公开(公告)号：US5584989A

公开(公告)日：1996-12-17

申请号：US134032

申请日：1993-10-12

申请人： Daniel G. Jameson

发明人： Daniel G. Jameson

IPC分类号： B01D11/00 ,  B01D11/02 ,  B01D11/04 ,  F04B9/04 ,  F04B15/08 ,  F04B49/06 ,  F16K15/18 ,  G01F1/34 ,  G01N1/34 ,  G01N1/40 ,  G01N30/02 ,  G01N30/28 ,  G01N30/60 ,  G01N35/04 ,  G21F5/015

CPC分类号： F04B9/042 ,  B01D11/0203 ,  B01D11/0407 ,  F04B15/08 ,  F04B49/065 ,  F16K15/183 ,  G01F1/34 ,  G01N1/34 ,  G01N1/40 ,  G01N30/28 ,  G21F5/015 ,  F04B2205/03 ,  F04B2205/05 ,  F04B2205/09 ,  F05B2230/41 ,  F05C2201/0493 ,  F05C2253/12 ,  G01N2001/4033 ,  G01N2001/4061 ,  G01N2030/6013 ,  G01N2035/0441 ,  G01N30/02

摘要： To collect analyte in a supercritical fluid extraction process, the extractant flows to a collection container under pressure. In one embodiment, the collection container contains collection solvent through which the extractant flows to partition analyte. The extractant adds to the liquid and when the collection solvent-extractant mixture rises to a heating zone, the extractant vaporizes selecively since its vapor pressure is higher than the vapor pressure of the collection solvent. When its pressure exceeds a preset valve pressure it is vented so that extractant continually leaves the collection container. After the extraction is complete, the analyte is concentrated in the collection solvent. In another embodiment, the collection vessel includes a solid material on which the analyte collects. It is removed under pressure by a solvent that is concentrated under pressure.

摘要翻译： 为了在超临界流体萃取过程中收集分析物，萃取剂在压力下流到收集容器。 在一个实施方案中，收集容器含有收集溶剂，萃取剂通过该溶剂流动以分配分析物。 萃取剂添加到液体中，并且当采集溶剂萃取剂混合物升至加热区时，萃取剂由于其蒸气压高于收集溶剂的蒸气压而选择性地蒸发。 当其压力超过预设的阀压力时，其被排出，使得萃取剂连续地离开收集容器。 萃取完成后，将分析物浓缩在收集溶剂中。 在另一个实施方案中，收集容器包括分析物在其上收集的固体材料。 在压力下通过在压力下浓缩的溶剂除去。

公开(公告)号：US5360320A

公开(公告)日：1994-11-01

申请号：US843624

申请日：1992-02-27

申请人： Daniel G. Jameson ,  Robert W. Allington

发明人： Daniel G. Jameson ,  Robert W. Allington

IPC分类号： G01N1/00 ,  G01N30/02 ,  G01N30/32 ,  G01N30/34 ,  G05D11/13 ,  G05D16/20 ,  F04B41/06

CPC分类号： G01N30/34 ,  G05D11/131

摘要： To control a solvent composition in a supercritical fluid system, a first pump pumps a first solvent through a first conduit into a mixer and a second pump pumps a second solvent through a second conduit into the mixer. First and second transducers measure the pressure in the first and second conduits and generate first and second signals proportional to the pressures. Each pressure signal is multiplied by a corresponding programmed concentration signal and compared to the programmed pressure in a feedback system to generate an error signal. The error signal is multiplied by concentration signals from a programmer to control the pumping rate of each pump. The pumps pressurize each fluid one at a time at the start of a run. The pressurization process is also used for producing disturbance-free flow as delivery is changed from one pump to another during prolonged runs.

摘要翻译： 为了控制超临界流体系统中的溶剂组成，第一泵将第一溶剂通过第一导管泵送到混合器中，并且第二泵将第二溶剂通过第二导管泵送到混合器中。 第一和第二换能器测量第一和第二导管中的压力并产生与压力成比例的第一和第二信号。 每个压力信号乘以相应的编程浓度信号，并与反馈系统中编程的压力进行比较，以产生误差信号。 误差信号乘以来自编程器的浓度信号，以控制每个泵的泵送速率。 泵在运行开始时一次加压每个流体。 加压过程也用于产生无扰动的流量，因为在长时间运行期间输送从一个泵改变到另一个泵。

公开(公告)号：US5296145A

公开(公告)日：1994-03-22

申请号：US75314

申请日：1993-06-11

申请人： Robert W. Allington ,  Daniel G. Jameson ,  Robin R. Winter ,  Dale L. Clay

发明人： Robert W. Allington ,  Daniel G. Jameson ,  Robin R. Winter ,  Dale L. Clay

IPC分类号： B01D11/02 ,  B01D11/04 ,  F04B9/04 ,  F04B15/08 ,  F04B49/06 ,  F16K15/18 ,  G01F1/34 ,  G01N1/34 ,  G01N1/40 ,  G01N30/02 ,  G01N30/28 ,  G01N30/60 ,  G01N35/04 ,  G21F5/015 ,  B01D11/00

CPC分类号： B01D11/0203 ,  B01D11/0407 ,  F04B15/08 ,  F04B49/065 ,  F04B9/042 ,  F16K15/183 ,  G01F1/34 ,  G01N1/34 ,  G01N1/40 ,  G01N30/28 ,  G21F5/015 ,  F04B2205/03 ,  F04B2205/05 ,  F04B2205/09 ,  F05B2230/41 ,  F05C2201/0493 ,  F05C2253/12 ,  G01N2001/4033 ,  G01N2001/4061 ,  G01N2030/6013 ,  G01N2035/0441 ,  G01N30/02

摘要： An apparatus for supercritical fluid extraction incorporates a removable extraction cartridge which in operation has insignificant pressure difference between its inside and outside walls. In one embodiment, the extractor includes a fraction collector for extractants, an automatic sample changer and an automatic cartridge transfer mechanism which provide completely automated extractions. To automatically perform extraction, valves for the fluids are automatically opened and closed in synchronism with the insertion and removal of the cartridges. These valves force a hard valve element into a softer valve seat with a valve stem that does not rotate significantly under the control of a rotary motor.

摘要翻译： 用于超临界流体萃取的装置包括可移除的提取筒，其在操作中在其内壁和外壁之间具有不显着的压力差。 在一个实施方案中，提取器包括用于萃取剂的馏分收集器，自动取样器和提供完全自动提取的自动送料机构。 为了自动执行萃取，流体的阀门将与插入和拆卸墨盒同步自动打开和关闭。 这些阀将硬阀元件压入较软的阀座，阀杆在旋转电机的控制下不会显着转动。

公开(公告)号：US5268103A

公开(公告)日：1993-12-07

申请号：US27257

申请日：1993-03-05

申请人： Daniel G. Jameson ,  Robert J. Macomber ,  Robert W. Allington

发明人： Daniel G. Jameson ,  Robert J. Macomber ,  Robert W. Allington

IPC分类号： B01D11/00 ,  B01D11/02 ,  B01D11/04 ,  F04B9/04 ,  F04B15/08 ,  F04B49/06 ,  F16K15/18 ,  G01F1/34 ,  G01N1/34 ,  G01N1/40 ,  G01N30/02 ,  G01N30/28 ,  G01N30/60 ,  G01N35/04 ,  G21F5/015

CPC分类号： G21F5/015 ,  B01D11/0203 ,  B01D11/0407 ,  F04B15/08 ,  F04B49/065 ,  F04B9/042 ,  F16K15/183 ,  G01F1/34 ,  G01N1/34 ,  G01N1/40 ,  G01N30/28 ,  F04B2205/03 ,  F04B2205/05 ,  F04B2205/09 ,  F05B2230/41 ,  F05C2201/0493 ,  F05C2253/12 ,  G01N2001/4033 ,  G01N2001/4061 ,  G01N2030/6013 ,  G01N2035/0441 ,  G01N30/02

摘要： To avoid deposits on the restrictor that channels extractant into a collector, a heated capillary tube pressure release restrictor, has a thermally insulated outlet end in a collecting trap substantially colder than the capillary tube. The restrictor is heated between the insulation and the capillary tube by Joulean heating. The solvent in the trap is at a pressure of 5 to 200 psi above atmospheric pressure. The thermal resistance of the insulation is selected to reduce the heat added to the extractant to a minimum and yet cause the temperature of the extractant to be in a range within which it is sufficiently hot so it does not freeze when added to the collection solvent but not so hot as to reduce partitioning of the extract and extractant before the extractant leaves the collection solvent. It has a thermal conductivity no greater than 60 BTU's per hour, per square foot, per inch for a one degree Fahrenheit difference.

摘要翻译： 为了避免限流器上的沉积物将通道提取到收集器中，加热的毛细管压力释放限制器在收集阱中具有基本上比毛细管冷的热绝缘出口端。 限流器通过Joulean加热在隔热层和毛细管之间加热。 捕集器中的溶剂的压力高于大气压力5至200 psi。 选择绝缘体的耐热性以将添加到萃取剂中的热量降至最低，并且使提取剂的温度处于足够热的范围内，使其在加入到收集溶剂中时不会冻结，但是 不那么热，以至于在萃取剂离开收集溶剂之前减少提取物和萃取剂的分配。 对于一华氏度的差值，其导热率不大于每小时60BTU，每平方英尺。

公开(公告)号：US5160624A

公开(公告)日：1992-11-03

申请号：US795987

申请日：1991-11-22

申请人： Dale L. Clay ,  Robert W. Allington ,  Daniel G. Jameson ,  Robin R. Winter

发明人： Dale L. Clay ,  Robert W. Allington ,  Daniel G. Jameson ,  Robin R. Winter

IPC分类号： B01D11/00 ,  B01D11/02 ,  B01D11/04 ,  F04B9/04 ,  F04B15/08 ,  F04B49/06 ,  F16K15/18 ,  G01F1/34 ,  G01N1/10 ,  G01N1/34 ,  G01N1/40 ,  G01N30/02 ,  G01N30/28 ,  G01N30/60 ,  G01N35/04 ,  G21F5/015

CPC分类号： B01D11/0407 ,  B01D11/0203 ,  F04B15/08 ,  F04B49/065 ,  F04B9/042 ,  F16K15/183 ,  G01F1/34 ,  G01N1/34 ,  G01N1/40 ,  G01N30/28 ,  G21F5/015 ,  F04B2205/03 ,  F04B2205/05 ,  F04B2205/09 ,  F05B2230/41 ,  F05C2201/0493 ,  F05C2253/12 ,  G01N2001/4033 ,  G01N2001/4061 ,  G01N2030/6013 ,  G01N2035/0441 ,  G01N30/02

摘要： An apparatus for supercritical fluid extraction incorporates a removable extraction cartridge which in operation has insignificant pressure difference between its inside and outside walls. Because of the low pressure difference, the extraction cartridge need not have the strength to withstand significant pressure and can be made out of molded plastic for disposable use as well as stainless steel and/or machined plastic for reusability. The extraction cartridge can be removed and opened for sample access without the use of tools. The outside of the cartridge can be purged after it is installed in a heated high pressure vessel to remove contamination from its exterior. In one embodiment, the extractor includes a fraction collector fr extractants, an automatic sample changer and an automatic cartridge transfer mechanism which provide completely automated extractions.

摘要翻译： 用于超临界流体萃取的装置包括可移除的提取筒，其在操作中在其内壁和外壁之间具有不显着的压力差。 由于低压差，提取筒不需要具有承受显着压力的强度，并且可以由用于一次性使用的模制塑料以及用于可重复使用的不锈钢和/或加工塑料制成。 提取盒可以拆卸和打开，无需使用工具进行样品通道。 在将其安装在加热的高压容器中以清除其外部的污染物之后，可将其清除。 在一个实施方案中，提取器包括馏分收集器fr萃取剂，自动样品更换器和提供完全自动提取的自动转移机构。

公开(公告)号：US4981597A

公开(公告)日：1991-01-01

申请号：US355881

申请日：1989-05-19

申请人： Robert W. Allington ,  Daniel G. Jameson

发明人： Robert W. Allington ,  Daniel G. Jameson

IPC分类号： G01N30/34

CPC分类号： G01N30/34 ,  G01N2030/347

摘要： To supply a programmed gradient to a high pressure pump for introduction into a column, a mixer, degasser and accumulator communicates with the high pressure pump to supply fluid thereto, having a volume no more than 150 times the chamber volume of the high pressure pump. The mixer, degasser and accumulator includes temperature sensors which sense when the mixer, degasser and accumulator has been emptied to a level where it cannot respond to a demand for fluid from said high pressure pump and provides a signal to a low pressure pump which responds by cycling to again fill the mixer, degasser and accumulator. Upon receiving a demand signal, the low pressure pump fills by drawing fluid from a plurality of fluid sources to compose the gradient being used at that time, with the pump slowing during valve opening and closing so as to avoid cavitation.

摘要翻译： 为了向高压泵提供编程梯度以引入塔中，混合器，脱气器和蓄能器与高压泵连通以向其提供流体，其体积不超过高压泵的室容积的150倍。 混合器，脱气机和蓄能器包括温度传感器，其感测混合器，脱气器和蓄能器何时被排空到不能响应来自所述高压泵的流体需求的水平，并且向低压泵提供信号，该低压泵由 循环再次填充混合器，脱气机和蓄压器。 在接收到需求信号时，通过从多个流体源抽取流体来填充低压泵以构成当时使用的梯度，同时在阀打开和关闭期间泵减慢，以避免空化。

公开(公告)号：US20080235081A1

公开(公告)日：2008-09-25

申请号：US12150224

申请日：2008-04-25

申请人： Dale A. Davison ,  Dale L. Meyer ,  Daniel G. Jameson ,  Jack E. Silver ,  Jon L. Curran ,  Ruth A. Pipes

发明人： Dale A. Davison ,  Dale L. Meyer ,  Daniel G. Jameson ,  Jack E. Silver ,  Jon L. Curran ,  Ruth A. Pipes

IPC分类号： G06Q10/00 ,  G06F17/30 ,  G06F15/16 ,  G05D7/06

CPC分类号： G06Q10/087 ,  B01D15/247 ,  B01D2201/52 ,  G01N35/00732 ,  G01N35/00871 ,  G01N35/0092 ,  G01N2030/889 ,  G06Q30/0202

摘要： Purchase orders for chromatographic columns and sampler tubing are entered into based on estimating usage for a year. An initial partial shipment is made of tagged columns or tubing as the tubing or columns are used. An RFID transmits trigger signals until an order point is reached at which time a new partial shipment is made. This process is repeated until the end of the year.

摘要翻译： 根据估计一年的使用量，输入色谱柱和采样管的采购订单。 当使用管道或柱时，初始部分装运由带标签的柱或管道制成。 RFID发送触发信号，直到到达订单点，此时进行新的部分发货。 这个过程重复直到年底。

公开(公告)号：US20080179251A1

公开(公告)日：2008-07-31

申请号：US11980024

申请日：2007-10-30

申请人： Dale A. Davison ,  Dale L. Meyer ,  Daniel G. Jameson ,  Jack E. Silver ,  Jon L. Curran ,  Ruth A. Pipes

发明人： Dale A. Davison ,  Dale L. Meyer ,  Daniel G. Jameson ,  Jack E. Silver ,  Jon L. Curran ,  Ruth A. Pipes

IPC分类号： B01D15/08 ,  B01D21/30 ,  B01D35/14 ,  B01D35/31 ,  B01D17/12

CPC分类号： G01N30/02 ,  B01D15/10 ,  G01N30/16 ,  G01N2030/0095

摘要： A liquid chromatographic system includes columns, column mounting fixtures to which the columns are mounted, a detector, a collector, a controller and a plurality of RFIDs. A first RFID communicates with the controller and cooperating RFIDs mounted to other components provide information such as the history of components, parameters and the like. They also receive information from sensors relating to the operation of the liquid chromatograph, store the information and transmit it. Moreover, the RFIDs may substitute for hard wiring in many applications and may enable a central computer to control several liquid chromatographic

摘要翻译： 液相色谱系统包括列，柱安装固定装置，柱安装在其上，检测器，收集器，控制器和多个RFID。 第一RFID与控制器通信，并且安装到其他组件的协作RFID​​提供诸如组件的历史，参数等的信息。 他们还从与液相色谱仪操作相关的传感器接收信息，存储信息并进行传输。 此外，RFID可以在许多应用中代替硬布线，并且可以使得中央计算机能够控制多个液相色谱

公开(公告)号：US5635070A

公开(公告)日：1997-06-03

申请号：US208121

申请日：1994-03-08

申请人： Robert W. Allington ,  Daniel G. Jameson ,  Dale A. Davison ,  Dale Clay ,  Robin R. Winter ,  Yoossef Tehrani

发明人： Robert W. Allington ,  Daniel G. Jameson ,  Dale A. Davison ,  Dale Clay ,  Robin R. Winter ,  Yoossef Tehrani

IPC分类号： B01D11/00 ,  B01D11/02 ,  B01D11/04 ,  F04B9/04 ,  F04B15/08 ,  F04B49/06 ,  F04B53/08 ,  F04B53/14 ,  F16K15/18 ,  G01F1/34 ,  G01N1/34 ,  G01N1/40 ,  G01N30/02 ,  G01N30/28 ,  G01N30/60 ,  G01N35/04 ,  G21F5/015

CPC分类号： G01N1/34 ,  B01D11/0203 ,  B01D11/0407 ,  F04B15/08 ,  F04B49/065 ,  F04B53/08 ,  F04B53/143 ,  F04B9/042 ,  F16K15/183 ,  G01F1/34 ,  G01N1/40 ,  G01N30/28 ,  G21F5/015 ,  F04B2201/0209 ,  F04B2205/03 ,  F04B2205/05 ,  F04B2205/09 ,  F05B2230/41 ,  F05C2201/0493 ,  F05C2253/12 ,  G01N2001/4033 ,  G01N2001/4061 ,  G01N2030/6013 ,  G01N2035/0441 ,  G01N30/02

摘要： To pump supercritical carbon dioxide into a supercritical extractor without overpressure in the reservoir and to record the volume being delivered, the pumping speed is controlled and the volume pumped is determined from a pressure-related signal used in a feedback circuit. The feedback controls the velocity of pumping in conjunction with programmed values to avoid destructive reverse torque. A cam in the pump controls piston stroke, has a depressurization portion with an initial slope equal to but in the opposite direction of the final slope, rounded transition slopes, increasing linear velocity to the refill portion and constant velocity in the refill portion.

公开(公告)号：US5614089A

公开(公告)日：1997-03-25

申请号：US542683

申请日：1995-10-13

申请人： Robert W. Allington ,  Henry L. Walters ,  Daniel G. Jameson ,  Yoossef Tehrani

发明人： Robert W. Allington ,  Henry L. Walters ,  Daniel G. Jameson ,  Yoossef Tehrani

IPC分类号： B01D11/02 ,  B01D11/04 ,  F04B9/04 ,  F04B15/08 ,  F04B49/06 ,  F16K15/18 ,  G01F1/34 ,  G01N1/34 ,  G01N1/40 ,  G01N30/02 ,  G01N30/28 ,  G01N30/32 ,  G01N30/60 ,  G01N30/82 ,  G01N35/04 ,  G21F5/015 ,  B01D15/08

CPC分类号： B01D11/0407 ,  B01D11/0203 ,  F04B15/08 ,  F04B49/065 ,  F04B9/042 ,  F16K15/183 ,  G01F1/34 ,  G01N1/34 ,  G01N1/40 ,  G01N30/28 ,  G01N30/82 ,  G21F5/015 ,  F04B2205/03 ,  F04B2205/05 ,  F04B2205/09 ,  F05B2230/41 ,  F05C2201/0493 ,  F05C2253/12 ,  G01N2001/4033 ,  G01N2001/4061 ,  G01N2030/6008 ,  G01N2030/6013 ,  G01N2035/0441 ,  G01N30/02 ,  G01N30/32 ,  G01N30/60

摘要： A variable-orifice fluid restrictor for use with a supercritical extractor or chromatograph includes an inlet line for fluid at a pressure above its critical pressure, an extended tubular probe having an inner and an outer surface and a proximal and a distal end. The proximal end of the probe is disposed toward the inlet line. The distal end of the probe includes an adjustable orifice means adapted for metering the fluid and having first and second orifice members and an adjusting stem having first and second ends. The adjustable orifice means is adjacent to the outer surface of the probe and the orifice means is adjustable with the adjusting stem. The end of the adjusting stem is located at the distal end of the probe and is adapted for moving the first orifice member with respect to the second orifice member to control the adjustable orifice for varying the restriction of fluid passing through the adjustable orifice.

摘要翻译： 用于超临界萃取器或色谱仪的可变孔口流体限制器包括用于高于其临界压力的压力的流体的入口管线，具有内外表面和近端和远端的延伸管状探针。 探针的近端朝向入口线设置。 探针的远端包括适于计量流体并具有第一和第二孔口构件的调节孔口装置和具有第一和第二端部的调节杆。 可调整的孔口装置与探针的外表面相邻，孔口装置可用调节杆调节。 调节杆的端部位于探针的远端，并且适于相对于第二孔构件移动第一孔构件以控制可调节孔，以改变通过可调节孔的流体的限制。