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公开(公告)号：US12203097B2
公开(公告)日：2025-01-21
申请号：US17355093
申请日：2021-06-22
Applicant: Cell Cure Neurosciences LTD
Inventor： Osnat Bohana-Kashtan , Ofer Wiser
IPC: C12N5/079
Abstract: A method of generating retinal pigment epithelium cells is disclosed. Cell populations comprising same and uses thereof are also disclosed.
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公开(公告)号：US20230119816A1
公开(公告)日：2023-04-20
申请号：US18081476
申请日：2022-12-14
Applicant: CELL CURE NEUROSCIENCES LTD.
Inventor： Nir Netzer , Ofer Wiser , Bat Shahaf , Orit Gamburg , Lior Rosenberg Belmaker , Dana Hayoun Neeman , Osnat Bohana Kashtan
Abstract: Presented herein are ready to administer (RTA) retinal pigment epithelium (RPE) cell therapy compositions for the treatment of retinal degenerative diseases and injuries. A method of formulating human RPE cells for administration to a subject directly after thawing and of formulating RPE cell therapy compositions for cryopreservation and administration of the cryopreserved composition to a subject subsequent to thawing are also presented. In another aspect, the RTA composition may be formulated as a thaw and inject (TAI) composition, whereby the composition is administered by injection subsequent to thawing.
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公开(公告)号：US20220169981A1
公开(公告)日：2022-06-02
申请号：US17546011
申请日：2021-12-08
Applicant: Cell Cure Neurosciences Ltd.
Inventor： Osnat Bohana-Kashtan , Lior Ann Rosenberg Belmaker , Ofer Wiser
Abstract: A population of human polygonal RPE cells is disclosed. At least 95% of the cells thereof co-express premelanosome protein (PMEL17) and cellular retinaldehyde binding protein (CRALBP), wherein the trans-epithelial electrical resistance of the cells is greater than 100 ohms. Methods of generating same are also disclosed.
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公开(公告)号：US11066642B2
公开(公告)日：2021-07-20
申请号：US15750108
申请日：2016-08-04
Applicant: CELL CURE NEUROSCIENCES LTD
Inventor： Osnat Bohana-Kashtan , Ofer Wiser
IPC: C12N5/079
Abstract: A method of generating retinal pigment epithelium cells is disclosed. Cell populations comprising same and uses thereof are also disclosed.
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公开(公告)号：US20210000102A1
公开(公告)日：2021-01-07
申请号：US16958399
申请日：2018-12-28
Applicant: Cell Cure Neurosciences Ltd.
Inventor： Nir NETZER , Ofer WISER , Bat SHAHAF , Orit GAMBURG , Lior ROSENBERG BELMAKER , Dana HAYOUN NEEMAN , Osnat BOHANA KASHTAN
Abstract: Presented herein are ready to administer (RTA) retinal pigment epithelium (RPE) cell therapy compositions for the treatment of retinal degenerative diseases and injuries. A method of formulating human RPE cells for administration to a subject directly after thawing and of formulating RPE cell therapy compositions for cryopreservation and administration of the cryopreserved composition to a subject subsequent to thawing are also presented. In another aspect, the RTA composition may be formulated as a thaw and inject (TAI) composition, whereby the composition is administered by injection subsequent to thawing.
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Patent Agency Ranking
公开(公告)号：US20180230426A1
公开(公告)日：2018-08-16
申请号：US15750108
申请日：2016-08-04
Applicant: CELL CURE NEUROSCIENCES LTD.
Inventor： Osnat Bohana-Kashtan , Ofer Wiser
IPC: C12N5/079
CPC classification number: C12N5/0621 , C12N2500/38 , C12N2500/98 , C12N2501/115 , C12N2501/15 , C12N2506/02 , C12N2533/52 , C12N2533/54
Abstract: A method of generating retinal pigment epithelium cells is disclosed. Cell populations comprising same and uses thereof are also disclosed.
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公开(公告)号：US20220169982A1
公开(公告)日：2022-06-02
申请号：US17552743
申请日：2021-12-16
Applicant: CELL CURE NEUROSCIENCES LTD.
Inventor： Osnat Bohana-Kashtan , Lior Ann Rosenberg Belmaker , Ofer Wiser
Abstract: A population of human polygonal RPE cells is disclosed. At least 95% of the cells thereof co-express premelanosome protein (PMEL17) and cellular retinaldehyde binding protein (CRALBP), wherein the trans-epithelial electrical resistance of the cells is greater than 100 ohms. Methods of generating same are also disclosed.
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公开(公告)号：US20210332325A1
公开(公告)日：2021-10-28
申请号：US17323441
申请日：2021-05-18
Applicant: Cell Cure Neurosciences Ltd.
Inventor： Osnat Bohana-Kashtan , Lior Ann Rosenberg Belmaker , Ofer Wiser
Abstract: A population of human polygonal RPE cells is disclosed. At least 95% of the cells thereof co-express premelanosome protein (PMEL17) and cellular retinaldehyde binding protein (CRALBP), wherein the trans-epithelial electrical resistance of the cells is greater than 100 ohms. Methods of generating same are also disclosed.
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公开(公告)号：US20180008458A1
公开(公告)日：2018-01-11
申请号：US15539565
申请日：2015-04-30
Applicant: Cell Cure Neurosciences Ltd.
Inventor： Eyal Banin , Benjamin Eithan Reubinoff , Osnat Bohana-Kashtan , Nir Netzer , Charles Sherard Irving
CPC classification number: A61F9/0008 , A61F9/00727 , A61K35/30 , A61K38/1709 , A61K2035/124 , C12N5/0621
Abstract: A method of treating a subject with dry-form age-related macular degeneration (AMD) is disclosed. The method comprises administering into the subretina of the subject a therapeutically effective amount of a pharmaceutical composition comprising human RPE cells, wherein at least 95% of the cells thereof co-express premelanosome protein (PMEL17) and cellular retinaldehyde binding protein (CRALBP), wherein the trans-epithelial electrical resistance of the cells is greater than 100 ohms to the subject, thereby treating the subject.
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公开(公告)号：US09658216B2
公开(公告)日：2017-05-23
申请号：US14375195
申请日：2013-01-29
Inventor： Benjamin Eithan Reubinoff , Nurit Yachimovich-Cohen , Limor Matzrafi
CPC classification number: G01N33/56966 , C12N5/0621 , C12N2501/15 , C12N2501/16 , C12N2506/45 , C12N2509/00 , G01N21/6486 , G01N33/52 , G01N33/582 , G01N2021/4704 , G01N2333/46
Abstract: A method of selecting retinal pigmented epithelial (RPE) cells from a mixed population of cells is disclosed. The method comprises: (a) analyzing the cells of the mixed population of cells for at least one of the following parameters: (i) cells which autofluorescence above a predetermined threshold; (ii) cells which express CD81 above a predetermined threshold; and (iii) cells which scatter light perpendicular to a laser beam above a predetermined threshold; and (b) selecting cells which are positive for at least one of the parameters, thereby sorting RPE cells from a mixed population of cells.
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