw-long ,  Cui, Jian ,  Yang, Xiaojing ,  Thiruvengadam, Tiruvettipuram, K. ,  Liao, Jing ,  Zavialov, Ilia ,  Nguyen, Hoa N. ,  Lim, Ngiap Kie

IPC分类号： C07D307/92 ,  C07C235/28 ,  C07D405/06 ,  C07C205/55 ,  C07D413/06 ,  C07D417/06 ,  C07C205/44 ,  C07C309/08 ,  C07D235/12 ,  C07D263/56 ,  C07D277/64

CPC分类号： C07D263/56 ,  C07C69/606 ,  C07C69/732 ,  C07C201/10 ,  C07C201/12 ,  C07C205/44 ,  C07C205/55 ,  C07C231/10 ,  C07C231/12 ,  C07C235/28 ,  C07C303/32 ,  C07C309/08 ,  C07C2601/16 ,  C07D277/64 ,  C07D307/92 ,  C07D333/56 ,  C07D405/06 ,  C07D413/06 ,  C07D417/06 ,  C07F7/1852 ,  C07F9/582 ,  Y02P20/55 ,  C07C233/28

摘要： The application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following. (I)

摘要翻译： 本申请公开了可用于制备烟肼类似物的化合物及其制备方法：

公开(公告)号：EP1425258A4

公开(公告)日：2005-02-16

申请号：EP02761383

申请日：2002-09-09

申请人： TAISHO PHARMA CO LTD ,  UNIV TEXAS

发明人： FALCK JOHN R ,  MIYATA NORIYUKI ,  ONO NAOYA ,  CHONAN TOMOMICHI ,  HIRANO HITOMI ,  TODA YOSHIHISA ,  TANAMI TOHRU ,  OKUYAMA SHIGERU

IPC分类号： C07D277/20 ,  A61K31/047 ,  A61K31/08 ,  A61K31/16 ,  A61K31/18 ,  A61K31/185 ,  A61K31/201 ,  A61K31/231 ,  A61K31/275 ,  A61K31/41 ,  A61K31/426 ,  A61P1/02 ,  A61P1/04 ,  A61P1/16 ,  A61P1/18 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P11/08 ,  A61P13/12 ,  A61P15/00 ,  A61P15/06 ,  A61P17/02 ,  A61P17/06 ,  A61P19/00 ,  A61P19/02 ,  A61P27/02 ,  A61P29/00 ,  A61P31/00 ,  A61P31/04 ,  A61P37/02 ,  A61P37/06 ,  A61P43/00 ,  C07C33/04 ,  C07C33/044 ,  C07C33/42 ,  C07C59/01 ,  C07C59/42 ,  C07C59/46 ,  C07C59/60 ,  C07C69/708 ,  C07C69/732 ,  C07C235/28 ,  C07C255/15 ,  C07C255/16 ,  C07C259/06 ,  C07C309/08 ,  C07C309/10 ,  C07C309/20 ,  C07C309/23 ,  C07C309/24 ,  C07C309/68 ,  C07C311/04 ,  C07C311/17 ,  C07C311/51 ,  C07C317/44 ,  C07C323/52 ,  C07C323/66 ,  C07D257/04 ,  C07D277/34 ,  C07C59/00 ,  A61K31/42 ,  A61K31/425 ,  C07C255/00 ,  C07D277/00

CPC分类号： C07D257/04 ,  C07C33/044 ,  C07C33/423 ,  C07C33/426 ,  C07C59/42 ,  C07C59/46 ,  C07C59/60 ,  C07C69/708 ,  C07C235/28 ,  C07C255/15 ,  C07C259/06 ,  C07C309/10 ,  C07C309/20 ,  C07C309/23 ,  C07C309/24 ,  C07C309/68 ,  C07C311/17 ,  C07C311/51 ,  C07C317/44 ,  C07C323/52 ,  C07C323/66 ,  C07C2601/08 ,  C07C2601/14 ,  C07D277/34

摘要： A hydroxyeicosenoic acid analog represented by the following Formula (I), the bond represents a cis-vinylene group or an ethynylene group; Y represents CH2, O or S(O)p wherein p is 0, 1 or 2; m represents an integer of 1 to 4 inclusive; n represents an integer of 0 to 3 inclusive; the sum of m and n is an integer of 3 to 7 inclusive; R1 represents a C1-4 alkyl group or a C3-8 cycloalkyl group; R2 represents a hydrogen atom or a methyl group; R3 represents COR4, a nitrile group, a halogen atom, a tetrazole group or a thiazolidinedione group; R4 represents OR6, NHR6, N(OH)R?6, NHSO2R5¿, glycerol or functionalized glycerols; R5 represents a C¿1-15? alkyl group, a C6-10 aryl group or a C7-14 aryl group substituted with alkyl groups, halogens or amino groups; R?6¿ represents a hydrogen, a C¿1-10? alkyl group or a C1-10 alkyl group substituted with a hydroxyl group, or a pharmaceutically acceptable salt or hydrate thereof. The compounds of the present invention are useful as an elastase release inhibitor.

摘要翻译： 由下式（I）表示的羟基二十碳烯酸类似物，该键代表顺式亚乙烯基或亚乙炔基; Y代表CH 2，O或S（O）p，其中p是0,1或2; m表示1〜4的整数， n表示0〜3的整数， m和n的总和是3〜7的整数， R1代表C1-4烷基或C3-8环烷基; R2代表氢原子或甲基; R3代表COR4，腈基，卤素原子，四唑基或噻唑烷二酮基; R4代表OR6，NHR6，N（OH）R6 6，NHSO2R5，甘油或官能化甘油; R5代表C 1-15？ 烷基，被烷基，卤素或氨基取代的C 6-10芳基或C 7-14芳基; R 6表示氢，C 1-10 - 烷基或被羟基取代的C1-10烷基，或其药学上可接受的盐或水合物。 本发明的化合物可用作弹性蛋白酶释放抑制剂。

公开(公告)号：EP1180096A4

公开(公告)日：2004-12-15

申请号：EP00928434

申请日：2000-04-27

申请人： SASOL NORTH AMERICA INC

发明人： WEERASOORIYA UPALI ,  LIN JOHN ,  FILLER PAUL A ,  GATES FRANK

IPC分类号： C07C303/02 ,  C07C303/06 ,  C07C303/44 ,  C07C309/04 ,  C07C309/08 ,  C07C309/20 ,  C07C309/62 ,  C07C309/00

CPC分类号： C07C303/44 ,  C07C303/06 ,  C07C309/20

摘要： A product for producing and recovering sulfonated internal olefins wherein an internal olefin is sulfonated to produce a reaction mixture containing intermediate sulfonated compounds, the reaction mixture is neutralized and hydrolyzed to form a product mixture containing hydroxyalkane sulfonates, alkene sulfonates, and hydrocarbon oil, and the product mixture is subjected to azeotropic distillation to effect separation of the hydrocarbon oil from the product mixture.

公开(公告)号：EP1206442A1

公开(公告)日：2002-05-22

申请号：EP00955827.1

申请日：2000-08-23

申请人： VIRGINIA COMMONWEALTH UNIVERSITY ,  Allos Therapeutics, Inc.

发明人： ABRAHAM, Donald, J. ,  JOSHI, Gajanan, S. ,  HOFFMAN, Stephen, J. ,  GRELLA, Melissa ,  DANSO-DANQUAH, Richmond ,  YOUSSEF, Amal ,  SAFO, Martin ,  KULKARNI, Sanjeev

IPC分类号： C07C229/02 ,  C07C229/50 ,  C07C309/08 ,  C07C311/02

CPC分类号： C07D309/08 ,  C07C235/38 ,  C07C235/40 ,  C07C323/59 ,  C07C2601/08 ,  C07C2602/08 ,  C07D207/16 ,  C07D209/20 ,  C07D307/24

摘要： A family of substituted chiral allosteric effectors of hemoglobin is useful for delivering more oxygen to hypoxic and ischemic tissues by reducing the oxygen affinity of hemoglobin in whole blood.

摘要翻译： 一系列取代的血红蛋白的手性变构效应物可用于通过降低全血血红蛋白的氧亲和力将更多的氧递送到缺氧和缺血组织。

公开(公告)号：EP2899257A4

公开(公告)日：2016-05-18

申请号：EP13838551

申请日：2013-09-19

申请人： KAO CORP

发明人： YOSHIKAWA YOHEI ,  MITSUDA YOSHINORI ,  HORI HIROSHI ,  NISHIMOTO YOSHIFUMI ,  DOI YASUHIRO

IPC分类号： A61K8/46 ,  A61Q5/02 ,  A61Q19/10 ,  C07C309/08 ,  C07C309/20 ,  C11D1/14 ,  C11D1/37 ,  C11D3/00

CPC分类号： A61Q5/02 ,  A61K8/466 ,  A61K2800/596 ,  A61Q19/10 ,  C07C309/08 ,  C07C309/20 ,  C11D1/143 ,  C11D1/37 ,  C11D3/0094

摘要： Provided is an internal olefin sulfonate composition which is capable of exerting good foamability together with good volume of foam, foaming speed, foam dissipation property, foam quality, foam durability in the presence of sebum, and volume of foam in the presence of sebum at high levels, and a cleansing composition containing the same. The internal olefin sulfonate composition comprises (A) an internal olefin sulfonate having 16 carbon atoms and/or (B) an internal olefin sulfonate having 18 carbon atoms, in which a total content of the component (A) and the component (B) is from 50 to 100% by mass, a content mass ratio of the component (A) to the component (B), (A/B), is from 91/9 to 100/0, a content of the internal olefin sulfonate in which a sulfonate group is present at a C-2 position is 25% by mass or less, and in which a mass ratio of a content of a hydroxy form in the internal olefin sulfonate of the component (A) and the component (B) to a content of an olefin form in the internal olefin sulfonate of the component (A) and the component (B), (hydroxy form/olefin form), is from 75/25 to 100/0.