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公开(公告)号:US08143241B2
公开(公告)日:2012-03-27
申请号:US11245735
申请日:2005-10-06
Applicant: Alan Ashworth , Stephen Jackson , Niall Martin , Graeme Smith , Mark O'Connor
Inventor: Alan Ashworth , Stephen Jackson , Niall Martin , Graeme Smith , Mark O'Connor
IPC: A61K31/50 , A61K31/44 , A61K31/415 , A01N43/00
CPC classification number: A61K31/366 , A61K31/405 , A61K31/4184 , A61K31/4706 , A61K31/473 , A61K31/502 , A61K31/517 , A61K31/522 , A61K31/675 , Y02A50/473
Abstract: The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR dependent DNA DSB repair. Methods and means relating to the treatment of cancers which are deficient in HR dependent DNA DSB repair using inhibitors which target base excision repair components, such as PARP, is provided herein.
Abstract translation: 本发明涉及对在HR依赖性DNA DSB修复缺陷的细胞中碱基切除修复途径的抑制选择性致死的认识。 本文提供了使用靶向基础切除修复组分(如PARP)的抑制剂治疗缺乏HR依赖性DNA DSB修复的癌症治疗方法和手段。
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公开(公告)号:US08444411B2
公开(公告)日:2013-05-21
申请号:US11719041
申请日:2005-11-14
Applicant: Simon Mark O'Connor , Richard James Price , Nigel Peter Webley , Mark Boss
Inventor: Simon Mark O'Connor , Richard James Price , Nigel Peter Webley , Mark Boss
IPC: F23G7/08
CPC classification number: F23G7/08 , B63J99/00 , B63J2099/003 , F23M5/085 , Y02T70/5263
Abstract: An incinerator (20) for disposing of boil-off gas on an LNG carrier comprises a combustion section (40) wherein the boil-off gas admitted at (42) is burned in the presence of combustion air admitted at (44), producing a flame (46) and combustion products (C). Dilution air (A) is delivered into the combustion section (40) and mixed with the combustion products (C) to produce a diluted mixture (M). The combustion section (40) has an inner wall (48) and an outer wall (50) together defining a first passage (52) through which the dilution air (A) is passed before being mixed with the combustion products (C), whereby the dilution air A cools the combustion section (40). The dilution air A in the first passage (52) also provides a thermally insulting layer limiting radial heat transmission from the combustion section (40). A proportion (AP) of the dilution air is mixed directly with the combustion products (C).
Abstract translation: 一种用于处理LNG运输工具上的蒸发气体的焚化炉(20)包括一个燃烧部分(40),其中在(42)中进入的蒸发气体在(44)中进入燃烧空气的存在下燃烧, 火焰(46)和燃烧产物(C)。 稀释空气(A)被输送到燃烧部分(40)中并与燃烧产物(C)混合以产生稀释的混合物(M)。 燃烧部分(40)具有内壁(48)和外壁(50),共同限定出第一通道(52),稀释空气(A)在与燃烧产物(C)混合之前通过该第一通道,从而 稀释空气A冷却燃烧部分(40)。 第一通道(52)中的稀释空气A还提供限制来自燃烧部分(40)的径向热传递的热绝缘层。 稀释空气的比例(AP)直接与燃烧产物(C)混合。
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公开(公告)号:US20060142231A1
公开(公告)日:2006-06-29
申请号:US11245735
申请日:2005-10-06
Applicant: Alan Ashworth , Stephen Jackson , Niall Martin , Graeme Smith , Mark O'Connor
Inventor: Alan Ashworth , Stephen Jackson , Niall Martin , Graeme Smith , Mark O'Connor
IPC: A61K48/00 , A61K31/522 , A61K31/502 , A61K31/473 , A61K31/517 , A61K31/4704 , A61K31/4035 , A61K31/366
CPC classification number: A61K31/366 , A61K31/405 , A61K31/4184 , A61K31/4706 , A61K31/473 , A61K31/502 , A61K31/517 , A61K31/522 , A61K31/675 , Y02A50/473
Abstract: DNA Damage Repair Inhibitors for Treatment of Cancer The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR dependent DNA DSB repair. Methods and means relating to the treatment of cancers which are deficient in HR dependent DNA DSB repair using inhibitors which target base excision repair components, such as PARP, is provided herein.
Abstract translation: 用于治疗癌症的DNA损伤修复抑制剂本发明涉及对在HR依赖性DNA DSB修复缺陷的细胞中碱基切除修复途径的抑制选择性致死的认识。 本文提供了使用靶向基础切除修复组分(如PARP)的抑制剂治疗缺乏HR依赖性DNA DSB修复的癌症治疗方法和手段。
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公开(公告)号:US20120291879A1
公开(公告)日:2012-11-22
申请号:US13575944
申请日:2010-12-22
Applicant: Simon Mark O'Connor
Inventor: Simon Mark O'Connor
IPC: F16K49/00
CPC classification number: F02C3/20 , B63B27/24 , B63J2099/003 , F02C1/06 , F05D2220/60 , F23G7/08 , Y02T70/34 , Y02T70/5263 , Y10T137/6443
Abstract: The loading of crude oil into a storage tank (12) at A causes vent gas comprising a. mixture of VOC and inert gas to be vented from the tank (12) at C. The vent gas is compressed and delivered at D to a burner (32) of a boiler (34). The burner also receives, at F, a supply of oil (14) as a support fuel to provide stable combustion, the supply of oil (14) being adjusted automatically according to the Wobbe Index and flow rate of the vent gas. Steam generated in the boiler (34) from the burning of the fuels is used to heat the oil (14), to counter waxiness, or for other purposes.
Abstract translation: 在A处将原油装载到储罐(12)中会导致排放气体包括a。 在C处将VOC和惰性气体的混合物从罐(12)排出。排气被压缩并在D处输送到锅炉(34)的燃烧器(32)。 燃烧器还在F处接收作为支撑燃料的油(14)的供应以提供稳定的燃烧,根据沃泊指数和排气的流量自动调节供油(14)。 在锅炉(34)中从燃料燃烧产生的蒸汽用于加热油(14),以防止蜡质或用于其它目的。
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公开(公告)号:US5140764A
公开(公告)日:1992-08-25
申请号:US724109
申请日:1985-04-17
Applicant: Mark O'Connor
Inventor: Mark O'Connor
CPC classification number: B42F7/02 , G03B21/64 , Y10T428/24769 , Y10T428/26
Abstract: A multi-channel transparent jacket for accommodating strips of microfilm to create a microfiche, the jacket having non-blocking characteristics, thereby minimizing the tendency of one jacket in a stack thereof to stick to an adjacent jacket. The jacket is constituted by front and rear panels formed of flexible polyethylene terephthalate film joined together by a parallel array of ribs to define the channels. The exposed surfaces of the panels have a friction-reducing layer thereon constituted by a multiplicity of discrete silicon dioxide nodules bonded to the film, the nodule shape approximating a surface segment of a sphere. The peaks of the segments form microscopic contact points which are bonded by molecular attraction to an abutting panel when the jacket is juxtaposed against a like jacket in frictional relationship thereto. The nodules have a relatively large average diameter whereby the population density thereof in a unit area of the layer produces multiple contact points resulting in a coefficient of friction whose value imparts non-blocking characteristics to the jacket to a degree permitting tangential displacement thereof with a like jacket sticking thereto.
Abstract translation: 一种多通道透明护套,用于容纳微缩胶卷条以产生缩微胶片,该夹克具有非阻挡特性,从而最小化其一个夹套在其叠层中粘附到相邻护套上的趋势。 护套由前后面板组成,前面板和后面板由柔性聚对苯二甲酸乙二醇酯薄膜组成,通过平行排列的棱线连接在一起,以限定通道。 面板的暴露表面在其上具有摩擦减小层,由多个离散的二氧化硅结块构成,其结合到膜上,结节形状接近球体的表面段。 这些段的峰形成微小的接触点,当夹套与其摩擦关系的相似的夹套并置时,它们通过分子吸引而与邻接面板结合。 结节具有相对较大的平均直径,由此其在该层的单位面积中的群体密度产生多个接触点,导致摩擦系数,其值赋予护套非阻塞特性至允许其与其相切的位移的程度 贴在其上的夹克
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公开(公告)号:US4497128A
公开(公告)日:1985-02-05
申请号:US174900
申请日:1980-08-04
Applicant: Mark O'Connor
Inventor: Mark O'Connor
CPC classification number: B42F15/0005
Abstract: A single-channel microfiche master housing a strip of microfilm containing one or more frames of reduced scale images, the master being manipulatable in one axial direction only by optical readers and other microfiche-handling machines. The master is constituted by a rectangular tab having a pair of keyhole notches at spaced positions in the lower edge thereof and a single channel transparent jacket accommodating the microfilm strip, one end of the jacket being secured to the tab at a position intermediate the notches to form a T-shaped structure. The microfiche master may be stored in a standard pull-out drawer by a raised pair of rails which is bridged by the tab, the rails passing through the notches whereby the jacket is suspended therebelow in the drawer.
Abstract translation: 单通道缩微胶片主机容纳包含一个或多个缩小比例图像的微缩胶片,该主机仅在光学读取器和其它缩微胶片处理机器的一个轴向方向上可操作。 主机由在其下边缘处的间隔位置处具有一对键孔凹口的矩形凸片和容纳微缩胶片条的单通道透明夹克构成,该夹套的一端在凹口至中间的位置固定到凸片 形成T形结构。 缩微胶片主机可以通过凸起的一对轨道存储在标准的拉出抽屉中,凸起的一对导轨通过凸片桥接,导轨穿过凹口,由此夹套在其下方悬挂在抽屉中。
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