利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

1429 条记录 (耗时 0.019 秒)

    ANTILIPEMIC AGENT
    94.
    发明专利
    ANTILIPEMIC AGENT 失效

    公开(公告)号：JPH01238554A

    公开(公告)日：1989-09-22

    申请号：JP6438688

    申请日：1988-03-17

    申请人： AJINOMOTO KK

    发明人： SUZUKI KATSUMI ,  HIWATARI OSAMU ,  NAKAMURA TORU ,  YASUNAMI MASABUMI ,  TAKASE KAHEI

    IPC分类号： C07C233/58 ,  A61K31/12 ,  A61K31/165 ,  A61K31/215 ,  A61K31/275 ,  A61P3/06 ,  A61P9/10 ,  C07C67/00 ,  C07C69/74 ,  C07C231/00 ,  C07C253/00

    摘要： NEW MATERIAL:The azulene derivative of formula I (R is 1-5C acyl, 2-5C alkyloxycarbonyl, carbamoyl, or carbamoyl or cyano having substituent on nitrogen atom; R is 1-5C alkyl; R is 1-6C alkyl, 6-9C aryl or 7-10C aralkyl). EXAMPLE:1-Methoxycarbonyl-3,6-diisopropylazulene. USE:Useful as a remedy for hyperlipemia. It has high activity and safety and usable as a preventive and remedy for hyperlipemia of human and other mammals. It can be administered orally or parenterally. PREPARATION:The compound of formula I can be produced by using a corresponding tropolone derivative as the starting substance, tosylating in the presence of a basic catalyst to obtain a 2-tosyloxytropolone derivative, reacting the compound with dimethyl malonate in the presence of methanolic alkali hydroxide and heating the obtained compound of formula II in the presence of a base.

    P-PHENYL-SUBSTITUTED 3-ALKYLCYCLOBUTANECARBOXYLATE
    98.
    发明专利
    P-PHENYL-SUBSTITUTED 3-ALKYLCYCLOBUTANECARBOXYLATE 失效

    公开(公告)号：JPS6475448A

    公开(公告)日：1989-03-22

    申请号：JP22859687

    申请日：1987-09-14

    申请人： SANKYO KAGAKU KK ,  HITACHI LTD

    发明人： NODA TAKESHI ,  ENOKI YASUHIRO ,  TORIYAMA KAZUHISA

    IPC分类号： C07C69/74 ,  C09K19/54

    摘要： NEW MATERIAL:A p-substituted phenyl 3-alkylcyclobutanecarboxylate expressed by formula I (R1 is 1-6C straight-chainlike alkyl; R2 is 1-6C straight-chainlike alkyl or alkoxy). EXAMPLE:2-n-Butyl-1,3-bis-p-toluenesulfonyloxypropane. USE:Useful as an electrooptical display material having excellent compatibility with nematic liquid crystals and effects of action of reducing viscosity of a nematic liquid crystal mixed system without reducing transition temperature of nematic liquid crystal-liquid in adding to the nematic liquid crystal mixed system. PREPARATION:A 2-alkyl-1,3-propanediol expressed by formula II is reacted with p-toluenesulfonyl chloride to provide a product, which is then successively reacted with ethyl malonate, hydrolyzed, decarboxylated, chlorinated and finally reacted with a compound expressed by a formula III to afford the aimed compound expressed by formula I.