公开(公告)号：US20050250133A1

公开(公告)日：2005-11-10

申请号：US11070519

申请日：2005-03-01

Applicant: David Ecker ,  Steven Hofstadler ,  Richard Griffey ,  Rangarajan Sampath ,  Kristin Lowery ,  Christian Massire

Inventor： David Ecker ,  Steven Hofstadler ,  Richard Griffey ,  Rangarajan Sampath ,  Kristin Lowery ,  Christian Massire

IPC: C12N5/02 ,  C12N15/11 ,  C12Q1/68 ,  G01N33/48 ,  G01N33/50 ,  G06F19/00

CPC classification number: C12N15/11

Abstract: Polynucleotides comprising molecular interaction sites of 16S rRNA that have particular secondary structure are provided. Methods of using such polynucleotides to screen, virtually or actually, combinatorial libraries of compounds that bind thereto are also provided. Method of modulating the activity of 16S rRNA by contacting 16S rRNA or prokaryotic cells containing the same with a compound identified by such virtual or actual screening are also provided.

Abstract translation: 提供了包含具有特定二级结构的16S rRNA的分子相互作用位点的多核苷酸。 还提供了使用这样的多核苷酸筛选，实际上或实际上筛选结合其的化合物的组合文库的方法。 还提供了通过将含有该酶的16S rRNA或原核细胞与通过这种虚拟或实际筛选鉴定的化合物接触来调节16S rRNA活性的方法。

公开(公告)号：US20070218467A1

公开(公告)日：2007-09-20

申请号：US11491376

申请日：2006-07-21

Applicant: David Ecker ,  Steven Hofstadler ,  Thomas Hall ,  Kristin Lowery

Inventor： David Ecker ,  Steven Hofstadler ,  Thomas Hall ,  Kristin Lowery

IPC: C12Q1/68 ,  C12P19/34

CPC classification number: C12Q1/6872 ,  C12Q1/6827 ,  C12Q1/6844 ,  C12Q1/6858 ,  C12Q1/6881 ,  C12Q2600/156 ,  C12Q2600/16 ,  C12Q2565/627 ,  C12Q2537/143 ,  C12Q2531/113 ,  C12Q2545/10

Abstract: There is a need for nucleic acid analysis which is both specific and rapid, and in which no nucleic acid sequencing is required. The present invention addresses this need, among others by providing a method of nucleic acid amplification of overlapping sub-segments of a nucleic acid followed by molecular mass measurement of resulting amplification products by mass spectrometry, and determination of the base compositions of the amplification products.

Abstract translation: 需要具有特异性和快速性的核酸分析，并且其中不需要核酸测序。 本发明除了提供核酸扩增核酸扩增方法之外，还通过质谱法对所得扩增产物进行分子量测定，以及确定扩增产物的碱基组成来解决这一需要。

公开(公告)号：US20050100885A1

公开(公告)日：2005-05-12

申请号：US10831901

申请日：2004-04-26

Applicant: Stanley Crooke ,  David Ecker ,  Rangarajan Sampath ,  Susan Freier ,  Christian Massire ,  Steven Hofstadler ,  Kristin Lowery ,  Eric Swayze ,  Brenda Baker ,  C. Bennett

Inventor： Stanley Crooke ,  David Ecker ,  Rangarajan Sampath ,  Susan Freier ,  Christian Massire ,  Steven Hofstadler ,  Kristin Lowery ,  Eric Swayze ,  Brenda Baker ,  C. Bennett

IPC: A01N43/04 ,  A61B20060101 ,  A61K31/07 ,  A61K48/00 ,  C07H21/02 ,  C07H21/04 ,  C07K16/10 ,  C12N15/113 ,  C12Q1/68 ,  C12Q1/70

CPC classification number: C12N15/1131 ,  C07K16/10 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3525

Abstract: The present invention provides design and synthesis of oligomeric compounds and compositions that can be administered to reduce the activity of SARS virus in vivo or in vitro, to prevent or treat SARS virus-associated disease, to detect AARS virus, and to diagnose SARS virus-associated diseases.

Abstract translation: 本发明提供可以施用以降低SARS病毒在体内或体外的活性，预防或治疗SARS病毒相关疾病，检测AARS病毒和诊断SARS病毒的寡聚化合物和组合物的设计和合成， 相关疾病