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1.Method of treatment for lymphedema comprising administering a polynucleotide encoding VEGF-D 失效
标题翻译: 治疗淋巴水肿的方法包括给予编码VEGF-D的多核苷酸公开(公告)号:US08357669B2
公开(公告)日:2013-01-22
申请号:US13242082
申请日:2011-09-23
IPC分类号: A61K48/00
CPC分类号: C12Q1/6883 , A61K35/44 , A61K38/1866 , A61K48/00 , C07K14/71 , C12Q2600/156 , A61K2300/00
摘要: The present invention provides materials and methods for screening for and treating hereditary lymphedema in human subjects.
摘要翻译: 本发明提供用于筛选和治疗人类受试者遗传性淋巴水肿的材料和方法。
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公开(公告)号:US07829536B2
公开(公告)日:2010-11-09
申请号:US12366359
申请日:2009-02-05
IPC分类号: A61K38/00
CPC分类号: C12Q1/6883 , A61K35/44 , A61K38/1866 , A61K48/00 , C07K14/71 , C12Q2600/156 , A61K2300/00
摘要: The present invention provides materials and methods for screening for and treating hereditary lymphedema in human subjects.
摘要翻译: 本发明提供用于筛选和治疗人类受试者遗传性淋巴水肿的材料和方法。
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3.SCREENING AND THERAPY FOR LYMPHATIC DISORDERS INVOLVING THE FLT4 RECEPTOR TYROSINE KINASE (VEGFR-3) 失效
标题翻译: 涉及FLT4受体酪氨酸激酶(VEGFR-3)的淋巴系统疾病的筛选和治疗公开(公告)号:US20090191166A1
公开(公告)日:2009-07-30
申请号:US12366359
申请日:2009-02-05
CPC分类号: C12Q1/6883 , A61K35/44 , A61K38/1866 , A61K48/00 , C07K14/71 , C12Q2600/156 , A61K2300/00
摘要: The present invention provides materials and methods for screening for and treating hereditary lymphedema in human subjects.
摘要翻译: 本发明提供用于筛选和治疗人类受试者遗传性淋巴水肿的材料和方法。
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公开(公告)号:US20080147045A1
公开(公告)日:2008-06-19
申请号:US11782225
申请日:2007-07-24
申请人: Kari Alitalo , Anne Saaristo , Marika Karkkainen , Tuomas Tammela , Sirpa Asko-Seljavaara , Seppo Yla-Herttuala , Yulong He
发明人: Kari Alitalo , Anne Saaristo , Marika Karkkainen , Tuomas Tammela , Sirpa Asko-Seljavaara , Seppo Yla-Herttuala , Yulong He
IPC分类号: A61M5/00 , A61F13/00 , A61K31/7088 , A61P41/00
CPC分类号: C07K14/52 , A61K35/36 , A61K38/1866 , A61K48/00 , A61L15/44 , A61L17/005 , A61L27/227 , A61L27/60 , A61L2300/252 , A61L2300/258 , A61L2300/414 , C07K2319/035 , A61K2300/00
摘要: The present invention provides materials and methods for repairing tissue and using vascular endothelial growth factor C (VEGF-C) genes and/or proteins. Methods and materials related to the use of VEGF-C for the reduction of edema and improvement of skin perfusion is provided. Also provided is are materials and methods for using VEGF-C before, during, and after reconstructive surgery.
摘要翻译: 本发明提供了修复组织并使用血管内皮生长因子C(VEGF-C)基因和/或蛋白质的材料和方法。 提供了与使用VEGF-C相关的用于减少水肿和改善皮肤灌注的方法和材料。 还提供了在重建手术之前,期间和之后使用VEGF-C的材料和方法。
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5.VEGF-C or VEGF-D materials and methods for treatment of neuropathologies 审中-公开
标题翻译: VEGF-C或VEGF-D材料及治疗神经病理学的方法公开(公告)号:US20070082848A1
公开(公告)日:2007-04-12
申请号:US11600479
申请日:2006-11-16
IPC分类号: A61K38/18
CPC分类号: A61K38/179 , A61K31/00 , A61K31/13 , A61K31/137 , A61K31/198 , A61K31/27 , A61K31/4045 , A61K31/445 , A61K31/473 , A61K31/55 , A61K35/30 , A61K38/177 , A61K38/185 , A61K38/1866 , A61K39/395 , C07K16/18 , C12N5/0623 , C12N2501/165 , G01N33/6863 , G01N33/74 , G01N2333/71 , G01N2500/00 , G01N2500/02 , A61K2300/00
摘要: The present invention relates to VEGF-C or VEGF-D materials and methods for promoting growth and differentiation of neural stem cells and materials and methods for administering said cells to inhibit neuropathology.
摘要翻译: 本发明涉及VEGF-C或VEGF-D材料以及用于促进神经干细胞的生长和分化的方法以及用于施用所述细胞以抑制神经病理学的材料和方法。
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6.Screening for lymphatic disorders involving the FLT4 receptor tyrosine kinase (VEGFR-3) 失效
标题翻译: 筛查涉及FLT4受体酪氨酸激酶(VEGFR-3)的淋巴系统疾病公开(公告)号:US06764820B2
公开(公告)日:2004-07-20
申请号:US09375248
申请日:1999-08-16
IPC分类号: C12Q168
CPC分类号: A61K38/1866 , A61K35/44 , A61K48/00 , C07K14/71 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , A61K2300/00
摘要: The present invention provides materials and methods for screening for and treating hereditary lymphedema in human subjects.
摘要翻译: 本发明提供用于筛选和治疗人类受试者遗传性淋巴水肿的材料和方法。
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7.Screening and Therapy for Lymphatic Disorders Involving the FLT4 Receptor Tyrosine Kinase (VEGFR-3) 审中-公开
标题翻译: 涉及FLT4受体酪氨酸激酶(VEGFR-3)的淋巴系统疾病筛查与治疗公开(公告)号:US20110065636A1
公开(公告)日:2011-03-17
申请号:US12941034
申请日:2010-11-06
CPC分类号: C12Q1/6883 , A61K35/44 , A61K38/1866 , A61K48/00 , C07K14/71 , C12Q2600/156 , A61K2300/00
摘要: The present invention provides materials and methods for screening for and treating hereditary lymphedema in human subjects.
摘要翻译: 本发明提供用于筛选和治疗人类受试者遗传性淋巴水肿的材料和方法。
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8.SCREENING AND THERAPY FOR LYMPHATIC DISORDERS INVOLVING THE FLT4 RECEPTOR TYROSINE KINASE (VEGFR-3) 失效
标题翻译: 涉及FLT4受体酪氨酸激酶(VEGFR-3)的淋巴系统疾病的筛选和治疗公开(公告)号:US20120010276A1
公开(公告)日:2012-01-12
申请号:US13242082
申请日:2011-09-23
IPC分类号: A61K31/7088 , A61P43/00
CPC分类号: C12Q1/6883 , A61K35/44 , A61K38/1866 , A61K48/00 , C07K14/71 , C12Q2600/156 , A61K2300/00
摘要: The present invention provides materials and methods for screening for and treating hereditary lymphedema in human subjects.
摘要翻译: 本发明提供用于筛选和治疗人类受试者遗传性淋巴水肿的材料和方法。
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公开(公告)号:US20100041605A1
公开(公告)日:2010-02-18
申请号:US12490037
申请日:2009-06-23
申请人: Kari Alitalo , Anne Saaristo , Marika Karkkainen , Tuomas Tammela , Sirpa Asko-Seljavaara , Seppo Yla-Herttuala , Yulong He
发明人: Kari Alitalo , Anne Saaristo , Marika Karkkainen , Tuomas Tammela , Sirpa Asko-Seljavaara , Seppo Yla-Herttuala , Yulong He
CPC分类号: C07K14/52 , A61K35/36 , A61K38/1866 , A61K48/00 , A61L15/44 , A61L17/005 , A61L27/227 , A61L27/60 , A61L2300/252 , A61L2300/258 , A61L2300/414 , C07K2319/035 , A61K2300/00
摘要: The present invention provides materials and methods for repairing tissue and using vascular endothelial growth factor C (VEGF-C) genes and/or proteins. Methods and materials related to the use of VEGF-C for the reduction of edema and improvement of skin perfusion is provided. Also provided is are materials and methods for using VEGF-C before, during, and after reconstructive surgery.
摘要翻译: 本发明提供了修复组织并使用血管内皮生长因子C(VEGF-C)基因和/或蛋白质的材料和方法。 提供了与使用VEGF-C相关的用于减少水肿和改善皮肤灌注的方法和材料。 还提供了在重建手术之前,期间和之后使用VEGF-C的材料和方法。
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10.Vegf-C or Vegf-D Materials and Methods for Stimulation of Neural Stem cells 审中-公开
标题翻译: Vegf-C或Vegf-D刺激神经干细胞的材料和方法公开(公告)号:US20080057028A1
公开(公告)日:2008-03-06
申请号:US10573135
申请日:2004-09-23
申请人: Kari Alitalo , Marika Karkkainen , Paula Haiko , Kirsi Sainio , Kirmo Wartiovaara , Jean L. Thomas , Anne Eichmann
发明人: Kari Alitalo , Marika Karkkainen , Paula Haiko , Kirsi Sainio , Kirmo Wartiovaara , Jean L. Thomas , Anne Eichmann
IPC分类号: A61K38/18 , A61K31/7088 , A61K35/28 , A61K38/21 , A61P43/00 , C12N5/00 , C12Q1/02 , C12N5/08 , C12N15/63 , A61P25/00 , A61K38/20 , A61K38/16
CPC分类号: C07K14/52 , A61K31/7088 , A61K38/18 , A61K38/1858 , A61K38/1866 , G01N33/5058 , G01N33/5073 , A61K2300/00
摘要: The present invention relates to VEGF-C or VEGF-D materials and methods for promoting growth and differentiation of neural stem cells, neuronal and neuronal precursor cells, oligodendrocytes and oligodendrocyte precursor cells and materials and methods for administering said cells to inhibit neuropathology.
摘要翻译: 本发明涉及VEGF-C或VEGF-D材料以及用于促进神经干细胞,神经元和神经元前体细胞,少突胶质细胞和少突胶质细胞前体细胞的生长和分化的方法以及用于施用所述细胞以抑制神经病理学的材料和方法。
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