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    Chemical Compounds-149
    1.
    发明申请
    Chemical Compounds-149 审中-公开
    化学成分-149

    公开(公告)号：US20080312206A1

    公开(公告)日：2008-12-18

    申请号：US12097652

    申请日：2006-12-19

    申请人： Brian Aquila ,  Donald Cook ,  Leslie Dakin ,  Stephanos Ioannidis ,  Paul Lyne ,  David Scott ,  Xiaolan Zheng

    发明人： Brian Aquila ,  Donald Cook ,  Leslie Dakin ,  Stephanos Ioannidis ,  Paul Lyne ,  David Scott ,  Xiaolan Zheng

    IPC分类号： A61K31/427 ,  C07D277/46 ,  A61K31/426 ,  A61P35/00 ,  C07D417/02

    CPC分类号： C07D277/46 ,  C07D417/12

    摘要： The invention relates to chemical compounds, or pharmaceutically acceptable salts thereof of the formula which possess CSF 1R kinase inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.

    摘要翻译： 本发明涉及具有CSF 1R激酶抑制活性的化学化合物或其药学上可接受的盐，其具有CSF 1R激酶抑制活性，因此可用于其抗癌活性，因此可用于治疗人或动物体的方法。 本发明还涉及制备所述化合物的方法，含有它们的药物组合物及其在制备用于在温血动物如人中产生抗癌作用的药物中的用途。

    CHEMICAL COMPOUNDS
    5.
    发明申请
    CHEMICAL COMPOUNDS 审中-公开
    化学化合物

    公开(公告)号：US20090270450A1

    公开(公告)日：2009-10-29

    申请号：US12435856

    申请日：2009-05-05

    申请人： Leslie Dakin ,  Kevin Daly ,  David Del Valle ,  Thomas Gero ,  Claude Afona Ogoe ,  David Scott ,  Xiaolan Zheng

    发明人： Leslie Dakin ,  Kevin Daly ,  David Del Valle ,  Thomas Gero ,  Claude Afona Ogoe ,  David Scott ,  Xiaolan Zheng

    IPC分类号： A61K31/47 ,  C07D215/44

    CPC分类号： C07D215/54 ,  C07D401/04

    摘要： The invention relates to chemical compounds of formula (I): or pharmaceutically acceptable salts thereof which possess CSF-1R kinase inhibitory activity and are accordingly useful for their anti-cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm-blooded animal such as man.

    摘要翻译： 本发明涉及具有CSF-1R激酶抑制活性的式（I）化合物或其药学上可接受的盐，因此可用于其抗癌活性，因此可用于治疗人或动物体的方法。 本发明还涉及制备所述化合物的方法，含有它们的药物组合物及其在制造用于在温血动物如人中产生抗癌作用的药物中的用途。

    3-CINNOLINECARBOXAMIDE DERIVATIVES AND THEIR USE FOR TREATING CANCER
    6.
    发明申请
    3-CINNOLINECARBOXAMIDE DERIVATIVES AND THEIR USE FOR TREATING CANCER 失效

    公开(公告)号：US20090012084A1

    公开(公告)日：2009-01-08

    申请号：US12210588

    申请日：2008-09-15

    申请人： Leslie Dakin ,  Claude Afona Ogoe ,  David Scott ,  XiaoLan Zheng

    发明人： Leslie Dakin ,  Claude Afona Ogoe ,  David Scott ,  XiaoLan Zheng

    IPC分类号： A61K31/502 ,  C07D237/28 ,  A61K31/5377 ,  A61P35/00 ,  C07D413/02

    CPC分类号： C07D237/28

    摘要： The invention relates to chemical compounds of formula (I): or pharmaceutically acceptable salts thereof which possess CSF-1R kinase inhibitory activity and are accordingly useful for their anti-cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm-blooded animal such as man.

    摘要翻译： 本发明涉及具有CSF-1R激酶抑制活性的式（I）化合物或其药学上可接受的盐，因此可用于其抗癌活性，因此可用于治疗人或动物体的方法。 本发明还涉及制备所述化合物的方法，含有它们的药物组合物及其在制造用于在温血动物如人中产生抗癌作用的药物中的用途。

    SYSTEM AND METHOD FOR SEPARATING HIGH MOLECULAR WEIGHT GASES FROM A COMBUSTION SOURCE
    10.
    发明申请
    SYSTEM AND METHOD FOR SEPARATING HIGH MOLECULAR WEIGHT GASES FROM A COMBUSTION SOURCE 失效
    从燃烧源分离高分子量气体的系统和方法

    公开(公告)号：US20120141352A1

    公开(公告)日：2012-06-07

    申请号：US13314110

    申请日：2011-12-07

    申请人： Jerry Lang ,  David Scott

    发明人： Jerry Lang ,  David Scott

    IPC分类号： C01D7/07 ,  B01D53/30 ,  B01D53/74 ,  B01D53/24

    CPC分类号： C01D7/07 ,  B01D53/24 ,  B01D53/62 ,  B01D2251/304 ,  B01D2257/504 ,  B01D2258/0283 ,  Y02C10/04 ,  Y02P20/152

    摘要： High molecular weight (HMW) gases are separated from an exhaust gas of a combustion source using a blower and an interior vent within the exhaust stack. The interior vent includes a vent wall having a top portion attached to the interior surface of the exhaust stack along the entire inner perimeter of the exhaust stack and a lower portion that extends downward into the exhaust stack to form an annular space or gap between the vent wall and the interior surface of the exhaust stack, and at least one opening in the interior surface of the exhaust stack between the top and bottom portions of the vent wall. The blower creates a tangential flow of the exhaust gas with sufficient centrifugal force to concentrate substantially all of the HMW gases along the inner surface of the exhaust stack. A transfer pipe removes the HMW gases from the interior vent.

    摘要翻译： 使用鼓风机和排气叠层内的内部通风口将高分子量（HMW）气体与燃烧源的废气分离。 内部排气口包括排气壁，排气壁具有沿着排气叠层的整个内周边连接到排气叠层的内表面的顶部部分，以及向下延伸到排气叠层中的下部，以在排气口之间形成环形空间或间隙 壁和排气叠层的内表面，以及排气叠层的内表面中至少一个开口，其位于排气壁的顶部和底部之间。 鼓风机以足够的离心力产生废气的切向流，以基本上将所有的HMW气体沿着排气叠层的内表面进行浓缩。 输送管从内部通风口去除HMW气体。