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公开(公告)号：US08992594B2
公开(公告)日：2015-03-31
申请号：US13515996
申请日：2010-12-16
CPC分类号： A61F2/82 , A61B17/11 , A61B17/122 , A61B2017/00252 , A61B2017/00969 , A61B2017/1107 , A61B2017/1135 , A61F2/06 , A61F2/064 , A61F2210/0076 , A61L27/44 , A61L27/507 , A61L27/56
摘要： A tubular graft device is provided comprising a tubular member and a fiber matrix of one or more polymers about a circumference of the tubular member. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a harvested saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided is method of preparing a tubular graft and connecting the graft between a first body space and a second body space, such as the aorta and a location on an occluded coronary artery, distal to the occlusion.
摘要翻译： 提供了管状移植装置，其包括管状构件和围绕管状构件的圆周的一种或多种聚合物的纤维基质。 基质可以电纺到管状组织上。 在一个实施例中，管状组织来自静脉，例如收获的隐静脉，可用作动脉移植物，例如但不限于冠状动脉旁路手术。 还提供了制备管状移植物并将移植物连接到第一身体空间和第二身体空间（例如主动脉）和封堵冠状动脉之间位于闭塞远端的位置的方法。
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公开(公告)号：US10085829B2
公开(公告)日：2018-10-02
申请号：US13979243
申请日：2012-01-13
摘要： An apparatus is provided for applying a restrictive fiber matrix to a conduit to create a graft device. A rotating assembly rotates the conduit, and a polymer delivery assembly delivers the restrictive fiber matrix. A controller controls the polymer deliver assembly and the rotating assembly.
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公开(公告)号：US20140303715A1
公开(公告)日：2014-10-09
申请号：US14234974
申请日：2012-07-24
IPC分类号： A61F2/82
CPC分类号： A61F2/82 , A61B17/00008 , A61B17/11 , A61B17/135 , A61B2017/00778 , A61B2017/00969 , A61B2017/1107 , A61B2017/1132 , A61B2017/22097 , A61L27/3625 , A61L27/3687 , A61L27/3691 , A61L27/507
摘要： Methods and devices for treating a vessel for use in a medical procedure are disclosed. A vein or other vessel can be modified in situ, prior to harvesting. Subsequently, at least a portion of the vessel is removed, and subsequently implanted to treat a patient, typically in a bypass procedure in which the vessel portion fluidly connects a source of oxygenated blood to an occluded artery.
摘要翻译： 公开了用于治疗用于医疗过程的血管的方法和装置。 在收获之前，静脉或其他血管可以在原位进行修改。 随后，移除血管的至少一部分，随后植入以治疗患者，通常在旁路过程中，血管部分将氧合血液源流体连接到闭塞动脉。
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公开(公告)号：US20140005470A1
公开(公告)日：2014-01-02
申请号：US13811206
申请日：2011-07-19
申请人： Lorenzo Soletti , Mohammed S. El-Kurdi , Jon McGrath , Andrew Ziegler , J. Christopher Flaherty , William R. Wagner , David Vorp
发明人： Lorenzo Soletti , Mohammed S. El-Kurdi , Jon McGrath , Andrew Ziegler , J. Christopher Flaherty , William R. Wagner , David Vorp
IPC分类号： A61B19/00
CPC分类号： B05B5/12 , A61B90/00 , A61F2/022 , A61F2/04 , A61F2/06 , A61F2/07 , A61F2002/043 , A61F2002/046 , A61F2002/047 , A61F2002/048 , A61F2240/001 , A61L27/3625 , B05B5/0255 , D01D5/0084 , D01D13/02
摘要： A cartridge device is provided for applying a fiber matrix to a tubular member such as a saphenous vein graft. The cartridge includes a housing, a tubular member holder, a rotational drive, and a polymer delivery assembly. The housing defines a chamber which surrounds the tubular member holder. The rotational drive rotates the tubular member during the fiber application process.
摘要翻译： 提供了用于将纤维基质施加到诸如隐静脉移植物的管状构件上的药筒装置。 盒包括壳体，管状构件保持器，旋转驱动器和聚合物输送组件。 壳体限定围绕管状构件保持器的腔室。 旋转驱动器在纤维施加过程中旋转管状构件。
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公开(公告)号：US20120296353A1
公开(公告)日：2012-11-22
申请号：US13520009
申请日：2010-12-30
申请人： David Wagner , Lorenzo Soletti , Mohammed S. El-Kurdi , Jon McGrath , John T. Garibotto , J. Christopher Flaherty
发明人： David Wagner , Lorenzo Soletti , Mohammed S. El-Kurdi , Jon McGrath , John T. Garibotto , J. Christopher Flaherty
IPC分类号： A61B17/11
CPC分类号： A61F2/06 , A61F2/04 , A61F2/064 , A61F2210/0076 , A61F2250/0039 , A61L27/047 , A61L27/14 , A61L27/16 , A61L27/18 , A61L27/34 , A61L27/36 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/412 , A61L2430/36
摘要： A graft device is provided comprising a flow conduit and a surrounding covering. The graft device is for connecting between a first body space and a second body space. In one embodiment, the flow conduit is a vein, such as a harvested saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided are methods of preparing a graft device and connecting the graft between a first body space and a second body space, such as the aorta and a location on an occluded coronary artery, distal to the occlusion.
摘要翻译： 提供了移植装置，其包括流动管道和周围的覆盖物。 移植装置用于在第一身体空间和第二身体空间之间连接。 在一个实施例中，流动导管是静脉，例如收获的隐静脉，可用作动脉移植物，例如但不限于冠状动脉旁路手术。 还提供了制备移植装置并将移植物连接到第一身体空间和第二身体空间（例如主动脉）和封堵冠状动脉远端的位置的方法。
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公开(公告)号：US09579224B2
公开(公告)日：2017-02-28
申请号：US14234974
申请日：2012-07-24
CPC分类号： A61F2/82 , A61B17/00008 , A61B17/11 , A61B17/135 , A61B2017/00778 , A61B2017/00969 , A61B2017/1107 , A61B2017/1132 , A61B2017/22097 , A61L27/3625 , A61L27/3687 , A61L27/3691 , A61L27/507
摘要： Methods and devices for treating a vessel for use in a medical procedure are disclosed. A vein or other vessel can be modified in situ, prior to harvesting. Subsequently, at least a portion of the vessel is removed, and subsequently implanted to treat a patient, typically in a bypass procedure in which the vessel portion fluidly connects a source of oxygenated blood to an occluded artery.
摘要翻译： 公开了用于治疗用于医疗过程的血管的方法和装置。 在收获之前，静脉或其他血管可以在原位进行修改。 随后，移除血管的至少一部分，随后植入以治疗患者，通常在旁路过程中，血管部分将氧合血液源流体连接到闭塞动脉。
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公开(公告)号：US09445874B2
公开(公告)日：2016-09-20
申请号：US13811206
申请日：2011-07-19
申请人： Lorenzo Soletti , Mohammed S. El-Kurdi , Jon McGrath , Andrew Ziegler , J. Christopher Flaherty , William R. Wagner , David Vorp
发明人： Lorenzo Soletti , Mohammed S. El-Kurdi , Jon McGrath , Andrew Ziegler , J. Christopher Flaherty , William R. Wagner , David Vorp
CPC分类号： B05B5/12 , A61B90/00 , A61F2/022 , A61F2/04 , A61F2/06 , A61F2/07 , A61F2002/043 , A61F2002/046 , A61F2002/047 , A61F2002/048 , A61F2240/001 , A61L27/3625 , B05B5/0255 , D01D5/0084 , D01D13/02
摘要： A cartridge device is provided for applying a fiber matrix to a tubular member such as a saphenous vein graft. The cartridge includes a housing, a tubular member holder, a rotational drive, and a polymer delivery assembly. The housing defines a chamber which surrounds the tubular member holder. The rotational drive rotates the tubular member during the fiber application process.
摘要翻译： 提供了用于将纤维基质施加到诸如隐静脉移植物的管状构件上的药筒装置。 盒包括壳体，管状构件保持器，旋转驱动器和聚合物输送组件。 壳体限定围绕管状构件保持器的腔室。 旋转驱动器在纤维施加过程中旋转管状构件。
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公开(公告)号：US20130337101A1
公开(公告)日：2013-12-19
申请号：US13997933
申请日：2011-12-22
申请人： Jon McGrath , Lorenzo Soletti , Mohammed S. El-Kurdi , William R. Wagner , Christopher J. Flaherty
发明人： Jon McGrath , Lorenzo Soletti , Mohammed S. El-Kurdi , William R. Wagner , Christopher J. Flaherty
IPC分类号： B29C47/00
CPC分类号： B29C47/0076 , A61F2/06 , A61F2/062 , A61F2240/001 , A61L27/14 , A61L27/38 , A61L27/50 , D01D5/0076 , D04H1/728
摘要： A system for electrospinning a fiber matrix on a tubular member includes at least one nozzle, a tubular member in a spaced relationship to the at least one nozzle, and a fluid source for pressurizing a lumen of the tubular member. An electrical potential is applied between the at least one nozzle and either the tubular member or fluid from the fluid source. The electrical potential draws at least one fiber from the at least one nozzle to the tubular member.
摘要翻译： 用于在管状构件上静电纺丝纤维基质的系统包括至少一个喷嘴，与至少一个喷嘴间隔开的管状构件，以及用于对管状构件的内腔加压的流体源。 在至少一个喷嘴与来自流体源的管状部件或流体之间施加电位。 电势从至少一个喷嘴吸取至少一根光纤到管状部件。
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公开(公告)号：US09656417B2
公开(公告)日：2017-05-23
申请号：US13997933
申请日：2011-12-22
申请人： Jon McGrath , Lorenzo Soletti , Mohammed S. El-Kurdi , William R. Wagner , J. Christopher Flaherty
发明人： Jon McGrath , Lorenzo Soletti , Mohammed S. El-Kurdi , William R. Wagner , J. Christopher Flaherty
CPC分类号： B29C47/0076 , A61F2/06 , A61F2/062 , A61F2240/001 , A61L27/14 , A61L27/38 , A61L27/50 , D01D5/0076 , D04H1/728
摘要： A system for electrospinning a fiber matrix on a tubular member includes at least one nozzle, a tubular member in a spaced relationship to the at least one nozzle, and a fluid source for pressurizing a lumen of the tubular member. An electrical potential is applied between the at least one nozzle and either the tubular member or fluid from the fluid source. The electrical potential draws at least one fiber from the at least one nozzle to the tubular member.
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公开(公告)号：US09295541B2
公开(公告)日：2016-03-29
申请号：US13520009
申请日：2010-12-30
申请人： David Wagner , Lorenzo Soletti , Mohammed S. El-Kurdi , Jon McGrath , John T. Garibotto , J. Christopher Flaherty
发明人： David Wagner , Lorenzo Soletti , Mohammed S. El-Kurdi , Jon McGrath , John T. Garibotto , J. Christopher Flaherty
CPC分类号： A61F2/06 , A61F2/04 , A61F2/064 , A61F2210/0076 , A61F2250/0039 , A61L27/047 , A61L27/14 , A61L27/16 , A61L27/18 , A61L27/34 , A61L27/36 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/412 , A61L2430/36
摘要： A graft device is provided comprising a flow conduit and a surrounding covering. The graft device is for connecting between a first body space and a second body space. In one embodiment, the flow conduit is a vein, such as a harvested saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided are methods of preparing a graft device and connecting the graft between a first body space and a second body space, such as the aorta and a location on an occluded coronary artery, distal to the occlusion.
摘要翻译： 提供了移植装置，其包括流动管道和周围的覆盖物。 移植装置用于在第一身体空间和第二身体空间之间连接。 在一个实施例中，流动导管是静脉，例如收获的隐静脉，可用作动脉移植物，例如但不限于冠状动脉旁路手术。 还提供了制备移植装置并将移植物连接到第一身体空间和第二身体空间（例如主动脉）和封堵冠状动脉远端的位置的方法。
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