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    Fused heterocyclic compounds
    4.
    发明授权
    Fused heterocyclic compounds 失效
    稠合杂环化合物

    公开(公告)号：US06809104B2

    公开(公告)日：2004-10-26

    申请号：US10289933

    申请日：2002-11-06

    Applicant: Xiaoqi Chen ,  Pingchen Fan ,  Juan Jaen ,  Leping Li ,  Mike Lizarzaburu ,  Jeffrey Thomas Mihalic ,  Stephen Joseph Shuttleworth

    Inventor： Xiaoqi Chen ,  Pingchen Fan ,  Juan Jaen ,  Leping Li ,  Mike Lizarzaburu ,  Jeffrey Thomas Mihalic ,  Stephen Joseph Shuttleworth

    IPC: C07D47104

    CPC classification number: C07D471/04

    Abstract: Compounds having the formula: wherein L is a bond or (C1-C4)alkylene, R″ is hydrogen or (C1-C8)alkyl, and R1, R2, R4, R, R′, and the subscript n are as described herein, are provided, which are useful in the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor. Pharmaceutical compositions and methods of using these compounds for the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor, such as eating disorders, obesity, anxiety disorders and mood disorders, are also provided.

    Abstract translation: 具有下式的化合物：其中L是一个键或（C 1 -C 4）亚烷基，R“是氢或（C 1 -C 8）烷基，R 1，R 2，R 4，R，R '和下标n如本文所述，其可用于治疗和/或预防由G蛋白偶联受体介导的病症或病症。 还提供了使用这些化合物治疗和/或预防由G蛋白偶联受体介导的病症或病症的药物组合物和方法，例如进食障碍，肥胖症，焦虑障碍和情绪障碍。

    Fused heterocyclic compounds
    5.
    发明申请
    Fused heterocyclic compounds 审中-公开
    稠合杂环化合物

    公开(公告)号：US20080058365A1

    公开(公告)日：2008-03-06

    申请号：US11881805

    申请日：2007-07-26

    Applicant: Xi Chen ,  Xiaoqi Chen ,  Pingchen Fan ,  Juan Jaen ,  Leping Li ,  Jeffrey Mihalic

    Inventor： Xi Chen ,  Xiaoqi Chen ,  Pingchen Fan ,  Juan Jaen ,  Leping Li ,  Jeffrey Mihalic

    IPC: A61K31/4353 ,  A61P3/04

    CPC classification number: C07D471/04

    Abstract: Compounds, compositions and methods are provided that are useful in the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor. In particular, the compounds of the invention are useful in the treatment and/or prevention of eating disorders, obesity, anxiety disorders and mood disorders.

    Abstract translation: 提供了可用于治疗和/或预防由G蛋白偶联受体介导的病症或病症的化合物，组合物和方法。 特别地，本发明的化合物可用于治疗和/或预防进食障碍，肥胖，焦虑障碍和情绪障碍。

    Combination therapeutic compositions and methods of use
    9.
    发明申请
    Combination therapeutic compositions and methods of use 失效
    组合治疗组合物和使用方法

    公开(公告)号：US20060035928A1

    公开(公告)日：2006-02-16

    申请号：US11258817

    申请日：2005-10-26

    Applicant: Juan Jaen ,  Jin-Long Chen

    Inventor： Juan Jaen ,  Jin-Long Chen

    IPC: A61K31/47 ,  A61K31/165

    CPC classification number: A61K45/06 ,  A61K31/00 ,  A61K31/165 ,  A61K31/47 ,  Y10S514/866 ,  A61K2300/00

    Abstract: The present invention provides pharmaceutical compositions and methods for the treatment of diabetes mellitus using combination therapy. The compositions relate to a compound of Formula I and an antidiabetic agent such as sulfonylureas, biguanides, glitazones, α-glucosidase inhibitors, potassium channel antagonists, aldose reductase inhibitors, glucagon antagonists, activators of RXR, insulin therapy or other anti-obesity agent. The methods include the administration of the combination of compound of Formula I with antidiabetic agent where the two components are delivered in a simultaneous manner, where the compound of Formula I is administered first, followed by the antidiabetic agent, as well as wherein the antidiabetic agent is delivered first followed by the compound of Formula I.

    Abstract translation: 本发明提供了使用组合疗法治疗糖尿病的药物组合物和方法。 组合物涉及式I化合物和抗糖尿病药如磺酰脲类，双胍类，格列酮，α-葡糖苷酶抑制剂，钾通道拮抗剂，醛糖还原酶抑制剂，胰高血糖素拮抗剂，RXR的激活剂，胰岛素治疗或其它抗肥胖剂。 所述方法包括施用式I化合物与抗糖尿病药物的组合，其中两种成分以同时方式递送，其中首先给予式I化合物，然后是抗糖尿病药，以及其中抗糖尿病药 首先交付，然后是式I的化合物。

    Bis-aryl thiazole derivatives
    10.
    发明申请
    Bis-aryl thiazole derivatives 失效
    双芳基噻唑衍生物

    公开(公告)号：US20050215608A1

    公开(公告)日：2005-09-29

    申请号：US10481218

    申请日：2002-06-27

    Applicant: M. Amaral ,  Jin-Long Chen ,  Juan Jaen ,  David Johnston ,  Paul Rafferty

    Inventor： M. Amaral ,  Jin-Long Chen ,  Juan Jaen ,  David Johnston ,  Paul Rafferty

    IPC: A61K31/427 ,  C07D417/04

    CPC classification number: C07D417/04 ,  A61K31/427

    Abstract: Compounds, compositions and methods are provided that are useful in the treatment or prevention of a condition or disorder mediated by an uncoupling protein. In particular, the compounds of the invention modulate the expression and/or activity of UCP3. The subject compositions are particularly useful in the treatment of obesity and type II diabetes, and associated diseases.

    Abstract translation: 提供了可用于治疗或预防解偶联蛋白介导的病症或病症的化合物，组合物和方法。 特别地，本发明的化合物调节UCP3的表达和/或活性。 本发明组合物特别可用于治疗肥胖症和II型糖尿病以及相关疾病。

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