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    Medicines for topic use based on sulfated hyaluronic acid as activating or inhibiting agent of the cytokine activity
    1.
    发明授权
    Medicines for topic use based on sulfated hyaluronic acid as activating or inhibiting agent of the cytokine activity 有权
    基于硫酸化透明质酸作为细胞因子活性的活化或抑制剂的主题使用药物

    公开(公告)号：US09504708B2

    公开(公告)日：2016-11-29

    申请号：US13320000

    申请日：2010-05-14

    申请人： Matteo D'Este ,  Giovanni Gennari

    发明人： Matteo D'Este ,  Giovanni Gennari

    IPC分类号： A61K31/737 ,  A61K45/06 ,  A61K31/136

    摘要： The object of the present invention relates to the new and surprising use of sulfated hyaluronic acid (HAS) as regulator agent of the cytokine activity (pro- and anti-inflammatory) and consequently the use of HAS for the preparation of a new medicine for topic use in the prevention and treatment of pathologies associated with the activation and/or deficiency of cytokines of a pro- and anti-inflammatory nature. The Applicant has in fact discovered the exclusive capacity of HAS in modulating the activity of these particular proteins, it has studied the action mechanism and demonstrated the substantial difference between the different sulfated types known in the state of the art, but above all it has demonstrated an unexpectedly high activity of HAS vs different types and strains of Herpes virus, Cytomegalovirus and the virus of vesicular stomatitis. Finally, a further object of the present invention is the use of HAS as a skin absorption promoter of drugs of an anti-inflammatory nature.

    摘要翻译： 本发明的目的涉及硫酸化透明质酸（HAS）作为细胞因子活性（促炎和消炎）的调节剂的新颖且令人惊奇的用途，因此使用HAS来制备用于主题的新药 用于预防和治疗与促炎和抗炎性质的细胞因子的活化和/或缺乏相关的病理学。 申请人实际上已经发现HAS在调节这些特定蛋白质的活性方面的排他能力，已经研究了作用机制，并证明了现有技术中已知的不同硫酸化类型之间的显着差异，但首先它已经证实 HAS对疱疹病毒，巨细胞病毒和水泡性口炎病毒的不同类型和毒株的意想不到的高活性。 最后，本发明的另一个目的是使用HAS作为抗炎性质的药物的皮肤吸收促进剂。

    NEW MEDICINES FOR TOPIC USE BASED ON SULFATED HYALURONIC ACID AS ACTIVATING OR INHIBITING AGENT OF THE CYTOKINE ACTIVITY
    4.
    发明申请
    NEW MEDICINES FOR TOPIC USE BASED ON SULFATED HYALURONIC ACID AS ACTIVATING OR INHIBITING AGENT OF THE CYTOKINE ACTIVITY 审中-公开
    用于基于硫酸化的丙二酸的主要用途的新药物作为细胞因子活性的活化剂或抑制剂

    公开(公告)号：US20120121572A1

    公开(公告)日：2012-05-17

    申请号：US13320000

    申请日：2010-05-14

    申请人： Matteo D'Este ,  Giovanni Gennari

    发明人： Matteo D'Este ,  Giovanni Gennari

    IPC分类号： A61K31/737 ,  A61P17/00 ,  A61P17/06 ,  A61P29/00 ,  A61P11/06 ,  A61K38/47 ,  A61P35/00 ,  A61K38/02 ,  A61P31/22 ,  A61P7/02 ,  A61K38/43 ,  A61K38/48 ,  C08B37/08 ,  A61P37/06

    CPC分类号： C08B37/00 ,  A61K8/735 ,  A61K9/0014 ,  A61K9/007 ,  A61K31/136 ,  A61K31/737 ,  A61K38/47 ,  A61K45/06 ,  A61Q1/06 ,  A61Q11/00 ,  C12Y302/01035 ,  A61K2300/00

    摘要： The object of the present invention relates to the new and surprising use of sulfated hyaluronic acid (HAS) as regulator agent of the cytokine activity (pro- and anti-inflammatory) and consequently the use of HAS for the preparation of a new medicine for topic use in the prevention and treatment of pathologies associated with the activation and/or deficiency of cytokines of a pro- and anti-inflammatory nature. The Applicant has in fact discovered the exclusive capacity of HAS in modulating the activity of these particular proteins, it has studied the action mechanism and demonstrated the substantial difference between the different sulfated types known in the state of the art, but above all it has demonstrated an unexpectedly high activity of HAS vs different types and strains of Herpes virus, Cytomegalovirus and the virus of vesicular stomatitis. Finally, a further object of the present invention is the use of HAS as a skin absorption promoter of drugs of an anti-inflammatory nature.

    摘要翻译： 本发明的目的涉及硫酸化透明质酸（HAS）作为细胞因子活性（促炎和消炎）的调节剂的新颖且令人惊奇的用途，因此使用HAS来制备用于主题的新药 用于预防和治疗与促炎和抗炎性质的细胞因子的活化和/或缺乏相关的病理学。 申请人实际上已经发现HAS在调节这些特定蛋白质的活性方面的排他能力，已经研究了作用机制，并证明了现有技术中已知的不同硫酸化类型之间的显着差异，但首先它已经证实 HAS对疱疹病毒，巨细胞病毒和水泡性口炎病毒的不同类型和毒株的意想不到的高活性。 最后，本发明的另一个目的是使用HAS作为抗炎性质的药物的皮肤吸收促进剂。

    Process for the synthesis of conjugates of glycosaminoglycanes (GAG) with biologically active molecules, polymeric conjugates and relative uses thereof
    6.
    发明授权
    Process for the synthesis of conjugates of glycosaminoglycanes (GAG) with biologically active molecules, polymeric conjugates and relative uses thereof 有权
    用于合成糖胺聚糖（GAG）与生物活性分子，聚合物共轭物的缀合物的方法及其相关用途

    公开(公告)号：US09034624B2

    公开(公告)日：2015-05-19

    申请号：US13378660

    申请日：2010-06-04

    申请人： Matteo D'Este ,  Davide Renier ,  Gianfranco Pasut ,  Antonio Rosato

    发明人： Matteo D'Este ,  Davide Renier ,  Gianfranco Pasut ,  Antonio Rosato

    IPC分类号： C08B37/08 ,  A61K31/726 ,  C08B37/00

    CPC分类号： C08B37/0072 ,  A61K31/726 ,  C08B37/0063 ,  C08B37/0069 ,  C08B37/0075

    摘要： The present invention relates to a process for the synthesis of conjugates of glycosaminoglycanes (GAG) with biologically active molecules of varying nature, comprising small molecules and macro-molecules. In particular, the present invention relates to the conjugation of hyaluronic acid (HA) and its derivatives with polypeptides and proteins with a biological action, such as, for example, interferons, erythropoietins, growth factors, insulin, cytokines, antibodies and hormones.An object of the present invention also relates to isolatable intermediates obtained by the partial or total reaction of GAG with protected amino aldehydes in the conjugation process mentioned above.

    摘要翻译： 本发明涉及一种用于合成糖胺聚糖（GAG）与不同性质的生物活性分子的缀合物的方法，其包含小分子和大分子。 特别地，本发明涉及透明质酸（HA）及其衍生物与具有生物作用的多肽和蛋白质（例如干扰素，促红细胞生成素，生长因子，胰岛素，细胞因子，抗体和激素）的缀合。 本发明的目的还涉及通过上述共轭方法中GAG与被保护的氨基醛的部分或全部反应获得的可分离的中间体。