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    RECONSTITUTED NIPPLE SKIN MODEL
    3.
    发明申请
    RECONSTITUTED NIPPLE SKIN MODEL 审中-公开
    重建鼻孔皮肤模型

    公开(公告)号：US20160326492A1

    公开(公告)日：2016-11-10

    申请号：US15110826

    申请日：2015-01-12

    Applicant: LABORATOIRES EXPANSCIENCE

    Inventor： Stephanie BREDIF ,  Caroline BAUDOUIN ,  Philippe MSIKA ,  Marisa MELONI

    IPC: C12N5/071 ,  G01N33/50 ,  C07K14/78

    CPC classification number: C12N5/0629 ,  C07K14/495 ,  C07K14/52 ,  C07K14/78 ,  C12N5/0698 ,  C12N9/0006 ,  C12N2533/54 ,  G01N33/5082 ,  G01N33/5088 ,  G01N2333/47 ,  G01N2333/495 ,  G01N2333/525 ,  G01N2333/7055 ,  G01N2333/904

    Abstract: A first subject of the invention is a skin model characterized in that it comprises keratinocytes capable of overexpressing filaggrin. A second subject of the invention is a method for evaluating the in vitro activity of a formulation or of at least one active agent on the healing of nipple skin and/or on the reduction of nipple skin inflammation, characterized in that said method comprises at least the following steps: a) bringing said active agent or said formulation into contact with a skin model comprising keratinocytes overexpressing filaggrin and also comprising a lesion; b) measuring the level of production of at least one biological marker in the nipple skin model of step a), characterized in that said biological marker can be chosen from lactate dehydrogenase (LDH), TNFα, filaggrin, TGFβ1 and β1 integrin; c) comparing the level of production of at least one biological marker obtained in step b) with a reference level of production; evaluating the efficacy of said active agent or of said formulation according to the comparison of step c).

    Abstract translation: 本发明的第一主题是皮肤模型，其特征在于其包含能够过表达丝聚蛋白的角质形成细胞。 本发明的第二个主题是用于评估制剂或至少一种活性剂对乳头皮肤愈合和/或降低乳头皮肤炎症的体外活性的方法，其特征在于所述方法至少包括 以下步骤：a）使所述活性剂或所述制剂与包含过表达丝聚蛋白并且还包含病变的角质形成细胞的皮肤模型接触; b）测量步骤a）的乳头皮肤模型中至少一种生物标志物的产生水平，其特征在于所述生物标志物可以选自乳酸脱氢酶（LDH），TNFα，丝聚蛋白，TGFβ1和β1整联蛋白; c）将步骤b）中获得的至少一种生物标志物的产量水平与参考生产水平进行比较; 根据步骤c）的比较评估所述活性剂或所述制剂的功效。

    Extract of Chlamydomonas Acidophila, Method for Preparing Same and Cosmetic Compositions and Dermatological Compositions Comprising Same
    7.
    发明申请
    Extract of Chlamydomonas Acidophila, Method for Preparing Same and Cosmetic Compositions and Dermatological Compositions Comprising Same 有权

    公开(公告)号：US20220071891A1

    公开(公告)日：2022-03-10

    申请号：US17416868

    申请日：2019-12-30

    Applicant: Laboratoires Expanscience

    Inventor： Sophie LECLERE-BIENFAIT ,  Stephanie BREDIF

    IPC: A61K8/9722 ,  A61Q19/00

    Abstract: The invention relates to a peptide extract of the microalga Chlamydomonas acidophila, and to a method for the preparation thereof. The invention also relates to a composition, advantageously a cosmetic or dermatological composition, comprising such an extract. The invention also relates to such a composition or such an extract for use in the prevention or treatment of disorders or diseases affecting the skin, mucous membranes or skin appendages, for use in the prevention or treatment of vascular disorders, or else for use in the prevention or treatment of adipose tissue modifications. The invention finally relates to a cosmetic care process for the skin, the skin appendages or the mucous membranes, with a view to improving the condition thereof or the appearance thereof, which process consists in administering such a composition or such an extract.

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