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1.发明授权Gem-disubstituted and spirocyclic amino pyridines/pyrimidines as cell cycle inhibitors 有权双 - 二取代和螺环氨基吡啶/嘧啶作为细胞周期抑制剂公开(公告)号：US08389533B2
公开(公告)日：2013-03-05
申请号：US12936725
申请日：2009-04-06
Applicant: Richard V. Connors , Kang Dai , John Eksterowicz , Pingchen Fan , Benjamin Fisher , Jiasheng Fu , Kexue Li , Zhihong Li , Lawrence R. McGee , Rajiv Sharma , Xiaodong Wang
Inventor： Richard V. Connors , Kang Dai , John Eksterowicz , Pingchen Fan , Benjamin Fisher , Jiasheng Fu , Kexue Li , Zhihong Li , Lawrence R. McGee , Rajiv Sharma , Xiaodong Wang
IPC: A01N43/54 , A61K31/505 , C07D237/00 , C07D239/00 , C07D241/00
CPC classification number: C07D471/04 , C07D239/70 , C07D401/12 , C07D471/10 , C07D487/10 , C07D491/10 , C07D491/107 , C07D491/20
Abstract: Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4-mediated disorders, such as cancer. The subject compounds are gem-disubstituted or spirocyclic pyridine, pyrimidine and triazine derivatives.
Abstract translation: 提供了可用于治疗CDK4介导的疾病如癌症的化合物，药物组合物和方法。 主题化合物是偕二取代或螺环吡啶，嘧啶和三嗪衍生物。
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公开(公告)号：US20070135425A1
公开(公告)日：2007-06-14
申请号：US11649938
申请日：2007-01-05
Applicant: Xiaoqi Chen , Kang Dai , Pingchen Fan , Shugui Huang , Leping Li , Jeffrey Mihalic
Inventor： Xiaoqi Chen , Kang Dai , Pingchen Fan , Shugui Huang , Leping Li , Jeffrey Mihalic
IPC: A61K31/541 , A61K31/5377 , A61K31/4745 , C07D471/02
CPC classification number: C07D471/04
Abstract: Compounds, compositions and methods are provided that are useful in the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor. In particular, the compounds of the invention are useful in the treatment and/or prevention of eating disorders, obesity, anxiety disorders and mood disorders.
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公开(公告)号：US07045527B2
公开(公告)日：2006-05-16
申请号：US10669606
申请日：2003-09-23
Applicant: Xiaoqi Chen , Kang Dai , Pingchen Fan , Ying Fu , Leping Li , Jeffrey T. Mihalic
Inventor： Xiaoqi Chen , Kang Dai , Pingchen Fan , Ying Fu , Leping Li , Jeffrey T. Mihalic
IPC: A61K31/438 , C07D401/06 , C07D401/14
CPC classification number: C07D401/06 , A61K31/4747 , C07D401/14 , C07D405/04 , C07D471/10 , C07D495/10
Abstract: Compounds, compositions and methods are provided that are useful in the treatment or prevention of conditions or disorders associated with a neuropeptide receptor. The subject methods are particularly useful in the treatment and/or prevention of endocrine, metabolic, cardiovascular, neurologic, psychiatric, gastrointestinal, genitourinary and other disorders.
Abstract translation: 提供了可用于治疗或预防与神经肽受体相关的病症或病症的化合物，组合物和方法。 本发明的方法在治疗和/或预防内分泌，代谢，心血管，神经系统，精神病学，胃肠道，泌尿生殖和其它疾病方面特别有用。
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公开(公告)号：US08623885B2
公开(公告)日：2014-01-07
申请号：US13425817
申请日：2012-03-21
Applicant: Xiaoqi Chen , Kang Dai , Jason Duquette , Michael W. Gribble, Jr. , Justin N. Huard , Kathleen S. Keegan , Zhihong Li , Sarah E. Lively , Lawrence R. McGee , Mark L. Ragains , Xianghong Wang , Margaret F. Weidner , Jian Zhang
Inventor： Xiaoqi Chen , Kang Dai , Jason Duquette , Michael W. Gribble, Jr. , Justin N. Huard , Kathleen S. Keegan , Zhihong Li , Sarah E. Lively , Lawrence R. McGee , Mark L. Ragains , Xianghong Wang , Margaret F. Weidner , Jian Zhang
IPC: A61K31/505 , C07D487/12
CPC classification number: C07D519/00 , C07D471/14
Abstract: Compounds of Formula I are useful inhibitors of CDK 4, CDK6, and FLT3. Such compounds are useful in treating cancer and various other disease conditions. Compounds of Formula I have the following structure: where R1 is a group of Formula IA, Formula IB, Formula IC, or Formula ID and the definitions of the other variables are provided herein.
Abstract translation: 式I化合物是CDK 4，CDK 6和FLT 3的有用抑制剂。 这些化合物可用于治疗癌症和各种其他疾病状况。 式I的化合物具有以下结构：其中R1是式IA，式IB，式IC或式ID的基团，并且本文提供了其它变量的定义。
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公开(公告)号：US20090226436A1
公开(公告)日：2009-09-10
申请号：US12384910
申请日：2009-04-09
Applicant: Hui Tian , Kang Dai , Jin-Long Chen , Jiagang Zhao , Gene Cutler
Inventor： Hui Tian , Kang Dai , Jin-Long Chen , Jiagang Zhao , Gene Cutler
IPC: A61K39/395 , G01N33/566 , C12N15/12 , C07K14/47 , C12Q1/68 , A61P25/00
CPC classification number: C07K14/705
Abstract: The invention provides isolated nucleic acid and amino acid sequences of novel receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of the receptors.
Abstract translation: 本发明提供了分离的新型受体的核酸和氨基酸序列，这种受体的抗体，检测这种核酸和受体的方法，以及筛选受体调节剂的方法。
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Patent Agency Ranking
公开(公告)号：US07572783B2
公开(公告)日：2009-08-11
申请号：US11203562
申请日：2005-08-12
Applicant: Xi Chen , Xiaoqi Chen , Richard Victor Connors , Kang Dai , Ying Fu , Juan C. Jaen , Yong-Jae Kim , Leping Li , Mike E. Lizarzaburu , Jeffrey T. Mihalic , Stephen J. Shuttleworth
Inventor： Xi Chen , Xiaoqi Chen , Richard Victor Connors , Kang Dai , Ying Fu , Juan C. Jaen , Yong-Jae Kim , Leping Li , Mike E. Lizarzaburu , Jeffrey T. Mihalic , Stephen J. Shuttleworth
IPC: A61K31/4709 , A61K31/553 , C07D217/02 , C07D267/02
CPC classification number: C07D417/06 , C07D217/24 , C07D223/16 , C07D243/14 , C07D401/06 , C07D401/12 , C07D487/04 , C07D491/10
Abstract: The present invention relates to the compounds of Formula I, their preparation and pharmaceutical compositions comprising them. The compounds and pharmaceutical compositions are useful, for example, for the treatment and prevention of obesity, obesity-related disorders and eating disorders.
Abstract translation: 本发明涉及式I化合物，其制备方法和包含它们的药物组合物。 化合物和药物组合物可用于例如治疗和预防肥胖，肥胖相关疾病和进食障碍。
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公开(公告)号：US20050170397A1
公开(公告)日：2005-08-04
申请号：US11038360
申请日：2005-01-18
Applicant: Hui Tian , Jiagang Zhao , Jin-Long Chen , Gene Cutler , Songzhu An , Kang Dai , Jamila Gupte
Inventor： Hui Tian , Jiagang Zhao , Jin-Long Chen , Gene Cutler , Songzhu An , Kang Dai , Jamila Gupte
CPC classification number: C07K14/723 , A61K38/00
Abstract: The invention provides isolated nucleic acid and amino acid sequences of novel G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of G-protein coupled receptors.
Abstract translation: 本发明提供了分离的新型G蛋白偶联受体的核酸和氨基酸序列，这种受体的抗体，检测此类核酸和受体的方法，以及筛选G蛋白偶联受体调节剂的方法。
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公开(公告)号：US20060199796A1
公开(公告)日：2006-09-07
申请号：US11203562
申请日：2005-08-12
Applicant: Xi Chen , Xiaoqi Chen , Richard Connors , Kang Dai , Ying Fu , Juan Jaen , Yong-Jae Kim , Leping Li , Mike Lizarzaburu , Jeffrey Mihalic , Stephen Shuttleworth
Inventor： Xi Chen , Xiaoqi Chen , Richard Connors , Kang Dai , Ying Fu , Juan Jaen , Yong-Jae Kim , Leping Li , Mike Lizarzaburu , Jeffrey Mihalic , Stephen Shuttleworth
IPC: A61K31/553 , A61K31/5513 , A61K31/4709
CPC classification number: C07D417/06 , C07D217/24 , C07D223/16 , C07D243/14 , C07D401/06 , C07D401/12 , C07D487/04 , C07D491/10
Abstract: The present invention relates to the compounds of Formula I, their preparation and pharmaceutical compositions comprising them. The compounds and pharmaceutical compositions are useful, for example, for the treatment and prevention of obesity, obesity-related disorders and eating disorders.
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公开(公告)号：US20120244110A1
公开(公告)日：2012-09-27
申请号：US13425817
申请日：2012-03-21
Applicant: Xiaoqi Chen , Kang Dai , Jason Duquette , Michael W. Gribble, JR. , Justin N. Huard , Kathleen S. Keegan , Zhihong Li , Sarah E. Lively , Lawrence R. McGee , Mark L. Ragains , Xianghong Wang , Margaret F. Weidner , Jian Zhang
Inventor： Xiaoqi Chen , Kang Dai , Jason Duquette , Michael W. Gribble, JR. , Justin N. Huard , Kathleen S. Keegan , Zhihong Li , Sarah E. Lively , Lawrence R. McGee , Mark L. Ragains , Xianghong Wang , Margaret F. Weidner , Jian Zhang
IPC: A61K31/519 , A61K31/7068 , A61K31/704 , A61P35/02 , A61K31/573 , A61K39/395 , A61K38/19 , A61P35/00 , C07D471/14 , A61K31/664
CPC classification number: C07D519/00 , C07D471/14
Abstract: Compounds of Formula I are useful inhibitors of CDK 4, CDK6, and FLT3. Such compounds are useful in treating cancer and various other disease conditions. Compounds of Formula I have the following structure: where R1 is a group of Formula IA, Formula IB, Formula IC, or Formula ID and the definitions of the other variables are provided herein.
Abstract translation: 式I化合物是CDK 4，CDK 6和FLT 3的有用抑制剂。 这些化合物可用于治疗癌症和各种其他疾病状况。 式I的化合物具有以下结构：其中R1是式IA，式IB，式IC或式ID的基团，并且本文提供了其它变量的定义。
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10.发明申请Fused Pyridine, Pyrimidine and Triazine Compounds as Cell Cycle Inhibitors 有权融合吡啶，嘧啶和三嗪化合物作为细胞周期抑制剂公开(公告)号：US20110142796A1
公开(公告)日：2011-06-16
申请号：US12808621
申请日：2008-12-18
Applicant: Richard V. Connors , Kang Dai , John Eksterowicz , Pingchen Fan , Benjamin Fisher , Jiasheng Fu , Kexue Li , Zhihong Li , Lawrence R. Mcgee , Rajiv Sharma , Xiaodong Wang , Dustin L. Mcminn , Jeffrey T. Mihalic , Jeffrey Deignan
Inventor： Richard V. Connors , Kang Dai , John Eksterowicz , Pingchen Fan , Benjamin Fisher , Jiasheng Fu , Kexue Li , Zhihong Li , Lawrence R. Mcgee , Rajiv Sharma , Xiaodong Wang , Dustin L. Mcminn , Jeffrey T. Mihalic , Jeffrey Deignan
IPC: A61K31/519 , C07D471/14 , C07D487/04 , A61K31/551 , C07D487/14 , A61K31/5377 , C07D513/14 , A61K31/496 , C07D498/10 , A61K31/5386 , A61P35/00 , A61P35/04 , A61K38/21
CPC classification number: C07D471/14 , A61K31/519 , A61K31/5377 , A61K31/5386 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/14 , C07D491/107 , C07D491/147 , C07D498/04 , C07D498/10 , C07D513/14
Abstract: Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4-mediated disorders, such as cancer. The subject compounds are fused pyridine, pyrimide and triazine derivatives.
Abstract translation: 提供了可用于治疗CDK4介导的疾病如癌症的化合物，药物组合物和方法。 本发明化合物是吡啶，吡嗪酰亚胺和三嗪衍生物。
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