公开(公告)号：US20070142880A1

公开(公告)日：2007-06-21

申请号：US11594570

申请日：2006-11-07

申请人： William Barnard ,  Phillip Burwell ,  James Chen ,  Julene Christophersen ,  William Gembala ,  David Shine

发明人： William Barnard ,  Phillip Burwell ,  James Chen ,  Julene Christophersen ,  William Gembala ,  David Shine

IPC分类号： A61N5/06

CPC分类号： A61N5/0603 ,  A61N5/0601 ,  A61N5/062

摘要： A light delivery apparatus to provide light treatment to a patient includes a catheter assembly having a light source that transmit light towards a target site within a patient. A balloon surrounds the light source and has a plurality of tissue engaging elements movable between first positions and second positions. In one embodiment, each element extends radially inward in the first position and radially outward in the second position. An insertion tool is used to deliver the light delivery apparatus. During use, the light delivery apparatus is rotationally locked with the insertion tool for improved steering, navigation, and aiming of emitted light.

摘要翻译： 为患者提供光治疗的光输送装置包括导管组件，所述导管组件具有将光发射到患者内的目标部位的光源。 气囊围绕光源并且具有可在第一位置和第二位置之间移动的多个组织接合元件。 在一个实施例中，每个元件在第一位置处径向向内延伸并且在第二位置中径向向外延伸。 插入工具用于输送光输送装置。 在使用期间，光输送装置与插入工具旋转地锁定，以改善对发射光的转向，导航和瞄准。

公开(公告)号：US07435756B2

公开(公告)日：2008-10-14

申请号：US10776188

申请日：2004-02-12

申请人： Peter James Jenkins ,  Minnie Wu ,  David Shine Wu

发明人： Peter James Jenkins ,  Minnie Wu ,  David Shine Wu

IPC分类号： A61K31/21

CPC分类号： A61K31/22 ,  A61K31/19 ,  A61K31/704

摘要： The present invention relates to application of compounds of formula (1) (Gibberellins) and their derivatives for the preparation of a pharmaceutical composition or medicaments for the treatment of diabetes, its complications and associated conditions, including obesity, micro and macro vascular diseases, nephropathy, neuropathy, eye diseases, diabetic ulcerations and the like. The method results the normalization of serum glucose level and other physiological conditions

摘要翻译： 本发明涉及式（1）化合物（赤霉素）及其衍生物在制备用于治疗糖尿病及其并发症及相关病症的药物组合物或药物中的应用，包括肥胖症，微血管病变和大血管病，肾病 ，神经病，眼病，糖尿病性溃疡等。 该方法使血清葡萄糖水平和其他生理条件正常化

公开(公告)号：US20070002582A1

公开(公告)日：2007-01-04

申请号：US11323319

申请日：2005-12-30

申请人： Phillip Burwell ,  James Chen ,  Zihong Guo ,  Steven Daly ,  David Shine ,  Gary Lichttenegger ,  Jennifer Matson ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

发明人： Phillip Burwell ,  James Chen ,  Zihong Guo ,  Steven Daly ,  David Shine ,  Gary Lichttenegger ,  Jennifer Matson ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

IPC分类号： A61B1/06

CPC分类号： A61N5/062 ,  A61N2005/0652

摘要： A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.

摘要翻译： 一种制造方法和医疗装置，其提供用于照亮身体的内腔的至少一部分的装置。 该装置包括细长的柔性构件和封装多个发光体的聚合物封装部分。 光发射器可以在不使用引线键的情况下彼此电耦合，并且在一些实施例中可以耦合而没有中间的电路径或迹线。 聚合物封装部分的最大横截面尺寸可以小于一个发光体的尺寸的两倍。 在一些实施例中，最大横截面尺寸小于或等于光发射器之一的尺寸之和和聚合物封装部分的外部部分延伸超过光发射器的边缘尺寸之和。 光发射器可以线性地，螺旋状地或以部分重叠的背靠背关系布置。

公开(公告)号：USD508999S1

公开(公告)日：2005-08-30

申请号：US29186915

申请日：2003-07-24

申请人： Mark Fanning ,  Dennis Sandstedt ,  Dave Pincus ,  Carla Cooper ,  Ray Shelton ,  Judy Lowe ,  Cynthia Somogye ,  Shelly Duboeuf ,  Richard Fauser ,  Laurie Kish ,  David Shine ,  Doug Hopper ,  Ross Blanton ,  Nancy Moss ,  Michael Gallagher

设计人： Mark Fanning ,  Dennis Sandstedt ,  Dave Pincus ,  Carla Cooper ,  Ray Shelton ,  Judy Lowe ,  Cynthia Somogye ,  Shelly Duboeuf ,  Richard Fauser ,  Laurie Kish ,  David Shine ,  Doug Hopper ,  Ross Blanton ,  Nancy Moss ,  Michael Gallagher

公开(公告)号：US6121317A

公开(公告)日：2000-09-19

申请号：US188593

申请日：1998-11-09

申请人： Minne Wu ,  David Shine Wu

发明人： Minne Wu ,  David Shine Wu

IPC分类号： A23K1/16 ,  A61K8/00 ,  A61K8/34 ,  A61K8/40 ,  A61K8/65 ,  A61K8/73 ,  A61K8/86 ,  A61K8/97 ,  A61K31/19 ,  A61K31/195 ,  A61K31/365 ,  A61K45/06 ,  A61P1/00 ,  A61P17/00 ,  A61P29/00 ,  A61P43/00 ,  A61Q5/00 ,  C07D307/93 ,  C12N5/22 ,  A61K31/215 ,  C07C69/74 ,  C07C229/00

CPC分类号： A61K45/06 ,  A61K31/19 ,  A61K31/365

摘要： Compounds of formula (1), (Gibberellins), and their pharmaceutically acceptable derivatives to promote ulcer-healing, healing of surgical wounds or open fractures and treatment of bronchitis or thrombophlebitis in animals including humans or cultivation of skin cell lines in vitro ##STR1## wherein A is COOR, where R is hydrogen, unsubstituted or substituted C.sub.1-20 alkyl, allyl, aryl, arylalkyl, amidine, NR.sup.4 R.sup.5 or an unsaturated or saturated ring containing one or more hetero-atoms selected from the group consisting of nitrogen, oxygen and sulfur; R.sup.4 and R.sup.5 may or may not be the same, are hydrogen, or C.sub.1-20 alkyl, allyl, aryl, arylalkyl or an unsaturated or saturated ring containing one or more hetero-atoms selected from the group consisting of nitrogen and sulfur; B is hydrogen, hydroxyl, mercaptan, or halogen, or A and B together form a --CO--O-- linkage; R.sup.1 is hydrogen, hydroxyl, mercaptan, halogen, amino, azido, NR.sup.4 R.sup.5, unsubstituted or substituted C.sub.1-20 alkyl, allyl, aryl, arylalkyl, and R.sup.2 is methylene, or a divalent hetero-atom.

摘要翻译： 式（1），（赤霉素）及其药学上可接受的衍生物的化合物，其用于促进溃疡愈合，手术伤口愈合或开放性骨折，以及治疗包括人在内的动物的支气管炎或血栓性静脉炎，或体外培养皮肤细胞系，其中A为 COOR，其中R是氢，未取代或取代的C 1-20烷基，烯丙基，芳基，芳烷基，脒，NR 4 R 5或含有一个或多个选自氮，氧和硫的杂原子的不饱和或饱和环; R 4和R 5可以相同也可以不相同，为氢或C1-20烷基，烯丙基，芳基，芳基烷基或含有一个或多个选自氮和硫的杂原子的不饱和或饱和环; B是氢，羟基，硫醇或卤素，或A和B一起形成-CO-O-键; R 1为氢，羟基，硫醇，卤素，氨基，叠氮基，NR 4 R 5，未取代或取代的C 1-20烷基，烯丙基，芳基，芳基烷基，R 2为亚甲基或二价杂原子。

公开(公告)号：US20080033519A1

公开(公告)日：2008-02-07

申请号：US11834572

申请日：2007-08-06

申请人： Phillip Burwell ,  Zihong Guo ,  Jennifer Matson ,  Steven Daly ,  David Shine ,  Gary Lichttenegger ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

发明人： Phillip Burwell ,  Zihong Guo ,  Jennifer Matson ,  Steven Daly ,  David Shine ,  Gary Lichttenegger ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

IPC分类号： A61N1/05 ,  A61M29/02 ,  F21S2/00

CPC分类号： A61N5/062 ,  A61B2018/2261 ,  A61N5/0601 ,  A61N2005/0602 ,  A61N2005/063 ,  A61N2005/0652

摘要： Light sources are incorporated into a guidewire for enabling the ability to render light therapy be added to catheters that do not have that capability. In one exemplary embodiment, a solid guidewire includes a conductive core, and light sources are added to compartments formed in a distal end of the guidewire. In another exemplary embodiment, a light source array is included in a distal end of a hollow guidewire. A plurality of openings are formed into the walls of the hollow guidewire surrounding the array, enabling light to pass through the openings. Conductors extend from the array though the hollow center of the guidewire, to a proximal end of the hollow guidewire. The hollow guidewire can be coated with a conductive material, so that the coating on the guidewire serves as a conductor.

摘要翻译： 光源被结合到导丝中，以使能够将光疗法添加到不具有该能力的导管的能力。 在一个示例性实施例中，实心导线包括导电芯，并且将光源添加到形成在导丝的远端中的隔室。 在另一示例性实施例中，光源阵列包括在中空导丝的远端中。 多个开口形成在围绕阵列的中空导丝的壁中，使得光能够穿过开口。 导体通过导丝的中空中心从阵列延伸到中空导丝的近端。 中空导丝可以用导电材料涂覆，使得导丝上的涂层用作导体。

公开(公告)号：US20070129776A1

公开(公告)日：2007-06-07

申请号：US11584345

申请日：2006-10-20

申请人： Anthony Robins ,  Phillip Burwell ,  David Shine ,  James Chen

发明人： Anthony Robins ,  Phillip Burwell ,  David Shine ,  James Chen

IPC分类号： A61N5/06

CPC分类号： A61N5/0613 ,  A61B2017/00057 ,  A61B2017/00084 ,  A61B2090/065 ,  A61N5/062 ,  A61N2005/0629 ,  A61N2005/0645 ,  A61N2005/0647 ,  A61N2005/0652

摘要： A light therapy system provides for self-alignment or positioning with respect to a joint of a subject. The light therapy system can provide light therapy to a body part of a subject. The therapy system has a main body configured to be placed adjacent a target site and an activatable light emitting system is coupled to the main body. The light emitting system is capable of delivering a therapeutic amount of light energy to the target site when the main body is placed adjacent the target site.

摘要翻译： 光疗系统提供相对于受试者的关节的自对准或定位。 光疗系统可以为受试者的身体部位提供光疗。 治疗系统具有被配置成邻近目标位置放置的主体，并且可激活的发​​光系统耦合到主体。 当主体放置在目标位置附近时，发光系统能够将治疗量的光能输送到目标位置。

公开(公告)号：US20070067199A1

公开(公告)日：2007-03-22

申请号：US11230195

申请日：2005-09-19

申请人： David Shine ,  Satheesh Parachoor

发明人： David Shine ,  Satheesh Parachoor

IPC分类号： G06F15/02

CPC分类号： G06Q10/06 ,  G06Q10/063112

摘要： The present invention provides a computer implemented system and method for selecting a best-suited individual for performing a task from a plurality of individuals. The method including identifying a plurality of individuals for performing a task, receiving a task to be assigned to an individual, assessing the suitability of each of the plurality of available individuals for performing the task, and determining a best-suited individual for performing the task. The method includes evaluating for each individual the individual's current workload, the individual's proximity to a location of the current task and the individual's responsibility for performing the current task. In a preferred embodiment, the present invention is utilized to balance the workload of a hospital's housekeeping staff assigned to dean beds in a hospital thereby decreasing the bed turnover time and increasing the patient throughput of the hospital.

摘要翻译： 本发明提供了一种用于从多个个体中选择用于执行任务的最适合个体的计算机实现的系统和方法。 所述方法包括识别用于执行任务的多个个人，接收要分配给个人的任务，评估所述多个可用个体中的每一个用于执行所述任务的适合性，以及确定用于执行所述任务的最适合个体 。 该方法包括评估每个人个人当前的工作量，个人与当前任务的位置的接近程度以及个人对执行当前任务的责任。 在一个优选实施例中，本发明用于平衡医院在医院院长的家务人员的工作量，从而减少床周转时间并增加医院的患者吞吐量。

公开(公告)号：US20050228260A1

公开(公告)日：2005-10-13

申请号：US10799357

申请日：2004-03-12

申请人： Phillip Burwell ,  Zihong Guo ,  Jennifer Matson ,  Steven Daly ,  David Shine ,  Gary Lichttenegger ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

发明人： Phillip Burwell ,  Zihong Guo ,  Jennifer Matson ,  Steven Daly ,  David Shine ,  Gary Lichttenegger ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

IPC分类号： A61B18/22 ,  A61M20060101 ,  A61N1/00 ,  A61N5/00 ,  A61N5/06 ,  A61N5/10

CPC分类号： A61N5/0601 ,  A61B2018/2261 ,  A61N5/062 ,  A61N2005/0602 ,  A61N2005/0652 ,  A61N2005/1003

摘要： Light generating devices for illuminating portions of vascular tissue, to render photodynamic therapy. In one embodiment, a light source array preferably including a plurality of light emitting diodes, a focusing lens, and a light diffusing element are included in a distal end of a catheter. A balloon is optionally provided to interrupt blood flow that can block the transmission of light, and to center the apparatus in a blood vessel. Optical fibers optionally direct light from the light source to the diffusing element. The light source array can have a radial or linear configuration and can produce more than one wavelength of light for activating different photoreactive agents. Linear light source elements are particularly useful to treat elongate portions of tissue in a vessel. One embodiment intended for use with a conventional balloon catheter integrates light sources into a guidewire.

摘要翻译： 用于照射血管组织部分的光产生装置，以进行光动力疗法。 在一个实施例中，优选地包括多个发光二极管的光源阵列，聚焦透镜和光漫射元件被包括在导管的远端中。 可选地提供气囊以中断可阻挡光的传播的血流，并使装置居中在血管中。 光纤可选地将来自光源的光引导到漫射元件。 光源阵列可以具有径向或线性配置并且可以产生多于一个波长的光以激活不同的光反应剂。 线性光源元件特别适用于处理容器中组织的细长部分。 旨在用于常规气囊导管的一个实施例将光源集成到导丝中。

公开(公告)号：US20050131510A1

公开(公告)日：2005-06-16

申请号：US10888572

申请日：2004-07-09

申请人： James Chen ,  David Shine ,  Gary Lichttenegger ,  Zihong Guo ,  Phillip Burwell ,  Steven Daly

发明人： James Chen ,  David Shine ,  Gary Lichttenegger ,  Zihong Guo ,  Phillip Burwell ,  Steven Daly

IPC分类号： A61B17/22 ,  A61M20060101 ,  A61N1/05 ,  A61N5/06

CPC分类号： A61N5/062 ,  A61B2017/22051 ,  A61N5/0601 ,  A61N2005/0652

摘要： Light generating devices for illuminating portions of vascular tissue to administer photodynamic therapy, and usable with, or including a distal protection device. A first device includes a hollow tip, a flushing lumen, a guidewire lumen, and at least one of a light source, and a hollow light transmissive shaft that is adapted to accommodate a light source. If desired, the device can include a balloon, so that a portion of a body lumen between the balloon and the distal protection device is isolated when the balloon is inflated. A second device includes inner and outer catheters, the outer catheter including a balloon, and the inner catheter including a light source and distal protection device comprising a shape memory polymer. Yet another device is a catheter having two balloons and a sleeve extending therebetween. Within the sleeve, the catheter includes a light source and an expanding member.

摘要翻译： 用于照射血管组织的部分以施用光动力学治疗并且可用于或包括远侧保护装置的光产生装置。 第一装置包括中空尖端，冲洗腔，导丝管腔以及适于容纳光源的光源和中空透光轴中的至少一个。 如果需要，装置可以包括气囊，使得当球囊膨胀时，球囊和远侧保护装置之间的体腔的一部分被隔离。 第二装置包括内导管和外导管，外导管包括气囊，并且内导管包括光源和包括形状记忆聚合物的远端保护装置。 另一个装置是具有两个气囊的导管和在它们之间延伸的套管。 在套管内，导管包括光源和扩张构件。