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公开(公告)号：US20150368250A1
公开(公告)日：2015-12-24
申请号：US14792205
申请日：2015-07-06
Applicant: Lars BÄRFACKER , William SCOTT , Andrea HÄGEBARTH , Stuart INCE , Hartmut REHWINKEL , Oliver POLITZ , Roland NEUHAUS , Hans BRIEM , Ulf BÖMER
Inventor： Lars BÄRFACKER , William SCOTT , Andrea HÄGEBARTH , Stuart INCE , Hartmut REHWINKEL , Oliver POLITZ , Roland NEUHAUS , Hans BRIEM , Ulf BÖMER
IPC: C07D487/04 , A61K31/5025 , A61K45/06
CPC classification number: C07D487/04 , A61K31/5025 , A61K45/06
Abstract: Imidazopyridazines of formula (I) a process for their production and the use thereof.
Abstract translation: 式（I）的咪唑并哒嗪其制备方法及其用途。
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![Substituted pyrimido[1,2-b]indazoles and their use as modulators of the Pi3K/Akt pathway](/abs-image/US/2015/03/24/US08987286B2/abs.jpg.150x150.jpg)
2.发明授权Substituted pyrimido[1,2-b]indazoles and their use as modulators of the Pi3K/Akt pathway 有权取代的嘧啶并[1,2-b]吲唑及其作为Pi3K / Akt途径的调节剂的用途公开(公告)号：US08987286B2
公开(公告)日：2015-03-24
申请号：US13994517
申请日：2011-12-13
Applicant: Hartmut Rehwinkel , Andrea Hägebarth , Oliver Politz , Roland Neuhaus , Ulf Bömer
Inventor： Hartmut Rehwinkel , Andrea Hägebarth , Oliver Politz , Roland Neuhaus , Ulf Bömer
IPC: C07D487/04 , A61K31/519 , A61K45/06
CPC classification number: C07D487/04 , A61K31/519 , A61K45/06
Abstract: Compounds of Formula (I), which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals. The compounds of formula (I) a: useful for the treatment of cancer.
Abstract translation: 作为Pi3K / Akt途径的有效抑制剂的式（I）化合物可用于生产和用作药物。 式（I）的化合物a：可用于治疗癌症。
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公开(公告)号：US20140113901A1
公开(公告)日：2014-04-24
申请号：US14007427
申请日：2011-04-07
Applicant: Lars Bärfacker , William Sott , Andrea Hägebarth , Stuart Ince , Hartmut Rehwinkel , Oliver Politz , Roland Neuhaus , Hans Briem , Ulf Bömer
Inventor： Lars Bärfacker , William Sott , Andrea Hägebarth , Stuart Ince , Hartmut Rehwinkel , Oliver Politz , Roland Neuhaus , Hans Briem , Ulf Bömer
IPC: C07D487/04 , A61K45/06 , A61K31/5025
CPC classification number: C07D487/04 , A61K31/5025 , A61K45/06
Abstract: Imidazopyridazines of formula (I) a process for their production and the use thereof.
Abstract translation: 式（I）的咪唑并哒嗪其制备方法及其用途。
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![5-[(3,3,3-trifluoro-2-hydroxy-1-arylpropyl)amino]-1H-quinolin-2-ones, a process for their production and their use as anti-inflammatory agents](/abs-image/US/2013/03/12/US08394958B2/abs.jpg.150x150.jpg)
4.发明授权5-[(3,3,3-trifluoro-2-hydroxy-1-arylpropyl)amino]-1H-quinolin-2-ones, a process for their production and their use as anti-inflammatory agents 有权5 - [（3,3,3-三氟-2-羟基-1-芳基丙基）氨基] -1H-喹啉-2-酮，其制备方法及其作为抗炎剂公开(公告)号：US08394958B2
公开(公告)日：2013-03-12
申请号：US12275392
申请日：2008-11-21
Applicant: Markus Berger , Hartmut Rehwinkel , Thomas Zollner , Ekkehard May , Jorma Hassfeld , Heike Schacke
Inventor： Markus Berger , Hartmut Rehwinkel , Thomas Zollner , Ekkehard May , Jorma Hassfeld , Heike Schacke
IPC: C07D215/38
CPC classification number: C07D215/38 , C07C45/00 , C07C45/58 , C07C45/71 , C07C49/82 , C07C49/84 , C07D303/32 , C07D405/12 , C07C47/575 , C07C47/565
Abstract: The present invention relates to compounds of formula I, processes for their production and their use as anti-inflammatory agents.
Abstract translation: 本发明涉及式I化合物，其制备方法及其作为抗炎剂的用途。
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公开(公告)号：US20120302617A1
公开(公告)日：2012-11-29
申请号：US13490204
申请日：2012-06-06
Applicant: Markus Berger , Hartmut Rehwinkel , Jan Dahmen , Anders Eriksson , Thomas Hansson , Nafizal Hossain , Per Tomas Klingstedt , Matti Lepistö , Stinabritt Nilsson , Martin Hemmerling , Karl Edman
Inventor： Markus Berger , Hartmut Rehwinkel , Jan Dahmen , Anders Eriksson , Thomas Hansson , Nafizal Hossain , Per Tomas Klingstedt , Matti Lepistö , Stinabritt Nilsson , Martin Hemmerling , Karl Edman
IPC: C07D405/14 , A61P11/02 , A61P11/00 , A61P11/06 , A61K31/416 , A61P29/00
CPC classification number: C07D409/14 , A61K31/416 , A61K31/4439 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D413/12
Abstract: A compound of formula Ia: The present invention relates to novel indazolyl derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments.
Abstract translation: 式Ia化合物：本发明涉及新的吲唑基衍生物，包含该衍生物的药物组合物，制备这种新型衍生物的方法以及使用这些衍生物作为药物。
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Patent Agency Ranking
6.发明申请公开(公告)号：US20120289510A1
公开(公告)日：2012-11-15
申请号：US13465746
申请日：2012-05-07
Applicant: Markus Berger , Jan Dahmen , Hartmut Rehwinkel , Stefan Jaroch , Heike Schäcke
Inventor： Markus Berger , Jan Dahmen , Hartmut Rehwinkel , Stefan Jaroch , Heike Schäcke
IPC: A61K31/47 , A61K31/517 , A61K31/506 , A61K31/4709 , A61K31/4164 , A61P1/00 , A61P17/00 , A61P17/06 , A61P17/14 , A61P35/00 , A61P37/08 , A61K31/502 , A61K31/13
CPC classification number: C07C215/16 , C07B2200/07 , C07C215/28 , C07C217/70 , C07C317/28 , C07D215/38 , C07D233/84 , C07D401/12 , C07D405/12 , C07D405/14
Abstract: The present invention relates to the compounds of formula I, processes for their production and their use as anti-inflammatory agents.
Abstract translation: 本发明涉及式I化合物，其制备方法及其作为抗炎剂的用途。
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公开(公告)号：US08211930B2
公开(公告)日：2012-07-03
申请号：US12468561
申请日：2009-05-19
Applicant: Markus Berger , Hartmut Rehwinkel , Jan Dahmén , Anders Eriksson , Thomas Hansson , Nafizal Hossain , Per Tomas Klingstedt , Matti Lepistö , Stinabritt Nilsson , Martin Hemmerling , Karl Edman
Inventor： Markus Berger , Hartmut Rehwinkel , Jan Dahmén , Anders Eriksson , Thomas Hansson , Nafizal Hossain , Per Tomas Klingstedt , Matti Lepistö , Stinabritt Nilsson , Martin Hemmerling , Karl Edman
IPC: A61K31/416 , C07D231/54
CPC classification number: C07D409/14 , A61K31/416 , A61K31/4439 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D413/12
Abstract: A compound of formula Ia: The present invention relates to novel indazolyl derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments
Abstract translation: 式Ia化合物：本发明涉及新的吲唑基衍生物，包含该衍生物的药物组合物，制备这种新型衍生物的方法以及使用这些衍生物作为药物。
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8.发明授权公开(公告)号：US08097627B2
公开(公告)日：2012-01-17
申请号：US12642121
申请日：2009-12-18
Applicant: Hartmut Rehwinkel , Stefan Baeurle , Markus Berger , Norbert Schmees , Heike Schaecke , Konrad Krolikiewicz , Anne Mengel , Duy Nguyen , Stefan Jaroch , Werner Skuballa
Inventor： Hartmut Rehwinkel , Stefan Baeurle , Markus Berger , Norbert Schmees , Heike Schaecke , Konrad Krolikiewicz , Anne Mengel , Duy Nguyen , Stefan Jaroch , Werner Skuballa
IPC: A61K31/50 , A61K31/517 , A61K31/47 , C07D237/30 , C07D287/72 , C07D217/22 , C07D215/02
CPC classification number: C07D217/24 , A61K31/47 , A61K31/472 , A61K31/517 , C07C215/44 , C07C255/58 , C07C2602/10 , C07D209/34 , C07D209/46 , C07D213/74 , C07D215/04 , C07D215/22 , C07D215/227 , C07D215/38 , C07D215/48 , C07D215/58 , C07D231/56 , C07D237/32 , C07D239/74 , C07D239/76 , C07D277/64 , C07D307/88 , C07D317/70 , C07D405/12 , C07D471/04
Abstract: The invention relates to multiply-substituted tetrahydronaphthalene derivatives of formula (I) process for their production and their use as anti-inflammatory agents.
Abstract translation: 本发明涉及式（I）的多取代四氢萘衍生物的制备方法及其作为抗炎剂的用途。
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9.发明授权公开(公告)号：US07880042B2
公开(公告)日：2011-02-01
申请号：US11717782
申请日：2007-03-14
Applicant: Markus Berger , Hartmut Rehwinkel , Heike Schäcke , Stefan Bäurle , Norbert Schmees
Inventor： Markus Berger , Hartmut Rehwinkel , Heike Schäcke , Stefan Bäurle , Norbert Schmees
IPC: C07C13/465
CPC classification number: C07D215/227 , C07D209/34 , C07D215/38 , C07D215/60 , C07D217/24 , C07D231/56 , C07D237/32 , C07D239/74 , C07D265/02 , C07D311/76
Abstract: The invention relates to multiply substituted tetrahydronaphthalene derivatives of the formula (Ia) to processes for preparing them and to their use as antiinflammatory agents.
Abstract translation: 本发明涉及式（Ia）的多取代四氢萘衍生物用于制备它们的方法及其作为抗炎剂的用途。
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公开(公告)号：US20100197644A1
公开(公告)日：2010-08-05
申请号：US12643504
申请日：2009-12-21
Applicant: Markus Berger , Jan Dahmén , Karl Edman , Anders Eriksson , Balint Gabos , Thomas Hansson , Martin Hemmerling , Krister Henriksson , Svetlana Ivanova , Matti Lepistö , Darren McKerrecher , Magnus Munck af Rosenschöld , Stinabritt Nilsson , Hartmut Rehwinkel , Camilla Taflin
Inventor： Markus Berger , Jan Dahmén , Karl Edman , Anders Eriksson , Balint Gabos , Thomas Hansson , Martin Hemmerling , Krister Henriksson , Svetlana Ivanova , Matti Lepistö , Darren McKerrecher , Magnus Munck af Rosenschöld , Stinabritt Nilsson , Hartmut Rehwinkel , Camilla Taflin
IPC: A61K31/56 , A61K31/5377 , A61K31/501 , A61K31/506 , A61K31/4709 , A61K31/4439 , A61K31/4245 , A61K31/427 , A61K31/428 , A61K31/422 , A61K31/4196 , A61K31/4184 , A61K31/4178 , A61K31/416 , C07D413/10 , C07D403/04 , C07D403/12 , C07D215/12 , C07D401/12 , C07D271/02 , C07D417/12 , C07D277/587 , C07D263/38 , C07D263/40 , C07D249/12 , C07D235/26 , C07D233/90 , C07D231/56 , A61P29/00 , A61P11/06
CPC classification number: C07D231/56 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
Abstract: Compounds of formula (I): The present invention relates to novel indazolyl ester or amide derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments
Abstract translation: 式（I）化合物：本发明涉及新的吲唑基酯或酰胺衍生物，包含这些衍生物的药物组合物，制备这种新衍生物的方法以及使用这些衍生物作为药物
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