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    QUINAZOLINONE DERIVATIVES AND THEIR USE AS B-RAF INHIBITORS
    2.
    发明申请
    QUINAZOLINONE DERIVATIVES AND THEIR USE AS B-RAF INHIBITORS 审中-公开

    公开(公告)号：US20090054469A1

    公开(公告)日：2009-02-26

    申请号：US11574036

    申请日：2005-08-28

    Applicant: Brian Aquila ,  Paul Lyne ,  Timothy Pontz

    Inventor： Brian Aquila ,  Paul Lyne ,  Timothy Pontz

    IPC: A61K31/517 ,  C07D239/72 ,  A61P35/04

    CPC classification number: C07D239/90

    Abstract: The invention relates to chemical compounds of the formula (I): or pharmaceutically acceptable salts thereof, which possess B Raf inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.

    Chemical Compounds-149
    6.
    发明申请
    Chemical Compounds-149 审中-公开
    化学成分-149

    公开(公告)号：US20080312206A1

    公开(公告)日：2008-12-18

    申请号：US12097652

    申请日：2006-12-19

    Applicant: Brian Aquila ,  Donald Cook ,  Leslie Dakin ,  Stephanos Ioannidis ,  Paul Lyne ,  David Scott ,  Xiaolan Zheng

    Inventor： Brian Aquila ,  Donald Cook ,  Leslie Dakin ,  Stephanos Ioannidis ,  Paul Lyne ,  David Scott ,  Xiaolan Zheng

    IPC: A61K31/427 ,  C07D277/46 ,  A61K31/426 ,  A61P35/00 ,  C07D417/02

    CPC classification number: C07D277/46 ,  C07D417/12

    Abstract: The invention relates to chemical compounds, or pharmaceutically acceptable salts thereof of the formula which possess CSF 1R kinase inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.

    Abstract translation: 本发明涉及具有CSF 1R激酶抑制活性的化学化合物或其药学上可接受的盐，其具有CSF 1R激酶抑制活性，因此可用于其抗癌活性，因此可用于治疗人或动物体的方法。 本发明还涉及制备所述化合物的方法，含有它们的药物组合物及其在制备用于在温血动物如人中产生抗癌作用的药物中的用途。

    Novel Fused Heterocycles and Uses Thereof
    10.
    发明申请
    Novel Fused Heterocycles and Uses Thereof 审中-公开
    新型融合杂环及其用途

    公开(公告)号：US20060270689A1

    公开(公告)日：2006-11-30

    申请号：US10548138

    申请日：2004-03-04

    Applicant: Brian Aquila

    Inventor： Brian Aquila

    IPC: A61K31/519 ,  C07D498/02

    CPC classification number: A61K31/519 ,  C07D513/04

    Abstract: This invention relates to novel compounds having the formula (I) (a chemical formula should be inserted here—please see paper copy enclosed herewith) m=0, 1, 2 n=0, 1 (I) wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined in the specification and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of cancer.

    Abstract translation: 本发明涉及具有式（I）的化合物（化学式应在此插入，请参见随附的纸质复合物）m = 0,1,2 n = 0,1（I）其中R1，R2，R3， R4，R5，R6，R7，R8和R9如说明书及其药物组合物及其使用方法中所定义。 这些新化合物提供癌症的治疗或预防。

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