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    Multi-stage, regression-based PCR analysis system
    1.
    发明授权
    Multi-stage, regression-based PCR analysis system 有权
    多阶段回归分析系统

    公开(公告)号：US09442891B2

    公开(公告)日：2016-09-13

    申请号：US14043786

    申请日：2013-10-01

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Jeffrey Lerner

    IPC: G01N33/48 ,  G06F17/10 ,  G06F11/30

    CPC classification number: G06F17/10 ,  C12Q1/6851 ,  C12Q1/686 ,  C12Q2537/165 ,  C12Q2545/10 ,  C12Q2545/114 ,  C12Q2531/113

    Abstract: Systems and methods are provided for analyzing data to determine properties of a PCR processor other process exhibiting amplification or growth. Data representing an amplification can be distinguished from data representing a jump or other error. A modified sigmoid function containing a drift term may be used in determining the properties. A multi-stage functional fit of the amplification data can provide increased accuracy and consistency of one or more of the properties. A baseline of the amplification data can be determined by analyzing an integrated area of a first derivative function of the data. A reference quantitation value can also be determined from locations of maxima of different derivative functions of the amplification data, e.g., a weighted average of the maxima locations for the second and third derivatives may be used.

    Abstract translation: 提供了系统和方法用于分析数据以确定PCR处理器表现出放大或生长的其他过程的性质。 表示放大的数据可以与表示跳跃或其他错误的数据区分开。 可以使用包含漂移项的修改后的S形函数来确定属性。 扩增数据的多阶段功能拟合可以提供一种或多种性质的增加的精度和一致性。 可以通过分析数据的一阶导数函数的积分区域来确定放大数据的基线。 参考定量值也可以从放大数据的不同导数函数的最大值的位置确定，例如可以使用第二和第三导数的最大值位置的加权平均值。

    MULTI-STAGE, REGRESSION-BASED PCR ANALYSIS SYSTEM
    4.
    发明申请
    MULTI-STAGE, REGRESSION-BASED PCR ANALYSIS SYSTEM 有权
    多阶段，基于回归的PCR分析系统

    公开(公告)号：US20100070190A1

    公开(公告)日：2010-03-18

    申请号：US12556416

    申请日：2009-09-09

    Applicant: Jeffrey Lerner

    Inventor： Jeffrey Lerner

    IPC: G06F17/18 ,  G06F19/00

    CPC classification number: G06F17/10 ,  C12Q1/6851 ,  C12Q1/686 ,  C12Q2537/165 ,  C12Q2545/10 ,  C12Q2545/114 ,  C12Q2531/113

    Abstract: Systems and methods are provided for analyzing data to determine properties of a PCR process or other process exhibiting amplification or growth. Data representing an amplification can be distinguished from data representing a jump or other error. A modified sigmoid function containing a drift term may be used in determining the properties. A multi-stage functional fit of the amplification data can provide increased accuracy and consistency of one or more of the properties. A baseline of the amplification data can be determined by analyzing an integrated area of a first derivative function of the data. A reference quantitation value can also be determined from locations of maxima of different derivative functions of the amplification data, e.g., a weighted average of the maxima locations for the second and third derivatives may be used.

    Abstract translation: 提供系统和方法用于分析数据以确定PCR过程的性质或显示放大或生长的其它过程。 表示放大的数据可以与表示跳跃或其他错误的数据区分开。 可以使用包含漂移项的修改后的S形函数来确定属性。 扩增数据的多阶段功能拟合可以提供一种或多种性质的增加的精度和一致性。 可以通过分析数据的一阶导数函数的积分区域来确定放大数据的基线。 参考定量值也可以从放大数据的不同导数函数的最大值的位置确定，例如，可以使用第二和第三导数的最大值位置的加权平均值。

    METHOD, KIT AND ARRAY FOR BIOMARKER VALIDATION AND CLINICAL USE
    6.
    发明申请
    METHOD, KIT AND ARRAY FOR BIOMARKER VALIDATION AND CLINICAL USE 审中-公开
    方法，用于生物标记验证和临床使用的套件和阵列

    公开(公告)号：US20150100242A1

    公开(公告)日：2015-04-09

    申请号：US14384913

    申请日：2013-03-15

    Applicant: QIAGEN SCIENCES LLC

    Inventor： Xiao Zeng ,  Song Tian ,  Jiaye Yu ,  John Dicarlo ,  George J. Quellhorst, JR. ,  Vikram Devgan

    IPC: C12Q1/68 ,  G06F19/10

    CPC classification number: C12Q1/686 ,  C12Q1/6811 ,  C12Q1/6851 ,  C12Q1/6883 ,  C12Q2600/158 ,  G16B99/00 ,  C12Q2537/165 ,  C12Q2531/113 ,  C12Q2545/10

    Abstract: The methods provided focus on a quantitative molecular assay tools that systematically measure a set of pre-selected targets, with proper controls in a biological sample for identification of biomarkers or novel targets for a disease status. This allows for systematically maximizing the power of multivariate feature selection tools on the analysis of high-throughput screening data (such as microarray) and use of the well selected target to generate a qPCR array with tissue specific controls and qPCR controls to serve the needs of biomarker study.

    Abstract translation: 所提供的方法侧重于定量分析测定工具，其系统地测量一组预先选定的靶标，在生物样品中进行适当的控制以鉴定生物标志物或用于疾病状态的新靶标。 这允许系统地最大化多变量特征选择工具对高通量筛选数据（例如微阵列）的分析的功能，以及使用选择良好的目标来生成具有组织特异性控制和qPCR控制的qPCR阵列，以满足 生物标志物研究。

    MULTI-STAGE, REGRESSION-BASED PCR ANALYSIS SYSTEM
    7.
    发明申请
    MULTI-STAGE, REGRESSION-BASED PCR ANALYSIS SYSTEM 有权
    多阶段，基于回归的PCR分析系统

    公开(公告)号：US20130018593A1

    公开(公告)日：2013-01-17

    申请号：US13625757

    申请日：2012-09-24

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Jeffrey Lerner

    IPC: G06F19/00

    CPC classification number: G06F17/10 ,  C12Q1/6851 ,  C12Q1/686 ,  C12Q2537/165 ,  C12Q2545/10 ,  C12Q2545/114 ,  C12Q2531/113

    Abstract: Systems and methods are provided for analyzing data to determine properties of a PCR process or other process exhibiting amplification or growth. Data representing an amplification can be distinguished from data representing a jump or other error. A modified sigmoid function containing a drift term may be used in determining the properties. A multi-stage functional fit of the amplification data can provide increased accuracy and consistency of one or more of the properties. A baseline of the amplification data can be determined by analyzing an integrated area of a first derivative function of the data. A reference quantitation value can also be determined from locations of maxima of different derivative functions of the amplification data, e.g., a weighted average of the maxima locations for the second and third derivatives may be used.

    Abstract translation: 提供系统和方法用于分析数据以确定PCR过程的性质或显示放大或生长的其它过程。 表示放大的数据可以与表示跳跃或其他错误的数据区分开。 可以使用包含漂移项的修改后的S形函数来确定属性。 扩增数据的多阶段功能拟合可以提供一种或多种性质的增加的精度和一致性。 可以通过分析数据的一阶导数函数的积分区域来确定放大数据的基线。 参考定量值也可以从放大数据的不同导数函数的最大值的位置确定，例如可以使用第二和第三导数的最大值位置的加权平均值。

    Multiplexed quantitative detection of pathogens
    10.
    发明申请
    Multiplexed quantitative detection of pathogens 审中-公开
    多重定量检测病原体

    公开(公告)号：US20070134652A1

    公开(公告)日：2007-06-14

    申请号：US11595459

    申请日：2006-11-09

    Applicant: Vladimir Slepnev ,  Kazumi Shiosaki ,  Kyle Hart ,  Elizabeth Garcia

    Inventor： Vladimir Slepnev ,  Kazumi Shiosaki ,  Kyle Hart ,  Elizabeth Garcia

    IPC: C12Q1/70 ,  C12Q1/68

    CPC classification number: C12Q1/6888 ,  C12Q1/6851 ,  C12Q1/686 ,  C12Q1/6865 ,  C12Q1/701 ,  C12Q1/705 ,  C12Q2600/16 ,  C12Q2561/113 ,  C12Q2545/10 ,  C12Q2537/143 ,  C12Q2545/107 ,  C12Q2525/204

    Abstract: The invention allows for the quantitative detection of a plurality of pathogens in a single sample. The method includes the amplification of a sample with a plurality of pathogen-specific primer pairs to generate amplicons of distinct sizes from each of the pathogen specific primer pairs. The method further includes the use of a plurality of competitor polynucleotide targets that correspond to each of the pathogen-specific primer pairs. The competitor polynucleotides are added to the reaction mixture at a known concentration to allow for the quantitation of the amount of pathogen in the sample. The method can be used for monitoring pathogen infection in an individual, preferably an immunocompromised individual.

    Abstract translation: 本发明允许在单个样品中定量检测多种病原体。 该方法包括用多个病原体特异性引物对扩增样品以从每个病原体特异性引物对产生不同大小的扩增子。 该方法还包括使用对应于每个病原体特异性引物对的多个竞争剂多核苷酸靶。 将竞争剂多核苷酸以已知浓度加入到反应混合物中，以允许定量样品中病原体的量。 该方法可用于监测个体，优选免疫受损个体中的病原体感染。

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