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公开(公告)号：US5750115A
公开(公告)日：1998-05-12
申请号：US420454
申请日：1995-04-10
IPC分类号： C12P21/00 , A61K39/00 , A61K39/02 , A61K39/108 , C07K14/00 , C07K14/005 , C07K14/195 , C07K14/245 , C07K14/41 , C12R1/19 , C12N1/20
CPC分类号： A61K39/0258 , C07K14/245 , A61K39/00
摘要： According to the present invention it has been found that a novel E. coli toxin or an immunogenic fragment thereof can be used in the preparation of vaccines for warm-blooded animals, and in particular for birds. Said toxin is found to be associated in flagellar structures attached to the bacteria, and these flagella or the free toxins can, after inactivation be used to immunize animals against E. coli infections.
摘要翻译： 根据本发明，已经发现新鲜的大肠杆菌毒素或其免疫原性片段可用于制备用于温血动物，特别是鸟类的疫苗。 发现所述毒素与附着于细菌的鞭毛结构相关联，并且这些鞭毛或游离毒素可以在灭活后用于免疫动物免受大肠杆菌感染。
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公开(公告)号：US5648081A
公开(公告)日：1997-07-15
申请号：US367908
申请日：1995-01-03
IPC分类号： A61K39/02 , A61K39/00 , A61P31/04 , C07K14/285 , A61K39/102 , C12N1/00
CPC分类号： C07K14/285 , A61K39/00
摘要： The present invention is concerned with vaccines effective in protecting pigs against porcine pleuropneumonia. Said vaccines comprising a hemolysin and/or macrophage toxin and a 42 kD OMP preparation derived from Actinobacillus pleuropneumoniae (App) cells induce a complete and heterologous protection against App infection.
摘要翻译： 本发明涉及有效保护猪免受猪胸膜肺炎的疫苗。 包含溶血素和/或巨噬细胞毒素的所述疫苗和源自胸膜肺炎放线杆菌（App）细胞的42kD OMP制剂诱导针对App感染的完全和异源保护。
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公开(公告)号：US06787137B1
公开(公告)日：2004-09-07
申请号：US09544683
申请日：2000-04-07
申请人： Antonius Arnoldus Christiaan Jacobs , Johannes Franciscus van den Bosch , Petrus Johannes Maria Nuijten
发明人： Antonius Arnoldus Christiaan Jacobs , Johannes Franciscus van den Bosch , Petrus Johannes Maria Nuijten
IPC分类号： A61K39395
CPC分类号： A61K39/105 , A61K2039/505 , A61K2039/5252 , C07K14/205 , C07K16/121 , Y02A50/47 , Y10S424/826
摘要： The present invention relates to vaccines comprising antiserum raised against a flagellaless Campylobacter strain for the prevention of Campylobacter colonisation in animals. The invention also relates to antigenic Campylobacter proteins visible in a Western blot of Campylobacter jejuni protein after incubation of said Western blot with antibodies against a flagellaless mutant of Campylobacter jejuni and not visible after incubation of said blot with antibodies against wild type Campylobacter jejuni, and to their use in vaccines and the manufacturing thereof. The invention further relates to vaccines comprising such proteins and antibodies against such proteins. The invention further relates to the use of such Campylobacter proteins and to antiserum and antibodies raised against Campylobacter antigens for the preparation of vaccines. Finally, the invention relates to methods for the preparation of such vaccines.
摘要翻译： 本发明涉及包含抗鞭毛弯曲杆菌菌株产生的用于预防动物弯曲杆菌定植的抗血清的疫苗。 本发明还涉及在所述蛋白质印迹与抗空肠弯曲杆菌的无鞭毛虫突变体的抗体孵育后在空肠弯曲杆菌蛋白质的Western印迹中可见的抗原性弯曲杆菌蛋白质，并且在用野生型空肠弯曲杆菌抗体孵育后不可见， 它们在疫苗中的应用及其制造。 本发明还涉及包含这种蛋白质和针对这种蛋白质的抗体的疫苗。 本发明还涉及这种弯曲杆菌蛋白质的用途以及抗弯曲杆菌抗原产生的用于制备疫苗的抗血清和抗体。 最后，本发明涉及制备这种疫苗的方法。
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公开(公告)号：US06770275B1
公开(公告)日：2004-08-03
申请号：US08866198
申请日：1997-05-30
IPC分类号： A01N6300
CPC分类号： C12R1/21 , A61K39/00 , C07K14/285 , C12R1/01
摘要： The present invention relates to live attenuated RTX-toxin producing bacteria of the family Pasteurellaceae, of which the attenuation is due to the fact that they produce RTX toxin in a non-activated form. The invention also relates to vaccines for the protection of mammals against infection with RTX-toxin producing bacteria of the family Pasteurellaceae, and to methods for the preparation of said live attenuated bacteria and vaccines.
摘要翻译： 本发明涉及巴斯德毕赤氏菌科的活减毒RTX-毒素生产菌，其衰减是由于它们以非活化形式产生RTX毒素的事实。 本发明还涉及用于保护哺乳动物免受感染巴斯德毕赤氏菌科的RTX-毒素产生细菌的疫苗以及制备所述活减毒细菌和疫苗的方法。
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公开(公告)号：US06790446B2
公开(公告)日：2004-09-14
申请号：US10192419
申请日：2002-07-10
申请人： Antonius Arnoldus Christiaan Jacobs , Johannes Franciscus van den Bosch , Petrus Johannes Maria Nuijten
发明人： Antonius Arnoldus Christiaan Jacobs , Johannes Franciscus van den Bosch , Petrus Johannes Maria Nuijten
IPC分类号： A61K3900
CPC分类号： A61K39/105 , A61K2039/505 , A61K2039/5252 , C07K14/205 , C07K16/121 , Y02A50/47 , Y10S424/826
摘要： The present invention relates to vaccines comprising antiserum raised against a flagellaless Campylobacter strain for the prevention of Campylobacter colonization in animals. The invention also relates to antigenic Campylobacter proteins visible in a Western blot of Campylobacter jejuni protein after incubation of said Western blot with antibodies against a flagellaless mutant of Campylobacter jejuni and not visible after incubation of said blot with antibodies against wild type Campylobacter jejuni, and to their use in vaccines and the manufacturing thereof. The invention further relates to vaccines comprising such proteins and antibodies against such proteins. The invention further relates to the use of such Campylobacter proteins and to antiserum and antibodies raised against Campylobacter antigens for the preparation of vaccines. Finally, the invention relates to methods for the preparation of such vaccines.
摘要翻译： 本发明涉及包含抗鞭毛弯曲杆菌菌株产生的用于预防动物弯曲杆菌定植的抗血清的疫苗。 本发明还涉及在所述蛋白质印迹与抗空肠弯曲杆菌的无鞭毛虫突变体的抗体孵育后在空肠弯曲杆菌蛋白质的Western印迹中可见的抗原性弯曲杆菌蛋白质，并且在用野生型空肠弯曲杆菌抗体孵育后不可见， 它们在疫苗中的应用及其制造。 本发明还涉及包含这种蛋白质和针对这种蛋白质的抗体的疫苗。 本发明还涉及这种弯曲杆菌蛋白质的用途以及抗弯曲杆菌抗原产生的用于制备疫苗的抗血清和抗体。 最后，本发明涉及制备这种疫苗的方法。
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