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公开(公告)号：US12061189B2
公开(公告)日：2024-08-13
申请号：US16624087
申请日：2018-06-21
Applicant: Laboratoires Expanscience
Inventor： Gaelle Bellemere , Stephanie Bredif , Gaetan Boyer , Caroline Baudouin
CPC classification number: G01N33/5088 , C12N5/0698 , C12N2503/06
Abstract: The present invention relates to models of reconstructed sensitive skin reproducing the features of sensitive skin, as well as to processes for obtaining such models. The present invention further relates to in vitro processes for testing formulations or active ingredients for the prevention or treatment of sensitive skin.
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公开(公告)号：US10444225B2
公开(公告)日：2019-10-15
申请号：US14418645
申请日：2013-08-02
Applicant: LABORATOIRES EXPANSCIENCE
Inventor： Philippe Msika , Nadège Lachmann , Joachim Fluhr
IPC: G01N33/50
Abstract: The present invention relates to a method for determining the isotropy of the skin surface of a subject, and hence the degree of maturation of the said skin surface, by examining various parameters reflecting the cell organization. Methods for identifying active agents, raw materials and formulation are also provided.
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3.发明申请公开(公告)号：US20190000902A1
公开(公告)日：2019-01-03
申请号：US16064312
申请日：2016-12-21
Applicant: LABORATOIRES EXPANSCIENCE
Inventor： Sophie LECLERE-BIENFAIT , Stéphanie BREDIF
IPC: A61K36/185 , A61K8/9789 , A61K8/49 , A61K8/368 , A61Q19/08 , A61Q17/04 , A61P17/16 , A61P29/00 , A61K31/353 , A61K31/192
Abstract: The invention relates to a polyphenolic extract of passion flower seeds, in particular Passiflora incarnata or Passiflora edulis seeds, comprising at least 30 percent by weight polyphenols, expressed as gallic acid equivalent, relative to the weight of the dry extract. The invention also relates to a method for preparing an extract of said type, a composition containing same, and the cosmetic, dermatological or therapeutic use thereof.
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公开(公告)号：US20180369193A1
公开(公告)日：2018-12-27
申请号：US16117511
申请日：2018-08-30
Applicant: LABORATOIRES EXPANSCIENCE
Inventor： Alex SAUNOIS , Caroline BAUDOUIN , Sophie LECLERE-BIENFAIT , Sebastien GARNIER , Philippe MSIKA
IPC: A61K31/353 , A23L33/105 , A61Q19/00 , A23L19/00 , A61K9/00 , A61K8/49 , A61Q19/08 , A61Q19/02 , A61Q17/00 , A61K36/54 , A61K8/97 , A61Q17/04 , A61Q5/12 , A61K45/06
Abstract: The invention relates to an avocado extract rich in polyphenols, containing at least 10% by weight of polyphenols, expressed in gallic acid equivalent relative to the dry extract obtained, wherein said polyphenols contain procyanidins, cafeic acid and cafeic acid derivatives, typically in a proportion of at least 70% by weight, expressed in gallic acid equivalent relative to the total polyphenol content by weight. The invention also relates to a composition comprising an extract according to the invention as active agent and a suitable excipient. The invention also relates to such a composition or such an extract for use thereof in preventing or treating disorders or pathological conditions of the skin, the mucous membranes or the superficial body growths. Finally, the invention relates to a cosmetic care process for the skin, the superficial body growths or the mucous membranes, with a view to improving the condition thereof or the appearance thereof, which consists in administering such a composition or such an extract.
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公开(公告)号：US10143648B2
公开(公告)日：2018-12-04
申请号：US15529694
申请日：2015-11-26
Applicant: LABORATOIRES EXPANSCIENCE
Inventor： Philippe Msika , Caroline Baudouin , Stéphanie Bredif
Abstract: The present invention relates to the use of a peptide and glycoside extract of Schizandra fruit as a cutaneous neurosensory agent, for improving the response of the cutaneous neurosensory system, in particular for: —improving cutaneous innervation in the basal state, —combatting age-related loss of cutaneous innervation in the basal state, advantageously for preventing loss of the cutaneous sensitivity and/or combatting thinning of the epidermis, and/or —improving cutaneous perception of the environment, more particularly for combatting burns, extreme cold and/or pain.
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Patent Agency Ranking
公开(公告)号：US20170241989A1
公开(公告)日：2017-08-24
申请号：US15128717
申请日：2015-03-31
Applicant: LABORATOIRES EXPANSCIENCE
Inventor： Caroline Baudouin
CPC classification number: G01N33/5088 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/5023 , G01N33/6881 , G01N2500/04 , G01N2500/10
Abstract: The invention relates to biomarkers of the skin of children and, in particular, that of infants, having altered expression in the presence of urine. Such markers are particularly advantageous as they allow the skin's response to urine to be monitored. The inventors have developed methods for evaluating the efficacy in vitro of formulations in preventing the harmful effects of urine on a child's skin, using a skin model specifically capable of reproducing the characteristics of children's skin.
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公开(公告)号：US09616009B2
公开(公告)日：2017-04-11
申请号：US14514646
申请日：2014-10-15
Applicant: LABORATOIRES EXPANSCIENCE
Inventor： Caroline Baudouin , Philippe Msika
IPC: A61K8/60 , A61K8/97 , A61K9/48 , A61K31/70 , A61K31/7004 , A61K36/54 , A61K45/06 , A61Q3/00 , A61Q7/00 , A23L2/52 , A61Q5/02 , A61Q5/06 , A61Q5/12 , A23L7/126 , A61Q5/00
CPC classification number: A61K8/60 , A23L2/52 , A23L7/126 , A23V2002/00 , A61K8/97 , A61K9/4858 , A61K31/70 , A61K31/7004 , A61K36/54 , A61K45/06 , A61K2800/5922 , A61K2800/92 , A61Q3/00 , A61Q5/00 , A61Q5/006 , A61Q5/02 , A61Q5/06 , A61Q5/12 , A61Q7/00 , A61K2300/00
Abstract: The present invention relates to a composition including at least one C7 sugar, or derivative from esterification of said sugar, and a pharmaceutically acceptable carrier for treating alopecia. The present invention also relates to a method for cosmetically treating hair and nails, said method being intended to stimulate the growth thereof and/or slow the loss thereof. According to said method, a cosmetic composition including at least one C7 sugar, or derivative from esterification of said sugar, is administered. The present invention finally relates to a method for cosmetic care of hair and/or eyelashes and/or nails.
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8.发明授权公开(公告)号：US09422504B2
公开(公告)日：2016-08-23
申请号：US14368895
申请日：2012-12-26
Applicant: LABORATOIRES EXPANSCIENCE
Inventor： Philippe Msika , Jacques Legrand
CPC classification number: C11B1/06 , A23L19/00 , A23L33/105 , A23L33/115 , A61K36/54 , C11B1/04 , C11B1/08 , C11B1/10 , C11B1/102
Abstract: The present invention relates to the use of whole soft avocados to obtain an avocado oil rich in unsaponifiable, said unsaponifiable containing aliphatic acetogenins and/or their derivatives. Advantageously, the oil has an acid value less than or equal to 3 mgKOH/g. The invention also relates to a process for obtaining an avocado oil rich in unsaponifiable from whole soft avocados. said unsaponifiable containing aliphatic acetogenins and/or their derivatives. The invention also relates to an avocado oil rich in unsaponifiable obtainable by this process. The invention also relates to the use of the avocado oil to prepare a concentrate of avocado oil enriched in unsaponifiable or an avocado unsaponifiable rich in aliphatic furans. Finally, the invention relates to an avocado unsaponifiable rich in aliphatic furans or a concentrate of avocado oil enriched in unsaponifiable, obtainable from said avocado oil, for its use as a drug, advantageously in the prevention and/or the treatment of connective tissue disorders such as arthrosis, articular pathologies such as rhumatisms, or parodontal disorders, such as gingivitis or parodontitis.
Abstract translation: 本发明涉及使用整个软的鳄梨来获得富含不皂化的所述不皂化的含脂肪酸乙偶姻和/或其衍生物的鳄梨油。 有利地，油的酸值小于或等于3mgKOH / g。 本发明还涉及一种从整个软鳄梨中获得不可皂化的鳄梨油的方法。 所述不可皂化的含脂肪族乙酰胆酸和/或其衍生物。 本发明还涉及一种富含不可皂化的鳄梨油，可通过该方法获得。 本发明还涉及鳄梨油用于制备富含不可皂化的鳄梨油的浓缩物或不可皂化的富含脂肪族呋喃的鳄梨油。 最后，本发明涉及不可皂化的富含脂肪呋喃的鳄梨或富含不皂化油的鳄梨油浓缩物，可从所述鳄梨油获得，用于药物，有利地用于预防和/或治疗结缔组织疾病，例如 作为关节病，关节病变如眩晕症或传染疾病，例如牙龈炎或牙菌斑。
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公开(公告)号：US11484559B2
公开(公告)日：2022-11-01
申请号：US16956220
申请日：2018-12-21
Applicant: Laboratoires Expanscience
Inventor： Sophie Leclere-Bienfait , Stéphanie Bredif
IPC: A61K36/185 , A61K8/9789 , A61K8/365 , A61Q19/00 , A61Q19/08
Abstract: The invention relates to an extract of flowers, preferably calyxes, from kapok trees, in particular Bombax costatum, to a process for preparing same and to the extract obtainable by said process. The invention also relates to a composition comprising such an extract, the composition being advantageously a cosmetic, pharmaceutical or dermatological composition. The invention also relates to such a composition or such an extract for use in preventing or treating disorders or diseases of the skin, the mucous membranes or keratinous appendages and for use in preventing or treating vascular disorders. The invention finally relates to a cosmetic care process for the skin, the keratinous appendages or the mucous membranes, with a view to improving the condition thereof or the appearance thereof, which process consists in administering such a composition or such an extract.
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公开(公告)号：US20220249446A1
公开(公告)日：2022-08-11
申请号：US17624692
申请日：2020-07-13
Applicant: Laboratoires Expanscience
Inventor： Stephanie BREDIF , Sophie LECLERE-BIENFAIT , David DURANCET
Abstract: The present invention relates to a composition comprising at least one oxazoline, such as OX100, for inhibiting the growth of Malassezia yeasts and/or for preventing and/or treating conditions caused by Malassezia yeasts, seborrheic dermatitis, cradle cap, Malassezia folliculitis, dandruff, Pityriasis versicolor or Pityriasis capitis. The present invention also relates to a composition comprising at least one oxazoline such as OX100, at least one compound such as malic acid diester and a vegetable oil oleodistillate and/or arabinogalactan, and to the use of same for preventing and/or treating, in particular, affections caused by Malassezia yeasts, seborrheic dermatitis, cradle cap, Malassezia folliculitis, dandruff, Pityriasis versicolor or Pityriasis capitis.
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