公开(公告)号：JP2926244B2

公开(公告)日：1999-07-28

申请号：JP19023989

申请日：1989-07-21

Applicant: CHITSUSO KK

Inventor： SAITO SHINICHI ,  INOE HIROMICHI ,  OONO KOJI

IPC: G02F1/13 ,  C07C49/84 ,  C07C69/007 ,  C07C69/24 ,  C07C69/76 ,  C07C69/94 ,  C07C255/31 ,  C07C255/32 ,  C07C255/37 ,  C07C255/38 ,  C07C255/41 ,  C07D213/30 ,  C07D213/55 ,  C07D213/63 ,  C07D213/79 ,  C07D237/08 ,  C07D239/26 ,  C07D239/34 ,  C07D241/12 ,  C09K19/12 ,  C09K19/14 ,  C09K19/20 ,  C09K19/30 ,  C09K19/34 ,  C09K19/58

公开(公告)号：JP2908069B2

公开(公告)日：1999-06-21

申请号：JP14493991

申请日：1991-06-17

Applicant: IISUTOMAN KODATSUKU CO

Inventor： IGUNAJIO SARUBATORU HONTEISERO ,  RICHAADO KARUBIN SATSUTON

IPC: C07C69/40 ,  C07C69/007 ,  C07C69/42 ,  C07C233/05 ,  C07C233/49 ,  C07C251/24 ,  C07C275/38 ,  C07C323/12 ,  C07C323/41 ,  C07C323/50 ,  C07C323/52 ,  C07C323/56 ,  C08F12/00 ,  C08F12/04 ,  C08F12/14 ,  C08F20/02 ,  C08F20/64 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/543

公开(公告)号：JP2906729B2

公开(公告)日：1999-06-21

申请号：JP11011691

申请日：1991-05-15

Applicant: SUMITOMO KAGAKU KOGYO KK

Inventor： AZUMAI TAKAYUKI ,  TODA SHOJI ,  MINAMII MASAYOSHI

IPC: C07C69/007 ,  C07C69/62 ,  C07C69/773 ,  C09K19/20 ,  C09K19/46 ,  G02F1/13

公开(公告)号：JPH11504914A

公开(公告)日：1999-05-11

申请号：JP53312196

申请日：1996-05-01

IPC: A61K47/48 ,  A23C20060101 ,  A23L20060101 ,  A61K20060101 ,  A61K31/23 ,  A61K31/397 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/405 ,  A61K31/415 ,  A61K31/44 ,  A61K31/54 ,  A61K31/5415 ,  A61K31/70 ,  A61K38/22 ,  A61K38/23 ,  A61K38/28 ,  A61P1/00 ,  A61P3/02 ,  A61P3/08 ,  A61P9/08 ,  A61P9/10 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P17/00 ,  A61P25/00 ,  A61P25/18 ,  A61P25/24 ,  A61P25/26 ,  A61P25/28 ,  A61P25/30 ,  A61P27/02 ,  A61P27/14 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  A61P37/08 ,  A61P43/00 ,  C07C20060101 ,  C07C69/007 ,  C07C69/30 ,  C07C69/58 ,  C07C69/587 ,  C07C69/602 ,  C07C69/76 ,  C07C69/767 ,  C07C229/08 ,  C07C317/34 ,  C07C323/52 ,  C07D20060101 ,  C07D207/16 ,  C07D209/28 ,  C07D209/40 ,  C07D213/30 ,  C07D213/66 ,  C07D213/67 ,  C07D213/68 ,  C07D233/60 ,  C07D233/94 ,  C07D279/32 ,  C07D279/36 ,  C07D321/00 ,  C07D339/04 ,  C07D477/00 ,  C07D499/00 ,  C07F9/00 ,  C07F9/09 ,  C07F9/655 ,  C07J1/00 ,  C07J5/00 ,  A61K31/71

Abstract: The invention relates to compounds of formula:wherein R1 is selected from the group consisting of fatty acid acyl groups of 12 to 30 carbon atoms and fatty alcohol groups of 12 to 30 carbon atoms, and wherein R2 is selected from the group consisting of H, fatty acid acyl of 12 to 30 carbon atoms and fatty alcohol groups of 12 to 30 carbon atoms, the same as or different from R1, and the residue of a nutrient, drug, or other bioactive compound, and to the use of these compounds to deliver drugs and other bioactive compounds.

公开(公告)号：JPH11504339A

公开(公告)日：1999-04-20

申请号：JP53312096

申请日：1996-05-01

IPC: A61K47/48 ,  A23C20060101 ,  A23L20060101 ,  A61K20060101 ,  A61K31/23 ,  A61K31/397 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/405 ,  A61K31/415 ,  A61K31/44 ,  A61K31/54 ,  A61K31/5415 ,  A61K31/70 ,  A61K38/22 ,  A61K38/23 ,  A61K38/28 ,  A61P1/00 ,  A61P3/02 ,  A61P3/08 ,  A61P9/08 ,  A61P9/10 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P17/00 ,  A61P25/00 ,  A61P25/18 ,  A61P25/24 ,  A61P25/26 ,  A61P25/28 ,  A61P25/30 ,  A61P27/02 ,  A61P27/14 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  A61P37/08 ,  A61P43/00 ,  C07C20060101 ,  C07C69/007 ,  C07C69/30 ,  C07C69/58 ,  C07C69/587 ,  C07C69/602 ,  C07C69/76 ,  C07C69/767 ,  C07C229/08 ,  C07C317/34 ,  C07C323/52 ,  C07D20060101 ,  C07D207/16 ,  C07D209/28 ,  C07D209/40 ,  C07D213/30 ,  C07D213/66 ,  C07D213/67 ,  C07D213/68 ,  C07D233/60 ,  C07D233/94 ,  C07D279/32 ,  C07D279/36 ,  C07D321/00 ,  C07D339/04 ,  C07D477/00 ,  C07D499/00 ,  C07F9/00 ,  C07F9/09 ,  C07F9/655 ,  C07J1/00 ,  C07J5/00

Abstract: The invention relates to compounds of formula:wherein R1 is selected from the group consisting of fatty acid acyl groups of 12 to 30 carbon atoms and fatty alcohol groups of 12 to 30 carbon atoms, and wherein R2 is selected from the group consisting of H, fatty acid acyl of 12 to 30 carbon atoms and fatty alcohol groups of 12 to 30 carbon atoms, the same as or different from R1, and the residue of a nutrient, drug, or other bioactive compound, and to the use of these compounds to deliver drugs and other bioactive compounds.

公开(公告)号：JPH10251205A

公开(公告)日：1998-09-22

申请号：JP3742798

申请日：1998-02-19

Applicant: SMITHKLINE LTD

Inventor： GILES ROBERT ,  WALSGROVE TIMOTHY C

IPC: A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61P9/08 ,  A61P9/10 ,  A61P25/00 ,  C07C69/007 ,  C07C69/025 ,  C07C69/78 ,  C07C205/40 ,  C07D20060101 ,  C07D209/34

Abstract: PROBLEM TO BE SOLVED: To obtain the subject new compound useful as an intermediate for a substituted indrone derivative which is a medicine effective as a therapeutic agent for cardiovascular diseases and Parkinson's diseases. SOLUTION: This compound is represented by formula I [(n) is 2 or 3; R is a 1-4C alkyl or a (substituted)phenyl; R is CHO or CH=CHNO ]. The compound of formula II (in formula I, R is CHO) is obtained by reacting a compound of formula III in R COCl, ZnCl2 or CH2 Cl2 at -10 to 0 deg.C, adding hexamethylenetetramine thereto, heating the mixture, extracting reaction mixture with CH2 Cl2 and repeating washing, etc., of the organic layer. The compound of formula IV (in formula I, R4 is CHNO2 ) is obtained by adding sodium methoxide/methanol solution and nitromethane at -10 to 0 deg.C to a compound of formula II and washing and drying the reaction mixture with an aqueous methanol. The compound is an intermediate especially useful for production of ropinirole.

公开(公告)号：JPH10251191A

公开(公告)日：1998-09-22

申请号：JP33154997

申请日：1997-12-02

Applicant: GEN ELECTRIC

Inventor： PICKETT JAMES EDWARD ,  SIMONIAN AMY KATHLEEN

IPC: C07B61/00 ,  C07C45/68 ,  C07C45/72 ,  C07C49/83 ,  C07C49/84 ,  C07C69/007 ,  C07C69/18 ,  C07D249/20 ,  C07D251/24 ,  C08K5/132 ,  C08K5/3475 ,  C08K5/3492 ,  C08L69/00 ,  C09D7/12 ,  C09D169/00 ,  C09K3/00

Abstract: PROBLEM TO BE SOLVED: To obtain a new methylene-bridged dibenzoyl resorcinol derivative having phenol group on the bridged methylene group and useful for absorbing UV rays. SOLUTION: This new high molecular dibenzoyl resorcinol UV absorbing agent is a compound of the formal (Ar1 , Ar2 are each a substituted or un- substituted single cyclic or multi-cyclic aryl; R is H, an aryl or a

公开(公告)号：JPH09176215A

公开(公告)日：1997-07-08

申请号：JP11545596

申请日：1996-04-12

Applicant: CIBA GEIGY AG

Inventor： PEETAA NESUBUADOBA ,  SAMUERU EBANSU ,  MASHIYU EDOWAADO GANDE ,  FUORUKAA HARUMUUTO FUON AAN ,  ROORANDO AASAA EDOUIN UINTAA

IPC: C07D295/16 ,  C07B63/04 ,  C07C7/20 ,  C07C15/46 ,  C07C45/51 ,  C07C49/603 ,  C07C49/647 ,  C07C49/683 ,  C07C49/747 ,  C07C49/753 ,  C07C49/798 ,  C07C59/80 ,  C07C59/82 ,  C07C67/62 ,  C07C69/007 ,  C07C69/145 ,  C07C69/24 ,  C07C69/54 ,  C07C69/738 ,  C07C69/78 ,  C07C205/45 ,  C07C235/78 ,  C07C255/31 ,  C07C255/40 ,  C07F9/38 ,  C07F9/40 ,  C08F2/38 ,  C08F2/40 ,  C08K5/00 ,  C09K15/08 ,  C09K15/24 ,  C09K15/32

公开(公告)号：JP2606275B2

公开(公告)日：1997-04-30

申请号：JP9409488

申请日：1988-04-15

IPC: C12P41/00 ,  B01J23/44 ,  C07B61/00 ,  C07C67/297 ,  C07C69/007 ,  C07C69/24 ,  C07C69/76

公开(公告)号：JPH0952882A

公开(公告)日：1997-02-25

申请号：JP32657195

申请日：1995-11-20

Applicant: JAPAN TOBACCO INC

Inventor： HARUTA JUNICHI ,  HASHIMOTO HIROMASA ,  MATSUSHITA MUTSUYOSHI

IPC: C12N9/99 ,  A61K31/42 ,  A61K31/421 ,  A61P25/04 ,  A61P29/00 ,  A61P43/00 ,  C07C45/00 ,  C07C49/563 ,  C07C49/567 ,  C07C49/792 ,  C07C49/813 ,  C07C69/007 ,  C07C233/31 ,  C07C233/47 ,  C07C235/74 ,  C07C251/40 ,  C07C251/42 ,  C07C251/48 ,  C07C311/16 ,  C07C311/29 ,  C07C311/32 ,  C07C311/37 ,  C07C317/22 ,  C07C317/24 ,  C07C317/32 ,  C07D207/333 ,  C07D263/30 ,  C07D263/32 ,  C07D265/30 ,  C07D295/10 ,  C07D307/46 ,  C07D333/22 ,  C07D413/02 ,  C07D413/04

Abstract: PROBLEM TO BE SOLVED: To obtain a new compound comprising a specific oxazole heterocylic aromatic compound, having antipyretic and analgesic actions, an antiallergic action, and especially a cyclooxygenease-inhibiting action, and useful for an antiinflammatory agent low in side effects such as digestive tract disorders. SOLUTION: A new oxazonal heterocyclic aromatic compound (salt) represented by formula I [Z is O; one of R and R1 is each a group of formula II (R3 is a lower alkyl, amino, a lower alkylamino; R4 to R7 are each H, a halogen, a lower alkyl, a lower alkoxy, trifluoromethyl, OH, amino; one of R4 -R7 is not H), and the other is a (substituted) cyclokyl, a (substituted) alkyl, etc.; R2 is a (halogenated) lower alkyl]. The compound is useful as an antiinflammatory agent low in side effects such as digestive tract disorders, etc. The compound is obtained by reacting a new ketomethylene compound of formula III with a compound of the formula: R2 COOH in the presence of manganese acetate and subsequently reacting the obtained new ester compound of formula IV with formic acid, etc., in the presence of an ammonium salt.