公开(公告)号：US08845794B2

公开(公告)日：2014-09-30

申请号：US14170719

申请日：2014-02-03

申请人： Matthew Spangler Klee

发明人： Matthew Spangler Klee

IPC分类号： B01D53/02 ,  G01N30/12 ,  G01N30/16 ,  G01N30/10 ,  G01N30/60 ,  G01N30/02

CPC分类号： G01N30/60 ,  B01D53/02 ,  B01D53/025 ,  G01N30/10 ,  G01N30/12 ,  G01N30/16 ,  G01N30/6004 ,  G01N30/6026 ,  G01N30/6034 ,  G01N30/6039 ,  G01N30/6078 ,  G01N2030/025 ,  G01N2030/167 ,  G01N2030/6008

摘要： A non-seizing taper used for purged capillary tubing connections in gas chromatography that stops capillary tubing at a predictable position within the taper during installation and maintains space for gas to flow past the capillary tubing. The disclosed taper is an improved component of commonly used purged devices such as inlet liners and purged unions. The arresting aspect of the taper simplifies the process of capillary tubing installation while ensuring that the tubing will reproducibly be positioned in the taper. One or more features of the taper prevent tubing from seizing within the taper so that the devices can be reused and ensure that there is open space for a portion of gas to flow around and past the tubing. The angle of the taper, the dimensions of the taper, and the nature of the features within the taper can be adjusted to meet specific performance, usability and/or manufacturability requirements.

摘要翻译： 用于气相色谱法中吹扫的毛细管连接件的非卡住锥度，可在安装过程中将毛细管管道停止在锥度内的可预测位置，并保持气体流过毛细管的空间。 公开的锥形是通常使用的清洗装置的改进部件，例如入口衬套和清洗的接头。 锥形的阻止方面简化了毛细管安装的过程，同时确保管道可重复地定位在锥度中。 该锥度的一个或多个特征防止管道在锥形内被卡住，使得装置可以重复使用，并且确保有一部分气体围绕并流过管道的开放空间。 可以调节锥度的角度，锥度的尺寸以及锥度内的特征的性质以满足特定性能，可用性和/或可制造性要求。

公开(公告)号：US07867325B2

公开(公告)日：2011-01-11

申请号：US12316256

申请日：2008-12-10

申请人： Brian A. Jones ,  Jaap De Zeeuw ,  Jack Cochran ,  Scott L. Grossman

发明人： Brian A. Jones ,  Jaap De Zeeuw ,  Jack Cochran ,  Scott L. Grossman

IPC分类号： B01D53/02

CPC分类号： G01N30/16 ,  B01D53/0415 ,  G01N30/32 ,  G01N2030/025 ,  G01N2030/167 ,  G01N2030/6008 ,  G01N2030/621

摘要： A gas chromatographic device comprises an inlet system and a chromatography column. The inlet system includes a liner having pressure reducing means contained therein for reducing pressure between an inlet of the pressure reducing means and an outlet of the pressure reducing means. When the devise is in use, the chromatography column is positioned in the liner of the inlet system downstream from the pressure reducing means, and the chromatography column is under vacuum at its outlet.

摘要翻译： 气相色谱装置包括入口系统和色谱柱。 入口系统包括其中包含减压装置的衬套，用于减小减压装置的入口与减压装置的出口之间的压力。 当设备使用时，色谱柱位于进口系统的衬垫中，位于减压装置的下游，色谱柱在其出口处处于真空状态。

公开(公告)号：US20040014143A1

公开(公告)日：2004-01-22

申请号：US10448163

申请日：2003-05-29

发明人： William E. Haskins ,  Robert T. Kennedy ,  David H. Powell ,  Christopher J. Watson

IPC分类号： G01N033/53 ,  C07K014/47 ,  C07K007/08 ,  C07K007/06

CPC分类号： C07K7/06 ,  A61K38/00 ,  B01D15/325 ,  C07K7/08 ,  C07K14/575 ,  C07K14/70 ,  C07K14/705 ,  C07K14/75 ,  G01N30/7266 ,  G01N2030/6008 ,  G01N2030/6013

摘要： The present invention concerns an apparatus and method for the rapid separation, detection, and characterization of molecules, such as biomolecules, within a sample. The present invention is particularly useful for the separation, detection, and characterization of peptides, such as neuropeptides, within a biological sample. The present invention also concerns neuropeptides identified using the apparatus and method of the subject invention.

摘要翻译： 本发明涉及用于在样品内快速分离，检测和表征分子（例如生物分子）的装置和方法。 本发明特别可用于生物样品中肽，如神经肽的分离，检测和表征。 本发明还涉及使用本发明的装置和方法鉴定的神经肽。

公开(公告)号：US20030190265A1

公开(公告)日：2003-10-09

申请号：US10380469

申请日：2003-03-20

发明人： Takanori Anazawa ,  Atsushi Teramae

IPC分类号： B01L003/00

CPC分类号： B81B1/00 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/0086 ,  B01J2219/00891 ,  B01L3/502738 ,  B01L2300/0887 ,  B01L2400/0655 ,  B01L2400/082 ,  F16K99/0001 ,  F16K99/0017 ,  F16K99/0023 ,  F16K2099/0074 ,  F16K2099/008 ,  F16K2099/0084 ,  G01N30/6095 ,  G01N2030/324 ,  G01N2030/6008 ,  Y10T137/1624 ,  Y10T137/1842 ,  Y10T137/206 ,  Y10T436/2575

摘要： There is provided a micro chemical device with a valve function for which the pressure resistance is high and the channel cross-sectional area does not depend on the fluid pressure, and which furthermore enables the suppression of the adsorption of biological matter and yet is easy to produce, as well as a flow regulation method using such a device. This has a valve function, in which a member (B) is bonded to a member (A) with a groove in the surface thereof, via the surface of the member (A) in which the groove is formed, a capillary type channel of width from 1 to 1000 nullm and height from 1 to 1000 nullm is formed by the groove of the member (A) and the member (B) at the bonding surface between the member (A) and the member (B), a cavity section is formed partway along the channel and the width of this cavity section is from 0.5 to 100 fold the width of the capillary type channel and the ratio of maximum height/maximum width for the cavity section is no more than 1, and either one of the member (A) and the member (B) is formed from a soft material with a tensile modulus of elasticity within a range from 0.1 MPa to 700 MPa, at least within the portion which corresponds with the position of the cavity section, wherein by selectively compressing the cavity section from the external surface of the member (A) and/or the member (B), the volume of the cavity section can be reduced in a reversible manner.

摘要翻译： 提供了具有阀功能的微型化学装置，其耐压性高，通道横截面积不依赖于流体压力，并且还能够抑制生物物质的吸附，而且容易 产生，以及使用这种装置的流量调节方法。 这具有阀功能，其中构件（B）经由其形成有凹槽的构件（A）的表面结合到具有其表面的凹槽的构件（A），毛细管型通道 在构件（A）和构件（B）之间的接合表面处由构件（A）和构件（B）的槽形成1至1000μm的宽度和1至1000μm的高度，空腔部 沿着通道形成中途，并且该空腔部分的宽度为毛细管型通道的宽度的0.5至100倍，空腔部分的最大高度/最大宽度比不大于1，并且 构件（A）和构件（B）由柔软材料形成，拉伸弹性模量在0.1MPa至700MPa的范围内，至少在与空腔部分的位置对应的部分内，其中通过选择性地 从构件（A）和/或构件（B）的外表面压缩空腔部分， 可以以可逆的方式减小空腔部分的体积。

公开(公告)号：US20030094206A1

公开(公告)日：2003-05-22

申请号：US09997491

申请日：2001-11-19

发明人： Geoff C. Gerhardt ,  Edouard S. P. Bouvier ,  Theodore Dourdeville

IPC分类号： F16K049/00

CPC分类号： F16K13/10 ,  B01L3/502738 ,  B01L2400/0677 ,  F16L55/103 ,  G01N30/20 ,  G01N30/6004 ,  G01N30/6065 ,  G01N2030/3038 ,  G01N2030/6008 ,  G01N2035/00267 ,  Y10T137/0391 ,  Y10T137/2196 ,  Y10T137/4643 ,  G01N30/30

摘要： Methods and devices for the management of fluid flow within nanoscale analytical systems, comprising a freeze thaw valve having differing geomentries to constrict a frozen plug within the freeze thaw segment. The freeze thaw valve is directed to use in high-pressure analytical systems. The geometry of an inner diameter of a channel or tube within a freeze thaw segment is configured to cause constriction of a freeze plug when axial force is applied. The constriction is used in the flow-path of a freeze thaw valve to prevent movement of the frozen plug at high pressures to avoid valve leakage.

摘要翻译： 用于管理纳米级分析系统内的流体流动的方法和装置，包括具有不同的几何形状的冻融阀，以收缩冻融段内的冷冻塞。 冷冻解冻阀用于高压分析系统。 冻融段内的通道或管的内径的几何形状构造成当施加轴向力时引起冷冻塞的收缩。 在冷冻解冻阀的流路中使用收缩部，以防止冷冻塞在高压下移动，以避免阀泄漏。

公开(公告)号：US4594159A

公开(公告)日：1986-06-10

申请号：US667155

申请日：1984-11-01

申请人： Ralph I. Stalberg

发明人： Ralph I. Stalberg

IPC分类号： B01D15/08 ,  G01N30/32 ,  G01N30/60

CPC分类号： G01N30/32 ,  B01D15/163 ,  B01D15/325 ,  G01N2030/328 ,  G01N2030/6008

摘要： The present invention is concerned with a process and apparatus for generating back pressure in a liquid chromatography system, in that the eluent after having passed through the detector cell is caused to pass through a valve, said valve generating a back pressure and having for this purpose a passage (A-B) which is formed, at an interface between two bodies (20, 24), only when a sufficiently high liquid pressure has been attained, at least one of said bodies being a body of an elastic material.

摘要翻译： 本发明涉及用于在液相色谱系统中产生背压的方法和装置，其中使已经通过检测器单元的洗脱液通过阀，所述阀产生背压并且为此目的 仅在达到足够高的液体压力时，在两个主体（20,24）之间的界面处形成的通道（AB），所述主体中的至少一个是弹性材料的主体。

公开(公告)号：US20170227507A1

公开(公告)日：2017-08-10

申请号：US15498340

申请日：2017-04-26

申请人： Thermo Finnigan LLC

发明人： John E. BRANN ,  Eric A. FRANCE

IPC分类号： G01N30/60 ,  B01D15/22 ,  B23P19/04 ,  F16L37/20 ,  B01L3/00 ,  G01N30/46

CPC分类号： G01N30/6004 ,  B01D15/22 ,  B01L3/563 ,  B01L2300/041 ,  B23P19/04 ,  F16L37/20 ,  G01N30/461 ,  G01N30/60 ,  G01N30/6039 ,  G01N2030/6008 ,  Y10T29/49904

摘要： A method for coupling a tubing to a liquid chromatography column comprises: passing an end of the tubing through a coupling apparatus comprising: (i) at least one chamber; (ii) a first spring within the at least one chamber configured to transmit a spring force to the tubing; (iii) a second spring within the at least one chamber; and (iv) a deformable sealing member configured to receive a second force from the second spring; inserting the tubing end into a receptacle of an end fitting of the column; and moving the coupling apparatus towards the chromatography column such that the first spring urges the tubing into the receptacle whereby a pressure of the tubing end against the end fitting exceeds a maximum operating fluid pressure of the column and, further, whereby the second spring causes the deformable sealing member to form a fluid seal between the column and the receptacle.

公开(公告)号：US20140150660A1

公开(公告)日：2014-06-05

申请号：US14170719

申请日：2014-02-03

申请人： Matthew Spangler Klee

发明人： Matthew Spangler Klee

IPC分类号： G01N30/60

CPC分类号： G01N30/60 ,  B01D53/02 ,  B01D53/025 ,  G01N30/10 ,  G01N30/12 ,  G01N30/16 ,  G01N30/6004 ,  G01N30/6026 ,  G01N30/6034 ,  G01N30/6039 ,  G01N30/6078 ,  G01N2030/025 ,  G01N2030/167 ,  G01N2030/6008

摘要： A non-seizing taper used for purged capillary tubing connections in gas chromatography that stops capillary tubing at a predictable position within the taper during installation and maintains space for gas to flow past the capillary tubing. The disclosed taper is an improved component of commonly used purged devices such as inlet liners and purged unions. The arresting aspect of the taper simplifies the process of capillary tubing installation while ensuring that the tubing will reproducibly be positioned in the taper. One or more features of the taper prevent tubing from seizing within the taper so that the devices can be reused and ensure that there is open space for a portion of gas to flow around and past the tubing. The angle of the taper, the dimensions of the taper, and the nature of the features within the taper can be adjusted to meet specific performance, usability and/or manufacturability requirements.

摘要翻译： 用于气相色谱法中吹扫的毛细管连接件的非卡住锥度，可在安装过程中将毛细管管道停止在锥度内的可预测位置，并保持气体流过毛细管的空间。 公开的锥形是通常使用的清洗装置的改进部件，例如入口衬套和清洗的接头。 锥形的阻止方面简化了毛细管安装的过程，同时确保管道可重复地定位在锥度中。 该锥度的一个或多个特征防止管道在锥形内被卡住，使得装置可以重复使用，并且确保有一部分气体围绕并流过管道的开放空间。 可以调节锥度的角度，锥度的尺寸以及锥度内的特征的性质以满足特定性能，可用性和/或可制造性要求。

公开(公告)号：US08506688B2

公开(公告)日：2013-08-13

申请号：US12009420

申请日：2008-01-18

申请人： Jaap De Zeeuw ,  Jack Cochran ,  Scott L. Grossman

发明人： Jaap De Zeeuw ,  Jack Cochran ,  Scott L. Grossman

IPC分类号： B01D53/02 ,  G01N30/02 ,  G01N30/60

CPC分类号： G01N30/16 ,  G01N30/32 ,  G01N2030/025 ,  G01N2030/167 ,  G01N2030/6008 ,  G01N2030/621

摘要： A gas chromatographic device comprises an inlet system and a chromatography column. The inlet system includes a liner having pressure reducing means contained therein for reducing pressure between an inlet of the pressure reducing means and an outlet of the pressure reducing means. When the devise is in use, the chromatography column is positioned in the liner of the inlet system downstream from the pressure reducing means, and the chromatography column is under vacuum at its outlet.

公开(公告)号：US07238325B2

公开(公告)日：2007-07-03

申请号：US10380469

申请日：2001-03-01

申请人： Takanori Anazawa ,  Atsushi Teramae

发明人： Takanori Anazawa ,  Atsushi Teramae

IPC分类号： B01L11/00

CPC分类号： B81B1/00 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/0086 ,  B01J2219/00891 ,  B01L3/502738 ,  B01L2300/0887 ,  B01L2400/0655 ,  B01L2400/082 ,  F16K99/0001 ,  F16K99/0017 ,  F16K99/0023 ,  F16K2099/0074 ,  F16K2099/008 ,  F16K2099/0084 ,  G01N30/6095 ,  G01N2030/324 ,  G01N2030/6008 ,  Y10T137/1624 ,  Y10T137/1842 ,  Y10T137/206 ,  Y10T436/2575

摘要： There is provided a micro chemical device with a valve function for which the pressure resistance is high and the channel cross-sectional area does not depend on the fluid pressure, and which furthermore enables the suppression of the adsorption of biological matter and yet is easy to produce, as well as a flow regulation method using such a device. This has a valve function, in which a member (B) is bonded to a member (A) with a groove in the surface thereof, via the surface of the member (A) in which the groove is formed, a capillary type channel of width from 1 to 1000 μm and height from 1 to 1000 μm is formed by the groove of the member (A) and the member (B) at the bonding surface between the member (A) and the member (B), a cavity section is formed partway along the channel and the width of this cavity section is from 0.5 to 100 fold the width of the capillary type channel and the ratio of maximum height/maximum width for the cavity section is no more than 1, and either one of the member (A) and the member (B) is formed from a soft material with a tensile modulus of elasticity within a range from 0.1 MPa to 700 MPa, at least within the portion which corresponds with the position of the cavity section, wherein by selectively compressing the cavity section from the external surface of the member (A) and/or the member (B), the volume of the cavity section can be reduced in a reversible manner.

摘要翻译： 提供了具有阀功能的微型化学装置，其耐压性高，通道横截面积不依赖于流体压力，并且还能够抑制生物物质的吸附，而且容易 产生，以及使用这种装置的流量调节方法。 这具有阀功能，其中构件（B）经由其形成有凹槽的构件（A）的表面结合到具有其表面的凹槽的构件（A），毛细管型通道 在构件（A）和构件（B）之间的接合表面处由构件（A）和构件（B）的槽形成1至1000μm的宽度和1至1000μm的高度，空腔部 沿着通道形成中途，并且该空腔部分的宽度为毛细管型通道的宽度的0.5至100倍，空腔部分的最大高度/最大宽度比不大于1，并且 构件（A）和构件（B）由柔软材料形成，拉伸弹性模量在0.1MPa至700MPa的范围内，至少在与空腔部分的位置对应的部分内，其中通过选择性地 从构件（A）和/或构件（B）的外表面压缩空腔部分， 可以以可逆的方式减小空腔部分的体积。